scholarly journals Patients with enthesitis related arthritis show similar monocyte function pattern as seen in adult axial spondyloarthropathy

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Shruti Bhattacharya ◽  
Ramnath Misra ◽  
Amita Aggarwal
Keyword(s):  
Enthesitis Related Arthritis ◽  
Monocyte Function ◽  
Axial Spondyloarthropathy

Monocyte Function in Rheumatoid Arthritis

1980 ◽  
Vol 9 (1) ◽  
pp. 17-23 ◽  
Author(s):  
Menashe Bar-Eli ◽  
Michael Ehrenfeld ◽  
Yair Litvin ◽  
Ruth Gallily
Keyword(s):  
Rheumatoid Arthritis ◽  
Monocyte Function

scholarly journals Gain-of-function Tibetan PHD2D4E;C127S variant suppresses monocyte function: A lesson in inflammatory response to inspired hypoxia

EBioMedicine ◽  
2021 ◽  
Vol 68 ◽  
pp. 103418
Author(s):  
Sulagna Bhattacharya ◽  
Nishith M Shrimali ◽  
Ghulam Mohammad ◽  
Parvaiz A Koul ◽  
Josef T Prchal ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Gain Of Function ◽  
Monocyte Function

In vivo effects of macrophage colony-stimulating factor on human monocyte function

1991 ◽  
Vol 77 (1) ◽  
pp. 25-31 ◽  
Author(s):  
Asim Khwaja ◽  
Beryl Johnson ◽  
Ian E. Addison ◽  
Kwee Yong ◽  
Karen Ruthven ◽  
...  
Keyword(s):  
Human Monocyte ◽  
Colony Stimulating Factor ◽  
Monocyte Function ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
In Vivo Effects ◽  
Stimulating Factor

Association of HLA-G, HLA-E and HLA-B*27 with susceptibility and clinical phenotype of enthesitis related arthritis (ERA)

2021 ◽  
Author(s):  
Reena Gulati ◽  
G. Chengappa Kavadichanda ◽  
Christina Mary Mariaselvam ◽  
Gunjan Kumar ◽  
Vir Singh Negi
Keyword(s):  
Clinical Phenotype ◽  
Enthesitis Related Arthritis

scholarly journals Cross-sectional and Longitudinal Evaluation of Bone Mass in Children and Young Adults with Juvenile Idiopathic Arthritis: The Role of Bone Mass Determinants in a Large Cohort of Patients

2010 ◽  
Vol 37 (9) ◽  
pp. 1935-1943 ◽  
Author(s):  
STEFANO STAGI ◽  
LAURA MASI ◽  
SERENA CAPANNINI ◽  
ROLANDO CIMAZ ◽  
GIULIA TONINI ◽  
...  
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Bone Mass ◽  
Bone Mineral ◽  
Large Cohort ◽  
Close Monitoring ◽  
Mineral Density ◽  
Cross Sectional ◽  
Bone Mineral Apparent Density ◽  
Longitudinal Evaluation ◽  
Enthesitis Related Arthritis

Objective.To assess the prevalence of reduced spine bone mineral apparent density (BMAD), and to identify the main predictors of reduced spine BMAD in a cross-sectional and longitudinal evaluation of the same large cohort of patients with juvenile idiopathic arthritis (JIA). There are few prospective data on bone mass evaluation in a large number of patients with JIA, and with enthesitis-related arthritis onset.Methods.Two hundred nineteen patients with JIA (median age 8.7 yrs, range 6.1–13.1 yrs; 104 oligoarticular JIA, 61 polyarticular, 20 systemic, and 34 enthesitis-related arthritis onset) were retrospectively evaluated. A dual-energy x-ray absorptiometry (DEXA) scan at the lumbar spine was performed in all subjects. Of these, 89 consecutive patients were followed up randomly and longitudinally with a second and a third DEXA evaluation. The data obtained were compared with 80 age-matched and sex-matched healthy subjects.Results.At the first DEXA, patients with JIA showed a reduced spine BMAD standard deviation score (SDS) in comparison to controls (p < 0.001). These results were confirmed when the subjects were divided into JIA subtypes (p < 0.005) with the exception of enthesitis-related arthritis onset. Spine BMAD SDS significantly correlated with JIA onset type (p < 0.01), age at JIA onset (p < 0.005), and flares (p = 0.008). The longitudinal evaluation showed that spine BMAD SDS did not significantly improve at the followup in comparison to controls, in all subsets with JIA except for systemic onset (p < 0.05). Spine BMAD correlated with sex (p < 0.01), systemic corticosteroid exposure (p < 0.01), the number of intraarticular corticosteroid injections (p < 0.01), the interval from last steroid injection (p < 0.05), erythrocyte sedimentation rate (p < 0.005), and C-reactive protein levels (p < 0.005).Conclusion.Patients with JIA have a low bone mass and, after a first increase due to therapy, do not reach a healthy condition over time despite our current more effective drugs. These patients have a high risk of osteoporosis in early adulthood. To reduce the risk and improve the bone mass, close monitoring of bone mineral density, better control of disease activity, physical activity, and intake of calcium and vitamin D are recommended. In patients with osteoporosis, therapeutic approaches including bisphosphonates should be considered.

