scholarly journals GCKR common functional polymorphisms are associated with metabolic syndrome and its components: a 10-year retrospective cohort study in Iranian adults

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Asiyeh Sadat Zahedi ◽  
Mahdi Akbarzadeh ◽  
Bahareh Sedaghati-Khayat ◽  
Atefeh Seyedhamzehzadeh ◽  
Maryam S. Daneshpour
Keyword(s):  
Metabolic Syndrome ◽  
Cohort Study ◽  
Blood Sugar ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Fasting Blood Sugar ◽  
The Metabolic Syndrome ◽  
Functional Variants ◽  
Sugar Levels ◽  
Metabolic Syndrome Components

Abstract Background Previous studies reported that common functional variants (rs780093, rs780094, and rs1260326) in the glucokinase regulator gene (GCKR) were associated with metabolic syndrome despite the simultaneous association with the favorable and unfavorable metabolic syndrome components. We decided to evaluate these findings in a cohort study with a large sample size of Iranian adult subjects, to our knowledge for the first time. We investigated the association of the GCKR variants with incident MetS in mean follow-up times for nearly 10 years. Methods Analysis of this retrospective cohort study was performed among 5666 participants of the Tehran Cardiometabolic Genetics Study (TCGS) at 19–88 years at baseline. Linear and logistic regression analyses were used to investigate the metabolic syndrome (JIS criteria) association and its components with rs780093, rs780094, and rs1260326 in an additive genetic model. Cox regression was carried out to peruse variants’ association with the incidence of metabolic syndrome in the TCGS cohort study. Results In the current study, we have consistently replicated the association of the GCKR SNPs with higher triglyceride and lower fasting blood sugar levels (p < 0.05) in Iranian adults. The CT genotype of the variants was associated with lower HDL-C levels. The proportional Cox adjusted model regression resulted that TT carriers of rs780094, rs780093, and rs1260326 were associated with 20%, 23%, and 21% excess risk metabolic syndrome incidence, respectively (p < 0.05). Conclusions Elevated triglyceride levels had the strongest association with GCKR selected variants among the metabolic syndrome components. Despite the association of these variants with decreased fasting blood sugar levels, T alleles of the variants were associated with metabolic syndrome incidence; so whether individuals are T allele carriers of the common functional variants, they have a risk factor for the future incidence of metabolic syndrome.

scholarly journals GCKR Common functional polymorphisms are associated with metabolic syndrome and its components: a 10-year retrospective cohort study in Iranian adults

2021 ◽  
Author(s):  
Asiyeh Sadat Zahedi ◽  
Mahdi Akbarzadeh ◽  
Bahareh Sedaghati-khayat ◽  
Atefeh Seyedhamzehzadeh ◽  
Maryam S Daneshpour
Keyword(s):  
Metabolic Syndrome ◽  
Cohort Study ◽  
Blood Sugar ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Fasting Blood Sugar ◽  
The Metabolic Syndrome ◽  
Functional Variants ◽  
Sugar Levels ◽  
Metabolic Syndrome Components

Abstract Background: Previous studies reported that common functional variants (rs780093, rs780094, and rs1260326) in the glucokinase regulator gene (GCKR) were associated with metabolic syndrome despite the simultaneous association with the favorable and unfavorable metabolic syndrome components. We decided to evaluate these findings in a cohort study with a large sample size of Iranian adult subjects, to our knowledge for the first time. We investigated the association of the GCKR variants with incident MetS in mean follow-up times for nearly ten years.Methods: Analysis of this retrospective cohort study was performed among 5666 participants of the Tehran Cardiometabolic Genetics Study (TCGS) at 19-88 years at baseline. Linear and logistic regression analyses were used to investigate the metabolic syndrome (JIS criteria) association and its components with rs780093, rs780094, and rs1260326 in an additive genetic model. Cox regression was carried out to peruse variants' association with the incidence of metabolic syndrome in the TCGS cohort study.Results: In the current study, we have consistently replicated the association of the GCKR SNPs with higher triglyceride and lower fasting blood sugar levels (p<0.05) in Iranian adults. The CT genotype of the variants was associated with lower HDL-C levels. The proportional Cox adjusted model regression resulted that TT carriers of rs780094, rs780093, and rs1260326 were associated with 20%, 23%, and 21% excess risk metabolic syndrome incidence, respectively (p<0.05).Conclusions: Elevated triglyceride levels had the strongest association with GCKR selected variants among the metabolic syndrome components. Despite the association of these variants with decreased fasting blood sugar levels, T alleles of the variants were associated with metabolic syndrome incidence; so whether individuals are T allele carriers of the common functional variants, they have a risk factor for the future incidence of metabolic syndrome.

