Ischemic proctitis 6 months after laparoscopic sigmoidectomy: a case report

Abstract Background Ischemic colitis is a common disease; however, its pathophysiology remains unclear, especially in ischemic proctitis after sigmoidectomy. We present a rare case of ischemic proctitis 6 months after laparoscopic sigmoidectomy. Case presentation The patient was a 60-year-old man with hypertension, type 2 diabetes, and hyperlipidemia. He was a smoker. He underwent laparoscopic sigmoidectomy for pathological stage I sigmoid colon cancer and was followed up without any adjuvant therapy. Six months after his surgery, he complained of lower abdominal discomfort, bloody stools, and tenesmus. Colonoscopy showed extensive rectal ulcers between the anastomotic site and the anal canal, which was particularly severe on the anal side several centimeters beyond the anastomosis. We provided non-surgical management, including hyperbaric oxygen therapy. The rectal ulcers had healed 48 days after the therapeutic intervention. He has not experienced any recurrence for 3.5 years. Conclusions While performing sigmoidectomy, it is important to consider the blood backflow from the anal side of the bowel carefully, especially for patients with risk factors of ischemic proctitis.

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Descending Cervical-Sacral Pain after the Administration of Antivenom to the Scorpion Sting Poisoning: A Case Report

Latin american journal of clinical sciences and medical technology ◽

10.34141/ljcs7951402 ◽

2020 ◽

Vol 2 (2) ◽

pp. 93-96

Author(s):

Josué Saúl Almaraz Lira ◽

Alfredo Luis Chávez Haro ◽

Cristian Alfredo López López ◽

Remedios del Pilar González Jiménez

Keyword(s):

Blood Pressure ◽

Type 2 Diabetes ◽

Case Report ◽

Signs And Symptoms ◽

Cervical Region ◽

Scorpion Sting ◽

Case Presentation ◽

Sacral Region ◽

Scorpion Stings

Introduction. Scorpion stings occur mainly in spring and summer, with an estimate of 1.2 million cases per year worldwide. About 300,000 poisonings occur within a year, primarily affecting children and adults older than 65 years. In 2019, Guanajuato (Mexico) ranked third in poisoning by scorpion sting with a total of 43,913 cases. The intoxication grades are three where the signs and symptoms are varied. There are two types of antivenom in the Mexican market, and we use Alacramyn® in our case. Case presentation. A 70-year-old female —with grade 1 scorpion sting poisoning, 30 minutes of evolution, with type 2 diabetes and high blood pressure— received two vials of antivenom according to current regulations. She presented transient vagal reaction and subsequent transient pain in the cervical region that radiates to the sacral region. At discharge, there are no data compatible with scorpion sting poisoning. Conclusions. Transient pain in the cervical region to the sacral region may be secondary to an anxiety crisis, hypersensitivity to IgG, or secondary reaction to administration in less time than recommended by the provider. The benefit was greater than the reactions that occurred.

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Familial hemiplegic migraine type 2 due to a novel missense mutation in ATP1A2

The Journal of Headache and Pain ◽

10.1186/s10194-021-01221-x ◽

2021 ◽

Vol 22 (1) ◽

Author(s):

Fabio Antonaci ◽

Sabrina Ravaglia ◽

Gaetano S. Grieco ◽

Stella Gagliardi ◽

Cristina Cereda ◽

...

Keyword(s):

Case Reports ◽

3D Structure ◽

Familial Hemiplegic Migraine ◽

Transmembrane Helices ◽

Hemiplegic Migraine ◽

Case Presentation ◽

Italian Family ◽

Protein Prediction ◽

Functional Consequences

Abstract Background The mechanisms of genotype-phenotype interaction in Familiar Hemiplegic migraine type 2 (FHM2) are still far from clear. Different ATP1A2 mutations have been described, with a spectrum of phenotypes ranging from mild to severe. No genotype-phenotype correlations have been attempted. Case presentation We describe an Italian family with FHM and a missense ATP1A2 variant (L425H) not previously described. The clinical picture was mild in all the affected members. Conclusions Co-segregation of the variant with the aura phenotype was complete in this family, suggesting a 100% penetrance. In silico protein prediction softwares indicate that this variant may change the 3D structure of ATPA1A2 at the cytoplasmic loop between the two central transmembrane helices. Milder FHM phenotypes are rarely reported in literature, likely because case reports are biased towards the most severe phenotypes, with milder forms possibly misdiagnosed as sporadic migraine with aura forms (MAs), even with complex auras. Further studies taking into account intra-familiar variability and functional consequences on the channel protein may help clarify genotype-phenotype correlations.

