scholarly journals Laboratory studies evaluating the efficacy of a novel orally administered combination product containing sarolaner, moxidectin and pyrantel (Simparica Trio™) for the treatment and control of flea infestations on dogs

2020 ◽  
Vol 13 (1) ◽  
Author(s):  
Kristina Kryda ◽  
Sean P. Mahabir ◽  
Lori Carter ◽  
William R. Everett ◽  
David R. Young ◽  
...  
1995 ◽  
Vol 80 (2) ◽  
pp. 411-415 ◽  
Author(s):  
Nancy Becker ◽  
Catherine Chambliss ◽  
Cathy Marsh ◽  
Roberta Montemayor

Previous research has yielded an inconclusive picture of the effects of music and scent on walking. Few laboratory studies have detected a beneficial effect of music; olfactory research has shown performance is positively affected for repetitive tasks but not yet on walking. The influence of these two types of stimuli in efficiency of exercise among seniors was assessed by measuring distance walked on an indoor course. Using a 3 × 3 factorial design [mellow music in 4:4 time, frenetic music in 2:8 time, and white noise by stimulating, relaxing, and control scent conditions], each of 20 volunteers from a senior center received nine randomized, 90-sec. exercise trials. Walking distance was reduced by mellow music but unaffected by stimulating music; there was no effect of scent.


Parasite ◽  
2021 ◽  
Vol 28 ◽  
pp. 26 ◽  
Author(s):  
Eric Tielemans ◽  
Joe Prullage ◽  
Otsuki Tomoko ◽  
Julian Liebenberg ◽  
Balázs Capári ◽  
...  

Esafoxolaner, a purified enantiomer of afoxolaner with insecticidal and acaricidal properties, is combined with eprinomectin and praziquantel, nematodicidal and cestodicidal compounds, in NexGard® Combo, a novel topical endectoparasiticide formulation for cats. The efficacy of this formulation was assessed against Otodectes cynotis in two laboratory studies conducted in South Africa and in the USA with local isolates, and in one field trial conducted in Europe. In each study, cats were randomly allocated to a placebo-treated control group and a novel formulation-treated group. In the laboratory studies, cats were treated at the minimum recommended dose; in the field trial, cats were treated at label dose. All included cats were diagnosed positive for O. cynotis prior to treatment by otoscopy. The main variable of efficacy was a comparison of the number of live O. cynotis collected in both ear canals of all cats in the treated and control groups, one month after treatment. Efficacy of the novel topical formulation exceeded 97% in the three studies. These studies demonstrated the high effectiveness of NexGard® Combo in cats for the treatment of O. cynotis infestations. No health abnormalities were attributed to the treatment in any of the studies.


1983 ◽  
Vol 15 (S2) ◽  
pp. 103-123
Author(s):  
C J Peters ◽  
R Perry

The occurrence and formation of trihalomethanes in water supplies in relation to source waters and treatment practice are evaluated. Factors influencing their formation are discussed with reference to detailed laboratory studies involving humic and fulvic materials as well as model compounds. The influence of temperature, pH and chlorine dose is related to the rate and mechanism of formation of these compounds and a direct aqueous injection analytical technique is used to evaluate the significance of unstable intermediate compounds formed. Bromide levels in the source waters are related to the balance of trihalomethanes produced during chlorination.


2009 ◽  
Vol 68 (1) ◽  
Author(s):  
O. Matthew Oriowo

Purpose: To investigate the relative cytotoxic effects of contact lens multipurpose solutions on cultured crystalline lenses.Methods: A comparison of the fluorescence emission levels of cultured bovine lenses as affected by three hour experimental exposure to three contact lens multipurpose solutions (COMPLETE Moisture Plus, AMO; OPTI-FREE Express, Alcon; and ReNu MultiPlus, Bausch & Lomb) was carried out. The pre- and post-exposure fluorescence levels of the lenses were obtained and values were compared to baseline and control measurements.Results: The solutions yielded varying degrees of cytotoxicity, demonstrating significant (p < 0.01) reversible reduction of cellular viability levels of the cultured crystalline lenses as revealed by the degree of fluorescence emissions in the following order (OPTI-FREE Express > ReNu MultiPlus > COMPLETE MoisturePlus multi-purpose solutions)Conclusions: The results show that OPTI-FREE Express and ReNu MultiPlus solutions exhibited more cytotoxic effect compared to COMPLETE MoisturePlus solution. The findings support reportsfrom previous clinical and laboratory studies. These results suggest that the in vitro approach herein presented would be a valuable system for relatively inexpensive and repeatable laboratory investigations of the possible ocular surface reactions of ophthal-mic solutions, cosmetics and pharmaceuticals at pre- and during commercial phases. 


2013 ◽  
Vol 17 (3 (67) p.1) ◽  
pp. 135-137
Author(s):  
N. A. Romanko

This paper assesses the state of the normative-legal base of the Russian Federation, regulating the procedure for making an examination of corpses, survivors, case materials and biological objects. The author comes to a conclusion about a need for an adaptation of the normative and methodological base for new research methods and for new types of examinations with the use of the high-tech equipment; the development of new criteria enabling, to regulate the production load and control the quality of a research.


2019 ◽  
Vol 12 (1) ◽  
Author(s):  
Kristina Kryda ◽  
Robert H. Six ◽  
Kelly F. Walsh ◽  
Susan J. Holzmer ◽  
Sara Chapin ◽  
...  

