scholarly journals Intratympanic versus intravenous corticosteroid treatment for sudden sensorineural hearing loss in diabetic patients: proposed study protocol for a prospective, randomized superiority trial

Trials ◽  
2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Weiqiang Yang ◽  
Xiaoling Li ◽  
Jiatao Zhong ◽  
Xueshuang Mei ◽  
Hongyu Liu ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Study Protocol ◽  
Corticosteroid Treatment ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Diabetic Patients ◽  
Intravenous Corticosteroid ◽  
Superiority Trial

scholarly journals The prognostic and predictive value of platelet parameters in diabetic and nondiabetic patients with sudden sensorineural hearing loss

2020 ◽  
Vol 15 (1) ◽  
pp. 884-889
Author(s):  
İbrahim Özcan ◽  
İbrahim Hira ◽  
Altan Kaya ◽  
Mehmet Yaşar ◽  
Murat Doğan ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Predictive Value ◽  
Study Groups ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Diabetic Patients ◽  
Microvascular Damage ◽  
Distribution Width ◽  
Group 1

AbstractBackgroundWe aimed to evaluate the association between mean platelet volume, platelet distribution width (PDW), platelet count (PC) and plateletcrit (PCT), and the presence of sudden sensorineural hearing loss (SSNHL) and treatment response. In the literature, there is no study that investigates the platelet functions in diabetic patients with SSNHL.MethodsThe patients were retrospectively assigned into Group 1 (68 diabetic patients with SSNHL), Group 2 (63 nondiabetic patients with SSNHL) and Group 3 (64 healthy controls).ResultsPC was not significantly different between the groups (p > 0.05). MPV, PDW and PCT values were significantly higher in Group 1 as compared to Groups 2 and 3 (p < 0.05). Platelet parameters were not significantly different between the patients who were responsive and nonresponsive to the treatment. Therefore, the platelet parameters did not affect prognosis significantly in this study samples (p > 0.05).ConclusionsThis study showed that platelet parameters did not have a significant effect as a prognostic and predictive value in diabetic and nondiabetic patients with SSNHL. Further studies with more homogenous and larger study groups investigating the platelet parameters are needed to demonstrate microvascular damage and vascular alterations induced by diabetes mellitus.

Clinical Features of Sudden Sensorineural Hearing Loss in Diabetic Patients

2005 ◽  
Vol 115 (9) ◽  
pp. 1676-1680 ◽  
Author(s):  
Shuen-Fu Weng ◽  
Yuh-Shyang Chen ◽  
Chuan-Jen Hsu ◽  
Fen-Yu Tseng
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Clinical Features ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Diabetic Patients

Prognostic Factors of Sudden Sensorineural Hearing Loss in Diabetic Patients

Diabetes Care ◽  
2004 ◽  
Vol 27 (10) ◽  
pp. 2560-2561 ◽  
Author(s):  
S.-F. Weng ◽  
Y.-S. Chen ◽  
T.-C. Liu ◽  
C.-J. Hsu ◽  
F.-Y. Tseng
Keyword(s):  
Hearing Loss ◽  
Prognostic Factors ◽  
Sensorineural Hearing Loss ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Diabetic Patients

Risk of Developing Sudden Sensorineural Hearing Loss in Diabetic Patients

2012 ◽  
Vol 33 (9) ◽  
pp. 1482-1488 ◽  
Author(s):  
Shih-Wei Lin ◽  
Yung-Song Lin ◽  
Shih-Feng Weng ◽  
Chien-Wen Chou
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Diabetic Patients

Effect of Diabetes on the Prognosis of Sudden Sensorineural Hearing Loss: Propensity Score Matching Analysis

2020 ◽  
Vol 162 (3) ◽  
pp. 346-352 ◽  
Author(s):  
Hee Won Seo ◽  
Jae Ho Chung ◽  
Hayoung Byun ◽  
Jin-Hyeok Jeong ◽  
Seung Hwan Lee
Keyword(s):  
Hearing Loss ◽  
Propensity Score ◽  
Sensorineural Hearing Loss ◽  
Propensity Score Matching ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Diabetic Patients ◽  
Hearing Level ◽  
Treatment Results ◽  
Similar Treatment

