Outcomes and factors affecting mortality and successful tracing among patients lost to follow-up from antiretroviral therapy in Pawi Hospital, Northwest Ethiopia

A total of 823 infants born at 28 weeks' gestation or less were admitted to a regional referral unit between 1980 and 1989. Four hundred and sixty five (56.5%) survived to be discharged home. Twenty one subsequently died and two were lost to follow up. Four hundred and forty two (53.7%) were assessed for disabilities at the age of 3 years. Eighty four (19%) had major disabilities, of which 40 (9%) were severe. A further 39 (9%) had lesser disabilities. Three hundred and nineteen (63%) survivors appeared to be functioning normally. Logistic regression showed the likelihood of survival to be independently related to gestational age, birthweight ratio, and more recent year of birth, and inversely related to male sex and ultrasound evidence of cerebral haemorrhage or infarction. The likelihood of later disability in survivors was only independently related to cerebral ultrasound appearances.

Download Full-text

Predictors of mortality among children on Antiretroviral Therapy at a referral hospital, Northwest Ethiopia: A retrospective follow up study

BMC Pediatrics ◽

10.1186/1471-2431-12-161 ◽

2012 ◽

Vol 12 (1) ◽

Cited By ~ 26

Author(s):

Digsu Negese Koye ◽

Tadesse Awoke Ayele ◽

Berihun Megabiaw Zeleke

Keyword(s):

Antiretroviral Therapy ◽

Northwest Ethiopia ◽

Referral Hospital ◽

Predictors Of Mortality ◽

Follow Up Study

Download Full-text

Understanding Reasons for and Outcomes of Patients Lost to Follow-Up in Antiretroviral Therapy Programs in Africa Through a Sampling-Based Approach

JAIDS Journal of Acquired Immune Deficiency Syndromes ◽

10.1097/qai.0b013e3181b843f0 ◽

2010 ◽

Vol 53 (3) ◽

pp. 405-411 ◽

Cited By ~ 180

Author(s):

Elvin H Geng ◽

David R Bangsberg ◽

Nicolas Musinguzi ◽

Nneka Emenyonu ◽

Mwebesa Bosco Bwana ◽

...

Keyword(s):

Antiretroviral Therapy ◽

Lost To Follow Up

Download Full-text

The social and clinical characteristics of patients on antiretroviral therapy who are ‘lost to follow-up’ in KwaZulu-Natal, South Africa: a prospective study

SAHARA-J Journal of Social Aspects of HIV/AIDS ◽

10.1080/17290376.2011.9725002 ◽

2011 ◽

Vol 8 (4) ◽

pp. 179-186 ◽

Cited By ~ 13

Author(s):

Karl Peltzer ◽

Shandir Ramlagan ◽

Mohamed Salim Khan ◽

Bernhard Gaede

Keyword(s):

South Africa ◽

Antiretroviral Therapy ◽

Prospective Study ◽

Clinical Characteristics ◽

The Social ◽

Kwazulu Natal ◽

A Prospective Study ◽

Lost To Follow Up

Download Full-text

Outcomes of Patients Lost to Follow-up in African Antiretroviral Therapy Programs: Individual Patient Data Meta-analysis

Clinical Infectious Diseases ◽

10.1093/cid/ciy347 ◽

2018 ◽

Vol 67 (11) ◽

pp. 1643-1652 ◽

Cited By ~ 23

Author(s):

Frédérique Chammartin ◽

Kathrin Zürcher ◽

Olivia Keiser ◽

Ralf Weigel ◽

Kathryn Chu ◽

...

Keyword(s):

Antiretroviral Therapy ◽

Individual Patient Data ◽

Meta Analysis ◽

Patient Data ◽

Lost To Follow Up

Download Full-text

Outcome of traumatic Extradural Hematoma (EDH) using Glasgow Outcome Scale (GOS)

International Surgery Journal ◽

10.18203/2349-2902.isj20184083 ◽

2018 ◽

Vol 5 (10) ◽

pp. 3327

Author(s):

Dixit V. Prajapati ◽

Nimish J. Shah

Keyword(s):

Traffic Accident ◽

Surgical Intervention ◽

Road Traffic ◽

Extradural Hematoma ◽

Factors Affecting ◽

Poor Outcome ◽

Ct Head ◽

Lost To Follow Up ◽

Time Of Intervention

Background: Outcome in patient with EDH depends on various factors like GCS at presentation, Volume of hematoma, time of intervention, age, location of hematoma, etc. This study was carried out to find out correlation (if any) between outcome and various factors affecting it. Aim and objectives of this study were to study outcome of patients with traumatic EDH in terms of poor outcome (GOS score 1,2,3), Good outcome (GOS Score 4,5)Methods: This study was carried out in 91 patients having positive CT Head for EDH. Follow up was done every monthly up to 3 months. GOS was recorded at each follow up. Results: Road traffic accident was the most common mode of trauma. 16 patients were operated. Four patients died immediately after diagnosis of traumatic EDH, before doing any intervention. One patient died on 1st post-operative day. After one month, two patients were lost to follow up, 80 patients had GOS 5, four patients had GOS 4. At 2nd and 3rd month, 83 patients had GOS 5, one patient had GOS 4. 17 patients had GCS 3-8, among them, 11 patients had GOS 5, one patient had GOS 4 and five patients died (GOS 1). 15 patients had GCS 9-12, among them, 15 patients had GOS 5. 57 patients had GCS 13-15, among them, 54 patients had GOS 5. 69 patients had EDH volume <30 ml and all patients had GOS 5. 20 patients had EDH volume ≥30 ml, among them, 14 patients had GOS 5, one patient had GOS 4 and five patients died. Conclusions: GOS in EDH patient is affected by GCS and EDH volume at presentation. Lower GCS and larger EDH volume have poor outcome. Surgical intervention in larger EDH volume improves outcome.

