scholarly journals Interferon-induced sarcoidosis with uveitis as the initial symptom: a case report and review of the literature

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Ai Kato ◽  
Mami Ishihara ◽  
Nobuhisa Mizuki
Keyword(s):  
Case Reports ◽  
Relevant Literature ◽  
Corticosteroid Treatment ◽  
Pegylated Interferon ◽  
Skin Lesions ◽  
Japanese Woman ◽  
Interferon Α ◽  
Initial Symptom ◽  
Initial Symptoms ◽  
Old Japanese

Abstract Background In recent years, numerous studies have reported the development or exacerbation of sarcoidosis due to interferon therapy. However, ocular lesions rarely present as initial symptoms. Herein, we describe a rare case of interferon-α-induced sarcoidosis with uveitis as the initial symptom, and present a review of the relevant literature. Case presentation This case involved a 62-year-old-Japanese woman with a history of a combination treatment of pegylated interferon-α-2a, ribavirin, and simeprevir, after which she developed granulomatous panuveitis. She was subsequently diagnosed with sarcoidosis following histological examination of skin biopsy specimens. In addition to reporting this case, we performed a literature review of 27 cases (24 case reports) of histopathologically diagnosed interferon-α-induced sarcoidosis published between January 2009 and November 2018. Conclusions Among the reviewed cases, 23 (85.1%) cases developed skin lesions and 19 (70.1%) had lung lesions. Only three cases (11.1%) had accompanying eye lesions. Interferon-α therapy was discontinued in 16 cases (52.9%), and the majority exhibited improvement after systemic corticosteroid treatment. There are few reported cases of interferon-α-induced sarcoidosis with uveitis as the initial symptom. However, if uveitis develops during or after interferon-α treatment, it might represent an initial symptom of interferon-α-induced sarcoidosis, as observed in the present case.

scholarly journals Dermoscopic Features of Pigmented Bowen's Disease in a Japanese Female Mimicking Malignant Melanoma

2010 ◽  
Vol 2010 ◽  
pp. 1-3 ◽  
Author(s):  
Takayuki Inoue ◽  
Ken Kobayashi ◽  
Mizuki Sawada ◽  
Sumiko Ishizaki ◽  
Haruo Ito ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Skin Lesions ◽  
Japanese Woman ◽  
Bowen’S Disease ◽  
Seborrheic Keratosis ◽  
Bowen's Disease ◽  
Pathologic Features ◽  
Old Japanese ◽  
History Of ◽  
Pigmented Skin Lesions

Various structures have been reported for dermoscopic features of pigmented Bowen's disease (BD), which could be a mimic of various pigmented skin lesions. A 79-year-old Japanese woman presented with a 3-year history of brown-black macule on her right upper arm without symptom. Dermoscopic examination demonstrated irregular flossy streaks, irregular brown dots/globules, blue-whitish regression structures, and overlaying whitish scaly areas. We suspected pigmented skin lesions including seborrheic keratosis, pigmented eccrine poroma, and malignant melanoma and excised completely with a 5 mm margin. Histopathological features were consistent with a diagnosis of pigmented BD. Although similar dermoscopic features might be revealed in pigmented skin lesions and it may occasionally be difficult to distinguish between pigmented BD and other pigmented skin lesions, dermoscopy would be useful in speculating pathologic features of pigmented BD.

scholarly journals Efficacy of Secukinumab for Plaque Psoriasis in a Patient on Hemodialysis

2019 ◽  
Vol 9 (1) ◽  
pp. 55-58 ◽  
Author(s):  
Daiuske Ikuma ◽  
Masahiko Oguro ◽  
Junichi Hoshino ◽  
Hiroki Mizuno ◽  
Akinari Sekine ◽  
...  
Keyword(s):  
Plaque Psoriasis ◽  
End Stage Renal Disease ◽  
Adverse Reactions ◽  
Severity Index ◽  
Skin Lesions ◽  
Japanese Woman ◽  
Old Japanese ◽  
Pasi Score ◽  
Stage Renal Disease ◽  
End Stage

Abstract Secukinumab is effective to treat plaque psoriasis. However, the safety and efficiency of secukinumab have not been clarified in patients on hemodialysis. We report a 60-year-old Japanese woman. Plaque psoriasis was diagnosed at the age of 25 years and hemodialysis was started at the age of 39 years. Her skin lesions persisted despite use of topical agents such as maxacalcitol and betamethasone. Accordingly, administration of secukinumab was started at a dose of 150 mg. The psoriasis area and severity index (PASI) score decreased from 49.8 to 14.8 after 2 weeks and to 0 after 6 weeks, with remission being maintained after 28 months. No adverse reactions were seen. This case indicates that secukinumab may be effective for severe psoriasis in patients on hemodialysis for end-stage renal disease.

scholarly journals Successful Treatment of Hemophagocytic Lymphohistiocytosis Associated with Lupus Nephritis by Using Mycophenolate Mofetil

