scholarly journals High anticancer efficacy of solid lipid nanoparticles containing Zataria multiflora essential oil against breast cancer and melanoma cell lines

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Alireza Valizadeh ◽  
Ali Asghar Khaleghi ◽  
Ghazaal Roozitalab ◽  
Mahmoud Osanloo
Keyword(s):  
Breast Cancer ◽  
Essential Oil ◽  
Solid Lipid Nanoparticles ◽  
Entrapment Efficiency ◽  
Lipid Nanoparticles ◽  
In Vivo Studies ◽  
Zataria Multiflora ◽  
Anticancer Efficacy ◽  
Solid Lipid

Abstract Background The cancer burden is rising rapidly worldwide, and it annually causes about 8.8 million deaths worldwide. Due to chemical drugs’ side effects and the emergence of resistance, the development of new green drugs has received much attention. We aimed to investigate whether solid-lipid nanoparticles containing essential oil of Zataria multiflora (ZMSLN) enhanced the anticancer efficacy of the essential oil against breast cancer (MDA-MB-468) and melanoma (A-375) cells. Results ZMSLN was prepared by the high-pressure homogenizer method; particle size 176 ± 8 nm, polydispersity index 0.22 ± 0.1, entrapment efficiency 67 ± 5%. The essential oil showed a dose-dependent antiproliferative effect on MDA-MB-468 and A-375 cells at all examined concentrations (75, 150, 300, 600, and 1200 μg/mL). Interestingly, after treating both cells with 75 μg/mL of ZMSLN, their viabilities were reduced to under 13%. Conclusion The finding showed that ZMSLN had a distinct antiproliferative efficacy; it could thus be considered a green anticancer candidate for further in vivo and in vivo studies.

scholarly journals FORMULATION AND QBD BASED OPTIMIZATION OF METHOTREXATE-LOADED SOLID LIPID NANOPARTICLES FOR AN EFFECTIVE ANTI-CANCER TREATMENT

2021 ◽  
pp. 132-143
Author(s):  
CHAITALI SURVE ◽  
RUCHI SINGH ◽  
ANANYA BANERJEE ◽  
SRINIVAS PATNAIK ◽  
SUPRIYA SHIDHAYE
Keyword(s):  
Particle Size ◽  
Solid Lipid Nanoparticles ◽  
Oral Delivery ◽  
Entrapment Efficiency ◽  
Lipid Nanoparticles ◽  
Polydispersity Index ◽  
In Vivo Studies ◽  
Solid Lipid

Objective: In the current study, the Quality by Design method was utilized for the formulation of solid lipid nanoparticles of Methotrexate (MTX SLNs). Methods: MTX SLNs formulated by melt emulsification method were studied for the effect of independent variables viz. concentration of lipid and surfactants on quality attributes viz. particle size, polydispersity index, and entrapment efficiency of SLNs using 32 factorial design. Results: The optimal formulation was spherical, had a particle size of 147.6±4.1 nm (z-average), a polydispersity index of 0.296±0.058, a zeta potential of −19±0.98 mV, encapsulation efficiency of 98.7±1.55%, and a cumulative drug release of 95.59±0.918% in 5 h. Conclusion: The  in vitro and in vivo studies revealed that SLNs provide a promising oral delivery system to improve the bioavailability of MTX.

Brain delivery of camptothecin by means of solid lipid nanoparticles: Formulation design, in vitro and in vivo studies

2012 ◽  
Vol 439 (1-2) ◽  
pp. 49-62 ◽  
Author(s):  
Susana Martins ◽  
Ingunn Tho ◽  
Isolde Reimold ◽  
Gert Fricker ◽  
Eliana Souto ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
In Vivo Studies ◽  
Brain Delivery ◽  
Formulation Design ◽  
Solid Lipid

scholarly journals Solid-lipid nanoparticles (SLN)s containing Zataria multiflora essential oil with no-cytotoxicity and potent repellent activity against Anopheles stephensi

2020 ◽  
Author(s):  
Hamid Reza Kelidari ◽  
Mohammad Djaefar Moemenbellah-Fard ◽  
Katayon Morteza-Semnani ◽  
Fatemeh Amoozegar ◽  
Marziae Shahriari-Namadi ◽  
...  
Keyword(s):  
Essential Oil ◽  
Solid Lipid Nanoparticles ◽  
Anopheles Stephensi ◽  
Lipid Nanoparticles ◽  
Repellent Activity ◽  
Zataria Multiflora ◽  
Solid Lipid

scholarly journals TOPICAL SOLID LIPID NANOPARTICLES BASED GEL OF LAVENDER ESSENTIAL OIL FOR ANTI‑INFLAMMATORY ACTIVITY

2019 ◽  
pp. 175-182
Author(s):  
PALLAVI M CHAUDHARI ◽  
VAISHNAVI M BIND
Keyword(s):  
Particle Size ◽  
Drug Release ◽  
Essential Oil ◽  
Solid Lipid Nanoparticles ◽  
Ex Vivo ◽  
Entrapment Efficiency ◽  
Lipid Nanoparticles ◽  
Inflammatory Activity ◽  
Solid Lipid ◽  
Anti Inflammatory

Objective: The main objective of the study was to formulate and evaluate and perform an optimization study of lavender essential oil loaded solid lipid nanoparticles (SLNs) based gel. Materials and Methods: SLNs were prepared by the hot homogenization technique. A total of eight formulations were formulated as per 23 factorial design by design expert 11 software. The formulated SLNs were further evaluated for particle size, entrapment efficiency, drug release profile. After evaluation, the optimized batch was further used for formulating gel. The formulated gel was further subjected to ex vivo studies. Results: After the evaluation of all the parameters, batch 7 was found to be optimized. Batch 7 was found to have the lowest particle size of 30.91±0.30, higher entrapment efficiency of 89.99±0.87, and higher drug release of 90.41±0.55. It was further used for formulating gel which was found to be consistent, homogenous, smooth, and spreadable. The % inhibition of the formulated SLN based gel was found to be 28±0.1%. Conclusion: The SLNs were prepared and were formulated into the gel. The gel showed anti-inflammatory activity.

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