scholarly journals Computed tomography-based multiple body composition parameters predict outcomes in Crohn’s disease

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Ziling Zhou ◽  
Ziman Xiong ◽  
Qingguo Xie ◽  
Peng Xiao ◽  
Qingpeng Zhang ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Skeletal Muscle ◽  
Body Composition ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Adverse Outcome ◽  
Principal Component ◽  
Composition Analysis ◽  
Disease Behavior ◽  
Lumbar Spinal

Abstract Background The efficacy of computed tomography-based multiple body composition parameters in assessing disease behavior and prognosis has not been comprehensively evaluated in Crohn’s disease. This study aimed to assess the association of body composition parameters with disease behavior and outcomes in Crohn’s disease and to compare the efficacies of indexes derived from body and lumbar spinal heights in body composition analysis. Results One hundred twenty-two patients with confirmed Crohn’s disease diagnoses and abdominal computed tomography scans were retrospectively included in this study. Skeletal muscle, visceral, and subcutaneous fat indexes were calculated by dividing each type of tissue area by height2 and lumbar spinal height2. Parameters reflecting the distribution of adiposity were also assessed. Principal component analysis was used to deal with parameters with multicollinearity. Patients were grouped according to their disease behavior (inflammatory vs. structuring/penetrating) and outcomes. Adverse outcome included need for intestinal surgery or anti-TNF therapy. Predictors of disease course from multiple parameters were evaluated using multivariate analysis. Indexes derived from body and lumbar spinal heights were strongly correlated (r, 0.934–0.995; p < 0.001). Low skeletal muscle-related parameters were significantly associated with complicated disease behavior in multivariate analysis (p = 0.048). Complicated disease behavior (p < 0.001) and adipose tissue parameters-related first principal component (p = 0.029) were independent biomarkers for predicting adverse outcomes. Conclusions Skeletal muscle and adipose tissue principle component were associated with complicated Crohn’s disease behavior and adverse outcome, respectively. Indexes derived from body and lumbar spinal heights have similar efficacies in body composition analysis.

Lower Subcutaneous or Visceral Adiposity Assessed by Abdominal Computed Tomography Could Predict Adverse Outcome in Patients With Crohn’s Disease

2018 ◽  
Vol 12 (12) ◽  
pp. 1429-1437 ◽  
Author(s):  
Claire Thiberge ◽  
Cloé Charpentier ◽  
André Gillibert ◽  
Romain Modzelewski ◽  
Jean-Nicolas Dacher ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Adverse Outcome ◽  
Visceral Adiposity ◽  
Abdominal Computed Tomography

scholarly journals Adults with Crohn’s disease exhibit elevated gynoid fat and reduced android fat irrespective of disease relapse or remission

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Lisa Dowling ◽  
Philip Jakeman ◽  
Catherine Norton ◽  
Maeve M. Skelly ◽  
Hamid Yousuf ◽  
...  
Keyword(s):  
Body Composition ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
The Body ◽  
Tissue Loss ◽  
Composition Analysis ◽  
Healthy Population ◽  
Regional Body Composition ◽  
Android Fat ◽  
Gynoid Fat

AbstractCrohn’s disease (CD) is a debilitating inflammatory bowel condition of unknown aetiology that is growing in prevalence globally. Large-scale studies have determined associations between female obesity or low body mass index (BMI) with risk of CD at all ages or 8– < 40 years, respectively. For males, low BMI entering adult life is associated with increased incidence of CD or ulcerative colitis up to 40 years later. Body composition analysis has shown that combinations of lean tissue loss and high visceral fat predict poor CD outcomes. Here, we assessed dietary intake, physical activity and whole or regional body composition of patients with CD relapse or remission. This anthropometric approach found people with CD, irrespective of relapse or remission, differed from a large representative healthy population sample in exhibiting elevated gynoid fat and reduced android fat. CD is associated with mesenteric adipose tissue, or “creeping fat”, that envelops affected intestine exclusive of other tissue; that fat is localised to the android region of the body. In this context, CD mesenteric adiposity represents a stark juxtaposition of organ-specific and regional adiposity. Although our study population was relatively small, we suggest tentatively that there is a rationale to refer to Crohn’s disease as a fatty intestine condition, akin to fatty liver conditions. We suggest that our data provide early insight into a subject that potentially warrants further investigation across a larger patient cohort.