scholarly journals GCKR Common Functional Polymorphisms are Associated with Metabolic Syndrome and its Components: A 10-Year Retrospective Cohort Study in Iranian Adults

2020 ◽  
Author(s):  
Asiyeh Sadat Zahedi ◽  
Mahdi Akbarzadeh ◽  
Bahareh Sedaghati-khayat ◽  
Atefeh Seyedhamzehzadeh ◽  
Maryam S Daneshpour
Keyword(s):  
Metabolic Syndrome ◽  
Cohort Study ◽  
Blood Sugar ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Fasting Blood Sugar ◽  
The Metabolic Syndrome ◽  
Functional Variants ◽  
Sugar Levels ◽  
Metabolic Syndrome Components

Abstract Background: Some previous studies reported that common functional variants (rs780093, rs780094, and rs1260326) in the glucokinase regulator gene (GCKR) were associated with metabolic syndrome despite the simultaneous association with the favorable and unfavorable metabolic syndrome components. We decided to examine these findings, to our knowledge for the first time, in Iranian adults. We investigated the association of the GCKR variants with incident MetS in mean follow-up times for nearly ten years.Methods: Analysis of this retrospective cohort study was performed among 5666 participants of the Tehran Cardiometabolic Genetics Study (TCGS) at 19-88 years at baseline. Linear and logistic regression analyses were used to investigate the metabolic syndrome (JIS criteria) association and its components with rs780093, rs780094, and rs1260326 in an additive genetic model. Cox regression was carried out to peruse variants' association with the incidence of metabolic syndrome in the TCGS cohort study.Results: In the current study, we have consistently replicated the association between the T-allele of GCKR SNPs and higher triglyceride levels and lower fasting blood sugar levels (p<0.05) in the Iranian population. The CT genotype of all three variants was associated with lower HDL-C levels. The proportional Cox adjusted model regression resulted that TT carriers of rs780094, rs780093, and rs1260326 were associated with 20%, 23%, and 21% excess risk metabolic syndrome incidence, respectively (p<0.05).Conclusions: Elevated triglyceride levels had the strongest association with GCKR selected variants among the metabolic syndrome components. Despite the association of these variants with decreased fasting blood sugar levels, T alleles of the variants were associated with metabolic syndrome incidence; so whether individuals are T allele carriers of the common functional variants, they have a risk factor for the future incidence of metabolic syndrome.

scholarly journals GCKR Common functional polymorphisms are associated with metabolic syndrome and its components: a 10-year retrospective cohort study in Iranian adults

2021 ◽  
Author(s):  
Asiyeh Sadat Zahedi ◽  
Mahdi Akbarzadeh ◽  
Bahareh Sedaghati-khayat ◽  
Atefeh Seyedhamzehzadeh ◽  
Maryam S Daneshpour
Keyword(s):  
Metabolic Syndrome ◽  
Cohort Study ◽  
Blood Sugar ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Fasting Blood Sugar ◽  
The Metabolic Syndrome ◽  
Functional Variants ◽  
Sugar Levels ◽  
Metabolic Syndrome Components

