scholarly journals Clinical characteristics of lactational breast abscess caused by methicillin-resistant Staphylococcus aureus: hospital-based study in China

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Yan Li ◽  
Xiang-jun Ma ◽  
Xiang-ping He
Keyword(s):  
Staphylococcus Aureus ◽  
Postpartum Period ◽  
Treatment Duration ◽  
Maternal Age ◽  
Clinical Characteristics ◽  
Antibiotic Use ◽  
Needle Aspiration ◽  
Breast Abscess ◽  
Methicillin Resistant ◽  
First Choice

Abstract Background This study aimed to identify the differences in clinical characteristics, puncture efficacy, antibiotic use, treatment duration, breastfeeding post-illness, and recurrence of patients with breast abscesses caused by methicillin-resistant Staphylococcus aureus (MRSA) or methicillin-susceptible Staphylococcus aureus (MSSA) infection during lactation. Methods The clinical data of patients with breast abscesses during lactation who were treated from January 2014 to February 2017 at Haidian Maternal and Child Health Hospital, Beijing, were reviewed. According to bacterial culture results, they were divided into MRSA (n = 260) and MSSA (n = 962) groups. Hospitalization (whether or not the patients were hospitalized), postpartum period, maternal age, location of abscess cavities, number of abscess cavities, amount of pus, frequency of needle aspiration, failure of needle aspiration, antibiotic use, treatment duration, cessation of breastfeeding and recurrence were compared between the two groups using a t-test and a chi-squared test. Results We noted that only the cessation of breastfeeding was statistically significantly different between the two groups (P = 0.018). Hospitalization, postpartum period, maternal age, location of abscess cavities, number of abscess cavities, amount of pus, number of needle aspiration, failure of needle aspiration, antibiotic use, treatment duration and recurrence showed no statistically significant differences (P = 0.488, P = 0.328, P = 0.494, P = 0.218, P = 0.088, P = 0.102, P = 0.712, P = 0.336, P = 0.512, P = 0.386 and P = 0.359, respectively). Conclusions There was no difference in clinical characteristics between breast abscesses infected by MRSA and those infected by MSSA. Ultrasound-guided needle aspiration could be the first choice for MRSA-infected breast abscess treatment. There is no need to increase antibiotic use because of MRSA infection, unless it is necessary. The reason why more patients with MRSA infected breast abscesses terminated breastfeeding is unclear from this study.

scholarly journals Clinical characteristics of breast abscesses induced by methicillin-resistant Staphylococcus aureus during lactation

2020 ◽  
Author(s):  
Yan Li ◽  
Xiangjun Ma ◽  
Xingping He
Keyword(s):  
Staphylococcus Aureus ◽  
Treatment Duration ◽  
Clinical Characteristics ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Clinical Manifestations ◽  
Antibiotic Use ◽  
Maximum Amount ◽  
Methicillin Resistant ◽  
Chi Squared ◽  
Mrsa Infection

Abstract Background This study aims to identify the differences in patients with breast abscesses in combination with the infection of methicillin-resistant Staphylococcus aureus (MRSA) or with methicillin-susceptible Staphylococcus aureus (MSSA) during lactation in the clinical characteristics, efficacy of puncture, antibiotic use, treatment duration, breastfeeding after illness and recurrence. Methods Clinical data of patients with breast abscesses during lactation who were treated in our hospital from January 2014 to February 2017 were reviewed. According to bacterial culture results, they were divided into MRSA (n = 260) and MSSA (n = 962) groups. The hospitalisation, postpartum time, age, location of abscess cavities, number of abscess cavities, maximum amount of punctured pus, frequency of punctures, failure of puncture, antibiotic use, treatment duration, delactation and recurrence were compared between groups using a t-test and a chi-squared test. Results The statistical analysis showed that only delactation was statistically significantly different between the groups (P = 0.018). Hospitalisation, postpartum time, age, location of abscess cavities, number of abscess cavities, maximum amount of punctured pus, frequency of punctures, failure of puncture, antibiotic use, treatment duration and recurrence showed no statistically significant differences (P = 0.488, P = 0.328, P = 0.494, P = 0.218, P = 0.088, P = 0.102, P = 0.712, P = 0.336, P = 0.512, P = 0.386 and P = 0.359, respectively). Conclusion Patients with breast abscesses combined with MRSA infection during lactation presented no significant differences in the clinical manifestations, efficacy of puncture, antibiotic use or treatment duration from those with MSSA infection. However, the patients infected with MRSA were more susceptible to delactation after illness.

scholarly journals Are Lactational Breast Abscesses caused by Methicillin-resistant Staphylococcus aureus Special?

