scholarly journals Conventional osteosarcoma of the mandible successfully treated with radical surgery and adjuvant chemotherapy after responding poorly to neoadjuvant chemotherapy: a case report

2017 ◽  
Vol 11 (1) ◽  
Author(s):  
Yutaro Kimura ◽  
Kei Tomihara ◽  
Hidetake Tachinami ◽  
Shuichi Imaue ◽  
Kenji Nakamori ◽  
...  
Keyword(s):  
Case Report ◽  
Adjuvant Chemotherapy ◽  
Neoadjuvant Chemotherapy ◽  
Radical Surgery ◽  
Conventional Osteosarcoma

Neoadjuvant chemotherapy plus radical surgery in locally advanced cervical cancer during pregnancy: a case report

2007 ◽  
Vol 197 (4) ◽  
pp. e5-e6 ◽  
Author(s):  
Innocenza Palaia ◽  
Milena Pernice ◽  
Marialida Graziano ◽  
Filippo Bellati ◽  
Pierluigi Benedetti Panici
Keyword(s):  
Cervical Cancer ◽  
Case Report ◽  
Neoadjuvant Chemotherapy ◽  
Radical Surgery ◽  
Locally Advanced ◽  
Advanced Cervical Cancer ◽  
Locally Advanced Cervical Cancer

scholarly journals Neoadjuvant Chemotherapy and Radical Surgery in Locally Advanced Cervical Cancer During Pregnancy: Case Report and Review of Literature

2013 ◽  
Vol 28 (1) ◽  
pp. 60-62 ◽  
Author(s):  
Zohreh Yousefi ◽  
Azam Hoseini Hoshyar ◽  
Sima Kadkhodayan ◽  
Maliheh Hasanzade ◽  
Mahmoud Reza Kalantari ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Case Report ◽  
Neoadjuvant Chemotherapy ◽  
Radical Surgery ◽  
Locally Advanced ◽  
Advanced Cervical Cancer ◽  
Review Of Literature ◽  
Locally Advanced Cervical Cancer

Comparison of radical surgery followed by adjuvant chemotherapy with radical surgery following neoadjuvant chemotherapy as initial treatment for patients with locally advanced thoracic esophageal squamous cell carcinoma.

2015 ◽  
Vol 33 (3_suppl) ◽  
pp. 187-187
Author(s):  
Yasuhiro Tsubosa ◽  
Masahiro Niihara ◽  
Satoru Matsuda ◽  
Katsuhisa Ogi ◽  
Katsushi Takebayashi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Adjuvant Chemotherapy ◽  
Neoadjuvant Chemotherapy ◽  
Radical Surgery ◽  
Locally Advanced ◽  
Complete Resection ◽  
Resection Rate ◽  
Complete Resection Rate ◽  
Significant Difference ◽  
Treat Analysis

187 Background: Although radical surgery with neoadjuvant chemotherapy (NAC) is a standard therapy for locally advanced thoracic esophageal squamous cell carcinoma (ESCC) in response to the result of JCOG 9907 study in Japan, there was no significant difference in survival rate at adjuvant chemotherapy and neoadjuvant chemotherapy in cStage III at subanalysis. Methods: Consecutive patients histologically diagnosed with ESCC and planned to undergo radical surgery followed by adjuvant chemotherapy (ADJ) from September 2002 to April 2007 and radical surgery following NAC from May 2007 to December 2011 as initial treatment were eligible for this retrospective study. To select patients who could tolerate transthoracic esophagectomy, respiratory function, Eastern Cooperative Oncology Group performance status, and preoperative complications were considered. As adjuvant and neoadjuvant chemotherapy, cisplatin and 5-fluorouracil were administered every 3 weeks for 2 cycles (FP). Patient characteristics, 3-year overall survival (3yOS) and non complete resection rate were investigated. We analyzed in intent-to-treat analysis. Results: Ninety patients were included in ADJ group, 98 included in NAC group. No significant differences were observed in clinicopathological factors between ADJ group (cStage IB/II/III/IV=6/22/57/5) and NAC group (cStage IB/II/III/IV=10/28/52/8). In intention-to-treat analysis, there was no significant difference in 3yOS rate by ADJ group and NAC group (ADJ group, 67.2%; NAC group, 66.0%; p = 0.301). However, non complete resection rate was significantly higher for NAC group than for ADJ group {ADJ group, 16.7% (3/90); NAC group, 3.4% (14/98); p = 0.009}. In cStage III, non complete resection rate of ADJ group was 3.5% (2/57) and NAC group was 25% (13/52). In the patients with cStage III, NAC group had a tendency for 3yOS rate to be low rather than ADJ group (ADJ group, 66.3%; NAC group, 51.1%; p = 0.09). Conclusions: In cStage III advanced ESCC, FP as NAC may be insufficient and development of the more powerful NAC is desired.