Abstract Background Previous studies reported that common functional variants (rs780093, rs780094, and rs1260326) in the glucokinase regulator gene (GCKR) were associated with metabolic syndrome despite the simultaneous association with the favorable and unfavorable metabolic syndrome components. We decided to evaluate these findings in a cohort study with a large sample size of Iranian adult subjects, to our knowledge for the first time. We investigated the association of the GCKR variants with incident MetS in mean follow-up times for nearly ten years. Methods Analysis of this retrospective cohort study was performed among 5666 participants of the Tehran Cardiometabolic Genetics Study (TCGS) at 19–88 years at baseline. Linear and logistic regression analyses were used to investigate the metabolic syndrome (JIS criteria) association and its components with rs780093, rs780094, and rs1260326 in an additive genetic model. Cox regression was carried out to peruse variants' association with the incidence of metabolic syndrome in the TCGS cohort study. Results In the current study, we have consistently replicated the association of the GCKR SNPs with higher triglyceride and lower fasting blood sugar levels (p < 0.05) in Iranian adults. The CT genotype of the variants was associated with lower HDL-C levels. The proportional Cox adjusted model regression resulted that TT carriers of rs780094, rs780093, and rs1260326 were associated with 20%, 23%, and 21% excess risk metabolic syndrome incidence, respectively (p < 0.05). Conclusions Elevated triglyceride levels had the strongest association with GCKR selected variants among the metabolic syndrome components. Despite the association of these variants with decreased fasting blood sugar levels, T alleles of the variants were associated with metabolic syndrome incidence; so whether individuals are T allele carriers of the common functional variants, they have a risk factor for the future incidence of metabolic syndrome.

scholarly journals Association of metabolic syndrome with glioblastoma: a retrospective cohort study and review

2020 ◽  
Vol 7 (5) ◽  
pp. 541-548
Author(s):  
Lisa R Rogers ◽  
Quinn T Ostrom ◽  
Julia Schroer ◽  
Jaime Vengoechea ◽  
Li Li ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Overall Survival ◽  
Risk Factor ◽  
Cohort Study ◽  
General Population ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Laboratory Data ◽  
The Metabolic Syndrome ◽  
Clinical Records

Abstract Background Metabolic syndrome is identified as a risk factor for the development of several systemic cancers, but its frequency among patients with glioblastoma and its association with clinical outcomes have yet to be determined. The aim of this study was to investigate metabolic syndrome as a risk factor for and affecting survival in glioblastoma patients. Methods A retrospective cohort study, consisting of patients with diagnoses at a single institution between 2007 and 2013, was conducted. Clinical records were reviewed, and clinical and laboratory data pertaining to 5 metabolic criteria were extrapolated. Overall survival was determined by time from initial surgical diagnosis to date of death or last follow-up. Results The frequency of metabolic syndrome among patients diagnosed with glioblastoma was slightly greater than the frequency of metabolic syndrome among the general population. Within a subset of patients (n = 91) receiving the full schedule of concurrent radiation and temozolomide and adjuvant temozolomide, median overall survival was significantly shorter for patients with metabolic syndrome compared with those without. In addition, the presence of all 5 elements of the metabolic syndrome resulted in significantly decreased median survival in these patients. Conclusions We identified the metabolic syndrome at a slightly higher frequency in patients with diagnosed glioblastoma compared with the general population. In addition, metabolic syndrome with each of its individual components is associated with an overall worse prognosis in patients receiving the standard schedule of radiation and temozolomide after adjustment for age.

scholarly journals Contribution of Metabolic Syndrome in Controlling Diabetes Mellitus According to Gender in Indonesia (RISKESDAS 2018)

2020 ◽  
Vol 13 (1) ◽  
pp. 46
Author(s):  
Julianty Pradono ◽  
Delima Delima ◽  
Nunik Kusumawardani ◽  
Frans Dany ◽  
Yudi Kristanto
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Blood Sugar ◽  
Fasting Blood Glucose ◽  
Population Characteristics ◽  
Fasting Blood Sugar ◽  
The Metabolic Syndrome ◽  
Sugar Levels