Download Full-text

Incidence and Predictors of Tuberculosis Occurrence among Adults on Antiretroviral Therapy at Debre Markos Referral Hospital, Northwest Ethiopia: Retrospective Follow-up Study

10.21203/rs.2.12735/v3 ◽

2020 ◽

Author(s):

Agazhe Aemro ◽

Abebaw Jember ◽

Degefaye Zelalem Anlay

Keyword(s):

Antiretroviral Therapy ◽

Incidence Rate ◽

Northwest Ethiopia ◽

Referral Hospital ◽

Hiv Care ◽

First Year ◽

Art Adherence ◽

Follow Up Study ◽

Debre Markos

Abstract Background : In resource limited settings, Tuberculosis (TB) is a major cause of morbidity and mortality among patients on antiretroviral treatment. Ethiopia is one of the 30 high TB burden countries. TB causes burden in healthcare system and challenge the effectiveness of HIV care. This study was to assess incidence and predictors of Tuberculosis among adults on antiretroviral therapy at Debre Markos Referral Hospital, Northwest Ethiopia, 2019. Methods : Institution based retrospective follow up study was conducted among adults on ART newly enrolled from 2014 to 2018 at Debre Markos Referral Hospital. Simple random sampling technique was used to select patients chart. Data was entered to EPI- INFO version 7.2.2.6 and analyzed using Stata 14.0. Tuberculosis incidence rate was computed and described using frequency tables. Both bivariable and multivariable Cox proportional hazard models was fitted to identify predictors of TB. Results : Out of the 536 patients chart reviewed, 494 patient records were included in the analysis. A total of 62 patients developed new TB cases during the follow up period of 1000.22 Person Years (PY); which gives an overall incidence rate of 6.19 cases per 100 PY (95% CI: 4.83 - 7.95). The highest rate was seen within the first year of follow up. After adjustment base line Hemoglobin < 10 g/dl (AHR= 5.25; 95% CI: 2.52 - 10.95), ambulatory/bedridden patients at enrolment (AHR = 2.31; 95% CI: 1.13 - 4.73), having fair or poor ART adherence (AHR = 3.22; 95% CI: 1.64 – 6.31) were associated with increased risk of tuberculosis whereas taking Isoniazid Preventive Therapy (IPT) (AHR = 0.33; 95% CI: 0.12 - 0.85) were protective factors of TB occurrence. Conclusion : TB incidence was high among adults on ART especially in the first year of enrollment to ART. Low hemoglobin level, ambulatory or bedridden functional status, non-adherence to ART and IPT usage status were found to be independent predictors. Hence, continuous follow up for ART adherence and provision of IPT has a great importance to reduce the risk of TB.

Download Full-text

1319. Events of Disengagement from HIV care and Subsequent Reengagement in a Kenyan Pastoralist Community: Frequency, Determinants, and Patient Views

Open Forum Infectious Diseases ◽

10.1093/ofid/ofz360.1182 ◽

2019 ◽

Vol 6 (Supplement_2) ◽

pp. S476-S477

Author(s):

Paul Otieno Yonga ◽

Stephen Kiplimo Kalya ◽

Lutgarde Lynen ◽

Tom Decroo

Keyword(s):

Antiretroviral Therapy ◽

Hiv Transmission ◽

Hospital Admissions ◽

Hiv Care ◽

Engagement In Care ◽

Work Related ◽

Medication Side ◽

Competing Priorities ◽

Lost To Follow Up

Abstract Background Regular follow-up HIV-infected patients on antiretroviral therapy (ART) is vital to ensure viral suppression, thus reducing HIV transmission, and HIV-related morbidity and mortality. However, some patients have been reported to have events of disengagement from care with subsequent re-engagement in care, though knowledge on the magnitude and determinants of this phenomenon, particularly in pastoralist communities is scarce. Methods A mixed-methods study was carried out among HIV-infected patients on antiretroviral therapy (ART) follow-up between January 2014 and June 2017 at the Baringo County Referral Hospital, Kabarnet, Kenya. Records on their clinic attendance and laboratory follow-up were extracted, and those noted to have a recent event of disengagement from care who later re-engaged in care, were then purposively sampled for in-depth interviews. Results 342 patient records were analyzed, of which 48% (166/342) of the patients were noted to be active at the end of the study period, with 63.3% (105/166) of them noted to have one or more events of disengagement from care. Female patients, patients with baseline CD4 counts ≥200 cells/mm3, and patients with a low WHO stage category (I and II) were more likely to return to care after an experience of disengagement from HIV care (P < 0.05). Eight interviewee transcripts showed the following reported reasons for disengagement in care: long distances, stigma, work-related problems, medication side effects, competing priorities, perceived recovery of the health status, medication fatigue, and not being informed of their clinic return dates. Motivators for re-engagement in care included hospital admissions, fear of getting sick like their spouse, and phone reminders. Conclusion A vast majority of patients currently active in care experienced multiple events of disengagement from care. Thus, early identification of those who disengage from care is recommended, before they become lost to follow-up. Disclosures All authors: No reported disclosures.

Download Full-text