Abstract Background Dirofilaria immitis is a filarial parasite of dogs that can cause serious or fatal cardiopulmonary disease. Three studies were conducted to evaluate the efficacy and safety of monthly treatment with moxidectin in a chewable tablet product in combination with sarolaner and pyrantel to prevent heartworm disease in dogs after experimental challenge and in a clinical field study in the USA. Methods In two laboratory studies, dogs (8 per group) that had been inoculated 30 days prior with 50 third-stage D. immitis larvae were randomized to treatment on Day 0 with placebo or combination product, at the minimum dose of 24 µg/kg moxidectin, 2 mg/kg sarolaner and 5 mg/kg pyrantel (as pamoate salt). Study 2 also included groups treated with tablets containing moxidectin-alone (24 µg/kg) or sarolaner-alone (2 mg/kg). Efficacy was evaluated ~ 5 months after inoculation by adult heartworm counts at necropsy. In the field study, 410 dogs ≥ 8 weeks-old from 23 USA veterinary clinics were treated for 11 months with either combination product at 24–48 µg/kg moxidectin, 2–4 mg/kg sarolaner and 5–10 mg/kg pyrantel (n = 272) or Heartgard® Plus (ivermectin/pyrantel) at the label recommended dose rate (n = 138). Efficacy was evaluated on Day 330 using antigen and microfilaria testing to assess adult heartworm infection. Results In the laboratory studies, there were no heartworms recovered from any dog treated with the combination product or moxidectin alone and all dogs treated with placebo or sarolaner-alone were infected with 20–44 adult heartworms. In the field study, all dogs treated with the combination product tested negative for heartworm infection on Day 330, whereas two dogs treated with Heartgard® Plus tested positive. The Heartgard® Plus-treated dogs that tested heartworm positive were from the lower Mississippi River Valley region, where heartworm resistance has been confirmed to occur. The combination product was well tolerated in all studies. Conclusions In laboratory studies, no heartworms were recovered from dogs treated with a single dose of the novel combination product containing moxidectin, sarolaner and pyrantel. Additionally, in the field study no dog tested positive for adult heartworm infection when dosed with the combination product monthly for 11 months, while two dogs treated with Heartgard® Plus tested positive.


Weed Science ◽  
2004 ◽  
Vol 52 (4) ◽  
pp. 513-517 ◽  
Author(s):  
Jeffrey A. Bunting ◽  
Christy L. Sprague ◽  
Dean E. Riechers

Greenhouse and laboratory studies were conducted to examine the activity and foliar absorption of foramsulfuron in giant foxtail and woolly cupgrass with various adjuvants. Adjuvant selection was important for giant foxtail control. Foramsulfuron provided 90% or greater giant foxtail control with the addition of methylated seed oil (MSO) or MSO plus 28% urea ammonium nitrate (UAN). When a crop oil concentrate (COC) or a nonionic surfactant (NIS) was added to foramsulfuron, giant foxtail control was only 20%. However, when 28% UAN was added to COC or NIS, control was increased to 90 and 85%, respectively. Foramsulfuron absorption and control were closely related in giant foxtail. Foliar absorption of14C-foramsulfuron in giant foxtail ranged between 35 and 90% 24 h after treatment (HAT) depending on adjuvant selection. The rate of absorption was greatest when MSO plus 28% UAN was added to foramsulfuron and absorption was maximized 4 HAT. Foramsulfuron absorption in woolly cupgrass reached its maximum levels 2 HAT with all adjuvant combinations. Although the rate of foramsulfuron absorption was quicker in woolly cupgrass, absorption trends by adjuvants were similar to those in giant foxtail. Maximum absorption of14C-foramsulfuron in woolly cupgrass was 84% with the addition of MSO plus 28% UAN. However, even with high levels of absorption, woolly cupgrass control with foramsulfuron was poor and may be related to rapid metabolism to nonphytotoxic compounds.


1964 ◽  
Vol 55 (2) ◽  
pp. 327-337 ◽  
Author(s):  
Gordon Surtees

The effect upon the three-dimensional dispersion of experimental populations of Tribolium castaneum (Hbst.) of internal pockets of grain at 18 per cent, moisture content, either mouldy or free from mould, and superficial ones of 25 per cent, moisture content, in a larger bulk of 14 per cent, moisture content, was investigated at 25°C. The behaviour under these circumstances of insects reared and maintained at 70 per cent, relative humidity was compared with those conditioned at 40 per cent. R.H. for 14 days. It was found that insects reared at 70 per cent. E.H. did not accumulate in the damp grain whereas conditioned ones did. The underlying response was shown to be hygrokinetic and the mechanism an orthokinetic one. The rate of movement of unconditioned adults in grain of 18 per cent, moisture content was approximately twice that in grain of 14 per cent, moisture content. Conditioned adults moved very slowly in the damper grain. There were no significant variations in irregularity of pathway (klinokinesis) under any of these circumstances. When grain of 18 per cent, moisture content supporting a mould growth was used, unconditioned adults did, however, accumulate in it due to trophic behaviour.While there is considerable plasticity of behaviour in this species a synthesis is attempted of the causal behavioural mechanisms underlying the spatial structure of populations in ecological situations involving humidity gradients; the results are also discussed in relation to grain storage conditions, and the detection and control of the species.


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