scholarly journals Platelet-rich plasma (PRP) a biogenic stimulator in treatment of primary atrophic rhinitis

2020 ◽  
Vol 36 (1) ◽  
Author(s):  
Hany Samir Mostafa ◽  
Essam Ezzat Ayad
Keyword(s):  
Nasal Obstruction ◽  
Transit Time ◽  
Mucociliary Clearance ◽  
Platelet Rich Plasma ◽  
Treatment Modalities ◽  
Atrophic Rhinitis ◽  
Invasive Approach ◽  
Plasma Injection ◽  
Group A ◽  
Time Test

Abstract Background Primary atrophic rhinitis (1ry AR) is a chronic nasal disease characterized by the loss of mucociliary clearance and presence of viscid secretions and dried crusts that causes a characteristic foul odor, usually bilateral. A large range of treatment modalities had been tried, yet there is still no agreement upon a curative treatment with long-lasting success. The purpose of the study was to assess the value of platelet-rich plasma as a biogenic stimulator for healing acceleration in primary atrophic rhinitis. A total of 78 cases clinically diagnosed to have primary atrophic rhinitis were included. Nasal endoscopy, Sino-Nasal Outcome Test-25 questionnaire, mucociliary clearance assessment by saccharine transit time test, and biopsy specimens were achieved before 1 month and 6 months after the application of platelet-rich plasma in group A (cases) and platelet-poor plasma in group B (controls). Results All patients in group A showed endoscopic improvement and reduction in the incidence of the most frequently encountered symptoms before platelet-rich plasma injection including nasal crusts, 36 (92.30%); foetor, 31 (79.48%); nasal obstruction, 30 (76.92%); anosmia, 17 (43.58%); and epistaxis, 7 (17.94%) to nasal crusts, 9 (23.07%); foetor, 13 (33.33%); nasal obstruction, 14 (35.89%); anosmia, 13 (33.33%); and epistaxis, 3 (7.69%), 6 months after, and this was reflected in the reduction of the Sino-Nasal Outcome Test-25 scores which was averaged 40 before platelet-rich plasma to 9, 6 months after. Similarly, the mucociliary clearance time was significantly reduced after platelet-rich plasma injection; saccharine transit time test was initially averaged at 1980 s and got reduced to 920 s, 6 months after platelet-rich plasma injection. Conclusion The use of platelet-rich plasma as a biogenic stimulator is a possible innovative less invasive approach that can be effective in repairing tissue dystrophy through further future studies.

scholarly journals Platelet-Rich Plasma Injection in Patients with Atrophic Rhinitis

ORL ◽  
2021 ◽  
pp. 1-8
Author(s):  
Do Hyun Kim ◽  
Min Hyeong Lee ◽  
Jaeyoon Lee ◽  
Eun A. Song ◽  
Soo Whan Kim ◽  
...  
Keyword(s):  
Platelet Rich Plasma ◽  
Inferior Turbinate ◽  
Nasal Symptom ◽  
Atrophic Rhinitis ◽  
Symptom Improvement ◽  
Plasma Injection ◽  
Group A ◽  
Group B ◽  
Contrast Group ◽  
Snot 22

<b><i>Objective:</i></b> To investigate the effect of platelet-rich plasma (PRP) injection in patients with atrophic rhinitis. <b><i>Methods:</i></b> Prepared PRP was injected into the inferior turbinate bilaterally, and nasal bacterial cultures were conducted. Improvement of symptoms was assessed with the Nasal Obstruction Symptom Evaluation (NOSE) and the Sino-Nasal Outcome Test-22 (SNOT-22). Nasal mucociliary clearance was assessed using the saccharin transit time (STT). <b><i>Results:</i></b> In the PRP-injected group (group A), NOSE (throughout the study) and SNOT-22 (1 month after injection) scores were significantly decreased during the study. However, the saline spray group (group B) showed no significant nasal symptom improvement during the study period. In group A, the STT was improved until 3 months after the injection. In contrast, group B showed STT improvement after 2 months that was maintained throughout the study. <b><i>Conclusion:</i></b> PRP injections can improve nasal symptoms and nasal mucociliary function in patients with atrophic rhinitis.

scholarly journals Different Treatments in Patients with Temporomandibular Joint Disorders: A Comparative Randomized Study