BACKGROUND: Metabolic syndrome (MetS) is a multiple risk factor for the development of type 2 diabetes mellitus (DM). It is important to understand the contribution of MetS in developing DM in different population characteristics. This study aims to obtain the prevalence of MetS and the magnitude of the contribution of MetS risk factors as a basis for developing targeted DM intervention programs. METHODS: This study used data from the 2018 Riskesdas survey, an Indonesia national health survey, with a total sample of 24,545 individuals aged 15 years and over. This study selected only respondents who had never been diagnosed with diabetes mellitus before the survey was conducted and have complete MetS data according to the National Cholesterol Education Program or Adult Treatment Panel III (NCEP/ATP III) criteria. Data had been analyzed for the Population Attributable Fraction (PAF) statistical test. RESULTS: A total of 29.2 percents of the population with MetS and the prevalence in women (17.2%) was higher than in men (11.9%) Three components of MetS that contribute greatly to DM were fasting blood glucose levels, hypertension and high triglyceride levels. If the men population can maintain two risk factors (fasting blood sugar levels and blood pressure) under normal conditions, the prevalence of DM can be reduced by as much as 15 percent. In women, if three factors (fasting blood sugar levels, blood pressure, and triglyceride levels) can be maintained under normal conditions, the prevalence of DM can be reduced by 29.9 percent. CONCLUSION: Prevention strategy of DM need to include monitoring and controlling of the metabolic syndrome and behavioral risk factors, that can be applied in primary health center as well as in community-based setting of health program.

scholarly journals Abdominal Obesity and Short-term Mortality in Critically Ill Patients with Sepsis: A Retrospective Cohort Study Based on the MIMIC-IV Database

2021 ◽  
Author(s):  
Zhou Lv ◽  
Minglu Gu ◽  
Miao Zhou ◽  
Yanfei Mao ◽  
Lai Jiang
Keyword(s):  
Metabolic Syndrome ◽  
Cohort Study ◽  
Intensive Care ◽  
Abdominal Obesity ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Obese Patients ◽  
Short Term ◽  
Icu Admission ◽  
Short Term Mortality

Abstract Purpose: Multiple studies have demonstrated an obesity paradox such that obese septic patients have a lower mortality rate and a relatively favorable prognosis. However, less is known on the association between abdominal obesity and short-term mortality in patients with sepsis. We conducted this study to determine whether the obesity-related survival benefit remains among abdominal obese patients.Methods: A retrospective cohort study was conducted using data derived from the Medical Information Mart for Intensive Care IV database. Septic patients (≥18 years) with or without abdominal obesity of first intensive care units (ICU) admission in the database were enrolled. The primary outcome was mortality within 28 days of ICU admission and multivariable logistic regression analyses were employed to assess any association between abdominal obesity and the outcome variable.Results: A total of 21534 patients were enrolled finally, the crude 28-day mortality benefit after ICU admission was not observed in patients with abdominal obesity (15.8% vs. 15.3%, p=0.32). In the extended multivariable logistic models, the odds ratio (OR) of abdominal obesity was significantly inversed after incorporating metabolic variables into the logistic model (OR range 1.094-2.872, p = 0.02). The subgroup analysis showed interaction effects in impaired fasting blood glucose/diabetes and metabolic syndrome subgroups (P = 0.001 and <0.001, respectively). In the subgroups of blood pressure, high-density lipoprotein cholesterol, and triglyceride level, no interaction was detected in the association between abdominal obesity and mortality. After propensity score matching, 6523 pairs of patients were selected. The mortality significantly higher in the abdominal obesity group (17.0% vs. 14.8%, p = 0.015). Notably, the non-abdominal obese patients were weaned off vasopressors and mechanical ventilation more quickly than those in the abdominal obesity group (vasopressor‑free days on day 28 of 27.0 vs. 26.8, p < 0.001; ventilation-free days on day 28 of 26.7 vs. 25.6, p < 0.001).Conclusion: Abdominal obesity was associated with increased risk of adjusted sepsis-related mortality within 28 days after ICU admission and was partially mediated through metabolic syndrome components.

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