scholarly journals Methods for inferring neural circuit interactions and neuromodulation from local field potential and electroencephalogram measures

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Pablo Martínez-Cañada ◽  
Shahryar Noei ◽  
Stefano Panzeri
Keyword(s):  
Local Field ◽  
Brain Function ◽  
Neural Circuit ◽  
Field Potential ◽  
Future Research ◽  
Neural Network Modeling ◽  
Neural Signals ◽  
Neural Mass ◽  
Future Challenges ◽  
Mass Activity

AbstractElectrical recordings of neural mass activity, such as local field potentials (LFPs) and electroencephalograms (EEGs), have been instrumental in studying brain function. However, these aggregate signals lack cellular resolution and thus are not easy to be interpreted directly in terms of parameters of neural microcircuits. Developing tools for a reliable estimation of key neural parameters from these signals, such as the interaction between excitation and inhibition or the level of neuromodulation, is important for both neuroscientific and clinical applications. Over the years, we have developed tools based on neural network modeling and computational analysis of empirical data to estimate neural parameters from aggregate neural signals. This review article gives an overview of the main computational tools that we have developed and employed to invert LFPs and EEGs in terms of circuit-level neural phenomena, and outlines future challenges and directions for future research.

Vagus Nerve Stimulation Induced Synchrony Modulation of Local Field Potential in the Rat Cerebral Cortex

2013 ◽  
Vol 133 (8) ◽  
pp. 1493-1500 ◽  
Author(s):  
Ryuji Kano ◽  
Kenichi Usami ◽  
Takahiro Noda ◽  
Tomoyo I. Shiramatsu ◽  
Ryohei Kanzaki ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Vagus Nerve ◽  
Local Field ◽  
Nerve Stimulation ◽  
Local Field Potential ◽  
Vagus Nerve Stimulation ◽  
Field Potential ◽  
Rat Cerebral Cortex

scholarly journals Sensory feedback-dependent coding of arm position in local field potentials of the posterior parietal cortex

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Paul VanGilder ◽  
Ying Shi ◽  
Gregory Apker ◽  
Christopher A. Buneo
Keyword(s):  
Local Field ◽  
Sensory Feedback ◽  
Posterior Parietal Cortex ◽  
Spectral Power ◽  
Field Potential ◽  
Beta Activity ◽  
Beta Band ◽  
Arm Position ◽  
Multisensory Interactions ◽  
Spiking Activity

AbstractAlthough multisensory integration is crucial for sensorimotor function, it is unclear how visual and proprioceptive sensory cues are combined in the brain during motor behaviors. Here we characterized the effects of multisensory interactions on local field potential (LFP) activity obtained from the superior parietal lobule (SPL) as non-human primates performed a reaching task with either unimodal (proprioceptive) or bimodal (visual-proprioceptive) sensory feedback. Based on previous analyses of spiking activity, we hypothesized that evoked LFP responses would be tuned to arm location but would be suppressed on bimodal trials, relative to unimodal trials. We also expected to see a substantial number of recording sites with enhanced beta band spectral power for only one set of feedback conditions (e.g. unimodal or bimodal), as was previously observed for spiking activity. We found that evoked activity and beta band power were tuned to arm location at many individual sites, though this tuning often differed between unimodal and bimodal trials. Across the population, both evoked and beta activity were consistent with feedback-dependent tuning to arm location, while beta band activity also showed evidence of response suppression on bimodal trials. The results suggest that multisensory interactions can alter the tuning and gain of arm position-related LFP activity in the SPL.

Exploiting the directional local field potential recording capability of a new DBS lead for functional targeting in Parkinson’s disease

2015 ◽  
Vol 8 (2) ◽  
pp. 380
Author(s):  
M.A.J. Lourens ◽  
M.F. Contarino ◽  
R. Verhagen ◽  
P. van den Munckhof ◽  
P.R. Schuurman ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Local Field ◽  
Local Field Potential ◽  
Field Potential ◽  
Potential Recording ◽  
Field Potential Recording

Cultured olfactory interneurons from Limax maximus: optical and electrophysiological studies of transmitter-evoked responses

1993 ◽  
Vol 69 (6) ◽  
pp. 1940-1947 ◽  
Author(s):  
L. D. Rhines ◽  
P. G. Sokolove ◽  
J. Flores ◽  
D. W. Tank ◽  
A. Gelperin
Keyword(s):  
Action Potential ◽  
Intracellular Calcium ◽  
Local Field ◽  
Local Field Potential ◽  
Field Potential ◽  
Optical Measurements ◽  
Optical Studies ◽  
Isolated Cells ◽  
Fura 2 ◽  
Limax Maximus

1. The olfactory processing network in the procerebral (PC) lobe of the terrestrial mollusk Limax maximus exhibits a coherent oscillation of local field potential that is modulated by odor input. To understand the cellular basis of this oscillation, we developed a cell culture preparation of isolated PC neurons and studied the responses of isolated cells to stimulation with neurotransmitters known to be present in the PC lobe. 2. The distribution of PC soma diameters suggests at least two different populations of neurons. Approximately 95% of isolated cells had soma diameters of 7-8 microns, with the remaining cells having larger diameters (10-15 microns). 3. Extracellular measurements of action potentials and optical measurements of intracellular calcium concentrations in fura-2-loaded cells were made. Serotonin and dopamine excited PC neurons and promoted transitions from steady to bursty activity. Both amines elicited increases in intracellular calcium, presumably concomitant with the increase in action-potential frequency. 4. Glutamate suppressed action-potential firing and reduced intracellular calcium. This effect was seen most clearly when glutamate was applied to cells excited by high potassium medium. Quisqualate is an effective glutamate agonist in this system, whereas kainate is not. 5. Combined with anatomic and biochemical data and with studies of the effects of these neurotransmitters on the oscillating local field potential of the intact PC network, the data from isolated PC neurons are consistent with the hypothesis that dopamine and serotonin modulate network dynamics, whereas glutamate is involved in generating the basic oscillation of local field potential in the PC. 6. The optical studies of fura-2-loaded cells showed that several treatments that increase the rate of action-potential production lead to elevations in intracellular calcium. Optical studies of intracellular calcium may be useful for multisite measurements of activity in the intact, oscillating PC lobe network.

scholarly journals Creatine Supplementation and Brain Health

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 586 ◽  
Author(s):  
Hamilton Roschel ◽  
Bruno Gualano ◽  
Sergej M. Ostojic ◽  
Eric S. Rawson
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cognitive Function ◽  
Cognitive Processing ◽  
Brain Function ◽  
Creatine Supplementation ◽  
Short Review ◽  
Future Research ◽  
Brain Health

There is a robust and compelling body of evidence supporting the ergogenic and therapeutic role of creatine supplementation in muscle. Beyond these well-described effects and mechanisms, there is literature to suggest that creatine may also be beneficial to brain health (e.g., cognitive processing, brain function, and recovery from trauma). This is a growing field of research, and the purpose of this short review is to provide an update on the effects of creatine supplementation on brain health in humans. There is a potential for creatine supplementation to improve cognitive processing, especially in conditions characterized by brain creatine deficits, which could be induced by acute stressors (e.g., exercise, sleep deprivation) or chronic, pathologic conditions (e.g., creatine synthesis enzyme deficiencies, mild traumatic brain injury, aging, Alzheimer’s disease, depression). Despite this, the optimal creatine protocol able to increase brain creatine levels is still to be determined. Similarly, supplementation studies concomitantly assessing brain creatine and cognitive function are needed. Collectively, data available are promising and future research in the area is warranted.

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