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Congenital nephrogenic diabetes insipidus accompanied with central nephrogenic diabetes secondary to pituitary surgery -a case report

BMC Endocrine Disorders ◽

10.1186/s12902-021-00749-y ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Wei Zhang ◽

Yimin Shen ◽

Yuezhong Ren ◽

Yvbo Xin ◽

Lijun Wang

Keyword(s):

Diabetes Insipidus ◽

Nephrogenic Diabetes Insipidus ◽

Direct Detection ◽

Urine Volume ◽

Pituitary Surgery ◽

Accurate Method ◽

Heterozygous Mutation ◽

Case Presentation ◽

Congenital Nephrogenic Diabetes Insipidus

Abstract Background Diabetes insipidus (DI) can be a common cause of polydipsia and polyuria. Here, we present a case of congenital nephrogenic diabetes insipidus (CNDI) accompanied with central diabetes insipidus (CDI) secondary to pituitary surgery. Case presentation A 24-year-old Chinese woman came to our hospital with the complaints of polydipsia and polyuria for 6 months. Six months ago, she was detected with pituitary apoplexy, and thereby getting pituitary surgery. However, the water deprivation test demonstrated no significant changes in urine volume and urine gravity in response to fluid depression or AVP administration. In addition, the genetic results confirmed a heterozygous mutation in arginine vasopressin receptor type 2 (AVPR2) genes. Conclusions She was considered with CNDI as well as acquired CDI secondary to pituitary surgery. She was given with hydrochlorothiazide (HCTZ) 25 mg twice a day as well as desmopressin (DDAVP, Minirin) 0.1 mg three times a day. There is no recurrence of polyuria or polydipsia observed for more than 6 months. It can be hard to consider AVPR2 mutation in female carriers, especially in those with subtle clinical presentation. Hence, direct detection of DNA sequencing with AVPR2 is a convenient and accurate method in CNDI diagnosis.

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Synchronous NET and colorectal cancer development: a case report

Surgical Case Reports ◽

10.1186/s40792-020-0777-4 ◽

2020 ◽

Vol 6 (1) ◽

Author(s):

Shinsei Yumoto ◽

Yuji Miyamoto ◽

Takahiko Akiyama ◽

Yuki Kiyozumi ◽

Kojiro Eto ◽

...

Keyword(s):

Colorectal Cancer ◽

Colon Cancer ◽

Systemic Therapy ◽

Multiple Organ ◽

Cancer Development ◽

Sigmoid Colon Cancer ◽

Synchronous Tumors ◽

Case Presentation ◽

The Difference ◽

Rectal Neuroendocrine Tumor

Abstract Background The incidence of synchronous gastrointestinal neuroendocrine tumors (GI-NETs) and colorectal cancer is very low. Case presentation We present a 72-year-old man diagnosed with a rectal neuroendocrine tumor (NET) with multiple organ metastases and simultaneous sigmoid colon cancer. Although the NET was his prognostic factor, he underwent a laparoscopic sigmoidectomy at first because it was expected that the colon cancer would cause obstruction or bleeding during NET treatment. Subsequently, he started taking everolimus. Conclusions We should consider surgical resection of the synchronous cancer before systemic therapy for a GI-NET regardless of the difference in prognosis between synchronous tumors, if the cancer may impair the continuation of systemic therapy.

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The Fluctuation of Serum PTH Level of Type 2 Diabetes mellitus’ Patient on Oral Dapagliflozin

Austin Journal of Endocrinology and Diabetes ◽

10.26420/austinjendocrinoldiabetes.2021.1082 ◽

2021 ◽

Vol 8 (1) ◽

Author(s):

Jiang G ◽

◽

Wenzhou Jiang ◽

Jin Zhou ◽

◽

...

Keyword(s):

Type 2 Diabetes ◽

Insulin Injection ◽

Diabetes Mellitus Patient ◽

Sglt2 Inhibitors ◽

Case Presentation ◽

Risk Factor Management ◽

Serum Pth ◽

High Level ◽

In The Beginning

Background: Sodium-Glucose co-Transporter 2 (SGLT2) inhibitors, a set of relatively new medicines treating type 2 diabetes showed a great number of merits in control of glycemia and cardiovascular risk factor management, but also attracted attention on bone fracture. One of those major effects on skeleton might be Parathyroid Hormone (PTH). Case Presentation: We present the case of a 68-year-old female patient with type 2 diabetes on insulin injection and oral acarbose therapy who was admitted with constant hyperglycemia to our hospital. In the beginning, she showed a high level of serum PTH. In the process of oral dapagliflozin treatment, PTH concentration firstly increased and then decreased to the normal range. Diagnostic tests are completed to exclude hyperparathyroidism. Conclusions: The use of SGLT2 inhibitors among diabetes and nondiabetic populations is increasing, a great deal of undiscovered influence, such as hormone and ion fluctuation needs further investigation.

