scholarly journals The role of MDCT in the assessment of cardiac and extra-cardiac vascular defects among Egyptian children with tetralogy of Fallot and its surgical implementation

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Ahmed Elshimy ◽  
Rasha Tolba Khattab ◽  
Hend Galal Eldeen Mohamed Ali Hassan
Keyword(s):  
Tetralogy Of Fallot ◽  
Heart Diseases ◽  
Preoperative Evaluation ◽  
Vena Cava ◽  
Predictive Values ◽  
Surgical Interventions ◽  
Vascular Abnormalities ◽  
Egyptian Children ◽  
Cardiac Lesions ◽  
Cyanotic Congenital Heart Diseases

Abstract Background Tetralogy of Fallot (TOF) is considered the most common form of cyanotic congenital heart diseases (CHD), accounting for about 10% of cases. It includes four main cardiac defects, in addition to various extra-cardiac anomalies. Aim This study aimed to evaluate cardiac and extra-cardiac vascular defects associated with TOF among Egyptian children, regarding frequency and types with assessment of multi-slice or multi-detector computed tomography (MDCT) role in their diagnosis. Definitely, full detection of these vascular anomalies has utmost importance when evaluating such patients particularly before surgical intervention. Methods This study included 60 pediatric patients diagnosed as TOF, who underwent MDCT examination in our institute during period of 6 months from (March to September 2020), to confirm their trans-thoracic echocardiography (TTE) findings and detect other vascular abnormalities which cannot be precisely detected with TTE before their surgical interventions. Results The incidence of different extra-cardiac vascular defects diagnosed by MDCT among our patients was 85% which was significantly higher than that detected by TTE (55%). Moreover, MDCT was superior to TTE assessment as regards its diagnostic accuracy (96.6% vs. 80%), sensitivity (98% vs. 76.9%), and specificity (88.9% vs. 85.7%), in addition to both positive and negative predictive values. The most common anomalies detected were affecting the pulmonary artery (80%), followed by aorto-pulmonary vessels (45%), then aortic artery (40%), coronary arteries (20%), and lastly vena cava connection (6.7%). Patients’ demographic characteristics and clinical presentations were also presented. Conclusion This study confirmed that many extra-cardiac vascular defects are commonly associating cardiac lesions in TOF and emphasizing the great value of MDCT in their diagnosis. Certainly, proper detection of these anomalies will help decision-making during preoperative evaluation, corrective interventions, and further management of these cases.

scholarly journals The prevalence and types of coronary artery abnormalities in pediatric patients with Tetralogy of Fallot

2021 ◽  
Author(s):  
Nima Mehdizadegan ◽  
Kholud Saeidi ◽  
Kambiz Keshavarz
Keyword(s):  
Coronary Artery ◽  
Tetralogy Of Fallot ◽  
Coronary Arteries ◽  
Heart Diseases ◽  
Common Finding ◽  
P Value ◽  
Coronary Anomalies ◽  
Coronary Artery Abnormalities ◽  
Operation Knowledge ◽  
Cyanotic Congenital Heart Diseases

Abstract Objectives: Tetralogy of fallot (TOF) is one of the most common diseases among cyanotic congenital heart diseases which is associated with 2-23% of coronary artery abnormalities. Pre-operation knowledge the anatomy of coronary arteries in patients with TOF eliminates damage to them during surgery and prevents post-operative complications such as myocardial ischemia and heart failure.Materials and methods:This retrospective study was done on all patients with TOF who were referred for diagnostic catheterization and angiography before total surgical correction from 2006-2016. All patients entered the study and all angiographic views including extreme caudal, LAO cranial , and selective coronary artery angiography were evaluated and reviewed accurately.Results: 332 cases of patients with TOF including from one month to 36 years old were reviewed. The prevalence of coronary artery abnormalities among them was 11.4% (38 from 322 individual). 9.1% and 15.3% of males and females had abnormal coronary anomalies but it was not significant statically (p-value: 0.064). In 13 of 38 patients with coronary anomalies , coronary arteries crossed right ventricular out flow tract (RVOT)(3.4%). The most common coronary abnormality was origin of the both main coronary arteries from left sinus of Valsalva.Conclusion:Compared with other populations, the abnormal arteries among the patients with TOF in our study is significant (11.4%) and accurate assessment of their courses is necessary before surgery. Single origin of coronary arteries from the left side was the most common finding in our study too.

