Body mass index at age 18 years and recent body mass index in relation to risk of breast cancer overall and ER/PR/HER2-defined subtypes in white women and African-American women: a pooled analysis

African American woman are 43% more likely to die from breast cancer than white women and have increased the risk of tumor recurrence despite lower incidence. We investigate variations in microsatellite genomic regions—a type of repetitive DNA—and possible links to the breast cancer mortality gap. We screen 33 854 microsatellites in germline DNA of African American women with and without breast cancer: 4 are statistically significant. These are located in the 3′ UTR (untranslated region) of gene ZDHHC3, an intron of transcribed pseudogene INTS4L1, an intron of ribosomal gene RNA5-8S5, and an intergenic region of chromosome 16. The marker in ZDHHC3 is interesting for 3 reasons: (a) the ZDHHC3 gene is located in region 3p21 which has already been linked to early invasive breast cancer, (b) the Kaplan-Meier estimator demonstrates that ZDHHC3 alterations are associated with poor breast cancer survival in all racial/ethnic groups combined, and (c) data from cBioPortal suggest that ZDHHC3 messenger RNA expression is significantly lower in African Americans compared with whites. These independent lines of evidence make ZDHHC3 a candidate for further investigation.

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Triple negative breast cancer in African American women: Disparity between women in New Orleans versus Louisiana.

Journal of Clinical Oncology ◽

10.1200/jco.2013.31.15_suppl.e12501 ◽

2013 ◽

Vol 31 (15_suppl) ◽

pp. e12501-e12501 ◽

Cited By ~ 1

Author(s):

Michelle Marie Loch ◽

John Estrada ◽

Thomas Reske ◽

Xiangrong Li ◽

Vivien Chen ◽

...

Keyword(s):

Breast Cancer ◽

African American ◽

African American Women ◽

New Orleans ◽

White Women ◽

Triple Negative ◽

Her2 Status ◽

Tumor Characteristics ◽

Empirical Observation ◽

American Women

e12501 Background: For years clinicians have made the empirical observation that there is an unusually high number of African American women (AAW) with triple-negative (Tneg) breast cancer (BC) in New Orleans (NO). Knowing the rate of Tneg BC in AAW is higher than white women (WW), we explored the hypothesis that AAW in NO have a higher rate of Tneg BC when compared to AAW in the rest of Louisiana (LA). Methods: We analyzed data from the Louisiana Tumor Registry, one of the NCI funded SEER registries, for the tumor characteristics of invasive female BC diagnosed in 2010, focusing on racial disparities; HER2 status was not available for prior to 2010 diagnosis. We explored the association of HER2 status with age, race, ER, PR, HER2, T, N, M to determine crude and adjusted odds ratios and rate distribution of subtypes using SEER*Stat and SAS programs. Results: Overall age-adjusted incidence rate of Tneg BC in AAW was 30 per 100,000 in NO, which was 24% higher than that in AAW in the rest of LA and two-fold the rate in WW of both NO and LA. The highest rate of Tneg BC was seen in AAW aged 65-69 in NO (184.97 per 100,000) compared with 81.5 per 100,000 in AAW aged 55-59 in LA. AAW with Tneg BC in NO were more likely to have more aggressive BC. Young age, black race, large tumor size, higher grade and TNM stage were significantly associated with the high risk of Tneg BC. After adjusting for age, geographic area, and other tumor characteristics, the higher risk of Tneg BC in AAW remained in NO compared with the rest of LA (OR=1.4; 95% CI: 1.01-1.87). Conclusions: AAW in NO are more likely to have poorly differentiated and Tneg BC compared to AAW in the rest of LA. This disparity remains when comparing our data to previously published literature in other parts of the US. We plan to continue our data analysis and compare NO data to the national average as the HER2 data become available in the SEER Program to better characterize the disparity. This newly identified disparity in the AAW population in NO has clinical implications and translational research potential as it enables us to broaden the understanding and treatment of this aggressive disease.

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Underinsured African-American Women Have Worse Breast Cancer Outcomes Than Underinsured White Women

JNCI Journal of the National Cancer Institute ◽

10.1093/jnci/djq250 ◽

2010 ◽

Vol 102 (15) ◽

pp. NP-NP

Keyword(s):

Breast Cancer ◽

African American ◽

African American Women ◽

White Women ◽

Cancer Outcomes ◽

American Women ◽

Breast Cancer Outcomes

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Associations between fiber intake and Body Mass Index (BMI) among African-American women participating in a randomized weight loss and maintenance trial

Eating Behaviors ◽

10.1016/j.eatbeh.2018.02.005 ◽

2018 ◽

Vol 29 ◽

pp. 48-53 ◽

Cited By ~ 4

Author(s):

Joanna Buscemi ◽

Oksana Pugach ◽

Sparkle Springfield ◽

Jiyeong Jang ◽

Lisa Tussing-Humphreys ◽

...

Keyword(s):

Body Mass Index ◽

Weight Loss ◽

African American ◽

African American Women ◽

Body Mass ◽

Fiber Intake ◽

American Women

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Relationship Between Social Support and Body Mass Index Among Overweight and Obese African American Women in the Rural Deep South, 2011–2013

Preventing Chronic Disease ◽

10.5888/pcd11.140340 ◽

2014 ◽

Vol 11 ◽

Cited By ~ 9

Author(s):

Erica R. Johnson ◽

Tiffany L. Carson ◽

Olivia Affuso ◽

Claudia M. Hardy ◽

Monica L. Baskin

Keyword(s):

Social Support ◽

Body Mass Index ◽

African American ◽

African American Women ◽

Body Mass ◽

Deep South ◽

American Women

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The Role of Enculturation, Racial Identity, and Body Mass Index in the Prediction of Body Dissatisfaction in African American Women

Journal of Black Psychology ◽

10.1177/0095798420904273 ◽

2020 ◽

Vol 46 (1) ◽

pp. 3-28

Author(s):

Germine H. Awad ◽

Susan Kashubeck-West ◽

Rashanta A. Bledman ◽

Angela D. Coker ◽

Rebecca D. Stinson ◽

...

Keyword(s):

Body Mass Index ◽

African American ◽

Racial Identity ◽

Body Dissatisfaction ◽

African American Women ◽

Body Mass ◽

Female College Students ◽

African American Female ◽

American Women

The purpose of the current study was to examine the role of enculturation and racial identity in the prediction of body dissatisfaction and weight preoccupation in a sample of African American women. Participants consisted of 278 African American female college students enrolled in a large Midwestern university who completed a racial identity measure, an African American enculturation measure, and body dissatisfaction measures. Simultaneous regression results suggested that preencounter self-hatred attitudes were the only racial identity dimension to significantly predict body dissatisfaction. In addition, the level of enculturation significantly predicted body dissatisfaction, suggesting that African American women who were highly enculturated experienced greater body dissatisfaction. Subsequent mediational analyses found that body mass index fully mediated the relationship between enculturation and body dissatisfaction for African American women. Greater enculturation was associated with a higher body mass index, which in turn predicted greater overweight preoccupation. Study implications are discussed.

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