Effect of Zanthoxylum alkylamides on glucose metabolism in streptozotocin-induced diabetic Sprague–Dawley rats

AbstractThis research aimed at investigating the hypoglycemic effect of Zanthoxylum alkylamides and whether TRPV1 receptor could participate in the glucose metabolism by using streptozotocin-induced diabetic rat model. The results showed that the blood glucose measured in the Zanthoxylum alkylamides treated group (ALK) showed significantly lower values than that in the model group (Model). Significant improvements in the oral glucose tolerance as well as plasma insulin and hepatic glycogen were also observed in the ALK group, when compared to the model group. However, the improving effects of Zanthoxylum alkylamides on glucose metabolism disorder in diabetic rats were markedly inhibited by capsazepine as the TRPV1 receptor antagonist. In addition, there were significant differences in the levels of mRNA and protein of phosphoenolpyruvate carboxylase (PEPCK), gucose-6-phosphatase (G6Pase), glucokinase (GK) and cannabinoid receptor l (CB1) in the livers of the ALK group compared to model group. Meanwhile, ALK group also exhibited a remarkable increase in the pancreatic-duodenal homeobox 1 (PDX-1), glucose transporter 2 (GLUT 2), GK levels and a significant decrease in the expression levels of CB1 in the pancreas, while the presence of capsazepine would affected the expression of these genes. These findings indicate that Zanthoxylum alkylamides could ameliorate the glucose metabolism disorder in diabetic rats. Furthermore, the TRPV1 receptor could participate in regulating the expressions of genes and proteins related to glucose metabolism and insulin secretion in the liver and pancreas, and takes a role in the hypoglycemic process of Zanthoxylum alkylamides.

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Elevated hepcidin, ferroportin associated with glucose metabolism disorder in midpregnancy

10.21203/rs.3.rs-18111/v1 ◽

2020 ◽

Author(s):

Ziwen Ma ◽

Yan Cheng ◽

Qingying Zhang ◽

Kui Wu ◽

Tingting Li ◽

...

Keyword(s):

Diabetes Mellitus ◽

Glucose Metabolism ◽

Iron Metabolism ◽

Plasma Glucose ◽

Tolerance Test ◽

Control Group ◽

Oral Glucose ◽

Model Assessment ◽

Metabolism Disorder ◽

Glucose Metabolism Disorder

Abstract [Objective]: Hepcidin and ferroportin are major regulators of iron metabolism. Although many previous studies have shown that iron metabolism disorder may contribute to the pathogenesis of Type 2 diabetes mellitus (DM), few studies have investigated hepcidin and other iron metabolism parameters in women with gestational diabetes mellitus (GDM). The purpose of this study was to determine the relationship between hepcidin, ferroportin and GDM. [Methods]: A case-control study was conducted in 85 women with GDM and 85 women without GDM (controls) who received regular prenatal care at the Obstetrics and Gynecology Hospital of Fudan University from October 2015 to May 2016. Serum ferritin (SF), hepcidin (Hepc), ferroportin (FPN), and soluble transferrin receptor (sTfR), as well as other clinical parameters, were detected and analyzed in all groups. [Results]: The levels of fasting plasma glucose (FPG), oral glucose tolerance test (OGTT) 1-h and 2-h plasma glucose, glycated hemoglobin (HbA1c), SF, Hepc, FPN and sTfR as well as homeostasis model assessment for insulin resistance (HOMA-IR) were significantly higher in the GDM group (P<0.05 for all). In the GDM group, FPN was positively correlated OGTT-1 h and OGTT-2 h In the control group, only sTfR was positively correlated with OGTT-1 h. There was no correlation between the iron metabolism indicators in both GDM and control group.[Conclusion]: Hepc, FPN sRfR and SF levels were higher in the GDM group. Elevated Hepc and FPN are associated with glucose metabolism disorder and may play an important role in GDM.

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Carnosine Ameliorates Stress-Induced Glucose Metabolism Disorder in Restrained Mice

Journal of Pharmacological Sciences ◽

10.1254/jphs.11131fp ◽

2011 ◽

Vol 117 (4) ◽

pp. 223-229 ◽

Cited By ~ 21

Author(s):

Bun Tsoi ◽

Rong-Rong He ◽

Dong-Hui Yang ◽

Yi-Fang Li ◽

Xiao-Di Li ◽

...