Tetralogy of Fallot with Neurological Manisfistation

JMS SKIMS ◽  
2009 ◽  
Vol 12 (1) ◽  
pp. 18-20
Author(s):  
R K Kotokey ◽  
Swarup Kar ◽  
Arup Sharma ◽  
Libe Nyorak ◽  
S Rupshi ◽  
...  
Keyword(s):  
Tetralogy Of Fallot ◽  
Heart Diseases ◽  
Pulmonary Stenosis ◽  
Term Survival ◽  
North East ◽  
Fallot's Tetralogy ◽  
Fallot’S Tetralogy ◽  
Brain Abscesses ◽  
Cyanotic Congenital Heart Diseases

Fallot's Tetralogy is one of the most common cyanotic congenital heart diseases. Most of the patients though die during adulthood (depending upon the severity of pulmonary stenosis) but long term survival has also been recorded in the literature. Though there are various complications of Tetralogy of Fallot; multiple brain abscesses as a sequele of Fallot's Tetralogy leading to neurological manifestations is not frequently encountered in this part of North East. A case of Fallot's Tetralogy presenting with severe neurological deficit due to multiple brain abscesses who was treated conservatively is presented. The patient responded to the conservative management. (.1MedSci 2009;12(1):18-20)

Absence of the arterial duct in a neonate with tricuspid atresia

1994 ◽  
Vol 4 (2) ◽  
pp. 187-189
Author(s):  
Beth Bubolz ◽  
Christopher L. Case ◽  
Robert M. Sade
Keyword(s):  
Aortic Arch ◽  
Tetralogy Of Fallot ◽  
Congenital Heart ◽  
Clinical Course ◽  
Heart Diseases ◽  
Pulmonary Stenosis ◽  
Tricuspid Atresia ◽  
Congenital Heart Diseases ◽  
Arterial Duct ◽  
Cyanotic Congenital Heart Diseases

SummarySummary Absence of the arterial duct has been reported in association with tetralogy of Fallot, with pulmonary stenosis or atresia, other complex cyanotic congenital heart diseases, and anomalies of the aortic arch but not, as far as we are aware, with tricuspid atresia. We report the clinical, surgical, and autopsy findings of a patient with tricuspid atresia whose initial clinical course was influenced by the absence of thearterial duct.

Pediatrics: Tetralogy of Fallot

2018 ◽  
pp. 147-152
Author(s):  
Kseniya Khmara ◽  
Ruchir Gupta
Keyword(s):  
Right Ventricular ◽  
Antibiotic Prophylaxis ◽  
Tetralogy Of Fallot ◽  
Postoperative Care ◽  
Preoperative Evaluation ◽  
Onset Time ◽  
Right Ventricular Hypertrophy ◽  
Main Topic ◽  
Anesthetic Agents ◽  
Cardiac Lesions

In this chapter the essential aspects of anesthesia for repair of tetralogy of Fallot (TOF) are reviewed. Subtopics include hemodynamic considerations in TOF patients such as right ventricular hypertrophy, components of TOF, and circulation in the TOF patient. The chapter is divided into preoperative, intraoperative, and postoperative sections with important subtopics related to the main topic in each section. Issues discussed that are related to preoperative evaluation include differentiating between cyanotic and acyanotic cardiac lesions, recognizing Tet spells and systemic vascular resistance, and use of antibiotic prophylaxis. Intraoperative topics include induction, onset time of anesthetic agents, and blood therapy. Postoperative care addressed includes extubation, hypothermia, and hypoxia.

scholarly journals Construction and Investigation of a circRNA-Associated ceRNA Regulatory Network in Tetralogy of Fallot

2020 ◽  
Author(s):  
Haifei Yu ◽  
Xinrui Wang ◽  
Hua Cao
Keyword(s):  
Tetralogy Of Fallot ◽  
Heart Development ◽  
Heart Diseases ◽  
Expression Profiles ◽  
Circular Rna ◽  
Screening Strategy ◽  
Differentially Expressed ◽  
Tissue Samples ◽  
Cerna Network ◽  
Cyanotic Congenital Heart Diseases

