Image guided interventions play a critical role in the multifactorial approach to acute and chronic pain management. In this chapter we discuss the indications, contraindications, patient evaluation, procedural technique, periprocedural care, and expected outcomes associated with various pain interventions. Interventions covered in this chapter include sacroiliac and facet joint injections, facet joint ablation, epidural injection, and nerve plexus blockade (celiac, lumbar sympathetic, and superior hypogastric). For each intervention, a comprehensive approach to the patient is discussed, including pertinent physical exam findings, providing the proceduralist with an algorithm to provide the appropriate intervention for their patient. In addition, detailed descriptions of optimal technique with referenced images are provided to guide the novice interventionalist first approaching pain interventions.