scholarly journals Prostate cancer and therapeutic challenges

2020 ◽  
Vol 27 (1) ◽  
Author(s):  
Yousef MohammedRabaa Hawsawi ◽  
Samar Abdullah Zailaie ◽  
Atif Abdulwahab A. Oyouni ◽  
Othman Rashed Alzahrani ◽  
Osama Mohamed Alamer ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Steroid Hormones ◽  
Acquired Resistance ◽  
Sex Steroid Hormones ◽  
Sex Steroid ◽  
Androgen Independence ◽  
Major Health ◽  
Shock Proteins ◽  
Related Proteins ◽  
Hormone Deprivation

AbstractProstate cancer (PC) is the most prevalent type of cancer in men worldwide. In Saudi Arabia, the rate of PC is increasing annually. The sex steroid hormones androgens and their receptors have critical roles in PC development and progression. Additionally, apoptosis-related proteins such as heat-shock proteins are vital molecules in PC development. Steroid hormone-deprivation therapies remain the essential treatment for patients with metastatic PCs; however, acquired resistance to hormone deprivation and the transition to PC androgen independence is a major health obstacle. In this review, we aim to detail the roles of androgens, androgen receptors and sex steroid hormones in inducing apoptosis in PC.

scholarly journals Quantitative trait loci predicting circulating sex steroid hormones in men from the NCI-Breast and Prostate Cancer Cohort Consortium (BPC3)

2009 ◽  
Vol 18 (19) ◽  
pp. 3749-3757 ◽  
Author(s):  
Jiyoung Ahn ◽  
Fredrick R. Schumacher ◽  
Sonja I. Berndt ◽  
Ruth Pfeiffer ◽  
Demetrius Albanes ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Quantitative Trait Loci ◽  
Steroid Hormones ◽  
Quantitative Trait ◽  
Sex Steroid Hormones ◽  
Sex Steroid ◽  
Trait Loci ◽  
Breast And Prostate Cancer

scholarly journals Association of serum α-tocopherol with sex steroid hormones and interactions with smoking: implications for prostate cancer risk

2011 ◽  
Vol 22 (6) ◽  
pp. 827-836 ◽  
Author(s):  
Alison M. Mondul ◽  
Sabine Rohrmann ◽  
Andy Menke ◽  
Manning Feinleib ◽  
William G. Nelson ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Steroid Hormones ◽  
Prostate Cancer Risk ◽  
Sex Steroid Hormones ◽  
Sex Steroid

Sex Steroid Hormones and Genetic Susceptibility to Breast and Prostate Cancer

1998 ◽  
Vol 30 (2) ◽  
pp. 421-434 ◽  
Author(s):  
Heather Spencer Feigelson ◽  
Ronald K. Ross ◽  
Mimi C. Yu ◽  
Gerhard A. Coetzee ◽  
Juergen K. V. Reichardt ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Genetic Susceptibility ◽  
Steroid Hormones ◽  
Sex Steroid Hormones ◽  
Sex Steroid ◽  
Breast And Prostate Cancer

Sex steroid hormones in young manhood and the risk of subsequent prostate cancer: a longitudinal study in African-Americans and Caucasians (United States)

2006 ◽  
Vol 17 (10) ◽  
pp. 1237-1244 ◽  
Author(s):  
Chiaojung J. Tsai ◽  
Barbara A. Cohn ◽  
Piera M. Cirillo ◽  
David Feldman ◽  
Frank Z. Stanczyk ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
United States ◽  
Longitudinal Study ◽  
African Americans ◽  
Steroid Hormones ◽  
Sex Steroid Hormones ◽  
Sex Steroid

scholarly journals Oligoadenylate synthetase 1 (OAS1) expression in human breast and prostate cancer cases, and its regulation by sex steroid hormones

2016 ◽  
Vol 2 (2) ◽  
pp. 97 ◽  
Author(s):  
Cláudio Jorge Maia ◽  
Sandra Moreira Rocha ◽  
Sílvia Socorro ◽  
Fernando Schmitt ◽  
Cecília Reis Santos
Keyword(s):  
Prostate Cancer ◽  
Steroid Hormones ◽  
Cell Lines ◽  
Cancer Cell ◽  
Sex Steroid Hormones ◽  
Sex Steroid ◽  
Human Breast ◽  
Oligoadenylate Synthetase ◽  
Breast And Prostate Cancer ◽  
Mcf 7

<p>Oligoadenylate synthetase 1 (OAS1) is an interferon-induced protein characterised by its capacity to catalyse the synthesis of 2ʹ-5ʹ-linked oligomers of adenosine from adenosine triphosphate (2-5A). The 2-5A binds to a latent Ribonuclease L (RNase L), which subsequently dimerises into its active form and may play an important role in the control of cell growth, differentiation and apoptosis. Previously, our research group identified <em>OAS1</em> as a differentially-expressed gene in breast and prostate cancer cell lines when compared to normal cells. This study evaluates: i) the expression of <em>OAS1</em> in human breast and prostate cancer specimens; and ii) the effect of sex steroid hormones in regulating the expression of <em>OAS1</em> in breast (MCF-7) and prostate (LNCaP) cancer cell lines. The obtained results showed that <em>OAS1</em> expression was down-regulated in human infiltrative ductal carcinoma of breast, adenocarcinoma of prostate, and benign prostate hyperplasia, both at mRNA and protein level. In addition, <em>OAS1</em> expression was negatively correlated with the progression of breast and prostate cancer. With regards to the regulation of <em>OAS1</em> gene, it was demonstrated that 17β-estradiol (E<sub>2</sub>) down-regulates <em>OAS1</em> gene in MCF-7 cell lines, an effect that seems to be dependent on the activation of oestrogen receptor (ER). On the other hand, 5α‑dihydrotestosterone (DHT) treatment showed no effect on the expression of OAS1 in LNCaP cell lines. The lower levels of OAS1 in breast and prostate cancer cases indicated that the OAS1/RNaseL apoptotic pathway may be compromised in breast and prostate tumours. Moreover, the present findings suggested that this effect may be enhanced by oestrogen in ER-positive breast cancers.</p>

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