Medicina ◽  
2020 ◽  
Vol 56 (3) ◽  
pp. 113
Author(s):  
Bruno Macedo De Sousa ◽  
Nansi López-Valverde ◽  
Antonio López-Valverde ◽  
Francisco Caramelo ◽  
Javier Flores Fraile ◽  
...  
Keyword(s):  
Temporomandibular Joint ◽  
Platelet Rich Plasma ◽  
Randomized Study ◽  
Mouth Opening ◽  
Sodium Hyaluronate ◽  
Temporomandibular Joint Disorders ◽  
Treatment Modalities ◽  
Plasma Injection ◽  
Maximum Pain

Background and Objectives: Temporomandibular joint disorders (TMJDs) are associated with pain and reduced jaw mobility. The aim of this study was to compare the outcome of patients with TMJ arthralgia when submitted to four different treatment modalities, in some cases using intra-articular injections of substances with anti-inflammatory properties and in others, a more conservative approach consisting only of a bite splint. Materials and Methods: The sample was made up of 80 patients, randomly distributed into 4 groups of 20 patients each. Each patient was given a nocturnal bite splint. One of the groups was treated with the bite splint only, while each patient in the other 3 was injected with betamethasone, sodium hyaluronate, or platelet-rich plasma in addition to using the bite splint. Two variables were assessed, namely pain intensity between 0 to 10 according to the visual analogue scale and maximum pain-free mouth opening in mm. The patients were evaluated at four different points: at the beginning of the treatment, as well as one week, one month and six months after initiation. Results: The results showed that maximum pain-free mouth opening improved in all the groups that made up the sample, with either a reduction in pain severity or with no pain. However, the group injected with platelet-rich plasma yielded the best results after six months, while patients treated with sodium hyaluronate or betamethasone obtained the best results at the end of the first week. Conclusions: We concluded that all the treatments used caused a reduction in pain and increased pain-free mouth opening. The splint combined with the platelet-rich plasma injection achieved long-term success.

scholarly journals Particularities and Clinical Applicability of Saccharin Transit Time Test

2019 ◽  
Vol 23 (02) ◽  
pp. 229-240 ◽  
Author(s):  
Fernanda Rodrigues ◽  
Ana Paula Freire ◽  
Juliana Uzeloto ◽  
Rafaella Xavier ◽  
Juliana Ito ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Transit Time ◽  
Mucociliary Clearance ◽  
Defense Mechanism ◽  
Basic Information ◽  
Data Synthesis ◽  
Clinical Applicability ◽  
Time Test ◽  
Proper Interpretation ◽  
Interesting Alternative

Introduction The importance of mucociliary clearance (MCC) for the respiratory system homeostasis is clear. Therefore, evaluating this defense mechanism is fundamental in scientific research and in the clinical practice of pulmonology and of associated areas. However, MCC evaluation has not been so usual due to the complexity of methods that use radiolabeled particles. Nevertheless, as an interesting alternative, there is the saccharin transit time (STT) test. This method is reproducible, simple to perform, noninvasive, does not demand high costs, and has been widely used in studies of nasal MCC. Although the STT test is widely used, there is still lack of a detailed description of its realization. Objective The present literature review aims to provide basic information related to the STT test and to present the findings of the previous studies that used this method, discussing variations in its execution, possible influences on the obtained results and limitations of the method, as well as to relate our experience with the use of STT in researches. Data Synthesis There are several factors that can alter the results obtained from STT tests, which would raise difficulties with proper interpretation and with the discussion of the results among different studies. Conclusions Saccharin transit time is a widely used method for the evaluation of nasal MCC, and therefore, the standardization related to the previous and concurrent to test orientations, and also its execution, become essential to improve its accuracy, and allow comparisons among different studies.

scholarly journals Laser for post acne scars with or without growth factors: a comparative clinical trial

2020 ◽  
Vol 6 (2) ◽  
pp. 224
Author(s):  
Lakkireddygari Sujana ◽  
Balachandra S. Ankad ◽  
Savitha L. Beergouder
Keyword(s):  
Growth Factors ◽  
Platelet Rich Plasma ◽  
Objective Assessment ◽  
Subjective Assessment ◽  
Primary Objective ◽  
Treatment Modalities ◽  
Acne Scars ◽  
New Strategy ◽  
Group A ◽  
Group B

