scholarly journals Comparisons of simulation results between passive and active fluid structure interaction models for left ventricle in hypertrophic obstructive cardiomyopathy

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Xueying Huang ◽  
Long Deng ◽  
Heng Zuo ◽  
Chun Yang ◽  
Yunhu Song ◽  
...  
Keyword(s):  
Shear Stress ◽  
Left Ventricle ◽  
Boundary Conditions ◽  
Pressure Difference ◽  
Patient Specific ◽  
Mitral Valve Leaflet ◽  
Fluid Structure ◽  
Active Fluid ◽  
Significant Difference ◽  
Simulation Results

Abstract Background Patient-specific active fluid–structure interactions (FSI) model is a useful approach to non-invasively investigate the hemodynamics in the heart. However, it takes a lot of effort to obtain the proper external force boundary conditions for active models, which heavily restrained the time-sensitive clinical applications of active computational models. Methods The simulation results of 12 passive FSI models based on 6 patients’ pre-operative and post-operative CT images were compared with corresponding active models to investigate the differences in hemodynamics and cardiac mechanics between these models. Results In comparing the passive and active models, it was found that there was no significant difference in pressure difference and shear stress on mitral valve leaflet (MVL) at the pre-SAM time point, but a significant difference was found in wall stress on the inner boundary of left ventricle (endocardium). It was also found that pressure difference on the coapted MVL and the shear stress on MVL were significantly decreased after successful surgery in both active and passive models. Conclusion Our results suggested that the passive models may provide good approximated hemodynamic results at 5% RR interval, which is crucial for analyzing the initiation of systolic anterior motion (SAM). Comparing to active models, the passive models decrease the complexity of the modeling construction and the difficulty of convergence significantly. These findings suggest that, with proper boundary conditions and sufficient clinical data, the passive computational model may be a good substitution model for the active model to perform hemodynamic analysis of the initiation of SAM.

scholarly journals Comparisons of Simulation Results between Passive and Active Fluid Structure Interaction Models for Left Ventricle in Hypertrophic Obstructive Cardiomyopathy

2020 ◽  
Author(s):  
Xueying Huang ◽  
Long Deng ◽  
Heng Zuo ◽  
Chun Yang ◽  
Yunhu Song ◽  
...  
Keyword(s):  
Shear Stress ◽  
Left Ventricle ◽  
Boundary Conditions ◽  
Pressure Difference ◽  
Patient Specific ◽  
Mitral Valve Leaflet ◽  
Fluid Structure ◽  
Active Fluid ◽  
Significant Difference ◽  
Simulation Results

Abstract Background. Patient-specific active Fluid-Structure Interactions (FSI) model is a useful approach to non-invasively investigate the hemodynamics in the heart. However, it takes a lot of effort to obtain the proper external force boundary conditions for active models, which heavily restrained the time-sensitive clinical applications of active computational models. Methods. The simulation results of 12 passive FSI models based on 6 patients’ pre-operative and post-operative CT images were compared with corresponding active models to investigate the differences in hemodynamics and cardiac mechanics between these models. Results. In comparing the passive and active models, it was found that there was no significant difference in pressure difference and shear stress on mitral valve leaflet (MVL) at the pre-SAM time point, but a significant difference was found in wall stress on the inner boundary of left ventricle (Endocardium). It was also found that pressure difference on the coapted MVL and the shear stress on MVL were significantly decreased after successful surgery in both active and passive models. Conclusion. Our results suggested that the passive models may provide good approximated hemodynamic results at 5% RR interval, which is crucial for analyzing the initiation of systolic anterior motion (SAM). Comparing to active models, the passive models decrease the complexity of the modeling construction and the difficulty of convergence significantly. These findings suggest that, with proper boundary conditions and sufficient clinical data, the passive computational model may be a good substitution model for the active model to perform hemodynamic analysis of the initiation of SAM.

scholarly journals Comparisons of Simulation Results between Passive and Active FSI Models for Left Ventricle in Hypertrophic Obstructive Cardiomyopathy

2020 ◽  
Author(s):  
Xueying Huang ◽  
Long Deng ◽  
Heng Zuo ◽  
Chun Yang ◽  
Yunhu Song ◽  
...  
Keyword(s):  
Shear Stress ◽  
Left Ventricle ◽  
Boundary Conditions ◽  
Pressure Difference ◽  
Computational Models ◽  
Wall Stress ◽  
Patient Specific ◽  
Mitral Valve Leaflet ◽  
Significant Difference ◽  
Simulation Results

