scholarly journals Antimicrobial resistance profile of Staphylococcus aureus isolated from patients with infection at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia

2018 ◽  
Vol 19 (1) ◽  
Author(s):  
Sileshi Tadesse ◽  
Haile Alemayehu ◽  
Admasu Tenna ◽  
Getachew Tadesse ◽  
Tefaye Sisay Tessema ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Resistance ◽  
Addis Ababa ◽  
Resistance Profile ◽  
Specialized Hospital ◽  
Tikur Anbessa Specialized Hospital ◽  
Antimicrobial Resistance Profile

scholarly journals Antimicrobial Activity of the Circular Bacteriocin AS-48 against Clinical Multidrug-Resistant Staphylococcus aureus

Antibiotics ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 925
Author(s):  
Cristina Velázquez-Suárez ◽  
Rubén Cebrián ◽  
Carmen Gasca-Capote ◽  
Antonio Sorlózano-Puerto ◽  
José Gutiérrez-Fernández ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Resistance ◽  
Multidrug Resistant ◽  
Resistance Profile ◽  
Risk Of Death ◽  
Antimicrobial Resistance Profile ◽  
The Matrix ◽  
Division Process ◽  
Important Challenge ◽  
Clinical Source

The treatment and hospital-spread-control of methicillin-resistant Staphylococcus aureus (MRSA) is an important challenge since these bacteria are involved in a considerable number of nosocomial infections that are difficult to treat and produce prolonged hospitalization, thus also increasing the risk of death. In fact, MRSA strains are frequently resistant to all β-lactam antibiotics, and co-resistances with other drugs such as macrolides, aminoglycosides, and lincosamides are usually reported, limiting the therapeutical options. To this must be added that the ability of these bacteria to form biofilms on hospital surfaces and devices confer high antibiotic resistance and favors horizontal gene transfer of genetic-resistant mobile elements, the spreading of infections, and relapses. Here, we genotypically and phenotypically characterized 100 clinically isolated S. aureus for their resistance to 18 antibiotics (33% of them were OXA resistant MRSA) and ability to form biofilms. From them, we selected 48 strains on the basis on genotype group, antimicrobial-resistance profile, and existing OXA resistance to be assayed against bacteriocin AS-48. The results showed that AS-48 was active against all strains, regardless of their clinical source, genotype, antimicrobial resistance profile, or biofilm formation capacity, and this activity was enhanced in the presence of the antimicrobial peptide lysozyme. Finally, we explored the effect of AS-48 on formed S. aureus biofilms, observing a reduction in S. aureus S-33 viability. Changes in the matrix structure of the biofilms as well as in the cell division process were observed with scanning electron microscopy in both S-33 and S-48 S. aureus strains.

scholarly journals Prevalence and antimicrobial resistance profile of Staphylococcus in dairy farms, abattoir and humans in Addis Ababa, Ethiopia

2017 ◽  
Vol 10 (1) ◽  
Author(s):  
Takele Beyene ◽  
Halefom Hayishe ◽  
Fikru Gizaw ◽  
Ashenafi Feyisa Beyi ◽  
Fufa Abunna ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Addis Ababa ◽  
Dairy Farms ◽  
Resistance Profile ◽  
Antimicrobial Resistance Profile

scholarly journals Prevalence and antimicrobial resistance profile of Salmonella isolates from dairy products in Addis Ababa, Ethiopia

2013 ◽  
Vol 7 (43) ◽  
pp. 5046-5050 ◽  
Author(s):  
Tesfaw Liyuwork ◽  
Taye Biruhalem ◽  
Alemu Sefinew ◽  
Alemayehu Haile ◽  
Sisay Zufan ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Dairy Products ◽  
Addis Ababa ◽  
Resistance Profile ◽  
Antimicrobial Resistance Profile

scholarly journals Antimicrobial Resistance Profile of Planktonic and Biofilm Cells of Staphylococcus aureus and Coagulase-Negative Staphylococci

2016 ◽  
Vol 17 (9) ◽  
pp. 1423 ◽  
Author(s):  
Adilson de Oliveira ◽  
Valéria Cataneli Pereira ◽  
Luiza Pinheiro ◽  
Danilo Moraes Riboli ◽  
Katheryne Benini Martins ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Resistance ◽  
Coagulase Negative Staphylococci ◽  
Resistance Profile ◽  
Antimicrobial Resistance Profile

scholarly journals Change of the Frequency of Methicillin Resistance and Antibiogram Resistance Profile of Staphylococcus aureus within a Period of 15 Years

2021 ◽  
Author(s):  
Kamuran Şanlı ◽  
Selen Zeliha Mart Kömürcü ◽  
Nilgün Kansak ◽  
Rıza Adaleti
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Resistance ◽  
Methicillin Resistance ◽  
Erythromycin Resistance ◽  
Resistance Profile ◽  
Antimicrobial Resistance Profile ◽  
Gentamicin Resistance ◽  
Successful Control ◽  
Mrsa Strains ◽  
Hospital Acquired

Objective: The aim of this retrospective study was to evaluate the rate and antimicrobial resistance profile of community-acquired (CA) and hospital-acquired (HA) methicillin-resistant and sensitive Staphylococcus aureus (MRSA, MSSA) strains between 2004 and 2019. Method: Within the scope of the research, the rate of MRSA and MSSA and the change in antimicrobial resistance profile over time were investigated using two research data of 210 Staphylococcus aureus strains isolated in 2004, and 401 in 2019. Results: While any significant change was not seen in the rates of CA-MRSA (32.4%) and CA-MSSA (67.6%) in 2004, and of CA-MRSA (31.6%) and CA-MSSA (68.4%) in 2019, the prevalence of HA-MRSA decreased by 56.1% in 2004 and 30.7% in 2019 and of HA-MSSA increased by 43.9% in 2004 and 69.3% in 2019. No resistance to vancomycin and teikoplanin was observed in MRSA strains. Resistance of CA-MRSA against ciprofloxacin, levofloxacin, clindamycin and gentamicin decreased. In CA-MSSA an increase of penicillin resistance as well as a decrease in gentamicin resistance was observed. In resistance of HA-MRSA against ciprofloxacin, levofloxacin, erythromycin, clindamycin, gentamicin decreased. HA-Resistance of MSSA against fusidic acid increased and against ciprofloxacin and trimethoprim/sulfamethoxazole and erythromycin resistance decreased. Conclusion: It was found that the rate of HA-MRSA decreased during the given period of 15 years. Vancomycin or teicoplanin resistance was not observed in MRSA and MSSA. While against ciprofloxacin, levofloxacin, clindamycin, gentamicin decreased in both CA-MRSA and HA-MRSA. A closer follow-up of the prevalence and antimicrobial resistance profiles of these strains is of utmost importance for the successful control of the infections caused by MRSA and MSSA.

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