The lung microbiome in end-stage Lymphangioleiomyomatosis

AbstractLymphangioleiomyomatosis (LAM) is a progressive cystic lung disease with mortality driven primarily by respiratory failure. Patients with LAM frequently have respiratory infections, suggestive of a dysregulated microbiome. Here we demonstrate that end-stage LAM patients have a distinct microbiome signature compared to patients with end-stage chronic obstructive pulmonary disease.

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Noninvasive Ventilation in Hypercapnic Acute Respiratory Failure Due to Chronic Obstructive Pulmonary Disease vs Other Conditions: Effectiveness and Predictors of Failure

Yearbook of Pulmonary Disease ◽

10.1016/s8756-3452(08)70221-4 ◽

2006 ◽

Vol 2006 ◽

pp. 275-276

Author(s):

J.A. Barker

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Respiratory Failure ◽

Acute Respiratory Failure ◽

Pulmonary Disease ◽

Noninvasive Ventilation ◽

Chronic Obstructive ◽

Obstructive Pulmonary Disease ◽

Hypercapnic Acute Respiratory Failure

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Treatment of respiratory failure in patients with chronic obstructive pulmonary disease with traditional Chinese medicine

Journal of Chinese Integrative Medicine ◽

10.3736/jcim20050121 ◽

2005 ◽

Vol 3 (1) ◽

pp. 66-69 ◽

Cited By ~ 2

Author(s):

Hui-Qun Pang

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Respiratory Failure ◽

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Pulmonary Disease ◽

Chronic Obstructive ◽

Obstructive Pulmonary Disease

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Microbiome in Chronic Obstructive Pulmonary Disease: Role of Natural Products Against Microbial Pathogens

Current Medicinal Chemistry ◽

10.2174/0929867327666191213110551 ◽

2020 ◽

Vol 27 (18) ◽

pp. 2931-2948

Author(s):

Alessia Santoro ◽

Carlo Tomino ◽

Giulia Prinzi ◽

Vittorio Cardaci ◽

Massimo Fini ◽

...

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Microbial Communities ◽

Pulmonary Disease ◽

Bacterial Infections ◽

Microbial Pathogens ◽

Resistant Bacteria ◽

Chronic Obstructive ◽

Detection Rates ◽

Obstructive Pulmonary Disease ◽

Lung Microbiome

The “microbiome” is the operative term to refer to a collection of all taxa constituting microbial communities, such as bacteria, archaea, fungi and protists (originally microbiota). The microbiome consists of the indigenous microbial communities and of the host environment that they inhabit. Actually, it has been shown that there is a close relationship between the microbiome and human health and disease condition. Although, initially, the lung was considered sterile, actually, the existence of a healthy lung microbiome is usually accepted. Lung microbiome changes are reported in Chronic Obstructive Pulmonary Disease (COPD) and in its exacerbation. Viral and bacterial infections of the respiratory system are a major cause of COPD exacerbations (AECOPD) leading to increased local and systemic inflammation. Detection rates of virus in AECOPD are variable between 25-62% according to the detection method. The study of human airway and lung disease virome is quite recent and still very limited. The purpose of this review is to summarize recent findings on the lung microbiome composition with a special emphasis on virome in COPD and in AECOPD. Some drugs of natural origins active against resistant bacteria and virus are described.

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