Abstract Background. Patient-specific active Fluid-Structure Interactions (FSI) model is a useful approach to non-invasively investigate the hemodynamics in the heart. However, it takes a lot of effort to obtain the proper external force boundary conditions for active models, which heavily restrained the time-sensitive clinical applications for active computational models. Methods. The simulation results of 12 passive FSI models based on 6 patients’ pre-operative and post-operative CT images were compared with corresponding active models to investigate the differences in hemodynamics and cardiac mechanics between these models. Results. It was found that there was no significant difference in shear stress and pressure difference on mitral valve leaflet (MVL) between passive and active models, but a significant difference was found in wall stress on the inner boundary of left ventricle (Endocardium). It was also found that flow shear stress and pressure difference on the MVL were significantly decreased after successful surgery in both active and passive models. Conclusion. Our results suggested that the passive models may provide good approximated hemodynamic results at 5% RR interval, which is crucial for analyzing the initiation of systolic anterior motion (SAM). Comparing to active models, the passive models decrease the complexity of the modeling construction and the difficulty of convergence significantly. Therefore, with proper boundary conditions and sufficient clinical data, the passive computational model may be a good substitution model for the active model to perform hemodynamic analysis for left ventricle to investigate the mechanisms of the initiation of SAM.

scholarly journals Comparisons of Simulation Results between Passive and Active FSI Models for Left Ventricle in Hypertrophic Obstructive Cardiomyopathy

2020 ◽  
Author(s):  
Xueying Huang ◽  
Long Deng ◽  
Heng Zuo ◽  
Chun Yang ◽  
Yunhu Song ◽  
...  
Keyword(s):  
Shear Stress ◽  
Left Ventricle ◽  
Boundary Conditions ◽  
Pressure Difference ◽  
Computational Models ◽  
Wall Stress ◽  
Patient Specific ◽  
Mitral Valve Leaflet ◽  
Significant Difference ◽  
Simulation Results

Abstract Background. Patient-specific active Fluid-Structure Interactions (FSI) model is a useful approach to non-invasively investigate the hemodynamics in the heart. However, it takes a lot of effort to obtain the proper external force boundary conditions for active models, which heavily restrained the time-sensitive clinical applications of active computational models. Methods. The simulation results of 12 passive FSI models based on 6 patients’ pre-operative and post-operative CT images were compared with corresponding active models to investigate the differences in hemodynamics and cardiac mechanics between these models. Results. It was found that there was no significant difference in shear stress and pressure difference on mitral valve leaflet (MVL) between passive and active models, but a significant difference was found in wall stress on the inner boundary of left ventricle (Endocardium). It was also found that flow shear stress and pressure difference on the MVL were significantly decreased after successful surgery in both active and passive models.Conclusion. Our results suggested that the passive models may provide good approximated hemodynamic results at 5% RR interval, which is crucial for analyzing the initiation of systolic anterior motion (SAM). Comparing to active models, the passive models decrease the complexity of the modeling construction and the difficulty of convergence significantly. Therefore, with proper boundary conditions and sufficient clinical data, the passive computational model may be a good substitution model for the active model to perform hemodynamic analysis for left ventricle to investigate the mechanisms of the initiation of SAM.

scholarly journals Fluid–structure interactions (FSI) based study of low-density lipoproteins (LDL) uptake in the left coronary artery

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xueping Chen ◽  
Jian Zhuang ◽  
Huanlei Huang ◽  
Yueheng Wu
Keyword(s):  
Shear Stress ◽  
Coronary Artery ◽  
Left Coronary Artery ◽  
Arterial Wall ◽  
Low Density Lipoproteins ◽  
Patient Specific ◽  
Low Density ◽  
Fluid Structure ◽  
Flowing Blood ◽  
Stress Dependent

AbstractThe purpose of this study is to compare the effect of the different physical factors on low-density lipoproteins (LDL) accumulation from flowing blood to the arterial wall of the left coronary arteries. The three-dimensional (3D) computational model of the left coronary arterial tree is reconstructed from a patient-specific computed tomography angiography (CTA) image. The endothelium of the coronary artery is represented by a shear stress dependent three-pore model. Fluid–structure interaction ($$FSI$$ FSI ) based numerical method is used to study the LDL transport from vascular lumen into the arterial wall. The results show that the high elastic property of the arterial wall decreases the complexity of the local flow field in the coronary bifurcation system. The places of high levels of LDL uptake coincide with the regions of low wall shear stress. In addition, hypertension promotes LDL uptake from flowing blood in the arterial wall, while the thickened arterial wall decreases this process. The present computer strategy combining the methods of coronary CTA image 3D reconstruction, $$FSI$$ FSI simulation, and three-pore modeling was illustrated to be effective on the simulation of the distribution and the uptake of LDL. This may have great potential for the early prediction of the local atherosclerosis lesion in the human left coronary artery.

