scholarly journals Comparison of intradialytic neuromuscular electrical stimulation and oral nutritional supplements in hemodialysis patients: study protocol for a multicenter, parallel-group, randomized controlled trial in Korea

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Mi-yeon Yu ◽  
Jae Hyeon Park ◽  
Yong Chul Kim ◽  
Jae Yoon Park ◽  
Ran-hui Cha
Keyword(s):  
Electrical Stimulation ◽  
Muscle Strength ◽  
Physical Function ◽  
Muscle Mass ◽  
Nutritional Support ◽  
Neuromuscular Electrical Stimulation ◽  
Protein Supplementation ◽  
Randomized Controlled ◽  
Parallel Group ◽  
Oral Nutritional Supplements

Abstract Background The prevalence of sarcopenia increases as renal function decreases, and a considerable number of hemodialysis (HD) patients have sarcopenia. Exercise and nutritional support are established interventions to prevent and treat sarcopenia. Recently, many studies evaluating intradialytic neuromuscular electrical stimulation (NMES) showed improvement of muscular strength and mass, functional capacity, and quality of life (QOL). However, there has been no research about the effect of simultaneous nutritional support and NMES in HD patients. Methods This is a 12-week, randomized controlled, parallel-group, multicenter trial of intradialytic NMES and protein supplementation for HD patients. Seventy-two patients receiving HD will be randomly assigned in a 1:1:1:1 ratio to control, intradialytic NMES only, protein supplementation only, and intradialytic NMES combined with protein supplementation groups. NMES will be delivered to a total of four areas of the bilateral vastus medialis and vastus lateralis using a 4-channel NMES instrument. A total of 25 g of protein supplements will be provided at the beginning of every dialysis session or after the NMES. The primary endpoint is the difference of hand grip and leg muscle strength at 12 weeks among 4 treatment groups. Secondary endpoints include muscle mass, physical performances, and questionnaires about QOL and physical activity. Discussion In this study, we will evaluate the differential effectiveness of nutritional support and NMES during HD on muscle strength, muscle mass, physical function, and QOL. We expect that this study can provide guidelines for a new therapeutic option for HD patients who are unable or hesitant to exercise. Furthermore, this option can offer an opportunity to improve the physical function, QOL, and prognosis of HD patients. Trial registration Clinical Research Information Service (CRIS), Korea, KCT0005573. Retrospectively registered on 03 November 2020

scholarly journals Feasibility of eccentric overloading and neuromuscular electrical stimulation to improve muscle strength and muscle mass after treatment for head and neck cancer

2019 ◽  
Author(s):  
Colin Lavigne ◽  
Rosemary Twomey ◽  
Harold Lau ◽  
George Francis ◽  
S. Nicole Culos-Reed ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Electrical Stimulation ◽  
Muscle Strength ◽  
Strength Training ◽  
Head And Neck ◽  
Muscle Mass ◽  
Neck Cancer ◽  
Neuromuscular Electrical Stimulation ◽  
Knee Extensors ◽  
Patient Reported

Purpose: Treatment of head and neck cancer (HNC) results in severe weight loss, mainly due to loss of lean body mass. Consequently, decreases in muscular strength and health-related quality of life (HRQL) occur. This study investigated the feasibility of a 12-week experimental (EXP) and conventional (CON) strength training intervention delivered after HNC treatment.Methods: Participants were randomized to an EXP group (n=11) involving eccentric strength training and neuromuscular electrical stimulation (NMES), or a CON group (n=11) involving dynamic strength training matched for training volume. Feasibility outcomes included recruitment, completion, adherence and evidence of progression. A neuromuscular assessment involving maximal isometric voluntary contractions (MIVCs) in the knee extensors was evaluated prior to and during incremental cycling to volitional exhaustion at baseline and after the interventions. Anthropometrics and patient-reported outcomes (PROs) were also assessed.Results: Although recruitment was challenging, completion was 82% in CON and 100% in EXP. Adherence was 81% in CON and 92% in EXP. Overall, MIVC increased by 19 ± 23%, muscle mass improved 18 ± 22%, cycling exercise time improved by 18 ± 13%, and improvements in HRQL and fatigue were clinically relevant.Conclusions: Both interventions were found to be feasible for HNC patients after treatment. Strength training significantly improved maximal muscle strength, muscle mass, and PROs after HNC treatment. Future research should include fully powered trials and consider the use of eccentric overloading and NMES during HNC treatment.Implications for Cancer Survivors: Eccentric overloading and NMES may be useful alternatives to conventional strength training after HNC treatment.

Egg protein supplementation improved upper body muscle strength and protein intake in community-dwelling older adult females who attended congregate meal sites or adult learning centers: A pilot randomized controlled trial

2021 ◽  
pp. 026010602110515
Author(s):  
Sarah L. Ullevig ◽  
Krystle Zuniga ◽  
C. Austin Lobitz ◽  
Alejandra Santoyo ◽  
Zenong Yin
Keyword(s):  
Older Adults ◽  
Muscle Strength ◽  
Muscle Mass ◽  
Protein Intake ◽  
Egg White ◽  
Protein Supplementation ◽  
Community Dwelling ◽  
Upper Body ◽  
Egg White Protein ◽  
Randomized Controlled

Background: Older adults that utilize community-based nutrition services are at higher nutritional risk than the general aging population, yet studies on the efficacy of protein interventions in this population are lacking. Aim: A double-blinded randomized controlled pilot study trial evaluated the impact of egg white protein supplementation on muscle mass, strength, and physical function in predominantly low-income Latina community-dwelling adult females aged 60 or older with reduced muscle strength or function. Methods: Participants (mean age = 73.6  ±  8.3 years) were randomly assigned to receive a daily dried egg white (20 g protein) or isocaloric maltodextrin supplement for 6 months (n = 16 intervention; n = 13 control). The primary outcome measure was appendicular skeletal muscle mass. Secondary outcomes were measures of muscle strength and function and dietary protein intake. Comparisons of baseline demographics were conducted using t-tests and χ2 or Fisher's exact tests. Differences between groups were assessed using general linear models, adjusted for baseline values, and differences within groups were assessed using paired t-tests or Kruskal–Wallis. Results: No significant between-group differences were found for all measures, but protein intake, handgrip strength, and the number of arm curls significantly improved in the intervention group. Under-recruitment of study participants and a high dropout rate impacted the ability of this study to detect significant differences between groups. Conclusion: Daily egg white protein supplementation increases protein intake and supports upper body physical function in older adults, but additional studies are needed to investigate its role in the prevention of age-related muscle mass decline in older adults. Trial #NCT03530774 ( https://clinicaltrials.gov/ct2/show/NCT03530774 ).

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