Computed tomography (CT) enteroclysis in comparison to lleo-colonoscopy in patients with Crohn's disease (CD)

2001 ◽  
Vol 120 (5) ◽  
pp. A3-A3
Author(s):  
C HASSAN ◽  
P CERRO ◽  
A ZULLO ◽  
C SPINA ◽  
S MORINI
Keyword(s):  
Computed Tomography ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Ct Enteroclysis

Clinical profile and predictors of disease behavior and surgery in Indian patients with Crohn's disease

2013 ◽  
Vol 32 (3) ◽  
pp. 184-189 ◽  
Author(s):  
Ashish Goel ◽  
Amit Kumar Dutta ◽  
Anna B. Pulimood ◽  
Anu Eapen ◽  
Ashok Chacko
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Clinical Profile ◽  
Indian Patients ◽  
Disease Behavior

79 Disease Behavior in Crohn's Disease Patients Diagnosed in the Biological Era - A Dutch Population-Based IBD-SL Cohort Study

2015 ◽  
Vol 148 (4) ◽  
pp. S-22-S-23 ◽  
Author(s):  
Steven Jeuring ◽  
Tim Van den Heuvel ◽  
Maurice Zeegers ◽  
Wim Hameeteman ◽  
Mariëlle Romberg-Camps ◽  
...  
Keyword(s):  
Cohort Study ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Population Based ◽  
Dutch Population ◽  
Disease Behavior

Musculoskeletal Complications of Crohn's Disease: The Role of Computed Tomography in Diagnosis and Patient Management

Orthopedics ◽  
2000 ◽  
Vol 23 (11) ◽  
pp. 1181-1185
Author(s):  
Howard I Brenner ◽  
Elliot K Fishman ◽  
Mary L Harris ◽  
Theodore M Bayless
Keyword(s):  
Computed Tomography ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Patient Management

Long-term Disease Behavior and Surgical Intervention Analysis in Hospitalized Patients with Crohn's Disease in China: A Retrospective Cohort Study

2021 ◽  
Author(s):  
Xiaoyin Bai ◽  
Huimin Zhang ◽  
Gechong Ruan ◽  
Hong Lv ◽  
Yue Li ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Large Scale ◽  
Hospitalized Patients ◽  
Disease Classification ◽  
Real World Data ◽  
Disease Behavior ◽  
Initial Classification

Abstract Background There is lack of real-world data for disease behavior and surgery of Crohn’s disease (CD) from large-scale Chinese cohorts. Methods Hospitalized patients diagnosed with CD in our center were consecutively included from January 2000 to December 2018. Disease behavior progression was defined as the initial classification of B1 to the progression to B2 or B3. Clinical characteristics including demographics, disease classification and activity, medical therapy, development of cancers, and death were collected. Results Overall, 504 patients were included. Two hundred and thirty one (45.8%) patients were initially classified as B1; 30 (13.0%), 71 (30.7%), and 95 (41.1%) of them had disease progression at the 1-year follow-up, 5-year follow-up, and overall, respectively. Patients without location transition before behavior transition were less likely to experience behavior progression. However, patients without previous exposure to a corticosteroid, immunomodulator, or biological agent had a greater chance of experiencing behavior progression. When the long-term prognosis was evaluated, 211 (41.9%) patients underwent at least one CD-related surgery; 108 (21.4%) and 120 (23.8%) of these patients underwent surgery before and after their diagnosis, respectively. An initial classification as B1, no behavior transition, no surgery prior to diagnosis, and previous corticosteroid exposure during follow-up were associated with a lower risk of undergoing surgery. Conclusions This study depicts the clinical features and factors associated with behavior progression and surgery among hospitalized CD patients in a Chinese center. Behavior progression is associated with a higher probability of CD-related surgery, and strengthened therapies are necessary for them in the early phase.

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