Dermoscopic Features of Pigmented Bowen's Disease in a Japanese Female Mimicking Malignant Melanoma

Various structures have been reported for dermoscopic features of pigmented Bowen's disease (BD), which could be a mimic of various pigmented skin lesions. A 79-year-old Japanese woman presented with a 3-year history of brown-black macule on her right upper arm without symptom. Dermoscopic examination demonstrated irregular flossy streaks, irregular brown dots/globules, blue-whitish regression structures, and overlaying whitish scaly areas. We suspected pigmented skin lesions including seborrheic keratosis, pigmented eccrine poroma, and malignant melanoma and excised completely with a 5 mm margin. Histopathological features were consistent with a diagnosis of pigmented BD. Although similar dermoscopic features might be revealed in pigmented skin lesions and it may occasionally be difficult to distinguish between pigmented BD and other pigmented skin lesions, dermoscopy would be useful in speculating pathologic features of pigmented BD.

Download Full-text

Squamous Cell Carcinoma and Multiple Bowen's Disease in a Patient with a History of Consumption of Traditional Chinese Herbal Balls

Case Reports in Dermatology ◽

10.1159/000437250 ◽

2015 ◽

Vol 7 (2) ◽

pp. 151-155 ◽

Cited By ~ 4

Author(s):

Joon Seok ◽

Kui Young Park ◽

Kapsok Li ◽

Beom Joon Kim ◽

Joo Hyun Shim ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Skin Lesions ◽

Sufficient Evidence ◽

Bowen’S Disease ◽

Bowen's Disease ◽

Chinese Herbal ◽

History Of ◽

The Right

Arsenic has been classified as a class I human carcinogen, meaning that there is sufficient evidence of carcinogenicity to humans. Arsenic, however, remains a common contaminant in a number of traditional Chinese herbal balls. A 64-year-old man presented with an erythematous erosive patch on the left palm, multiple yellowish scaly patches on the right palm and an erythematous hyperkeratotic patch with bleeding on the left foot dorsum. He also had similar skin lesions on the back and buttock. He had a past medical history of chronic exposure to arsenic through consumption of traditional Chinese herbal balls. Skin biopsy revealed Bowen's disease on the left palm and squamous cell carcinoma on left foot dorsum. We report this case to emphasize that we should investigate patient's history thoroughly, including the use of Chinese herbal balls to find out arsenicism.

Download Full-text

A challenging case of pigmented Bowen’s disease and differential diagnosis of pagetoid pigmented skin lesions

Pathologica ◽

10.32074/1591-951x-21-19 ◽

2019 ◽

Vol 111 (3) ◽

pp. 98-104

Author(s):

V. Caputo ◽

E. Caselli ◽

M. Ribotta ◽

E. Bonoldi

Keyword(s):

Differential Diagnosis ◽

Skin Lesions ◽

Bowen’S Disease ◽

Bowen's Disease ◽

Pigmented Skin Lesions

Download Full-text

Pigmented Bowen’s disease mimicking melanoma clinically and dermoscopically

Revista da Sociedade Portuguesa de Dermatologia e Venereologia ◽

10.29021/spdv.72.1.152 ◽

2014 ◽

Vol 72 (1) ◽

Author(s):

Daniel Holanda Daniel

Keyword(s):

Carcinoma In Situ ◽

Clinical Case ◽

Left Thigh ◽

Bowen’S Disease ◽

Seborrheic Keratosis ◽

Cutaneous Lesions ◽

Rare Form ◽

Bowen's Disease ◽

Basal Cell Carcinomas

A variety of cutaneous lesions can mimic melanoma, such as melanocytic nevi, lentigines, seborrheic keratosis, blue nevi, pigmented basal cell carcinomas and dermatofibromas. This report describes a rare clinical case of a female patient who presented a lesion on the left thigh, which was clinically and dermoscopically compatible with melanoma. The patient underwent excision of the lesion, and histopathology confirmed a diagnosis of pigmented Bowen’s disease. The purpose of this report is to draw attention to the fact that pigmented Bowen’s disease, a rare form of squamous cell carcinoma in situ, should also be considered as a differential diagnosis of malignant melanoma.

Download Full-text

MALIGNANT MELANOMA AND PREGNANCY

Romanian Medical Journal ◽

10.37897/rmj.2021.2.2 ◽

2021 ◽

Vol 68 (2) ◽

pp. 143-146

Author(s):

Delia Cudalbă ◽

◽

Nicolae Gică ◽

Radu Botezatu ◽

Corina Gică ◽

...

Keyword(s):

Malignant Melanoma ◽

Poor Prognosis ◽

Skin Lesions ◽

Fetal Medicine ◽

Treatment Need ◽

Pigmented Skin Lesions ◽

Pregnant State ◽

State Diagnosis ◽

Patients With Poor Prognosis ◽

In Pregnancy

Malignant melanoma is one of the most frequent cancers diagnosed during pregnancy. Any pigmented skin lesions that change the color should be examined by an experienced dermatologist and if suspected, should be biopsied. Recent studies showed that malignant melanoma in pregnancy has not a worse outcome compared with non-pregnant state. Diagnosis of melanoma does not require an early delivery excepted pregnant patients with poor prognosis that need more aggressive treatment. Diagnosis and treatment need to be established in specialized centers with a multidisciplinary team. Pregnancy monitoring should be performed by team consisting of an obstetrician, a neonatologist and a specialist in fetal medicine.