scholarly journals Effects of a Short-Term Left Ventricular Assist Device on Hemodynamics in a Heart Failure Patient-Specific Aorta Model: A CFD Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Yu Wang ◽  
Junwei Wang ◽  
Jing Peng ◽  
Mingming Huo ◽  
Zhiqiang Yang ◽  
...  
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Pressure Difference ◽  
Left Ventricular ◽  
Patient Specific ◽  
Short Term ◽  
Ventricular Assist ◽  
Left Ventricular Assist ◽  
Wall Shear ◽  
Hemodynamic Performance

Patients with heart failure (HF) or undergoing cardiogenic shock and percutaneous coronary intervention require short-term cardiac support. Short-term cardiac support using a left ventricular assist device (LVAD) alters the pressure and flows of the vasculature by enhancing perfusion and improving the hemodynamic performance for the HF patients. However, due to the position of the inflow and outflow of the LVAD, the local hemodynamics within the aorta is altered with the LVAD support. Specifically, blood velocity, wall shear stress, and pressure difference are altered within the aorta. In this study, computational fluid dynamics (CFD) was used to elucidate the effects of a short-term LVAD for hemodynamic performance in a patient-specific aorta model. The three-dimensional (3D) geometric models of a patient-specific aorta and a short-term LVAD, Impella CP, were created. Velocity, wall shear stress, and pressure difference in the patient-specific aorta model with the Impella CP assistance were calculated and compared with the baseline values of the aorta without Impella CP support. Impella CP support augmented cardiac output, blood velocity, wall shear stress, and pressure difference in the aorta. The proposed CFD study could analyze the quantitative changes in the important hemodynamic parameters while considering the effects of Impella CP, and provide a scientific basis for further predicting and assessing the effects of these hemodynamic signals on the aorta.

scholarly journals Numerical investigation of the impact of branching vessel boundary conditions on aortic hemodynamics

2017 ◽  
Vol 3 (2) ◽  
pp. 321-324 ◽  
Author(s):  
Pavlo Yevtushenko ◽  
Florian Hellmeier ◽  
Jan Bruening ◽  
Titus Kuehne ◽  
Leonid Goubergrits
Keyword(s):  
Shear Stress ◽  
Pressure Drop ◽  
Boundary Conditions ◽  
Reference Method ◽  
Patient Specific ◽  
Simplified Method ◽  
The Mean ◽  
The Impact ◽  
Significant Attention ◽  
Aortic Hemodynamics

AbstractCFD has gained significant attention as a tool to model aortic hemodynamics. However, obtaining accurate patient-specific boundary conditions still poses a major challenge and represents a major source of uncertainties, which are difficult to quantify. This study presents an attempt to quantify these uncertainties by comparing 14 patient-specific simulations of the aorta (reference method), each exhibiting stenosis, against simulations using the same geometries without the branching vessels of the aortic arch (simplified method).Results were evaluated by comparing pressure drop along the aorta, secondary flow degree (SFD) and surface-averaged wall shear stress (WSS) for each patient. The comparison shows little difference in pressure drop between the two methods (simplified-reference) with the mean difference being 1.2 mmHg (standard deviation: 3.0 mmHg). SFD and WSS, however, show striking differences between the methods: SFD downstream of the stenosis is on average 61 % higher in the simplified cases, while WSS is on average 3.0 Pa lower in the simplified cases.Although unphysiological, the comparison of both methods gives an upper bound for the error introduced by uncertainties in branching vessel boundary conditions. For the pressure drop this error appears to be remarkably low, while being unacceptably high for SFD and WSS.

