scholarly journals Intrafractional 6D head movement increases with time of mask fixation during stereotactic intracranial RT-sessions

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Julian Mangesius ◽  
Thomas Seppi ◽  
Rocco Weigel ◽  
Christoph Reinhold Arnold ◽  
Danijela Vasiljevic ◽  
...  
Keyword(s):  
Treatment Duration ◽  
Treatment Time ◽  
Treatment Session ◽  
Head Movements ◽  
Random Errors ◽  
Non Invasive ◽  
Image Guided ◽  
Thermoplastic Mask ◽  
Head Positions ◽  
Entire Treatment

Abstract Background The present study investigates the intrafractional accuracy of a frameless thermoplastic mask used for head immobilization during stereotactic radiotherapy. Non-invasive masks cannot completely prohibit head movements. Previous studies attempted to estimate the magnitude of intrafractional inaccuracy by means of pre- and postfractional measurements only. However, this might not be sufficient to accurately map also intrafractional head movements. Materials and methods Intrafractional deviation of mask-fixed head positions was measured in five patients during a total of 94 fractions by means of close-meshed repeated ExacTrac measurements (every 1.4 min) conducted during the entire treatment session. A median of six (range: 4 to 11) measurements were recorded per fraction, delivering a dataset of 453 measurements. Results Random errors (SD) for the x, y and z axes were 0.27 mm, 0.29 mm and 0.29 mm, respectively. Median 3D deviation was 0.29 mm. Of all 3D intrafractional motions, 5.5 and 0.4% exceeded 1 mm and 2 mm, respectively. A moderate correlation between treatment duration and mean 3D displacement was determined (rs = 0.45). Mean 3D deviation increased from 0.21 mm (SD = 0.26 mm) in the first 2 min to a maximum of 0.53 mm (SD = 0.31 mm) after 10 min of treatment time. Conclusion Pre- and post-treatment measurement is not sufficient to adequately determine the range of intrafractional head motion. Thermoplastic masks provide both reliable interfractional and intrafractional immobilization for image-guided stereotactic hypofractionated radiotherapy. Greater positioning accuracy may be obtained by reducing treatment duration (< 6 min) and applying intrafractional correction. Trial registration Clinicaltrials.gov, NCT03896555, Registered 01 April 2019 - retrospectively registered.

scholarly journals SO093LONGITUDINAL DATA ON TREATMENT DURATION AND COMPLIANCE FROM AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE CLINICAL TRIALS WITH TOLVAPTAN

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Xiaolei Zhou ◽  
Diana Garbinsky ◽  
John Ouyang ◽  
Eric Davenport ◽  
Indra Agarwal ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Clinical Trials ◽  
Treatment Duration ◽  
Treatment Time ◽  
Treatment Compliance ◽  
Kidney Volume ◽  
Total Kidney Volume ◽  
Treatment Gaps ◽  
Clinical Trial Program

Abstract Background and Aims : Observation of impactful clinical outcomes in a clinical trial setting for ADPKD is challenging due to the life-long progressive nature of ADPKD and longer-term associated outcomes of interest in this population (e.g., renal function decline, cardiovascular events, and mortality). Since 2004, the tolvaptan (TOL) clinical trial program enrolled subjects in multiple clinical studies with the opportunity to enroll in subsequent clinical trials for treatment and outcomes evaluation. Method : Data from 6 ADPKD studies (protocols 156-04-250, 156-04-251, 156-06-260, 156-09-284, 156-09-290, 156-08-271) were pooled and evaluated over time for overall treatment duration, treatment time, and treatment gaps. Treatment duration for the individual clinical trials ranged from 1 week to up to 3 years. Results : Overall, 1,437 subjects received TOL in these ADPKD clinical trials. For these subjects, the mean overall treatment duration was 4.1 years (3.8 years on treatment) with a maximum of 9.7 years (9.0 years on treatment). In this cohort, 513 subjects (35.7%) received TOL treatment for more than 5 years. Mean treatment compliance was 94.1%. Overall, 723 subjects (50.3%) received TOL treatment in ≥2 trials, with a median treatment gap duration between trials of 0.1 years (maximum, 5.6 years). At least 7 years of follow-up data are available for estimated glomerular filtration rate in 241 subjects (mean at baseline, 78.6 mL/min/1.73m2) and for total kidney volume in 130 subjects (mean at baseline, 1,816.9 mL). Conclusion : This analysis provides longitudinal follow-up over an extended timeframe in a large number of subjects treated with TOL, with the greatest number of subjects being enrolled in clinical trials enriched for rapidly progressing ADPKD. Treatment compliance over years was reasonably good despite treatment gaps.

