scholarly journals Development of coronary artery lesions in indolent kawasaki disease following initial spontaneous defervescence: a retrospective cohort study

2015 ◽  
Vol 13 (1) ◽  
Author(s):  
Takuto Takahashi ◽  
Hiroshi Sakakibara ◽  
Yoshihiko Morikawa ◽  
Masaru Miura
Keyword(s):  
Cohort Study ◽  
Coronary Artery ◽  
Kawasaki Disease ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Coronary Artery Lesions

scholarly journals Incidence of Kawasaki disease before and during the COVID-19 pandemic: a retrospective cohort study in Japan

2021 ◽  
Vol 5 (1) ◽  
pp. e001034
Author(s):  
Kyohei Iio ◽  
Kousaku Matsubara ◽  
Chisato Miyakoshi ◽  
Kunitaka Ota ◽  
Rika Yamaoka ◽  
...  
Keyword(s):  
Cohort Study ◽  
Kawasaki Disease ◽  
Infectious Diseases ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Bacterial Infections ◽  
Epidemiological Studies ◽  
Primary Objective ◽  
Temporal Association ◽  
Difference In Difference

BackgroundEpidemiological studies in Kawasaki disease (KD) have suggested infectious aetiology. During the COVID-19 pandemic, measures for mitigating SARS-CoV-2 transmission also suppress the circulation of other contagious microorganisms. The primary objective is to compare the number and incidence of KD before and during the COVID-19 pandemic in Japan, and the secondary objective is to investigate temporal association between the KD epidemiology and activities of SARS-CoV-2 and other viral and bacterial infections.MethodsA retrospective cohort study was conducted between 2016 and 2020 in Kobe, Japan. We collected information of hospitalised KD children in Kobe. Child population was identified through the resident registry system. Activity of COVID-19 and 11 other infectious diseases was derived from a public health monitoring system. Monthly change of KD incidence was analysed using a difference-in-difference regression model.ResultsThroughout the study period, 1027 KD children were identified. KD had begun to decline in April 2020, coinciding with the beginning of the COVID-19 pandemic. The number of KD cases (n=66) between April and December 2020 was 40% of the average in the same period in 2016–2019 (165/year). Annual KD incidence was 315, 300, 353, 347 and 188/100 000 children aged 0–4 years in 2016–2020, respectively. The difference-in-difference value of KD incidence was significantly reduced in the fourth quarter in 2020 (−15.8, 95% CI −28.0 to −3.5), compared with that in 2016–2019. Sentinel surveillance showed a marked decrease of all infectious diseases except exanthema subitum after the beginning of the COVID-19 pandemic. There were 86 COVID-19 cases aged <10 years and no KD children associated with COVID-19.ConclusionThis study showed that the number and incidence of KD was dramatically reduced during the COVID-19 pandemic in Japan. This change was temporally associated with decreased activities of various infectious diseases other than COVID-19, supporting the hypothesis of infection-triggered pathogenesis in KD.

Pericardial Effusion in Children Admitted With Kawasaki Disease: A Multicenter Retrospective Cohort Study From the Pediatric Health Information System

2020 ◽  
Vol 60 (1) ◽  
pp. 9-15
Author(s):  
Amy G. Schexnayder ◽  
Xinyu Tang ◽  
R. Thomas Collins ◽  
Stephen M. Schexnayder ◽  
Elijah Holbrook Bolin
Keyword(s):  
Information System ◽  
Cohort Study ◽  
Pericardial Effusion ◽  
Kawasaki Disease ◽  
Length Of Stay ◽  
Health Information ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Health Information System ◽  
Black Children

Pericardial effusion (PCE) can be associated with Kawasaki disease (KD). We performed a multicenter, retrospective cohort study of the Pediatric Health Information System of children admitted with KD to determine the association between PCE and adverse outcomes. A total of 17 422 patients were in the cohort, of which 440 (3%) had PCE. PCE was associated with longer hospital length of stay (adjusted odds ratio [aOR] = 1.23; P < .01) and risk of readmission at 30 days (aOR = 1.42; P = .03). Black children were more likely to have a PCE (aOR = 1.54, P < .01) and longer length of stay (aOR = 1.05; P < .001). These data may support delayed discharge in children with PCE and KD in the hopes of preventing readmission. Special consideration needs to be given to how black children with KD are managed.

scholarly journals Nonlinear Relationship Between HbA1c and Coronary Artery Calcium Score Progression: A Secondary Analysis Based on a Retrospective Cohort Study

2021 ◽  
Author(s):  
Jing Yu ◽  
Bo Gao
Keyword(s):  
Cohort Study ◽  
Heart Disease ◽  
Coronary Artery ◽  
Retrospective Cohort Study ◽  
Coronary Artery Calcium ◽  
Retrospective Cohort ◽  
Coronary Artery Calcium Score ◽  
Secondary Analysis ◽  
Calcium Score ◽  
Non Linear

Abstract ObjectiveSome previous studies was to clarify the correlation between glycated hemoglobin(HbA1c) and coronary heart disease (CHD) and the evidence regarding the correlation was still debated. However, there are fewer scientific dissertations about the correlation between HbA1c and coronary artery calcium score progression. Consequently, the present study was undertaken to explore the link of HbA1c on coronary artery calcium score progression in South Korea.MethodsThis study is a secondary analysis based on a retrospective cohort study. 8151 participants received a health check-up program at the Health Promotion Center of the Samsung Medical Center in Seoul, South Korea, from March 1, 2003 to December 31, 2013. We then used Cox proportional-hazards regression model to evaluate the independent relationship between HbA1c and coronary artery calcium score progression.ResultsAfter adjusting potential confounders (age, sex, BMI, height, weight, SBP, DBP, TC, LDL-C, HDL-C, triglycerides,smoking status, alcohol consumption, reflux esophagitis status, hypertension, diabetes, dyslipidemia, ischemic heart disease and cerebrovascular disease), non-linear relationship was detected between HbA1c and coronary artery calcium score progression, whose point was 5.8%. The effect sizes and the confidence intervals on the left and right sides of inflection point were 2.05 (1.85 to 2.27) and 1.04 (0.99 to 1.10) , respectively. ConclusionThe relationship between HbA1c and coronary artery calcium score progression is non-linear. HbA1c is positively related with coronary artery calcium score progression when HbA1c was less than 5.8%.

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