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In iodine-induced thyrotoxicosis, steroid therapy today could keep the surgical knife at bay

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2017-0485 ◽

2018 ◽

Vol 31 (5) ◽

pp. 585-588 ◽

Cited By ~ 3

Author(s):

Rohan K. Henry ◽

Monika Chaudhari

Keyword(s):

Steroid Therapy ◽

Medical Literature ◽

Urinary Iodine ◽

Thyroid Stimulating Hormone ◽

Thyroid Function Tests ◽

Case Presentation ◽

Total Triiodothyronine ◽

History Of ◽

Daily Allowance

Abstract Background: Amiodarone-induced thyrotoxicosis (AIT) type 2, characterized as a destructive thyroiditis, is well described in the medical literature; however, iodine-induced thyrotoxicosis (IIT) is not, though the latter has similar features and can be managed similarly. Case presentation: We present a 17-year-old female who presented with a history of an intermittent goiter with thyroid function tests (TFTs): thyroid-stimulating hormone (TSH)<0.015 (0.4–4 μU/mL), free thyroxine (T4)≥6 (0.7–2.1 ng/dL) and total triiodothyronine (T3) 651 (50–200 mg/dL). Thyroid antibodies were all negative. Despite methimazole therapy for 6 weeks, hyperthyroidism proved refractory to medical management. 123I scan uptake was suppressed. With hyperthyroidism being recalcitrant to therapy, a nutritional history revealed consumption of an iodine supplement containing at least 7 times the recommended daily allowance (RDA) for 5 years, contributing to the Jod-Basedow phenomenon. Urinary spot and 24-hour urinary iodine were both elevated. Though a surgical consult was obtained, surgery was cancelled once TFTs improved and then normalized with steroid therapy. The TFTs and urinary iodine levels remained normal post steroid therapy. Conclusions: We suggest that in addition to the need for a thorough nutritional history, a trial of corticosteroids should be utilized in the management of IIT which can present with findings similar to AIT type 2 which is recalcitrant to thionamide therapy. If successful, corticosteroids may delay or prevent surgical management thus avoiding possible complications with the latter approach.

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Two Cases of Laparoscopic Sigmoidectomy for Sigmoid Colon Cancer with Extraction through the Orifice of an External Inguinal Hernia

Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) ◽

10.3919/jjsa.79.1901 ◽

2018 ◽

Vol 79 (9) ◽

pp. 1901-1904

Author(s):

Akira KUBOTA ◽

Atsushi NISHIMURA ◽

Akio MATSUMOTO ◽

Mikako KAWAHARA ◽

Tie KITAMI ◽

...

Keyword(s):

Colon Cancer ◽

Inguinal Hernia ◽

Sigmoid Colon ◽

Sigmoid Colon Cancer ◽

Laparoscopic Sigmoidectomy

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Clinical Features of Infantile GM1 Gangliosidosis: Report of an Iranian Patient

World Journal of Peri & Neonatology ◽

10.18502/wjpn.v3i1.5066 ◽

2020 ◽

Author(s):

Mahtab Ordooei ◽

Razieh Fallah ◽

Fatemeh Abdi ◽

Fahimeh Soheilipour

Keyword(s):

Lysosomal Storage ◽

Gm1 Gangliosidosis ◽

Case Presentation ◽

Iranian Patient ◽

Cherry Red Spot ◽

Type 3 ◽

Initial Check ◽

Infantile Type

Background: GM1 gangliosidosis is an autosomal recessive lysosomal storage disease due to a lack of β-galactosidase activity, exactly because of mutations in the GLB1 gene. GM1 gangliosidosis is a rare disease that could occur either during infancy (infantile type 1), as a juvenile (type 2), or in adulthood (type 3) in both nervous and skeletal systems. Type 1 is characterized by premature psychomotor deterioration, visceromegaly, macular cherry-red spot, skeletal deformities, and death in the first 2 years of life. Case Presentation: We reported an Iranian infant who, on initial check-up, had coarse face, visceromegaly, dystonia, and hepatosplenomegaly that increased at 15 months of age. At the initial check-up, a genetic test was performed and GM1 gangliosidosis type 1 was diagnosed. Conclusion: infant form is characterized by early-onset before the age of 6 months and rapidly progressive psychomotor deterioration, facial abnormalities, and visceromegaly.

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Leptospirosis presented with erythema nodosum on four limbs: an unusual presenting

Oxford Medical Case Reports ◽

10.1093/omcr/omz130 ◽

2020 ◽

Vol 2020 (1) ◽

Cited By ~ 1

Author(s):

Lotfollah Davoodi ◽

Armaghan Kazeminejad ◽

Hamed Jafarpour ◽

Alireza Razavi

Keyword(s):

Rare Case ◽

Erythema Nodosum ◽

Clinical Manifestations ◽

Common Disease ◽

Clinical Form ◽

Case Presentation ◽

Typical Form ◽

Wide Range ◽

Adipose Inflammation ◽

Subcutaneous Adipose

Abstract Leptospirosis is a common disease between humans and animals characterized by a wide range of clinical manifestations. Erythema nodosum (EN) is a common clinical form of panniculitis or subcutaneous adipose inflammation caused by hypersensitivity responses to antigens, but the presence of EN in a subject with leptospirosis is a very rare case presentation. We will present a 42-year-old man with a headache, myalgia, nausea and rigid tender on the shin and both forearms, which was a typical form of EN lesions.

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