Recurrence of rare malignant Brenner ovarian tumor

2021 ◽  
Vol 86 (4) ◽  
pp. 250-257
Author(s):  
Beáta Feckaninová ◽  
◽  
Radovan Pilka ◽  
Zuzana Slobodová
Keyword(s):  
Case Report ◽  
Adjuvant Chemotherapy ◽  
Ovarian Tumor ◽  
Radical Surgery ◽  
Abdominal Hysterectomy ◽  
Ovarian Tumour ◽  
Rare Occurrence ◽  
Paraaortic Lymphadenectomy ◽  
Objective Description

Summary: Objective: Description of the case of recurrence of a  rare malignant Brenner ovarian tumour. Methods: Author observation and literature resources. Results: Occurrence of a rare malignant Brenner's tumor in a 66-year-old patient. After radical surgery (abdominal hysterectomy with bilateral adnexectomy, pelvic and paraaortic lymphadenectomy, omentectomy and appendectomy) and after adjuvant chemotherapy, recurrence of the disease was observed after 30 months. Conclusions: The case report describes rare occurrence of a malignant Brenner tumour and its relapse.

scholarly journals Primary malignant mucosal melanoma of the larynx: A case report and literature review

2015 ◽  
Vol 5 (10) ◽  
pp. 872-874
Author(s):  
S Shrestha Khadka ◽  
MC Lee ◽  
AB Karki
Keyword(s):  
Case Report ◽  
Adjuvant Chemotherapy ◽  
Malignant Melanoma ◽  
Literature Review ◽  
Head And Neck ◽  
Radical Surgery ◽  
Mucosal Melanoma ◽  
Rare Entity ◽  
Mucous Membranes ◽  
Female Genital

Malignant mucosal melanoma is very rare entity. It comprises about 1% of all malignant melanoma and exhibit more aggressive behaviour than that of skin melanomas. Mucosal melanoma arises mainly from the mucous membranes of head and neck, the female genital organs or the anorectal and the urinary tracts.  Laryngeal malignant melanoma constitutes 3.8% to 7.4% of all cases of malignant mucosal melanoma of head and neck. In this article we report a case of primary malignant mucosal melanoma of larynx in 27 years old male who was treated with radical surgery and adjuvant chemotherapy in BPKM Cancer Hospital, Chitwan.

scholarly journals Nomogram for Predicting Survival in Advanced Gastric Cancer after Neoadjuvant Chemotherapy and Radical Surgery

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Yonghe Chen ◽  
Dan Liu ◽  
Jian Xiao ◽  
Jun Xiang ◽  
Aihong Liu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Adjuvant Chemotherapy ◽  
Neoadjuvant Chemotherapy ◽  
Advanced Gastric Cancer ◽  
Cox Regression ◽  
Radical Surgery ◽  
Survival Rates ◽  
Receiver Operating Curve ◽  
R0 Resection ◽  
Clinical Parameters