“ADMINISTRATION OF PLATELET RICH PLASMA- A SHIFT IN ACCELERATED ORTHODONTICS– A REVIEW “

2021 ◽  
pp. 44-45
Author(s):  
Saraa Angel .L ◽  
Abhijeet Jaiswal
Keyword(s):  
Human Population ◽  
Orthodontic Treatment ◽  
Tooth Movement ◽  
Treatment Time ◽  
Platelet Rich Plasma ◽  
Invasive Procedures ◽  
Non Invasive ◽  
Surgical Methods ◽  
Accelerated Orthodontics ◽  
Economical Alternative

Increasing awareness towards self-appearance and aesthetics has led to increase in overall patients willing to undergo orthodontic treatment. Various surgical and non surgical methods have been tried to reduce the overall orthodontic treatment time. Painless, non invasive procedures are preferred over the traumatic methods. Platelet Rich Plasma (PRP) injection has recently gained popularity due to its safe , relatively painless and economical alternative in accelerating the tooth movement. This article briefs on the researches done in animal and human population so far using PRPand their cumulative effects on tooth movement.

scholarly journals No Survival Benefit in Octogenarians and Nonagenarians with Extended Hemodialysis Treatment Time

2018 ◽  
Vol 48 (5) ◽  
pp. 389-398 ◽  
Author(s):  
Gang Jee Ko ◽  
Yoshitsugu Obi ◽  
Melissa Soohoo ◽  
Tae Ik Chang ◽  
Soo Jeong Choi ◽  
...  
Keyword(s):  
Treatment Time ◽  
Age Groups ◽  
Treatment Session ◽  
Comorbid Conditions ◽  
Session Length ◽  
Fluid Removal ◽  
All Cause Mortality ◽  
Stage Renal Disease ◽  
End Stage ◽  
Solute Clearance

Background: The population of elderly end-stage renal disease patients initiating dialysis is rapidly growing. Although longer treatment is supposed to benefit for hemodialysis (HD) patients through more solute clearance and slower fluid removal, it is not yet clear how treatment session length affects mortality risk in octogenarians and nonagenarians. Methods: In a cohort of 112,026 incident HD patients between 2007 and 2011, we examined the association of treatment session length with all-cause mortality, adjusting for demographics and comorbid conditions. We also used restricted spline functions for age to evaluate continuous changes in the association of short (< 210 min) and extended (≥240 min) HD treatment (vs. 210 to < 240 min) with all-cause mortality over continuous age. Results: During the first 91 days of dialysis, patients aged ≥80 years tended to have the lowest treatment session length (median [interquartile range] 211 [193–230] min, r > 0.5). Longer treatment was associated with better survival in patients < 65 and 65 to < 80 years but not in octogenarians/nonagenarians. The association of extended treatment (≥240 min) with better survival was attenuated across age and not significant among patients aged ≥80 years with a hazard ratio of 1.10 (95% CI 0.99–1.20). Shorter treatment sessions (< 210 min) was associated with higher mortality across all age groups. Conclusion: Extended HD was not associated with lower mortality among octogenarians and nonagenarians, while it was associated with better survival among younger patients. Further studies are needed to determine the optimal treatment session length in elderly incident HD patients.

scholarly journals Failure patterns of different bracket systems and their influence on treatment duration: A retrospective cohort study

2018 ◽  
Vol 88 (3) ◽  
pp. 338-347 ◽  
Author(s):  
Dimitrios Stasinopoulos ◽  
Spyridon N. Papageorgiou ◽  
Frank Kirsch ◽  
Nikolaos Daratsianos ◽  
Andreas Jäger ◽  
...  
Keyword(s):  
Stainless Steel ◽  
Cohort Study ◽  
Confidence Interval ◽  
Retrospective Cohort Study ◽  
Treatment Duration ◽  
Retrospective Cohort ◽  
Treatment Time ◽  
Failure Patterns ◽  
Ceramic Brackets ◽  
Bracket Failure

ABSTRACT Objectives: To compare the failure pattern of four different bracket types and to assess its effect on treatment duration. Materials and Methods: A total of 78 white patients (28 male, 50 female) with a mean age of 12.6 years were included in this retrospective cohort study and treated for a mean period of 30.6 months. The patients were treated in a private practice with stainless steel conventionally ligated brackets, ceramic conventionally ligated brackets, stainless steel self-ligating brackets, or nickel-free self-ligating brackets. The loss of at least one bracket during the course of treatment was analyzed with Cox proportional hazards survival analyses and generalized linear regression. Results: The overall bracket failure rate at the tooth level was 14.1% (217 brackets), with significant differences according to tooth type (between 8.0%–23.4%) and bracket type (between 11.2%–20.0%). After taking confounders into account, patients treated with ceramic brackets lost more brackets (hazard ratio = 1.62; 95% confidence interval = 1.14–2.29; P = .007) than patients with stainless steel brackets. On average, treatment time increased by 0.6 months (95% confidence interval = 0.21–1.05; P = .004) for each additional failed bracket. Conclusions: Bracket failure was more often observed with ceramic brackets and was associated with increased treatment duration.