2020 ◽  
Author(s):  
Yan Li ◽  
Xiangjun Ma ◽  
Xiangping He
Keyword(s):  
Staphylococcus Aureus ◽  
Treatment Duration ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Clinical Manifestations ◽  
Antibiotic Use ◽  
Needle Aspiration ◽  
Methicillin Resistant ◽  
Chi Squared ◽  
Mrsa Infection ◽  
Mssa Infection

Abstract Background: This study aimed to identify the differences in clinical characteristics, puncture efficacy, antibiotic use, treatment duration, breastfeeding postillness, and recurrence of patients with breast abscesses caused by methicillin-resistant Staphylococcus aureus (MRSA) or methicillin-susceptible Staphylococcus aureus (MSSA) infection during lactation.Methods: The clinical data of patients with breast abscesses during lactation who were treated in our hospital from January 2014 to February 2017 were reviewed. According to bacterial culture results, they were divided into MRSA (n = 260) and MSSA (n = 962) groups. Hospitalization (whether or not the patients were hospitalized), postpartum time, age, location of abscess cavities, number of abscess cavities, amount of pus, frequency of needle aspiration, failure of needle aspiration, antibiotic use, treatment duration, delactation and recurrence were compared between the two groups using a t-test and a chi-squared test.Results: We noted that only delactation was statistically significantly different between the two groups (P = 0.018). Hospitalization, postpartum time, age, location of abscess cavities, number of abscess cavities, amount of pus, frequency of needle aspiration, failure of needle aspiration, antibiotic use, treatment duration and recurrence showed no statistically significant differences (P = 0.488, P = 0.328, P = 0.494, P = 0.218, P = 0.088, P = 0.102, P = 0.712, P = 0.336, P = 0.512, P = 0.386 and P = 0.359, respectively). Conclusion: Patients with breast abscesses caused by MRSA infection during lactation presented no significant differences in the clinical manifestations, needle aspiration efficacy, antibiotic use or treatment duration compare with those caused by MSSA infection. However, patients with MRSA infected were more susceptible to delectation.

scholarly journals Multimicrobial Pneumonia during the Early Stages of a Global Pandemic

2021 ◽  
Vol 8 (6) ◽  
Author(s):  
Jalal H ◽  
◽  
Henriksen G ◽  
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Acute Infection ◽  
Standard Of Care ◽  
Antibiotic Use ◽  
Lung Parenchyma ◽  
Community Acquired Pneumonia ◽  
Methicillin Resistant ◽  
Global Pandemic

Community-acquired pneumonia is an acute infection of lung parenchyma which causes local and systemic inflammatory changes via cytokines. Several bacteria and viruses are responsible for this type of pneumonia, and the most common bacterial cause is Streptococcus pneumoniae. The classic symptoms are cough, fever, and pleuritic chest pain. In the Winter of 2020, a new strain of coronavirus known as SARS-CoV-2 spread throughout the world and was responsible for a global pandemic that transformed the way we live our lives. A 93-year old female presented to the hospital with respiratory distress and was found to have not only COVID-19 pneumonia but also superimposed Methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa pneumonia. Following the most up-to-date guidelines, she was determined to have community-acquired pneumonia. Methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa are uncommon causes of communityacquired pneumonia. She was treated with the standard of care at the time, which included vancomycin, piperacillin-tazobactam, and hydroxychloroquine. This case highlights the rarity of this specific presentation of community acquired pneumonia in regards to microbial etiology. It showcases that patients may develop certain diseases despite not having any risk factors. A major takeaway point is that apt decision making is a critical and time sensitive matter when determining whether a bacterial co-infection is present since it can affect patient outcomes. Since co-infections are relatively infrequent, antibiotic use in COVID-19 positive patients needs to be tailored accordingly. At the same time, it is crucial to keep in mind that co-infections are associated with increased severity of COVID-19 as well as poorer outcomes.