2017 ◽  
Vol 2017 ◽  
pp. 1-3 ◽  
Author(s):  
Takashi Nawata ◽  
Makoto Kubo ◽  
Kosaku Shiragami ◽  
Yukinori Nakamura ◽  
Masafumi Yano
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Mycophenolate Mofetil ◽  
Lupus Nephritis ◽  
Lupus Erythematosus ◽  
Hemophagocytic Lymphohistiocytosis ◽  
Corticosteroid Treatment ◽  
Immunosuppressive Drugs ◽  
Japanese Woman ◽  
Systemic Lupus ◽  
Old Japanese

An estimated 0.9% to 2.4% of patients with systemic lupus erythematosus (SLE) also have hemophagocytic lymphohistiocytosis (HLH). HLH associated with autoimmune diseases is often refractory to corticosteroid treatment; thus, additional immunosuppressive drugs, such as cyclosporine, cyclophosphamide, or tacrolimus, are required. Here, we describe the case of a 44-year-old Japanese woman who developed HLH associated with lupus nephritis. Initially, her HLH was refractory to treatment with a corticosteroid, tacrolimus, and mizoribine. However, alternative treatment with a corticosteroid, mycophenolate mofetil, and tacrolimus improved both her HLH and lupus nephritis. This case suggests the possibility of mycophenolate mofetil as a key drug for treating HLH associated with SLE.

Catatonia in High-Functioning Autism Spectrum Disorders: Case Report and Review of Literature

2007 ◽  
Vol 101 (3) ◽  
pp. 961-969 ◽  
Author(s):  
Ken Takaoka ◽  
Tomoji Takata
Keyword(s):  
Autism Spectrum Disorders ◽  
Mood Disorder ◽  
High Functioning Autism ◽  
Single Case ◽  
Case Reports ◽  
Autism Spectrum ◽  
Japanese Woman ◽  
High Functioning ◽  
Old Japanese ◽  
Spectrum Disorders

Although catatonia has been identified in individuals with autism spectrum disorders, little is known about this relationship. Studies on previous case reports dealing with the relationship between catatonia and autism spectrum disorders are reviewed, then the case of a 28-yr.-old Japanese woman with high-functioning autism spectrum disorder who exhibited mood disorder and catatonia is described. Her mood disorder was apparently induced by a crisis of her “inner world,” constituted as a way of coping with a sense of alienation, related to her impaired development in reciprocal social interaction. Environmental change, a precipitating factor, induced alternation between catatonia and depression. Fluvoxamine ameliorated both features. The catatonia identified in this patient is considered to be symptom derived from depression. Given the limitation of this single case, such a conclusion is necessarily tentative. Closer investigation into cases in which patients with high-functioning autism spectrum disorders describe their own psychological experiences should be pursued.

scholarly journals Clinically amyopathic dermatomyositis during the COVID-19 pandemic

2021 ◽  
Vol 2021 (8) ◽  
Author(s):  
Masakazu Kitamura ◽  
Hiroshi Sugimoto
Keyword(s):  
Computed Tomography ◽  
Ct Scan ◽  
Oral Prednisolone ◽  
Skin Lesions ◽  
Japanese Woman ◽  
Ground Glass ◽  
Amyopathic Dermatomyositis ◽  
Chest Computed Tomography ◽  
Clinically Amyopathic Dermatomyositis ◽  
Old Japanese

ABSTRACT An 84-year-old Japanese woman presented to our hospital with a month-long dry cough during the coronavirus disease 2019 (COVID-19) pandemic. She also had skin lesions on her fingers from 3 months prior. A chest computed tomography (CT) scan showed bilateral ground- glass opacities with a subpleural distribution, similar to the findings of COVID-19. The results of COVID-19 tests were negative. The titer of the anti-melanoma differentiation-associated gene 5 (MDA5) antibody was elevated. Consequently, we confirmed the diagnosis of clinically amyopathic dermatomyositis (CADM) and then administered oral prednisolone combined with tacrolimus. After the treatment, her symptoms, skin lesions and CT findings were gradually resolved.

scholarly journals Gastrointestinal perforation in anti-NXP2 antibody-associated juvenile dermatomyositis: Case reports and a review of the literature

2020 ◽  
Author(s):  
Yingjie Xu ◽  
Xiaolin Ma ◽  
Zhixuan Zhou ◽  
Jianguo Li ◽  
jun Huo ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Early Diagnosis ◽  
Juvenile Dermatomyositis ◽  
Case Reports ◽  
Relevant Literature ◽  
Ureteral Stricture ◽  
Ureteral Calculus ◽  
Intermittent Fever ◽  
Fatal Complication ◽  
Initial Symptoms