Objective The aim of this study was to investigate the clinical implications of diabetes for the management of idiopathic sudden sensorineural hearing loss (ISSNHL). Study Design Retrospective study. Setting Tertiary referral center. Subjects and Methods ISSNHL patients (N = 403) who received inpatient management between January 2015 and December 2018 were analyzed. All were managed by a uniform treatment protocol of high-dose steroid therapy and salvage intratympanic steroid injections. Treatment results were evaluated according to the American Academy of Otolaryngology—Head and Neck Surgery’s criteria 3 months after the start of treatment. We compared the clinical parameters and treatment outcomes of ISSNHL with and without diabetes. We also evaluated the influence of diabetes on the prognosis of ISSNHL by propensity score matching. Results Overall, of the 403 ISSNHL patients, 94 (23.3%) had diabetes, and 11 were newly diagnosed with diabetes. The patients with diabetes were older than those without diabetes ( P < .001), and their initial hearing threshold was significantly higher ( P < .001). The diabetic patients were hospitalized for a longer period, and their hearing recovery rate was lower. However, when age, sex, and initial hearing level were adjusted by propensity score matching, the diabetic patients and matched controls yielded similar treatment results. Conclusions ISSNHL with diabetes usually presents with severe hearing loss and requires longer hospitalization. However, diabetes itself may not influence the prognosis of ISSNHL. Proper management must be provided in ISSNHL with diabetes.

scholarly journals Association of Glycosylated Hemoglobin A1c Level With Sudden Sensorineural Hearing Loss: A Prospective Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Ying Shen ◽  
Zhong Zheng ◽  
Lili Xiao ◽  
Chengqi Liu ◽  
Jingyi Guo ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Hba1c Level ◽  
Hemoglobin A1c ◽  
Glycosylated Hemoglobin ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Diabetic Patients ◽  
Glycosylated Hemoglobin A1c ◽  
A Prospective Study

Glycosylated hemoglobin A1c (HbA1c) level has strong relevance to microvascular disorders, which are also thought to be the current main aspect of sudden sensorineural hearing loss (SSNHL), so we aim to elucidate the association of the HbA1c level with the severity, types, and prognosis of SSNHL. In this study, comparative analyses based on propensity score matching of the severity, types, and prognosis of SSNHL with the HbA1c level in 116 patients diagnosed as SSNHL were conducted, where they were divided into diabetes mellitus (DM) group and non-DM group. We finally found that, among patients with SSNHL, diabetic patients had a higher HbA1c level, more severe hearing loss, and poorer prognosis than non-diabetic patients. The HbA1c level was found to be significantly correlated with the severity and types of SSNHL, while no strong relevance was found between the higher HbA1c level and the poorer prognosis of SSNHL.

scholarly journals The Expression of TNFα, IL-6, IL-2 and IL-8 in the Serum of Patients with Idiopathic Sudden Sensorineural Hearing Loss: Possible Prognostic Factors of Response to Corticosteroid Treatment

2016 ◽  
Vol 6 (1) ◽  
pp. 9-19 ◽  
Author(s):  
Zinovia Tsinaslanidou ◽  
Miltiadis Tsaligopoulos ◽  
Nikolaos Angouridakis ◽  
Victor Vital ◽  
Georgios Kekes ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Treatment Outcome ◽  
Prognostic Factors ◽  
Sensorineural Hearing Loss ◽  
Proinflammatory Cytokines ◽  
Corticosteroid Treatment ◽  
Sudden Sensorineural Hearing Loss ◽  
Therapeutic Outcome ◽  
Sensorineural Hearing ◽  
Enzyme Linked Immunosorbent Assay

Introduction: Idiopathic sudden sensorineural hearing loss (ISSNHL) remains one of the major unsolved otologic emergencies. A viral infection, a systemic inflammatory disorder, as well as physical, mental and metabolic stress can trigger an innate immune response in the inner ear resulting in ISSNHL. Proinflammatory cytokines play a central role in this cochlear immunological cascade. Objective: To examine the expression of proinflammatory cytokines in the serum of patients with ISSNHL in correlation with the therapeutic outcome of intravenous administration of corticosteroids. Method: Forty-three patients primarily diagnosed with ISSNHL underwent intravenous corticosteroid treatment for 8 days. The expression of tumor necrosis factor-α (TNFα), interleukin-6 (IL-6), interleukin-2 (IL-2) and interleukin-8 (IL-8) was detected with the use of enzyme-linked immunosorbent assay in serum specimens on the 1st and 8th day of treatment and it was correlated with the treatment outcome. Results: TNFα reduction and IL-6 increase strongly correlate with a good therapeutic result [χ2(2) = 13.12, p = 0.001 and χ2(2) = 16.78, p = 0.0001]. IL-8 increase reflects negatively on the outcome, however, not in a statistically significant way. No association was established between IL-2 variations and the therapeutic outcome. Conclusions: TNFα and IL-6 can be used as prognostic factors for the treatment outcome, whereas the prognostic value of IL-8 requires further statistical confirmation.

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