Adiposity influences airway wall thickness and the asthma phenotype of HIV-associated obstructive lung disease: a cross-sectional study

Abstract Background Functional Respiratory Imaging (FRI) combines HRCT scans with computational fluid dynamics to provide objective and quantitative information about lung structure and function. FRI has proven its value in pulmonary diseases such as COPD and asthma, but limited studies have focused on cystic fibrosis (CF). This study aims to investigate the relation of multiple FRI parameters to validated imaging parameters and classical respiratory outcomes in a CF population. Methods CF patients aged > 5 years scheduled for a chest CT were recruited in a cross-sectional study. FRI outcomes included regional airway volume, airway wall volume, airway resistance, lobar volume, air trapping and pulmonary blood distribution. Besides FRI, CT scans were independently evaluated by 2 readers using the CF-CT score. Spirometry and the 6-Minute Walk Test (6MWT) were also performed. Statistical tests included linear mixed-effects models, repeated measures correlations, Pearson and Spearman correlations. Results 39 CT scans of 24 (17M/7F) subjects were analyzed. Patients were 24 ± 9 years old and had a ppFEV1 of 71 ± 25% at the time of the first CT. All FRI parameters showed significant low-to-moderate correlations with the total CF-CT score, except for lobar volume. When considering the relation between FRI parameters and similar CF-CT subscores, significant correlations were found between parameters related to airway volume, air trapping and airway wall thickening. Air trapping, lobar volume after normal expiration and pulmonary blood distribution showed significant associations with all spirometric parameters and oxygen saturation at the end of 6MWT. In addition, air trapping was the only parameter related to the distance covered during 6MWT. A subgroup analysis showed considerably higher correlations in patients with mild lung disease (ppFEV1 ≥ 70%) compared to patients with moderate to severe lung disease (ppFEV1 < 70%) when comparing FRI to CF-CT scores. Conclusions Multiple structural characteristics determined by FRI were associated with abnormalities determined by CF-CT score. Air trapping and pulmonary blood distribution appeared to be the most clinically relevant FRI parameters for CF patients due to their associations with classical outcome measures. The FRI methodology could particularly be of interest for patients with mild lung disease, although this should be confirmed in future research.

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Prevalence and management of patients using medication targeting obstructive lung disease: A cross-sectional study in primary healthcare in Greenland

International Journal of Circumpolar Health ◽

10.3402/ijch.v72i0.20108 ◽

2013 ◽

Vol 72 (1) ◽

pp. 20108 ◽

Cited By ~ 2

Author(s):

Sequssuna Olsen ◽

Dorte Ejg Jarbøl ◽

Mette Kofoed ◽

Kim Abildskov ◽

Michael Lynge Pedersen

Keyword(s):

Lung Disease ◽

Primary Healthcare ◽

Obstructive Lung Disease ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional

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Prevalence and quality of care among patients using medication targeting obstructive lung disease: a cross-sectional study in the five regions of Greenland

International Journal of Circumpolar Health ◽

10.1080/22423982.2021.1948244 ◽

2021 ◽

Vol 80 (1) ◽

pp. 1948244

Author(s):

Mathilde Vesterager Lauridsen ◽

Marie Balslev Backe ◽

Eva Cecilie Bonefeld-Jørgensen ◽

Nils Skovgaard ◽

Michael Lynge Pedersen

Keyword(s):

Quality Of Care ◽

Lung Disease ◽

Obstructive Lung Disease ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional

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2318. Prevalence of Influenza-like Illness in Sheltered Homeless Populations: A Cross-Sectional Study in Seattle, WA

Open Forum Infectious Diseases ◽

10.1093/ofid/ofz360.1996 ◽

2019 ◽

Vol 6 (Supplement_2) ◽

pp. S795-S795 ◽

Cited By ~ 1

Author(s):

Julia H Rogers ◽

Elisabeth Brandstetter ◽

Caitlin Wolf ◽

Jennifer Logue ◽

Ashley E Kim ◽

...

Keyword(s):