Abstract Background: To summarize the characteristics of gastrointestinal (GI) perforation in anti-NXP2 antibody-associated juvenile dermatomyositis (JDM). Methods: Five patients with GI perforation from a JDM cohort of 120 cases are described. Relevant literature was reviewed. Results: Five patients, including 4 females and 1 male, were involved in the study. The average age of the 5 patients was 5.74 years (5.74 ±2.82). Myositis-specific antibody (MAS) spectrum analysis indicated that the five patients were anti-NXP2 antibody positive. The initial symptoms of GI perforation were progressive abdominal pain and intermittent fever. Two patients also presented with ureteral calculus with hydronephrosis and ureteral stricture. Surgery was performed in four patients, which was successful in only one patient through fistulization. Four patients died (4/5, 80%), and 1 patient was completely relieved after 2 years of treatment. Combined with 16 patients described in the literature, the onset symptom was progressive abdominal pain, which often occurred within 10 months after JDM was diagnosed. Perforation most often occurred in the duodenum, although perforations at multiple sites or recurrent perforations also occurred. The mortality rate of GI perforation in JDM was 38% (8/21). Conclusions: All perforation cases subjected to MAS analysis were anti-NXP2 antibody positive. The onset symptom was abdominal pain. The most common site of perforation was the duodenum in the retroperitoneum, and the lack of acute abdominal manifestations complicated early diagnosis. GI perforation is a fatal complication in JDM, and early diagnosis is very important. More research is needed to determine the pathogenesis and predictive factors of GI perforation in JDM.

scholarly journals Anti-MDA5 Antibody-Positive Dermatomyositis Presenting with Cellulitis-Like Erythema on the Mandible as an Initial Symptom

2018 ◽  
Vol 10 (2) ◽  
pp. 110-114 ◽  
Author(s):  
Yuki Hattori ◽  
Kanako Matsuyama ◽  
Tomoko Takahashi ◽  
En Shu ◽  
Hiroyuki Kanoh ◽  
...  
Keyword(s):  
Muscle Weakness ◽  
Oral Prednisolone ◽  
Pulse Therapy ◽  
Japanese Woman ◽  
Initial Symptom ◽  
Steroid Pulse ◽  
Intravenous Steroid ◽  
Old Japanese ◽  
The Face ◽  
Typical Skin

Panniculitis is an uncommon skin eruption observed in patients with dermatomyositis (DM)/clinically amyopathic dermatomyositis (CADM), especially in anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive DM. We present here a 51-year-old Japanese woman with an anti-MDA5 antibody-positive DM who initially had cellulitis-like erythema on her right mandible. Histopathological findings showed a subcutaneous lobular infiltration of lymphocytes. The patient developed typical skin eruptions of DM/CADM, rapidly progressive interstitial lung disease, and severe muscle weakness 2 weeks after the first visit. After the diagnosis of anti-MDA5 antibody-positive DM, she was treated with intravenous steroid pulse therapy (methylprednisolone, 1,000 mg/day for 3 days), oral prednisolone at 1.0 mg/kg/day, and tacrolimus at 4.0 mg/day. The lesions of panniculitis associated with DM/CADM typically present on the buttocks, thighs, arms, and abdomen. This is the first DM/CADM case with localized panniculitis on the face. Panniculitis and myositis usually show simultaneous improvement during treatment. Although panniculitis disappeared with steroid and tacrolimus treatment and did not recur, muscle weakness was intractable and recurred in this case. This indicates that the clinical courses of panniculitis and myositis of DM/CADM do not always change in parallel.

scholarly journals Neuroendocrine carcinoma arising in a wound of the postoperative maxillary sinus

2012 ◽  
Vol 2 (1) ◽  
pp. 16
Author(s):  
Takeshi Kusunoki ◽  
Katsuhisa Ikeda
Keyword(s):  
Maxillary Sinus ◽  
Neuroendocrine Carcinoma ◽  
Past History ◽  
Japanese Woman ◽  
Old Japanese ◽  
Weighted Magnetic Resonance Imaging ◽  
Maxillary Cyst ◽  
Left Maxillary Sinus ◽  
Eye Movement Disorders ◽  
Cheek Swelling

We report a case of a neuroendocrine carcinoma arising in a wound of the postoperative maxillary sinus that was difficult to distinguish from a postoperative maxillary cyst. The patient was a 65-year-old Japanese woman who complained of left exophthalmos with cheek swelling and eye movement disorders. In past history, she had, 40 years previously undergone operation on the bilateral maxillary sinus by Caldwell-Luc’s method. In a preoperative computed tomography, a mass occupied the left maxillary sinus showing irregular densities with destruction of the posterior bone walls and invasion into the left orbital. Both TI and T2 weighted magnetic resonance imaging showed low intensities and unevenness in the mass. We performed a biopsy of the maxillary tumor according to Caldwell-Luc’s method. Histological examination diagnosed neuroendocrine carcinoma. Radiation therapy (total 66Gy) resulted in partial response for this tumor. However, sinonasal neuroendocrine carcinoma has been identified as highly aggressive, with a high probability of recurrence and metastasis.

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