Abstract Background: As the most frequent type of cyanotic congenital heart diseases (CHD), Tetralogy of Fallot (TOF) has a relatively poor prognosis without the corrective surgery. Circular RNA (circRNA) represents a novel class of endogenous noncoding RNAs that regulate target gene expression post-transcriptionally in heart development. Here, we investigate the potential role of ceRNA network in the pathogenesis of TOF. Methods: To identify circRNAs expression profiles in Tetralogy of Fallot, microarrays were used to screen the differentially expressed circRNA between 3 TOF and 3 control human myocardial tissue samples. Then, a dysregulated circRNA- associated ceRNA network was constructed via using the established multi-step screening strategy.Results: In summary, total 276 differentially expressed circRNAs were identified, including 214 up-regulated and 62 down-regulated ones in TOF samples. By constructing the circRNA-associated ceRNA network based on the bioinformatics data, a total of 19 key circRNAs, 9 key miRNAs and 34 key mRNAs were further screened. Moreover, by enlarging the samples size, the qPCR results validated that the positive correlations between hsa_circ_0007798 and HIF1A.Conclusions: The findings in this study provide a comprehensive understanding of the ceRNA network involved in TOF biology, such as hsa_circ_0007798/miR-199b-5p/HIF1A signal axis, and may offer candidate diagnostic biomarkers or potential therapeutic targets for TOF. In addtion, we propose that the ceRNA network regulates TOF progression.

scholarly journals Construction and Investigation of a circRNA-Associated ceRNA Regulatory Network in Tetralogy of Fallot

2020 ◽  
Author(s):  
Haifei Yu ◽  
Xinrui Wang ◽  
Hua Cao
Keyword(s):  
Tetralogy Of Fallot ◽  
Heart Development ◽  
Heart Diseases ◽  
Expression Profiles ◽  
Circular Rna ◽  
Screening Strategy ◽  
Differentially Expressed ◽  
Tissue Samples ◽  
Cerna Network ◽  
Cyanotic Congenital Heart Diseases

Abstract Background: As the most frequent type of cyanotic congenital heart diseases (CHD), Tetralogy of Fallot (TOF) has a relatively poor prognosis without the corrective surgery. Circular RNA (circRNA) represents a novel class of endogenous noncoding RNAs that regulate target gene expression post-transcriptionally in heart development. Here, we investigate the potential role of ceRNA network in the pathogenesis of TOF. Methods: To identify circRNAs expression profiles in Tetralogy of Fallot, microarrays were used to screen the differentially expressed circRNA between 3 TOF and 3 control human myocardial tissue samples. Then, a dysregulated circRNA- associated ceRNA network was constructed via using the established multi-step screening strategy.Results: In summary, total 276 differentially expressed circRNAs were identified, including 214 up-regulated and 62 down-regulated ones in TOF samples. By constructing the circRNA-associated ceRNA network based on the bioinformatics data, a total of 19 key circRNAs, 9 key miRNAs and 34 key mRNAs were further screened. Moreover, by enlarging the samples size, the qPCR results validated that the positive correlations between hsa_circ_0007798 and HIF1A.Conclusions: The findings in this study provide a comprehensive understanding of the ceRNA network involved in TOF biology, such as hsa_circ_0007798/miR-199b-5p/HIF1A signal axis, and may offer candidate diagnostic biomarkers or potential therapeutic targets for TOF. In addtion, we propose that the ceRNA network regulates TOF progression.

scholarly journals Three-dimensional printing for heart diseases: clinical application review

2021 ◽  
Author(s):  
Yanyan Ma ◽  
Peng Ding ◽  
Lanlan Li ◽  
Yang Liu ◽  
Ping Jin ◽  
...  
Keyword(s):  
3D Printing ◽  
Clinical Application ◽  
Heart Diseases ◽  
Three Dimensional ◽  
Convincing Evidence ◽  
Surgical Interventions ◽  
Three Dimensional Printing ◽  
Complex Anatomy ◽  
Precise Understanding ◽  
3D Printed

AbstractHeart diseases remain the top threat to human health, and the treatment of heart diseases changes with each passing day. Convincing evidence shows that three-dimensional (3D) printing allows for a more precise understanding of the complex anatomy associated with various heart diseases. In addition, 3D-printed models of cardiac diseases may serve as effective educational tools and for hands-on simulation of surgical interventions. We introduce examples of the clinical applications of different types of 3D printing based on specific cases and clinical application scenarios of 3D printing in treating heart diseases. We also discuss the limitations and clinically unmet needs of 3D printing in this context.

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