Health Insurance ◽

Lung Disease ◽

Chronic Lung Disease ◽

Respiratory Illness ◽

Cross Sectional Study ◽

Chronic Obstructive ◽

Sectional Study ◽

Cross Sectional ◽

Influenza Like Illness ◽

Increased Risk

Abstract Background Individuals experiencing homelessness are at an increased risk of respiratory illness due to high prevalence of underlying chronic conditions, inadequate ventilation and crowding in shelters, and difficulty accessing health services. Few studies have investigated the prevalence and transmission of viral respiratory infections within shelters. We sought to determine the prevalence and risk factors for influenza-like illness (ILI) at two homeless shelters in Seattle, WA. Methods Between January and April 2019, we conducted a cross-sectional study of adults experiencing homelessness who identified their primary residence as one of the two shelters in Seattle. Participants voluntarily enrolled if they self-reported at least two symptoms of acute respiratory illness in the past week. Demographic, clinical, and behavioral data were ascertained via questionnaire, and a mid-nasal swab was collected. ILI was defined as fever with cough or sore throat. Chronic lung disease was defined as chronic obstructive pulmonary disease, asthma, and/or chronic bronchitis. Results Among the 480 participants enrolled in the study, 204 (42.5%) reported ILI symptoms. Of those enrolled, 144 (30.0%) had chronic lung disease. The prevalence of ILI was higher among individuals with chronic lung disease (53.5% vs. 42.5%, P = 0.001). A total of 422 (87.9%) had health insurance; the prevalence of ILI was lower among those with health insurance (42.4% vs. 57.8%, P = 0.66). 216 (45.0%) of participants received flu vaccine; the prevalence of ILI was similar among those who received the vaccine than those that did not (42.6% vs. 42.4%, P = 1.00). 129 (30.6%) of those with health insurance sought care for their reported symptoms; ILI was more prevalent in those that sought care than those that did not throughout the observation period (33.8% vs. 21.7%, P = 0.002). Of those with ILI that sought care, 46 (54.8%, P = 0.42) received antivirals or antibiotics. Laboratory results for the corresponding mid-nasal swabs are pending. Conclusion A large proportion of our study population self-reported ILI and chronic lung disease. Despite high insurance coverage, a low proportion of homeless enrolled sought care for their symptoms or received treatment. Disclosures All authors: No reported disclosures.

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Noncommunicable Lung Disease in Sub-Saharan Africa. A Community-based Cross-Sectional Study of Adults in Urban Malawi

American Journal of Respiratory and Critical Care Medicine ◽

10.1164/rccm.201509-1807oc ◽

2016 ◽

Vol 194 (1) ◽

pp. 67-76 ◽

Cited By ~ 41

Author(s):

Jamilah Meghji ◽

Gilbert Nadeau ◽

Kourtney J. Davis ◽

Duolao Wang ◽

Moffat J. Nyirenda ◽

...

Keyword(s):

Lung Disease ◽

Cross Sectional Study ◽

Sub Saharan Africa ◽

Sectional Study ◽

Community Based ◽

Cross Sectional ◽

Sub Saharan

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A low prevalence of rapidly progressive interstitial lung disease in Latin American patients with dermatomyositis: A multicenter cross-sectional study

10.47660/cbr.2020.17022 ◽

2021 ◽

Author(s):

Pablo Arturo Olivo Pallo ◽

Leonardo Santos Hoff ◽

Samuel Katsuyuki Shinjo ◽

Jiram Torres ◽

Amelia Granel

Keyword(s):

Interstitial Lung Disease ◽

Lung Disease ◽

Latin American ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Low Prevalence

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A Comparative Study of the Sarcopenia Screening in Older Patients with Interstitial Lung Disease

10.21203/rs.3.rs-936545/v1 ◽

2021 ◽

Author(s):

Masatoshi Hanada ◽

Noriho Sakamoto ◽

Hiroshi Ishimoto ◽

Takashi Kido ◽

Takuto Miyamura ◽

...

Keyword(s):

Interstitial Lung Disease ◽

Lung Disease ◽

Operating Characteristic ◽

Cross Sectional Study ◽

Screening Tools ◽

Calf Circumference ◽

Sectional Study ◽

Cross Sectional ◽

Receiver Operating Characteristic Curves ◽

Climbing Stairs

Abstract Background: The calf circumference (CalF), the strength, assistance in walking, rising from a chair, climbing stairs, and falls (SARC-F) and the SARC-CalF questionnaires for sarcopenia screening have been used by Asian Working Group for Sarcopenia 2019 (AWGS 2019). The aim of this study was to assess accuracy of these three sarcopenia screening tools in patients with interstitial lung disease. Methods: In this cross-sectional study, stable patients with interstitial lung disease were enrolled. The SARC-F, SARC-CalF, and CalF, used in patients with interstitial lung disease, were compared to the diagnostic criteria proposed by AWGS 2019. The accuracy of screening tools was compared using sensitivity and specificity. Moreover, areas under the receiver operating characteristic curves (AUC) were computed. Results: Seventy eight patients were analyzed, and sarcopenia was identified in 25 (32.1%) patients with interstitial lung disease by the AWGS 2019 criteria. The sensitivity of the CalF was highest (96%) of the three screening tools, while the specificity was 60%. The sensitivity of SARC-F and SARC-CalF were 24% and 68%, while the specificity were 92% and 66%, respectively. The AUCs of CalF, SARC-F, and SARC-CalF in all patients were 0.78, 0.58, and 0.67, respectively. Conclusions: The CalF is most suitable for screening sarcopenia in patients with interstitial lung disease, while SARC-F and SARC-CalF are not.

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