Keyword(s):

Glucose Metabolism ◽

Metabolism Disorder ◽

Glucose Metabolism Disorder

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Risk and mechanism of glucose metabolism disorder in the offspring conceived by female fertility maintenance technology

Cryobiology ◽

10.1016/j.cryobiol.2020.08.001 ◽

2020 ◽

Vol 96 ◽

pp. 68-75

Author(s):

Xue Zhou ◽

Bei Yan ◽

Xian Xu ◽

Xiao-Li Yu ◽

Xu-Feng Fu ◽

...

Keyword(s):

Glucose Metabolism ◽

Female Fertility ◽

Metabolism Disorder ◽

Glucose Metabolism Disorder

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Relationship between age at menarche and risk of glucose metabolism disorder

Menopause ◽

10.1097/gme.0000000000001529 ◽

2020 ◽

Vol Publish Ahead of Print ◽

Author(s):

Yongcheng Ren ◽

Haiyin Zou ◽

Dongdong Zhang ◽

Chengyi Han ◽

Dongsheng Hu

Keyword(s):

Glucose Metabolism ◽

Age At Menarche ◽

Metabolism Disorder ◽

Glucose Metabolism Disorder

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From the insight of glucose metabolism disorder: Oxygen therapy and blood glucose monitoring are crucial for quarantined COVID-19 patients

Ecotoxicology and Environmental Safety ◽

10.1016/j.ecoenv.2020.110614 ◽

2020 ◽

Vol 197 ◽

pp. 110614 ◽

Cited By ~ 6

Author(s):

Zhi Li ◽

Guoliang Liu ◽

Ling Wang ◽

Yong Liang ◽

Qunfang Zhou ◽

...

Keyword(s):

Blood Glucose ◽

Glucose Metabolism ◽

Oxygen Therapy ◽

Glucose Monitoring ◽

Blood Glucose Monitoring ◽

Metabolism Disorder ◽

Glucose Metabolism Disorder

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Glucose metabolism disorder is a risk factor in ethanol exposure induced malformation in embryonic brain

Food and Chemical Toxicology ◽

10.1016/j.fct.2013.07.059 ◽

2013 ◽

Vol 60 ◽

pp. 238-245 ◽

Cited By ~ 9

Author(s):

Rui-Rong Tan ◽

Yi-Fang Li ◽

Xiao-Tan Zhang ◽

Yi-Hua Huang ◽

Yan-Ping Wu ◽

...

Keyword(s):

Risk Factor ◽

Glucose Metabolism ◽

Ethanol Exposure ◽

Embryonic Brain ◽

Metabolism Disorder ◽

Glucose Metabolism Disorder

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Characterization of the Antidiabetic Role ofParkinsonia aculeata(Caesalpineaceae)

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2011/692378 ◽

2011 ◽

Vol 2011 ◽

pp. 1-9 ◽

Cited By ~ 10

Author(s):

Ana Catarina Rezende Leite ◽

Tiago Gomes Araújo ◽

Bruno de Melo Carvalho ◽

Maria Bernadete Souza Maia ◽

Vera Lúcia de Menezes Lima

Keyword(s):

Glucose Tolerance ◽

Serum Triglyceride ◽

Diabetic Rats ◽

Epididymal Adipose Tissue ◽

Hepatic Glycogen ◽

Oral Glucose ◽

Phytochemical Analysis ◽

Oral Glucose Tolerance ◽

Urinary Glucose

This paper reports the characterization of the antidiabetic role of a hydroethanolic extract fromParkinsoniaaerial parts (HEPA), in normal and alloxan-induced diabetic rats, treated with HEPA (125 and 250 mg/kg; p.o.). Oral glucose tolerance test, acute oral toxicity test and preliminary phytochemical analyses were performed. The diabetic rats treated with HEPA showed a significant reduction in serum and urinary glucose, urinary urea and triglyceride levels, as compared to the diabetic untreated group. However, in the normal treated groups, a significant reduction was found only in serum triglyceride levels. In all treated diabetic groups, an improvement in hepatic glycogen was observed, as well as a decrease in liquid intake and urinary volume, and an enhancement in the weight of skeletal muscles (soleusandextensor digitorum longus), kidneys and epididymal adipose tissue. Nevertheless, body and liver weights were ameliorated only in the diabetic group treated with HEPA (250 mg/kg). Moreover, oral glucose tolerance was higher in animals treated with HEPA, while results also showed that HEPA could be considered toxicologically safe. Phytochemical analysis revealed the presence of tanins, flavonoids and steroids in HEPA. In conclusion,P. aculeatapresents an antidiabetic activity and other beneficial effects that ameliorate diabetes and associated complications.

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