Image-Guided Positioning in Intracranial Non-Invasive Stereotactic Radiosurgery for the Treatment of Brain Metastasis

2012 ◽  
Vol 98 (5) ◽  
pp. 630-635 ◽  
Author(s):  
Ferrat Dincoglan ◽  
Murat Beyzadeoglu ◽  
Omer Sager ◽  
Kaan Oysul ◽  
Sait Sirin ◽  
...  
Keyword(s):  
Brain Metastasis ◽  
Stereotactic Radiosurgery ◽  
Non Invasive ◽  
Image Guided

Accelerated Partial Breast Irradiation Using Non-Invasive Image-Guided Breast Brachytherapy: Feasibility and Early Experience

Brachytherapy ◽  
2013 ◽  
Vol 12 ◽  
pp. S16 ◽  
Author(s):  
Jaroslaw T. Hepel ◽  
Jessica R. Hiatt ◽  
Sandra Sha ◽  
Kara L. Leonard ◽  
Theresa A. Graves ◽  
...  
Keyword(s):  
Early Experience ◽  
Accelerated Partial Breast Irradiation ◽  
Partial Breast Irradiation ◽  
Breast Irradiation ◽  
Non Invasive ◽  
Image Guided ◽  
Breast Brachytherapy

SU-FF-J-32: A Feasibility Study of Image-Guided Non-Invasive Single-Fraction Stereotactic Radiosurgery Using the 2D2D Match of An On-Board Imaging System

2007 ◽  
Vol 34 (6Part5) ◽  
pp. 2375-2375
Author(s):  
J Chang ◽  
W O'Meara ◽  
J Mechalakos ◽  
Y Yamada ◽  
D Lovelock ◽  
...  
Keyword(s):  
Stereotactic Radiosurgery ◽  
Feasibility Study ◽  
Imaging System ◽  
Single Fraction ◽  
Non Invasive ◽  
Image Guided

SU-FF-T-75: Accuracy Assessment of a Non-Invasive Image Guided System for Intra-Cranial Linac Based Stereotactic Radiosurgery

2006 ◽  
Vol 33 (6Part7) ◽  
pp. 2066-2066 ◽  
Author(s):  
F Hacker ◽  
F Rosca ◽  
S Friesen ◽  
P Zygmanski ◽  
N Ramakrishna
Keyword(s):  
Stereotactic Radiosurgery ◽  
Accuracy Assessment ◽  
Non Invasive ◽  
Image Guided

scholarly journals Orthodontic Treatment Characteristics and Outcomes in an Educational Setting

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
T. Al-Jewair ◽  
V. Ryan ◽  
S. Warunek
Keyword(s):  
Treatment Duration ◽  
Orthodontic Treatment ◽  
Treatment Time ◽  
Pearson Correlation ◽  
Correlation Coefficients ◽  
Educational Setting ◽  
Dental Esthetics ◽  
Treatment Characteristics ◽  
The Mean

Background. To assess and correlate orthodontic treatment characteristics and outcomes in an educational setting. Methods. A total of 287 patients were included. Independent chart reviews were conducted to gather demographic and pretreatment diagnostic information. Posttreatment digital records were graded with the ABO C-R Eval and the CCA methods. Pearson correlation coefficients were calculated to determine associations between variables. Results. Of the 287 patients, 122 (42.5%) were male and 165 (57.5%) were female. The total average treatment time was 33.87 ± 10.28 months, with a range from 11 to 75 months. The mean ABO C-R Eval score was 29.10 ± 8.59 points. The parameters with the highest scores were buccolingual inclination and occlusal contacts. The mean CCA score was 3.36 ± 2.05 points. The highest scores were recorded for dental esthetics and management of the periodontium. Higher ABO DI scores were weakly correlated with longer treatment times (r = 0.258; p<0.001). ABO C-R Eval scores showed a weakly significant association with treatment duration (r = 0.162; p=0.006), while CCA scores were moderately associated with treatment duration (r = 0.451; p<0.001). Conclusions. As treatment duration increased, the total ABO C-R Eval and CCA scores tended to increase; thus, quality of treatment outcomes decreased. A significant positive correlation was also found with the ABO DI score and treatment duration.

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