scholarly journals Three-dimensional printing for heart diseases: clinical application review

Author(s):  
Yanyan Ma ◽  
Peng Ding ◽  
Lanlan Li ◽  
Yang Liu ◽  
Ping Jin ◽  
...  

AbstractHeart diseases remain the top threat to human health, and the treatment of heart diseases changes with each passing day. Convincing evidence shows that three-dimensional (3D) printing allows for a more precise understanding of the complex anatomy associated with various heart diseases. In addition, 3D-printed models of cardiac diseases may serve as effective educational tools and for hands-on simulation of surgical interventions. We introduce examples of the clinical applications of different types of 3D printing based on specific cases and clinical application scenarios of 3D printing in treating heart diseases. We also discuss the limitations and clinically unmet needs of 3D printing in this context.

Crystals ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 353
Author(s):  
Yanting Han ◽  
Qianqian Wei ◽  
Pengbo Chang ◽  
Kehui Hu ◽  
Oseweuba Valentine Okoro ◽  
...  

Hydroxyapatite (HA) and HA-based nanocomposites have been recognized as ideal biomaterials in hard tissue engineering because of their compositional similarity to bioapatite. However, the traditional HA-based nanocomposites fabrication techniques still limit the utilization of HA in bone, cartilage, dental, applications, and other fields. In recent years, three-dimensional (3D) printing has been shown to provide a fast, precise, controllable, and scalable fabrication approach for the synthesis of HA-based scaffolds. This review therefore explores available 3D printing technologies for the preparation of porous HA-based nanocomposites. In the present review, different 3D printed HA-based scaffolds composited with natural polymers and/or synthetic polymers are discussed. Furthermore, the desired properties of HA-based composites via 3D printing such as porosity, mechanical properties, biodegradability, and antibacterial properties are extensively explored. Lastly, the applications and the next generation of HA-based nanocomposites for tissue engineering are discussed.


2022 ◽  
Vol 14 (1) ◽  
pp. 32-39
Author(s):  
Sachit Anand ◽  
Nellai Krishnan ◽  
Prabudh Goel ◽  
Anjan Kumar Dhua ◽  
Vishesh Jain ◽  
...  

Background: In cases with solid tumors, preoperative radiological investigations provide valuable information on the anatomy of the tumor and the adjoining structures, thus helping in operative planning. However, due to a two-dimensional view in these investigations, a detailed spatial relationship is difficult to decipher. In contrast, three-dimensional (3D) printing technology provides a precise topographic view to perform safe surgical resections of these tumors. This systematic review aimed to summarize and analyze current evidence on the utility of 3D printing in pediatric extra-cranial solid tumors. Methods: The present study was registered on PROSPERO—international prospective register of systematic reviews (registration number: CRD42020206022). PubMed, Embase, SCOPUS, and Google Scholar databases were explored with appropriate search criteria to select the relevant studies. Data were extracted to study the bibliographic information of each article, the number of patients in each study, age of the patient(s), type of tumor, organ of involvement, application of 3D printing (surgical planning, training, and/or parental education). The details of 3D printing, such as type of imaging used, software details, printing technique, printing material, and cost were also synthesized. Results: Eight studies were finally included in the systematic review. Three-dimensional printing technology was used in thirty children with Wilms tumor (n = 13), neuroblastoma (n = 7), hepatic tumors (n = 8), retroperitoneal tumor (n = 1), and synovial sarcoma (n = 1). Among the included studies, the technology was utilized for preoperative surgical planning (five studies), improved understanding of the surgical anatomy of solid organs (two studies), and improving the parental understanding of the tumor and its management (one study). Computed tomography and magnetic resonance imaging were either performed alone or in combination for radiological evaluation in these children. Different types of printers and printing materials were used in the included studies. The cost of the 3D printed models and time involved (range 10 h to 4–5 days) were reported by two studies each. Conclusions: 3D printed models can be of great assistance to pediatric surgeons in understanding the spatial relationships of tumors with the adjacent anatomic structures. They also facilitate the understanding of families, improving doctor–patient communication.


