Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents

Christy C Ong; Sarah Gierke; Cameron Pitt; Meredith Sagolla; Christine K Cheng; Wei Zhou; Adrian M Jubb; Laura Strickland; Maike Schmidt; Sergio G Duron; David A Campbell; Wei Zheng; Seameen Dehdashti; Min Shen; Nora Yang; Mark L Behnke; Wenwei Huang; John C McKew; Jonathan Chernoff; William F Forrest; Peter M Haverty; Suet-Feung Chin; Emad A Rakha; Andrew R Green; Ian O Ellis; Carlos Caldas; Thomas O’Brien; Lori S Friedman; Hartmut Koeppen; Joachim Rudolph; Klaus P Hoeflich

doi:10.1186/s13058-015-0564-5

Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents

Breast Cancer Research ◽

10.1186/s13058-015-0564-5 ◽

2015 ◽

Vol 17 (1) ◽

Cited By ~ 34

Author(s):

Christy C Ong ◽

Sarah Gierke ◽

Cameron Pitt ◽

Meredith Sagolla ◽

Christine K Cheng ◽

...

Keyword(s):

Breast Cancer ◽

Small Molecule ◽

Stabilizing Agents ◽

Small Molecule Inhibition ◽

Group I

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Abstract 186: Small-molecule inhibition of cathepsins L and K as potential therapeutics for macrophage-driven breast cancer

10.1158/1538-7445.am2018-186 ◽

2018 ◽

Author(s):

Samantha S. Dykes ◽

Dietmar W. Siemann

Keyword(s):

Breast Cancer ◽

Small Molecule ◽

Small Molecule Inhibition ◽

Potential Therapeutics

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Genetic and small molecule inhibition of arylamine N -acetyltransferase 1 reduces anchorage-independent growth in human breast cancer cell line MDA-MB-231

Molecular Carcinogenesis ◽

10.1002/mc.22779 ◽

2018 ◽

Vol 57 (4) ◽

pp. 549-558 ◽

Cited By ~ 18

Author(s):

Marcus W. Stepp ◽

Mark A. Doll ◽

Samantha M. Carlisle ◽

J. Christopher States ◽

David W. Hein

Keyword(s):

Breast Cancer ◽

Cell Line ◽

Breast Cancer Cell ◽

Small Molecule ◽

Breast Cancer Cell Line ◽

Human Breast Cancer ◽

Cancer Cell Line ◽

Human Breast Cancer Cell ◽

Human Breast ◽

Small Molecule Inhibition

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Abstract P5-07-03: Small molecule inhibition of smoothened in triple negative breast cancer-associated fibroblasts depletes cancer stem cells and sensitizes to cytotoxic chemotherapy in mice and humans

10.1158/1538-7445.sabcs18-p5-07-03 ◽

2019 ◽

Author(s):

A Swarbrick ◽

A Cazet ◽

M Hui ◽

S O'Toole ◽

E Lim ◽

...

Keyword(s):

Breast Cancer ◽

Stem Cells ◽

Cancer Stem Cells ◽

Small Molecule ◽

Triple Negative Breast Cancer ◽

Triple Negative ◽

Cytotoxic Chemotherapy ◽

Cancer Associated Fibroblasts ◽

Small Molecule Inhibition

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Small-molecule inhibition of the uPAR·uPA interaction: Synthesis, biochemical, cellular, in vivo pharmacokinetics and efficacy studies in breast cancer metastasis

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2012.12.047 ◽

2013 ◽

Vol 21 (7) ◽

pp. 2145-2155 ◽

Cited By ~ 30

Author(s):

Timmy Mani ◽

Fang Wang ◽

William Eric Knabe ◽

Anthony L. Sinn ◽

May Khanna ◽

...

Keyword(s):

Breast Cancer ◽

Small Molecule ◽

Cancer Metastasis ◽

Breast Cancer Metastasis ◽

Small Molecule Inhibition ◽

In Vivo Pharmacokinetics ◽

Efficacy Studies

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Small molecule inhibition of DDAH1 significantly attenuates triple negative breast cancer cell vasculogenic mimicry in vitro

Biomedicine & Pharmacotherapy ◽

10.1016/j.biopha.2018.12.117 ◽

2019 ◽

Vol 111 ◽

pp. 602-612 ◽

Cited By ~ 7

Author(s):

Julie-Ann Hulin ◽

Sara Tommasi ◽

David Elliot ◽

Arduino A. Mangoni

Keyword(s):

Breast Cancer ◽

Cancer Cell ◽

Breast Cancer Cell ◽

Small Molecule ◽

Triple Negative Breast Cancer ◽

Triple Negative ◽

Vasculogenic Mimicry ◽

Small Molecule Inhibition

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Small molecule inhibition of arylamine N-acetyltransferase Type I inhibits proliferation and invasiveness of MDA-MB-231 breast cancer cells

Biochemical and Biophysical Research Communications ◽

10.1016/j.bbrc.2010.01.087 ◽

2010 ◽

Vol 393 (1) ◽

pp. 95-100 ◽

Cited By ~ 57

Author(s):

Jacky M. Tiang ◽

Neville J. Butcher ◽

Rodney F. Minchin

Keyword(s):

Breast Cancer ◽

Cancer Cells ◽

Small Molecule ◽

Breast Cancer Cells ◽

Type I ◽

Small Molecule Inhibition

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Faculty Opinions recommendation of Small-molecule inhibition of TNF-alpha.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1029076.342514 ◽

2005 ◽

Author(s):

Liang Tong

Keyword(s):

Small Molecule ◽

Tnf Alpha ◽

Small Molecule Inhibition

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Faculty Opinions recommendation of Small-molecule inhibition of BRDT for male contraception.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717953522.793460578 ◽

2012 ◽

Author(s):

Beverley Vollenhoven ◽

Alon Talmor

Keyword(s):

Small Molecule ◽

Male Contraception ◽

Small Molecule Inhibition

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Faculty Opinions recommendation of Small-molecule inhibition of MuRF1 attenuates skeletal muscle atrophy and dysfunction in cardiac cachexia.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.730933853.793547689 ◽

2018 ◽

Author(s):

George Booz ◽

Raffaele Altara

Keyword(s):

Skeletal Muscle ◽

Small Molecule ◽

Muscle Atrophy ◽

Skeletal Muscle Atrophy ◽

Cardiac Cachexia ◽

Small Molecule Inhibition

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Downregulation of Breast Cancer Gene Expression by Small Molecule Drugs

10.21236/ada427817 ◽

2004 ◽

Author(s):

Y. V. Gopal

Keyword(s):

Breast Cancer ◽

Gene Expression ◽

Small Molecule ◽

Cancer Gene ◽

Small Molecule Drugs ◽

Breast Cancer Gene

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