Background. Neoadjuvant chemotherapy (NAC) with subsequent radical surgery has become a popular treatment modality for advanced gastric cancer (AGC) worldwide. However, the survival benefit is still controversial, and prognostic factors remain undetermined. Aim. To identify clinical parameters that are associated with the survival of AGC patients after NAC and radical surgery and to establish a nomogram integrating multiple factors to predict survival. Methods. We reviewed the medical profiles of 215 AGC patients who received NAC and radical resection, and clinical parameters concerning NAC, surgery, pathological findings, and adjuvant chemotherapy were analyzed using a Cox regression model to determine their impact on survival. Based on these factors, a nomogram was developed and validated. Results. The overall 1-year and 3-year survival rates were 85.8% and 55.6%, respectively. Younger age (<60 years old), increased examined lymph nodes (exLNs), successful R0 resection, the achievement of pathological complete response (pCR), and acceptance of adjuvant chemotherapy were positive predictors of survival. The C-index of the established nomogram was 0.785. The area under receiver operating curve (ROC) at 1/3 years of prediction was 0.694/0.736, respectively. The model showed an ideal calibration following internal bootstrap validation. Conclusion. A nomogram predicting survival after NAC and surgery was established. Since this nomogram exhibited satisfactory and stable predictive power, it can be inferred that this is a practical tool for predicting AGC patient survival after NAC and radical surgery.

scholarly journals Large cell neuroendocrine cervical tumor treated by radical surgery and adjuvant chemotherapy: A case report and literature review

2015 ◽  
Vol 11 (1) ◽  
pp. 189-193 ◽  
Author(s):  
NICOLAE BACALBAȘA ◽  
CLAUDIA STOICA ◽  
MADALINA MARCU ◽  
DANIELA MIHALACHE ◽  
FLORINA VASILESCU ◽  
...  
Keyword(s):  
Case Report ◽  
Adjuvant Chemotherapy ◽  
Literature Review ◽  
Radical Surgery ◽  
Large Cell ◽  
Cervical Tumor

scholarly journals Nomogram for predicting survival in advanced gastric cancer after neoadjuvant chemotherapy and radical surgery

2020 ◽  
Author(s):  
Yonghe Chen ◽  
Dan Liu ◽  
Jian Xiao ◽  
Jun Xiang ◽  
Aihong Liu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Adjuvant Chemotherapy ◽  
Neoadjuvant Chemotherapy ◽  
Advanced Gastric Cancer ◽  
Cox Regression ◽  
Radical Surgery ◽  
Survival Rates ◽  
Radical Resection ◽  
R0 Resection ◽  
Clinical Parameters

Abstract BACKGROUND Neoadjuvant chemotherapy (NAC) with subsequent radical surgery has become a popular treatment modality for advanced gastric cancer (AGC) worldwide. However, the survival benefit is still controversial, and prognostic factors remain undetermined. AIM To identify clinical parameters that are associated with the survival of AGC patients after NAC and radical surgery and to establish a nomogram integrating multiple factors to predict survival. METHODS We reviewed the medical profiles of 215 AGC patients who received NAC and radical resection, and clinical parameters concerning NAC, surgery, pathological findings, and adjuvant chemotherapy were analyzed using a Cox regression model to determine their impact on survival. Based on these factors, a nomogram was developed and validated. RESULTS The overall 1-year and 3-year survival rates were 85.8% and 55.6%, respectively. Younger age (< 60 years old), increased examined lymph nodes (exLNs), successful R0 resection, achievement of pathological complete response (pCR), and acceptance of adjuvant chemotherapy were positive predictors of survival. The concordance statistic of the established nomogram was 0.785. The model showed an ideal calibration following internal bootstrap validation. CONCLUSION A nomogram predicting survival after NAC and surgery was established. Since this nomogram exhibited satisfactory and stable predictive power, it can be inferred that this it is a practical tool for predicting AGC patient survival after NAC and radical surgery.

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