<p class="abstract"><strong>Background:</strong> Treatment of acne scars presents a considerable challenge to dermatologists. But with advent of fractional CO<sub>2</sub> (FCO<sub>2</sub>) laser and platelet-rich plasma (PRP), new avenues can be explored. PRP provides various growth factors, so that the healing of laser-damaged skin is accelerated. The aim of this study was to assess the efficacy and safety of FCO<sub>2</sub> laser alone and in combination with PRP in patients with post-acne scars.</p><p class="abstract"><strong>Methods:</strong> Eighty patients with acne scars were counseled and randomly assigned into two groups of 40 each. Group A was treated with FCO<sub>2</sub> laser alone, while Group B was treated with FCO<sub>2</sub> laser and PRP for 6 months. Primary objective was assessment of efficacy of both treatment modalities. Secondary objective was evaluation of safety of treatments.<strong></strong></p><p class="abstract"><strong>Results:</strong> At the end of 6 months, group A showed about 18% reduction, while group B showed about 33% reduction in acne scars on objective assessment. Patient satisfaction as assessed by subjective assessment was greater in group B than in group A. Duration of erythema, edema and crusting was lesser in group B compared to group A.</p><p class="abstract"><strong>Conclusions:</strong> Combination of FCO<sub>2</sub> and PRP was found to be more efficacious as compared to FCO<sub>2</sub> laser alone. Combining the treatment modalities can provide a new strategy for treating the post-acne scars.</p>

scholarly journals Role of α-Tocopherol Acetate on Nasal Respiratory Functions: Mucociliary Clearance and Rhinomanometric Evaluations in Primary Atrophic Rhinitis

2019 ◽  
pp. 014556131987048 ◽  
Author(s):  
Domenico Testa ◽  
Giuseppina Marcuccio ◽  
Nicola Lombardo ◽  
Salvatore Giuseppe Cocuzza ◽  
Germano Guerra ◽  
...  
Keyword(s):  
Transit Time ◽  
Mucociliary Clearance ◽  
Mean Transit Time ◽  
Atrophic Rhinitis ◽  
Therapeutic Effects ◽  
Nasal Airflow ◽  
Loss Of Function ◽  
Endoscopic Evaluation ◽  
Paired Samples ◽  
Dry Nose

Primary atrophic rhinitis is a disease of the nose and of paranasalsinuses characterized by a progressive loss of function of nasal and paranasal mucosa caused by a gradual destruction of ciliary mucosalepithelium with atrophy of serous–mucous glands and loss of bonestructures.The aim of this study was to evaluate the therapeutic effects of topic α-tochopherol acetate (vitamin E) in patients with primary atrophicrhinitis based on subjective and objective data.We analyzed 44 patients with dry nose sensation and endoscopic evidence of atrophic nasal mucosa. We analyzed endoscopic mucosascore, anterior rhinomanometry, and nasal mucociliary clearance before and after 6 months of topic treatment with α-tochopherol acetate. For statistical analysis, we used paired samples t test (95% confidence interval [CI], P < .05) for rhinomanometric and muciliary transit time evaluations and analysis of variance 1-way test (95% CI, P < .05) for endoscopic evaluation. All patients showed an improvement in “dry nose” sensation and inperception of nasal airflow. Rhinomanometric examination showed increase of nasal airflow at follow-up ( P < .05); nasal mucociliaryclearance showed a reduction in mean transit time ( P < .05); and endoscopic evaluation showed significative improvement of hydration of nasalmucosa and significative decreasing nasal crusts and mucusaccumulation ( P < .05). Medical treatment for primary atrophic rhinitis is not clearly documented in the literature; in this research, it was demonstrated that α-ochopherol acetate could be a possible treatment for atrophic rhinitis.

scholarly journals Nasal irrigation using saline at room temperature or body temperature: which is more beneficial in chronic rhinosinusitis?