2020 ◽  
Vol 11 (1) ◽  
pp. 161-170
Author(s):  
J-R. R. Diego ◽  
Dan William C. Martinez ◽  
Gerald S. Robles ◽  
John Ryan C. Dizon

AbstractThis study addresses the need for assistive technology of people who lost control of their upper limbs as well as people who are undergoing rehabilitation. Loss of upper limb control causes lack of functionality and social acceptability especially for many people in developing countries with fewer available technology. The study develops a modern but low-cost prosthetic device that can be controlled by users using a smartphone and can be rapidly manufactured using three-dimensional printing (3D printing) of plastic materials. The development of the prosthetic device includes designing the mechanical and electronic parts, programming the Arduino board and Android application for control, simulation and analysis of 3D printed parts most subjected to stress, and 3D printing the parts under different settings. The device was tested in terms of time spent and capacity of lifting varying loads when not worn and when worn by users. The device can effectively lift 500 grams of load in one second for a person weighing between 50 to 60 kilograms.


Author(s):  
V. Kovan ◽  
G. Altan ◽  
E.S. Topal ◽  
H.E. Camurlu

Three-dimensional printing or 3D printing (also called additive manufacturing) is any of various processes used to make a three-dimensional object. Fused deposition modelling (FDM) is an additive manufacturing technology commonly used for modelling, prototyping, and production applications. It is one of the techniques used for 3D printing. FDM is somewhat restricted in the size and the variation of shapes that may be fabricated. For parts too large to fit on a single build, for faster job builds with less support material, or for parts with finer features, sectioning and bonding FDM parts is a great solution. The strength of adhesive bonded FDM parts is affected by the surface roughness. In this study, the layer thickness effect on bonding strength is experimentally studied and the results are discussed.


2018 ◽  
Vol 69 (6) ◽  
pp. 1455-1457
Author(s):  
Dragos Octavian Palade ◽  
Bogdan Mihail Cobzeanu ◽  
Petronela Zaharia ◽  
Marius Dabija

Three-dimensional printing has numerous applications and has gained much interest in the medical world. The constantly improving quality of 3D-printing applications has contributed to their increased use on patients. Nowadays, 3D printing is very well integrated in the surgical practice and research. Also, the field of head and neck reconstructive surgery is constantly evolving because of the three-dimensional printing, a technology which can be widely used in a variety of situations such as reconstruction of tissue defects, surgical planning, medical modeling and prosthesis. By using 3D printing into tissue engineering and materials, it may be possible for otolaryngologists to implant 3D printed functional grafts into patients and will also provide a rapid production of personalized patient-specific devices. Advances in 3D printed implants and future tissue-engineered constructs will bring great progress to the field of otorhinolaryngology.


Author(s):  
Angeliki Siamidi ◽  
Eleni Tsintavi ◽  
Dimitrios M. Rekkas ◽  
Marilena Vlachou

The broad spectrum of applications of three-dimensional printing (3D printing, 3DP) has attracted the attention of researchers working in diverse fields. In pharmaceutics, the main idea behind 3D printing products is to design and develop delivery systems that are suited to an individual’s needs. In this way, the size, appearance, shape, and rate of delivery of a wide array of medicines could be easily adjusted. The aim of this chapter is to provide a compilation of the 3D printing techniques, used for the fabrication of oral drug delivery systems, and review the relevant scientific developments in particular those with modified-release characteristics.