Download Full-text

Malignant melanoma

InnovAiT Education and inspiration for general practice ◽

10.1177/1755738019836450 ◽

2019 ◽

Vol 12 (6) ◽

pp. 297-303

Author(s):

Charlotte Sidebotham

Keyword(s):

Public Health ◽

Malignant Melanoma ◽

Skin Lesions ◽

Health Concern ◽

Public Health Concern ◽

Favourable Prognosis ◽

Younger Age ◽

Pigmented Skin Lesions ◽

Early Primary

Melanoma affects people at a younger age than other cancers, and can rapidly become fatal if not detected. Thus, pigmented skin lesions can cause concern in both doctors and patients. If discovered in the early primary stages, melanomas have a favourable prognosis. Over the last few decades, the incidence of melanoma has significantly increased, and is fast becoming an urgent public health concern. This article aims to shine a light on this dangerous adversary.

Download Full-text

Cochlear fistula found in a naturally healed tympanic cavity

The Journal of Laryngology & Otology ◽

10.1017/s0022215100116950 ◽

1991 ◽

Vol 105 (8) ◽

pp. 656-658 ◽

Cited By ~ 2

Author(s):

Mamoru Suzuki ◽

Isao Nishida ◽

Katsuhiro Hirakawa ◽

Masafumi Nikaido ◽

Yasuo Harada

Keyword(s):

Semicircular Canal ◽

Posterior Wall ◽

Japanese Woman ◽

Mastoid Cavity ◽

Tympanic Cavity ◽

Ear Canal ◽

Horizontal Semicircular Canal ◽

Old Japanese ◽

History Of ◽

Exploratory Surgery

AbstractA cochlear fistula found in a naturally healed mastoid cavity is reported. The patient is a 53-year-old Japanese woman who was complaining of unsteadiness. She hada long history of otorrhoea in childhood. Her tympanic and mastoid cavities were widely open and were covered by thin epithelium. The posterior wall of the ear canal was missing. She had no hearing in the ear but responded to electrical promontory testing. Exploratory surgery was indicated at which fistulae of the basal turn of the cochlea and the horizontal semicircular canal were found. These fistulae were sealed by pieces of bone andmuscle.

Download Full-text

Neuroleptic malignant syndrome as part of an akinetic crisis associated with sepsis in a patient with Lewy body disease

BMJ Case Reports ◽

10.1136/bcr-2018-227216 ◽

2019 ◽

Vol 12 (2) ◽

pp. bcr-2018-227216 ◽

Cited By ~ 1

Author(s):

Saki Manabe ◽

Hidetaka Yanagi ◽

Hideki Ozawa ◽

Atsushi Takagi

Keyword(s):

Neuroleptic Malignant Syndrome ◽

Lewy Body ◽

Cardiopulmonary Arrest ◽

Lewy Body Disease ◽

Kidney Injury ◽

Spontaneous Circulation ◽

Japanese Woman ◽

Old Japanese ◽

History Of ◽

Tentative Diagnosis

A 65-year-old Japanese woman with Parkinson’s disease, later diagnosed with Lewy body disease, presented with a 2-day history of systemic tremors. She also had fever without rigidity or creatine kinase (CK) elevation. She was diagnosed with sepsis caused by pyelonephritis with acute kidney injury and parkinsonism exacerbation. Although antibiotic and fluid therapy improved her pyuria and renal function, her fever and tremors persisted. On the fourth day, her symptoms worsened and resulted in cardiopulmonary arrest; however, quick resuscitation allowed the return of spontaneous circulation. Simultaneously, hyperthermia, altered consciousness, extrapyramidal symptoms, dysautonomia and CK elevation were noted. Thus, dantrolene administration was initiated with a tentative diagnosis of neuroleptic malignant syndrome (NMS). This caused her fever to subside, and her symptoms gradually improved. It was difficult to distinguish between parkinsonism exacerbation associated with sepsis and NMS. Physicians should consider NMS early on, even if the patient does not fulfil the diagnostic criteria.

Download Full-text

Tissue Hypoperfusion, Hypercoagulopathy, and Kidney and Liver Dysfunction after Ingestion of a Naphazoline-Containing Antiseptic

Case Reports in Emergency Medicine ◽

10.1155/2017/3968045 ◽

2017 ◽

Vol 2017 ◽

pp. 1-5

Author(s):

Yuko Ono ◽

Nozomi Ono ◽

Kazuaki Shinohara

Keyword(s):

Liver Dysfunction ◽

Laboratory Data ◽

Japanese Woman ◽

Over The Counter ◽

Tissue Hypoperfusion ◽

First Case ◽

Old Japanese ◽

History Of ◽

History Of Depression ◽

Adrenergic Receptor Agonist

Naphazoline is a peripheral α2-adrenergic receptor agonist commonly used as a topical decongestant. In Japan, over-the-counter antiseptics often contain naphazoline to effect local hemostasis. We present the first case involving the development of hypercoagulopathy, with kidney and liver dysfunction, following a naphazoline overdose. A 22-year-old Japanese woman with a history of depression ingested 160 mL of a commercially available antiseptic containing 0.1% naphazoline. Three days later, she was brought to the emergency department because of general fatigue, nausea, and vomiting. Physical examination revealed cool, pale extremities. Laboratory data showed evidence of severe kidney and liver dysfunction (creatinine, 9.2 mg/dL; alanine aminotransferase, 2948 IU/L), hypercoagulation (D-dimers, 58.3 μg/mL), and thrombocytopenia (platelet count, 90,000/μL). After infusion of normal saline, intravenous administration of alprostadil, and hemodiafiltration, her organ function completely recovered. Because both the kidney and liver express α2-adrenergic receptors, their failure was likely associated with naphazoline overdose-induced hypoperfusion. The most plausible causes of hypercoagulation are peripheral low perfusion and subsequent microthrombus formation. This case illustrates that severe organ dysfunction can occur following over-the-counter antiseptic ingestion and serves as a caution for both drug manufacturers and healthcare professionals.

Download Full-text