2019 ◽  
Vol 5 (4) ◽  
pp. 1005
Author(s):  
Subrat K. Behera ◽  
Sruthi Thattamparambil Radhakrishnan ◽  
Smruti Swain
Keyword(s):  
Body Temperature ◽  
Chronic Rhinosinusitis ◽  
Transit Time ◽  
Mucociliary Clearance ◽  
Cold Climate ◽  
Double Blind Study ◽  
Nasal Irrigation ◽  
Group A ◽  
Group B ◽  
Snot 22

<p class="abstract"><strong>Background:</strong> Mucociliary clearance in nasal mucosa shows changes with temperature. In cold climate, it is expected to decrease, thus contributing to exacerbation of rhinosinusitis symptoms. If we raise the temperature of saline used for nasal irrigation to the normal body temperature, can it overcome this problem in cold climate? This study aims to examine whether irrigation using saline that is heated to 37<sup>°</sup>C has any superiority compared to irrigation using saline at 18<sup>0</sup>C in rhino sinusitis treatment.</p><p class="abstract"><strong>Methods:</strong> Prospective double blind study done in a tertiary care centre from November 2017 to March 2018. 32 patients of chronic rhinosinusitis were divided into 2 groups. Group A received saline nasal irrigation using saline at 18<sup>o</sup>c and Group B received irrigation with saline at 37<sup>o</sup>c for 2 weeks. Saccharine transit time and sino nasal outcome test (SNOT-22) scores were calculated before and after treatment in both groups and the results compared.  </p><p class="abstract"><strong>Results:</strong> Saccharine transit time improved from mean pretreatment value of 12.4±5.52 minutes to 9.1±6.3 minutes in Group A and from 12.82±6.3 to 8.5±6.45 in Group B (p=0.0212). Mean SNOT-22 score decreased from 58.8±5.6 to 41.4±4.8 in Group A and from 57.5±4.2 to 37.9±5.1 in Group B after treatment (p&lt;0.05).</p><p><strong>Conclusions:</strong> Nasal irrigation using saline at 37<sup>0</sup>C is more effective than saline at 18<sup>°</sup>C in increasing mucociliary clearance and improving symptoms in chronic rhinosinusitis patients.</p>

scholarly journals Outcome of staged injection of autologous platelet rich plasma in treatment of mild to moderate knee osteoarthritis

2019 ◽  
Vol 6 (1) ◽  
pp. 26
Author(s):  
Rajat Gupta ◽  
Ram Avtar ◽  
Krishan Kumar
Keyword(s):  
Growth Factors ◽  
Single Injection ◽  
Platelet Rich Plasma ◽  
Low Cost ◽  
Biologically Active ◽  
Plasma Injection ◽  
Group A ◽  
Autologous Platelet Rich Plasma ◽  
Group B ◽  
Autologous Platelet

<p class="abstract"><strong>Background:</strong> Autologous platelet-rich plasma (PRP) offers an easy solution for delivering multiple growth factors needed for tissue repair. Intra-articular injections of PRP have been proposed as a simple low cost minimally invasive way to obtain the concentration of growth factors and biologically active molecules to promote cartilage healing in osteoarthritic (OA) knee joint. The objective of the present study was designed to<em> </em>evaluate the clinical efficacy of autologous platelet rich plasma injection in mild to moderate osteoarthritic knee and to assess the role of serial staged autologous platelet rich plasma injection.</p><p class="abstract"><strong>Methods:</strong> 50 patients with mild to moderate osteoarthritis of knee were divided into two groups. Group A was given staged injection of freshly prepared autologous PRP in the affected knee. Group B was given single injection of PRP. The Results were evaluated on the basis of the Western Ontario and McMaster Universities Arthritis Index (WOMAC) questionnaire and visual analog scale (VAS) before treatment and 3 weeks, 8 weeks, 16 weeks and 24 weeks after treatment.<strong></strong></p><p class="abstract"><strong>Results:</strong> At 24-weeks follow up the following observations were made; the MeanVAS in Group A decreased to 3.30 whereas in Group B it increased to 4.54. The Mean WOMAC score in Group A was reduced to a mere28.64 in Group A and in Group B it was 39.76.</p><p class="abstract"><strong>Conclusions:</strong> It is concluded from our study that concomitant use of serial staged injection (two) of PRP over four months is more effective than single injection in patients with mild to moderate OA of knee.</p>

scholarly journals Efficacy of intralesional corticosteroid versus autologous platelet rich plasma injection in the management of chronic plantar fasciitis