Investigation of two-way fluid-structure interaction of blood flow in a patient-specific left coronary artery

2021 ◽  
pp. 1-18
Author(s):  
Abdulgaphur Athani ◽  
N.N.N. Ghazali ◽  
Irfan Anjum Badruddin ◽  
Sarfaraz Kamangar ◽  
Ali E. Anqi ◽  
...  
Keyword(s):  
Blood Flow ◽  
Shear Stress ◽  
Coronary Artery ◽  
Wall Shear Stress ◽  
Left Coronary Artery ◽  
Fluid Structure Interaction ◽  
Patient Specific ◽  
Hemodynamic Parameters ◽  
Fluid Structure ◽  
Structure Interaction

BACKGROUND: The blood flow in the human artery has been a subject of sincere interest due to its prime importance linked with human health. The hemodynamic study has revealed an essential aspect of blood flow that eventually proved to be paramount to make a correct decision to treat patients suffering from cardiac disease. OBJECTIVE: The current study aims to elucidate the two-way fluid-structure interaction (FSI) analysis of the blood flow and the effect of stenosis on hemodynamic parameters. METHODS: A patient-specific 3D model of the left coronary artery was constructed based on computed tomography (CT) images. The blood is assumed to be incompressible, homogenous, and behaves as Non-Newtonian, while the artery is considered as a nonlinear elastic, anisotropic, and incompressible material. Pulsatile flow conditions were applied at the boundary. Two-way coupled FSI modeling approach was used between fluid and solid domain. The hemodynamic parameters such as the pressure, velocity streamline, and wall shear stress were analyzed in the fluid domain and the solid domain deformation. RESULTS: The simulated results reveal that pressure drop exists in the vicinity of stenosis and a recirculation region after the stenosis. It was noted that stenosis leads to high wall stress. The results also demonstrate an overestimation of wall shear stress and velocity in the rigid wall CFD model compared to the FSI model.

scholarly journals Fluid-Structure Interaction Modeling of Abdominal Aortic Aneurysms: The Impact of Patient-Specific Inflow Conditions and Fluid/Solid Coupling

2013 ◽  
Vol 135 (8) ◽  
Author(s):  
Santanu Chandra ◽  
Samarth S. Raut ◽  
Anirban Jana ◽  
Robert W. Biederman ◽  
Mark Doyle ◽  
...  
Keyword(s):  
Velocity Profile ◽  
Boundary Conditions ◽  
Fluid Structure Interaction ◽  
Aortic Aneurysms ◽  
Patient Specific ◽  
Fluid Structure ◽  
Inlet Velocity ◽  
Structure Interaction ◽  
Biomechanical Assessment ◽  
Fully Coupled

Rupture risk assessment of abdominal aortic aneurysms (AAA) by means of biomechanical analysis is a viable alternative to the traditional clinical practice of using a critical diameter for recommending elective repair. However, an accurate prediction of biomechanical parameters, such as mechanical stress, strain, and shear stress, is possible if the AAA models and boundary conditions are truly patient specific. In this work, we present a complete fluid-structure interaction (FSI) framework for patient-specific AAA passive mechanics assessment that utilizes individualized inflow and outflow boundary conditions. The purpose of the study is two-fold: (1) to develop a novel semiautomated methodology that derives velocity components from phase-contrast magnetic resonance images (PC-MRI) in the infrarenal aorta and successfully apply it as an inflow boundary condition for a patient-specific fully coupled FSI analysis and (2) to apply a one-way–coupled FSI analysis and test its efficiency compared to transient computational solid stress and fully coupled FSI analyses for the estimation of AAA biomechanical parameters. For a fully coupled FSI simulation, our results indicate that an inlet velocity profile modeled with three patient-specific velocity components and a velocity profile modeled with only the axial velocity component yield nearly identical maximum principal stress (σ1), maximum principal strain (ε1), and wall shear stress (WSS) distributions. An inlet Womersley velocity profile leads to a 5% difference in peak σ1, 3% in peak ε1, and 14% in peak WSS compared to the three-component inlet velocity profile in the fully coupled FSI analysis. The peak wall stress and strain were found to be in phase with the systolic inlet flow rate, therefore indicating the necessity to capture the patient-specific hemodynamics by means of FSI modeling. The proposed one-way–coupled FSI approach showed potential for reasonably accurate biomechanical assessment with less computational effort, leading to differences in peak σ1, ε1, and WSS of 14%, 4%, and 18%, respectively, compared to the axial component inlet velocity profile in the fully coupled FSI analysis. The transient computational solid stress approach yielded significantly higher differences in these parameters and is not recommended for accurate assessment of AAA wall passive mechanics. This work demonstrates the influence of the flow dynamics resulting from patient-specific inflow boundary conditions on AAA biomechanical assessment and describes methods to evaluate it through fully coupled and one-way–coupled fluid-structure interaction analysis.