scholarly journals Clinical predictors of methicillin-resistance and their impact on mortality associated with Staphylococcus aureus bacteraemia

2018 ◽  
Vol 146 (10) ◽  
pp. 1326-1336 ◽  
Author(s):  
Y. M. Wi ◽  
J. Y. Rhee ◽  
C. I. Kang ◽  
D. R. Chung ◽  
J. H. Song ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Clinical Characteristics ◽  
Independent Predictor ◽  
Methicillin Resistance ◽  
Antibiotic Use ◽  
Clinical Predictors ◽  
Clinical Difference ◽  
Epidemiological Risk ◽  
Patients At Risk ◽  
Community Onset

AbstractWe investigated the clinical predictors of methicillin-resistance and their impact on mortality in 371 patients with Staphylococcus aureus bacteraemia identified from two prospective multi-centre studies. Methicillin resistant S. aureus (MRSA) accounted for 42.2% of community-onset and 74.5% of hospital-onset cases. No significant clinical difference was found between patients infected with MRSA vs. methicillin-sensitive S. aureus (MSSA), except that the former were more likely to have had hospital-onset bacteraemia and received antibiotics in the preceding 90 days. After stratifying according to the acquisition site, prior antibiotic use was the only independent predictor of having MRSA in both community-onset and hospital-onset cases. The frequency of inappropriate empirical antibiotic therapy was higher in patients with MRSA than in those with MSSA bacteraemia. However, methicillin resistance was not a predictor of mortality in patients and the clinical characteristics and outcomes of both MRSA and MSSA bacteraemia were similar. This study indicates that there are no definitive clinical or epidemiological risk factors which could distinguish MRSA from MSSA cases with the exception of the previous use of antibiotics for having MRSA bacteraemia, which emphasises the prudent use of glycopeptide treatment of patients at risk for invasive MRSA infections.

scholarly journals Methicillin-Resistant Staphylococcus aureus among Clinical Isolates in Indonesia: A Systematic Review

2020 ◽  
Vol 13 (4) ◽  
pp. 1871-1878
Author(s):  
Rike Syahniar ◽  
Rayhana Rayhana ◽  
Dayu Swasti Kharisma ◽  
Muhammad Khatami ◽  
Dimas Bagus Bramasta Duarsa
Keyword(s):  
Systematic Review ◽  
Staphylococcus Aureus ◽  
Antimicrobial Susceptibility ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Antibiotic Use ◽  
Rapid Diagnosis ◽  
Methicillin Resistant ◽  
Control Programs ◽  
High Infection ◽  
Susceptibility Patterns

BACKGROUND: The high infection of methicillin-resistant Staphylococcus aureus (MRSA) accompanied by increased resistance to many groups of antibiotics is a major concern in the field of infection. This study aims to evaluate the prevalence of MRSA isolates and antimicrobial susceptibility to MRSA isolates in Indonesia. METHODS: We did searches in Pubmed, Proquest, DOAJ, GARUDA, and google scholar for studies published in 2006-2020. Study in Indonesian (Bahasa) and English with the keywords "methicillin-resistant Staphylococcus aureus", "MRSA" and "Indonesia". More than 30 S.aureus isolates derived from human samples were included. RESULTS: A total of 738 articles based on the search results, 13 studies were included in this systematic review. The prevalence of MRSA reported from all studies is 0.3%-52%. The study with the largest prevalence of MRSA was found in Jakarta. The susceptibility of vancomycin antibiotics to MRSA isolates is known to range from 87%-100%. Based on all studies, Linezolid, Tigecycline, Nitrofurantoin, and quinupristin/dalfopristin were reported to have 100% susceptibility. CONCLUSIONS: The prevalence of MRSA is still found high in one of the cities in Indonesia. Surveillance of antibiotic use, monitoring of antimicrobial susceptibility patterns, and antibiotic resistance control programs need to be optimized. MRSA screening is based on a rapid diagnosis when an inpatient admission is also necessary.

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