2018 ◽  
Vol 4 (5) ◽  
pp. 790
Author(s):  
Divya Anil Kumar ◽  
Harsha Kumar Koramutla
Keyword(s):  
Plantar Fasciitis ◽  
Platelet Rich Plasma ◽  
Vas Score ◽  
Plasma Injection ◽  
Intralesional Corticosteroid ◽  
Group A ◽  
Autologous Platelet Rich Plasma ◽  
Group B ◽  
Autologous Platelet

<p class="abstract"><strong>Background:</strong> Plantar fasciitis is a common pathological condition affecting the hind foot, and a common cause of heel pain. The present study was taken up to assess the efficacy of intralesional corticosteroid compared to autologous platelet rich plasma injection in the management of chronic plantar fasciitis.</p><p class="abstract"><strong>Methods:</strong> Patients were randomized into two groups (Group A and Group B) of 30 each. Group-A received Corticosteroid injection while Group-B received PRP injection. Patients were assessed functionally using American Orthopaedic Foot and ankle score (AOFAS), Visual analogue scale (VAS) scores before treatment and on follow-up visit at 6 weeks, 3rd month, and 6th month. Ultrasound of heel for plantar fascia thickness was measured before treatment and follow up visit at 6th month.<strong></strong></p><p class="abstract"><strong>Results:</strong> A significant decrease in VAS score was observed in the corticosteroid group compared to PRP group at 6 weeks while the VAS score continued to decrease in the PRP group at 3 months and 6 months with an increase in the corticosteroid group at 3 months and 6 months. A significant increase in AOFAS was observed in the Corticosteroid group compared to PRP group at 6 weeks which increased in the PRP group at 3 months and 6 months. However it decreased in the corticosteroid group at 3 months and 6 months. Ultrasonographic evaluation showed improvement in fascial thickness in both the groups, but was better in the PRP group.</p><p class="abstract"><strong>Conclusions:</strong> To conclude our study shows that corticosteroid is more effective for short term relief and PRP is more effective for long term relief.</p>

scholarly journals Comparative study of efficacy of minoxidil versus minoxidil with platelet rich plasma versus minoxidil with dermaroller in androgenetic alopecia

2021 ◽  
Vol 7 (2) ◽  
pp. 279
Author(s):  
Adarsh Gowda ◽  
Sana Mariam Sankey ◽  
Sharath Kumar B. C.
Keyword(s):  
Side Effect ◽  
Negative Impact ◽  
Platelet Rich Plasma ◽  
Seborrheic Dermatitis ◽  
Androgenetic Alopecia ◽  
Treatment Modalities ◽  
Common Side Effect ◽  
Efficacy Analysis ◽  
Therapeutic Modalities ◽  
Group A

<p class="abstract"><strong>Background:</strong> Androgenetic alopecia is characterized by progressive hair loss and is recognized as having significant psychological effects on affected patients with a negative impact on QOL. Drug therapies specifically approved by FDA for treating androgenetic alopecia (AGA) are limited to minoxidil and finasteride. There are limited three arm studies comparing treatment modalities in AGA, hence we undertook this study to compare the 3 most common, affordable therapeutic modalities used currently in AGA and their effects.</p><p class="abstract"><strong>Methods:</strong> This is a prospective comparative parallel group interventional study. 90 subjects recruited into 3 groups, group A treated with minoxidil alone, group B with minoxidil and dermaroller and group C with minoxidil and platelet rich plasma (PRP).<strong></strong></p><p class="abstract"><strong>Results:</strong> At the end of 5 months 50% patients in group C showed moderate improvement which was found to be superior to the other treatment groups. On the basis of global photographs secondary efficacy analysis was done and all arms were found to have slight improvement. Dermoscopic analysis done at baseline and 5 months showed that group C showed maximum improvement. Pain was the most common side effect noted in group C while pruritus and seborrheic dermatitis was seen more in group A.  </p><p class="abstract"><strong>Conclusions:</strong> Our study showed best results in patients treated with PRP and minoxidil. They have emerged as new non-surgical treatment modalities for AGA, with minimal side effects, good safety profile and patient satisfaction. There are limited three arm studies comparing the efficacy and side effect profile of these 3 modalities in AGA.  </p><p> </p>

Sign in / Sign up

Export Citation Format

Share Document