Th1 and Th17 Predominance in the Enthesitis-related Arthritis Form of Juvenile Idiopathic Arthritis

2009 ◽  
Vol 36 (8) ◽  
pp. 1730-1736 ◽  
Author(s):  
ANKIT MAHENDRA ◽  
RAMNATH MISRA ◽  
AMITA AGGARWAL
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Synovial Fluid ◽  
Peripheral Blood ◽  
Th17 Cells ◽  
Transforming Growth Factor ◽  
Health Assessment ◽  
Treg Cells ◽  
Th2 Cells ◽  
Median Frequency ◽  
Enthesitis Related Arthritis

Objective.A Th1 biased immune response in synovial fluid has been reported in children with polyarticular and extended oligoarticular-type juvenile idiopathic arthritis (JIA). We investigated T cell phenotypes including Th1, Th2, Th17, and Treg with emphasis on Th17 and Treg, in order to differentiate cytokines in the enthesitis-related arthritis (ERA) form of JIA.Methods.The frequencies of Th1, Th2, Th17, and Treg cells were determined by flow cytometry in peripheral blood (PB) and synovial fluid from patients with ERA and healthy subjects. Levels of interleukin 1ß (IL-1ß), IL-6, IL-21, IL-23, and transforming growth factor ß (TGF-ß), cytokines that influence Th17 lineage cells, were measured in paired plasma and synovial fluid (SF) samples by ELISA. Frequencies are expressed as percentages and cytokine levels as pg/ml.Results.There were no differences in blood samples in the frequency of Th1, Th2, Th17, and Treg cells between patients and controls. In paired samples, the median frequency of CD4+IFN-γ+ (20.49 vs 4.03; p < 0.005) and CD4+IL-17+ (2.27 vs 0.57; p < 0.01) cells was significantly higher in SF compared to PB, respectively; whereas the frequency of CD4+IL-4+ (1.79 vs 2.29; p < 0.04) cells was significantly reduced in the SF compared to PB. There was no difference in the frequency of regulatory T cells. Patients receiving methotrexate had fewer Th2 cells, whereas the Childhood Health Assessment Questionnaire score had a negative association with the frequency of Treg. Median levels of IL-1ß (p < 0.008), IL-6 (p < 0.0001), and IL-17 (p < 0.0001) were higher in SF than in plasma and levels of TGF-ß were lower (p < 0.001). Levels of IL-21 were similar in SF and plasma, whereas IL-23 was undetectable.Conclusion.In patients with ERA, peripheral blood Th1, Th2, Th17, and Treg cells were unchanged, but Th1 and Th17 cells were increased and Th2 cells were reduced in the SF compared to blood. Elevated IL-1ß and IL-6 in SF may be responsible for increased Th17 cells.

scholarly journals Diffusion-weighted imaging is a sensitive biomarker of response to biologic therapy in enthesitis-related arthritis

Rheumatology ◽  
2016 ◽  
pp. kew429
Author(s):  
Timothy J. P. Bray ◽  
Kanimozhi Vendhan ◽  
Nicola Ambrose ◽  
David Atkinson ◽  
Shonit Punwani ◽  
...  
Keyword(s):  
Diffusion Weighted Imaging ◽  
Biologic Therapy ◽  
Enthesitis Related Arthritis ◽  
Diffusion Weighted
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