Host-pathogen interaction for larvae oysters with salinity dependent transmission

Abstract Mathematical models of host-pathogen interactions are proposed and analyzed. Here hosts are oyster population in a free-swimming larval stage and assumably live in the closed homogeneous environment. In terms of an epidemic, they are classified into two states, namely susceptible and infectious hosts. The epidemic model of oyster hosts with seasonal forced transmission is firstly described by the SIS model where the region of attraction, the existence of equilibrium points, their stability conditions, and upper and lower bounds on the attack rate are investigated. Then free-living pathogen is introduced in the oyster area. Numerical simulations are finally carried out by making use of the various salinity-dependent transmissions in support of the hypothesis that the lower the salinity level, the lower oyster’s immunity.

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Faculty Opinions recommendation of A Novel Mechanism of Host-Pathogen Interaction through sRNA in Bacterial Outer Membrane Vesicles.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726419717.793534336 ◽

2017 ◽

Author(s):

Burkhard Tümmler

Keyword(s):

Outer Membrane ◽

Membrane Vesicles ◽

Outer Membrane Vesicles ◽

Host Pathogen Interaction ◽

Host Pathogen ◽

Bacterial Outer Membrane

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The Role of Macrophages in the Host’s Defense against Sporothrix schenckii

Pathogens ◽

10.3390/pathogens10070905 ◽

2021 ◽

Vol 10 (7) ◽

pp. 905

Author(s):

Estela Ruiz-Baca ◽

Armando Pérez-Torres ◽

Yolanda Romo-Lozano ◽

Daniel Cervantes-García ◽

Carlos A. Alba-Fierro ◽

...

Keyword(s):

Immune Responses ◽

Macrophage Polarization ◽

Sporothrix Schenckii ◽

Macrophage Cell ◽

Cell Recruitment ◽

Host Pathogen Interaction ◽

Interaction Processes ◽

Host Pathogen ◽

Molecular Patterns

The role of immune cells associated with sporotrichosis caused by Sporothrix schenckii is not yet fully clarified. Macrophages through pattern recognition receptors (PRRs) can recognize pathogen-associated molecular patterns (PAMPs) of Sporothrix, engulf it, activate respiratory burst, and secrete pro-inflammatory or anti-inflammatory biological mediators to control infection. It is important to consider that the characteristics associated with S. schenckii and/or the host may influence macrophage polarization (M1/M2), cell recruitment, and the type of immune response (1, 2, and 17). Currently, with the use of new monocyte-macrophage cell lines, it is possible to evaluate different host–pathogen interaction processes, which allows for the proposal of new mechanisms in human sporotrichosis. Therefore, in order to contribute to the understanding of these host–pathogen interactions, the aim of this review is to summarize and discuss the immune responses induced by macrophage-S. schenckii interactions, as well as the PRRs and PAMPs involved during the recognition of S. schenckii that favor the immune evasion by the fungus.

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