2020 ◽  
pp. 193864002097141
Author(s):  
Rishin J. Kadakia ◽  
Colleen M. Wixted ◽  
Cambre N. Kelly ◽  
Andrew E. Hanselman ◽  
Samuel B. Adams

Three-dimensional (3D) printing technology has advanced greatly over the past decade and is being used extensively throughout the field of medicine. Several orthopaedic surgery specialties have demonstrated that 3D printing technology can improve patient care and physician education. Foot and ankle pathology can be complex as the 3D anatomy can be challenging to appreciate. Deformity can occur in several planes simultaneously and bone defects either from previous surgery or trauma can further complicate surgical correction. Three-dimensional printing technology provides an avenue to tackle the challenges associated with complex foot and ankle pathology. A basic understanding of how these implants are designed and made is important for surgeons as this technology is becoming more widespread and the clinical applications continue to grow within foot and ankle surgery. Levels of Evidence: Level V


2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Chase Tenewitz ◽  
Rebecca T. Le ◽  
Mauricio Hernandez ◽  
Saif Baig ◽  
Travis E. Meyer

Abstract Rationale and objectives Three-dimensional (3D) printing has been utilized as a means of producing high-quality simulation models for trainees in procedure-intensive or surgical subspecialties. However, less is known about its role for trainee education within interventional radiology (IR). Thus, the purpose of this review was to assess the state of current literature regarding the use of 3D printed simulation models in IR procedural simulation experiences. Materials and methods A literature query was conducted through April 2020 for articles discussing three-dimensional printing for simulations in PubMed, Embase, CINAHL, Web of Science, and the Cochrane library databases using key terms relating to 3D printing, radiology, simulation, training, and interventional radiology. Results We identified a scarcity of published sources, 4 total articles, that appraised the use of three-dimensional printing for simulation training in IR. While trainee feedback is generally supportive of the use of three-dimensional printing within the field, current applications utilizing 3D printed models are heterogeneous, reflecting a lack of best practices standards in the realm of medical education. Conclusions Presently available literature endorses the use of three-dimensional printing within interventional radiology as a teaching tool. Literature documenting the benefits of 3D printed models for IR simulation has the potential to expand within the field, as it offers a straightforward, sustainable, and reproducible means for hands-on training that ought to be standardized.


2019 ◽  
Vol 5 (2) ◽  
Author(s):  
Yi Zhang

As microfluidic devices are designed to tackle more intricate tasks, the architecture of microfluidic devicesbecomes more complex, and more sophisticated fabrication techniques are in demand. Therefore, it is sensible to fabricatemicrofluidic devices by three-dimensional (3D)-printing, which is well-recognized for its unique ability to monolithicallyfabricate complex structures using a near-net-shape additive manufacturing process. Many 3D-printed microfluidic platformshave been demonstrated but can 3D-printed microfluidics meet the demanding requirements in today’s context, and hasmicrofluidics truly benefited from 3D-printing? In contrast to 3D-printed microfluidics, some go the other way around andexploit microfluidics for 3D-printing. Many innovative printing strategies have been made possible with microfluidicsenabled3D-printing, although the limitations are also largely evident. In this perspective article, we take a look at the currentdevelopment in 3D-printed microfluidics and microfluidics-enabled 3D printing with a strong focus on the limitations of thetwo technologies. More importantly, we attempt to identify the innovations required to overcome these limitations and todevelop new high-value applications that would make a scientific and social impact in the future.


2020 ◽  
Vol 10 (20) ◽  
pp. 7254
Author(s):  
Hoon Yeub Jeong ◽  
Soo-Chan An ◽  
Yeonsoo Lim ◽  
Min Ji Jeong ◽  
Namhun Kim ◽  
...  

Three-dimensional (3D) printing is a new paradigm in customized manufacturing and allows the fabrication of complex structures that are difficult to realize with other conventional methods. Four-dimensional (4D) printing adds active, responsive functions to 3D-printed components, which can respond to various environmental stimuli. This review introduces recent ideas in 3D and 4D printing of mechanical multistable structures. Three-dimensional printing of multistable structures can enable highly reconfigurable components, which can bring many new breakthroughs to 3D printing. By adopting smart materials in multistable structures, more advanced functionalities and enhanced controllability can also be obtained in 4D printing. This could be useful for various smart and programmable actuators. In this review, we first introduce three representative approaches for 3D printing of multistable structures: strained layers, compliant mechanisms, and mechanical metamaterials. Then, we discuss 4D printing of multistable structures that can help overcome the limitation of conventional 4D printing research. Lastly, we conclude with future prospects.


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