Efficacy and safety of fluconazole prophylaxis in extremely low birth weight infants: multicenter pre-post cohort study

Abstract Background: Peritoneal dialysis (PD) has been used occasionally in extremely-low-birth-weight (ELBW) infants with acute kidney injury (AKI). This study aimed to evaluate the clinical characteristics and outcomes of ELBW infants with AKI treated with PD.Methods: In this retrospective cohort study, the medical records of ELBW infants with AKI, who underwent PD from January 2008 to February 2018, were reviewed. A PD catheter (7.5–9.0 Fr) or central venous catheter (4 Fr) was used for the peritoneal access. Treatment with PD solutions (2.5 or 4.25%) was started at 10 mL/kg, which was increased to 20–30 mL/kg for 60–120 min/cycle continuing for 24 hours.Results: Twelve ELBW infants (seven male and five female infants) were treated, and their mean gestational age and birth weight were 27.2 (±3.3) weeks and 706.5 (±220.5) g, respectively. Two patients had severe perinatal asphyxia (5-min Apgar score ≤ 3). The most important indication for starting PD was AKI due to sepsis. The average duration of PD was 9.4 (± 7.7) days. The potassium levels in the ELBW infants with hyperkalemia decreased from 6.8 to 5.0 mg/mL after 9.3 (± 4.4) days. The most common complication of PD was mechanical dysfunction of the catheters, such as dialysate leakage (75 %). Two patients were successful weaned off PD. The mortality rate of the infants treated with PD was 91.7 %.Conclusions: The mortality rate of ELBW infants with AKI treated with PD is quite high because their organ system is not completely developed. Therefore, the use of PD should be carefully considered for the treatment of ELBW infants with AKI in terms of decisions regarding resuscitation.

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Effect of Peritoneal Dialysis on Extremely Low Birth Weight Infants: A Retrospective Cohort Study

10.21203/rs.2.17326/v2 ◽

2020 ◽

Author(s):

Jihyun Noh ◽

Chae Young Kim ◽

Euiseok Jung ◽

Joo Hoon Lee ◽

Young-Seo Park ◽

...

Keyword(s):

Cohort Study ◽

Peritoneal Dialysis ◽

Birth Weight ◽

Mortality Rate ◽

Low Birth Weight ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Perinatal Asphyxia ◽

Extremely Low Birth Weight ◽

Low Birth Weight Infants

Abstract Background: Peritoneal dialysis (PD) has been used occasionally in extremely-low-birth-weight (ELBW) infants with acute kidney injury (AKI). This study aimed to evaluate the clinical characteristics and outcomes of ELBW infants with AKI treated with PD.Methods: In this retrospective cohort study, the medical records of ELBW infants with AKI, who underwent PD from January 2008 to February 2018, were reviewed. A PD catheter (7.5–9.0 Fr) or central venous catheter (4 Fr) was used for the peritoneal access. Treatment with PD solutions (2.5 or 4.25%) was started at 10 mL/kg, which was increased to 20–30 mL/kg for 60–120 min/cycle continuing for 24 hours.Results: Twelve ELBW infants (seven male and five female infants) were treated, and their mean gestational age and birth weight were 27.2 (±3.3) weeks and 706.5 (±220.5) g, respectively. There were two patients who had severe perinatal asphyxia (5-min Apgar score ≤3). The most important indication for starting PD was AKI due to sepsis. The average duration of PD was 9.4 (±7.7) days. The potassium levels in the ELBW infants with hyperkalemia decreased from 6.8 to 5.0 mg/mL after 9.3 (±4.4) days. The most common complication of PD was mechanical dysfunction of the catheters, such as dialysate leakage (75%). Two patients were successful weaned off PD. The mortality rate of the infants treated with PD was 91.7%.Conclusions: The mortality rate of ELBW infants with AKI treated with PD is quite high because their organ system is not completely developed. Therefore, the use of PD should be carefully considered for the treatment of ELBW infants with AKI.

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PT10.1: The Efficacy and Safety of High Dose Intravenous Lipid Administration to Extremely Low Birth Weight Infants in the Early Neonatal Period

Clinical Nutrition ◽

10.1016/s0261-5614(16)30338-7 ◽

2016 ◽

Vol 35 ◽

pp. S41-S42

Author(s):

J. Yoon ◽

H. Park ◽

Y. In ◽

Y. Lee ◽

J. Seo

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Neonatal Period ◽

Extremely Low Birth Weight ◽

High Dose ◽

Efficacy And Safety ◽

Low Birth Weight Infants ◽

Early Neonatal Period

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Efficacy of Fluconazole Prophylaxis for Prevention of Invasive Fungal Infection in Extremely Low Birth Weight Infants

Yearbook of Neonatal and Perinatal Medicine ◽

10.1016/s8756-5005(10)79236-2 ◽

2010 ◽

Vol 2010 ◽

pp. 58-59

Author(s):

A.A. Fanaroff

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Fungal Infection ◽

Invasive Fungal Infection ◽

Extremely Low Birth Weight ◽

Low Birth Weight Infants ◽

Fluconazole Prophylaxis

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Clinical characteristics of newborn with different birth weight (results of a multicenter cohort study)

Pediatrician (St Petersburg) ◽

10.17816/ped7467-76 ◽

2016 ◽

Vol 7 (4) ◽

pp. 67-76 ◽

Cited By ~ 1

Author(s):

Ivan A Deev ◽

Kristina V Kulikova ◽

Olga S Kobyakova ◽

Evgeny S Kulikov ◽

Aleksandr V Holopov ◽

...

Keyword(s):

Cohort Study ◽

Birth Weight ◽

Low Birth Weight ◽

Clinical Characteristics ◽

Very Low Birth Weight ◽

Fruit Body ◽

Extremely Low Birth Weight ◽

Low Birth Weight Infants ◽

Multicenter Cohort Study ◽

Multicenter Cohort

This article is dedicated to analysis of clinical characteristics of children with different birth weight included in the multicenter cohort study of newborns. The study analyzed data 572 children who were stratified according to birth weight (normal, low, very low and extremely low body weight). As part of the protocol incorporating the patient’s visit was provided at the time of birth (visit 0), a retrospective collection of anamnestic data about the mother (Visit -1) and visit prospective study of children aged 12 months (Visit 1). As a result of the analysis, it was found that the increase in frequency of operative delivery, and reduction of Apgar score and the presence of the studied pathological conditions, to the greatest extent, common in children who had birth weight of less than 1500 in this case. The probability of a combination of 3 or more conditions (described in this paper), in the case of a child with an extremely low birth weight was higher in the 44-fold (OR = 44.52; CI95% 15,5-127,5), while when the newborn had very low birth weight - a chance of development was significantly higher only in the 7-fold (OR = 7.12; CI95% 2,4-20,9) compared with children who had a low birth weight. In this regard, there is a need not only to the use of modern technologies nursing of low birth weight infants, but also provide preventive care in a group of women with a high degree of perinatal risk and risk of preterm delivery, allowing prolong pregnancy up to 32 weeks and/or weight of the fruit body of more than 1000 g, which can improve the survival rates of patients and the prevention of premature severe disabling conditions in the future.

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