Sensitivity of patient-specific numerical simulation of cerebal aneurysm hemodynamics to inflow boundary conditions

2007 ◽  
Vol 106 (6) ◽  
pp. 1051-1060 ◽  
Author(s):  
Prem Venugopal ◽  
Daniel Valentino ◽  
Holger Schmitt ◽  
J. Pablo Villablanca ◽  
Fernando Viñuela ◽  
...  
Keyword(s):  
Blood Flow ◽  
Shear Stress ◽  
Boundary Conditions ◽  
Numerical Simulations ◽  
Flow Rate ◽  
Artery Aneurysm ◽  
Blood Flow Rate ◽  
Patient Specific ◽  
Stress Distributions ◽  
Flow Rates

Object Due to the difficulty of obtaining patient-specific velocity measurements during imaging, many assumptions have to be made while imposing inflow boundary conditions in numerical simulations conducted using patient-specific, imaging-based cerebral aneurysm models. These assumptions can introduce errors, resulting in lack of agreement between the computed flow fields and the true blood flow in the patient. The purpose of this study is to evaluate the effect of the assumptions made while imposing inflow boundary conditions on aneurysmal hemodynamics. Methods A patient-based anterior communicating artery aneurysm model was selected for this study. The effects of various inflow parameters on numerical simulations conducted using this model were then investigated by varying these parameters over ranges reported in the literature. Specifically, we investigated the effects of heart and blood flow rates as well as the distribution of flow rates in the A1 segments of the anterior cerebral artery. The simulations revealed that the shear stress distributions on the aneurysm surface were largely unaffected by changes in heart rate except at locations where the shear stress magnitudes were small. On the other hand, the shear stress distributions were found to be sensitive to the ratio of the flow rates in the feeding arteries as well as to variations in the blood flow rate. Conclusions Measurement of the blood flow rate as well as the distribution of the flow rates in the patient's feeding arteries may be needed for numerical simulations to accurately reproduce the intraaneurysmal hemodynamics in a specific aneurysm in the clinical setting.

Theoretical Analysis of Laminar Pipe Flow in a Porous Wall Cylinder

1971 ◽  
Vol 93 (2) ◽  
pp. 102-108 ◽  
Author(s):  
L. S. Galowin ◽  
M. J. Desantis
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Boundary Conditions ◽  
Pressure Difference ◽  
Static Pressure ◽  
Flow Direction ◽  
Axial Flow ◽  
Initial Pressure ◽  
Porous Wall ◽  
Wall Shear

A theoretical investigation was conducted to obtain velocity, pressure, and shear stress distributions for incompressible, steady, fully developed, laminar flow through a cylinder with a uniformly porous wall. Ejection/injection at the walls results from the pressure difference across the porous wall. Fluid flow phenomena in porous tubes and ducts have previously been investigated with the velocity prescribed as the boundary condition at the wall. An accurate wall condition must account for the variable wall velocity being dependent upon the pressure difference across the wall, the properties of the fluid, the thickness and the permeability of the structure. An integral momentum technique was employed to reduce the axisymmetric Navier-Stokes equations in cylindrical coordinates to a nonlinear, second-order ordinary differential equation with appropriate boundary conditions. The velocity condition at the wall was established for the ejection/injection at the surface resulting from the pressure difference across the porous wall derived from Darcy’s law. Numerical solutions were obtained for a range of axial flow Reynolds numbers, wall permeabilities, and initial pressure difference across the porous wall. The calculated static pressure variation in the axial flow direction, the velocity components, and the wall shear stress are presented. For the case of fluid ejection, the results of the analysis show that the wall shear stress and static pressure decrease in the axial flow direction. The rates of decrease are functions of the wall porosity, initial pressure gradient across the wall, and inlet flow Reynolds number. The present analysis treats the realistic problem of flow adjustment to the condition where zero pressure differential across the porous wall occurs (the normal wall velocity vanishes). Previous models are based upon the assumptions of constant radial velocity at the wall and/or prescribed wall shear stress without taking into account the pressure drop through the wall. Such assumptions imply that a variable pressure exists external to the pipe, or that the pipe has walls of variable permeability and thickness rather than the hypothesized condition that the pipe has uniformly porous walls. For one set of boundary conditions it is shown that the outflow through the walls completely discharges the entering flow. As a result no far downstream axial flow occurs. Such effects were not previously discussed by other investigators. For other sets of boundary conditions reductions in centerline velocity and shear stress occur.

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