Plasma free fatty acids in exercise

1964 ◽  
Vol 19 (3) ◽  
pp. 489-492 ◽  
Author(s):  
K. Rodahl ◽  
H. I. Miller ◽  
B. Issekutz
Keyword(s):  
Fatty Acids ◽  
Lipid Metabolism ◽  
Blood Glucose ◽  
Free Fatty Acids ◽  
Blood Sugar ◽  
Blood Lactate ◽  
Marked Change ◽  
Apparent Discrepancy ◽  
Plasma Free Fatty Acids ◽  
Plasma Ffa

The effects of exercise of different intensity and duration on plasma free fatty acids (FFA), blood glucose, and lactate were investigated in eight healthy young men. In heavy 10-min work the blood lactate rose rapidly and the FFA decreased. Blood sugar showed no marked change. Intermittent work caused a slight increase in blood lactate and no change in blood glucose. The FFA remained essentially unchanged but increased in three out of four subjects during recovery. In moderate 1-hr work the FFA remained essentially unchanged, but increased markedly during recovery when blood lactate had returned to resting levels. In prolonged exhausting work in fasting subjects, the blood lactate remained almost unchanged, while the FFA rose steadily and the blood sugar dropped. In nonfasting subjects the FFA also rose, but the ingestion of lunch caused, in all cases, a striking drop in the FFA, associated with a rise in blood sugar. Combined hormonal effects (insulin and norepinephrine) brought into play during exercise of different intensity and duration may well explain the apparent discrepancy in the results of different investigators concerning the effect of exercise on plasma FFA. work and FFA; FFA at different workloads; lipid metabolism in work Submitted on November 6, 1963

A fat-mobilizing substance in chicken urine

1969 ◽  
Vol 47 (5) ◽  
pp. 435-443 ◽  
Author(s):  
I. Nir ◽  
Mildred K. Dimick ◽  
S. Lepkovsky
Keyword(s):  
Fatty Acids ◽  
Blood Glucose ◽  
Food Intake ◽  
Free Fatty Acids ◽  
Plasma Cholesterol ◽  
Lipid Phosphorus ◽  
Male And Female ◽  
Plasma Free Fatty Acids ◽  
Plasma Triglycerides ◽  
Plasma Ffa

A fat-mobilizing substance (FMS) was extracted from the urine of fasting male and female chickens. Injection into chickens caused transient decreases in food intake and transient increases in plasma free fatty acids (FFA). These effects were accompanied by persisting decreases in plasma triglycerides. FMS also caused persistent decreases in plasma cholesterol and lipid phosphorus. Slight elevations of blood glucose occurred, but they were not statistically significant. FMS obtained from the urine of fed chickens by the same technique as that used with fasting chickens varied in its activity; at times it was similar to the FMS obtained from fasting chickens and at other times had little effect on plasma FFA and food intake. FMS elicited smaller increases in plasma FFA in laying hens than it did in males, possibly as a result of higher pre-injection levels in the hens. In contrast to findings in mammals, FMS was obtained from the urine of hypophysectomized chickens. Differences in response to FMS among mice, rats, and chickens are discussed.

Free fatty acid turnover and oxygen consumption. Effects of noradrenaline in nonfasted and nonanesthetized cold-adapted rats

1980 ◽  
Vol 58 (7) ◽  
pp. 797-804 ◽  
Author(s):  
Louise Lafrance ◽  
Georges Lagacé ◽  
Danièle Routhier
Keyword(s):  
Fatty Acids ◽  
Oxygen Consumption ◽  
Fatty Acid ◽  
Lipid Metabolism ◽  
Blood Glucose ◽  
Free Fatty Acid ◽  
Free Fatty Acids ◽  
Respiratory Quotient ◽  
Cold Adapted ◽  
Plasma Ffa

The effects of a 3-h noradrenaline (NA) infusion (1.5 μg kg−1 min−1) on the O2 consumption, the respiratory quotient (RQ), the concentration of plasma free fatty acids (FFA), and the rates of appearance (Ra) and disappearance (Rd) of plasma FFA were studied in nonfasted and nonanesthetized control and cold-adapted rats. To calculate the Ra FFA and Rd FFA, [1-14C]palmitate complexed to albumin was infused as a tracer. The concentrations of glucose and lactate in blood were also determined before and during the NA infusion. The enhanced O2 consumption produced by NA in cold-adapted rats was associated with a decreased RQ. The Ra FFA and Rd FFA were more enhanced by NA in cold-adapted than in control rats whereas the plasma FFA concentration was less elevated in cold-adapted rats. The blood lactate was barely increased by the NA infusion in cold-adapted rats and was not modified in control rats. Blood glucose was increased by NA in both control and cold-adapted rats but to a greater extent in control rats during the last 90 min of NA infusion. These results suggest that the enhanced calorigenic response to NA observed in nonfasted and nonanesthetized cold-adapted rats is related, at least partly, to an enhanced lipid metabolism; the RQ is low and Ra FFA and Rd FFA are greatly increased. However, the contribution of other energetic substrates like glucose will also be investigated in further studies.

Source of plasma free fatty acids in dogs receiving fat emulsion and heparin

1963 ◽  
Vol 204 (4) ◽  
pp. 691-695 ◽  
Author(s):  
H. C. Meng ◽  
B. Edgren
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Lipolytic Activity ◽  
Blocking Agent ◽  
Fat Emulsion ◽  
Similar Reduction ◽  
Plasma Free Fatty Acids ◽  
Fat Infusion ◽  
Plasma Ffa ◽  
Slight Rise

Unanesthetized dogs were given either 3.0 g fat/kg as a 20% fat emulsion or heparin (2 mg/kg) intravenously or both. Plasma free fatty acids (FFA) and lipolytic activity were determined at intervals. In some experiments hexamethonium (5 mg/kg), a sympathetic ganglionic blocking agent, was administered intravenously either before or after fat or heparin. In fasting dogs fat infusion produced a moderate and heparin caused a slight rise in plasma FFA. Heparin given during lipemia produced a marked elevation of plasma FFA. The plasma lipolytic activity was increased after fat emulsion or heparin. Hexamethonium reduced the fasting plasma FFA about 70% or 0.40–0.6 mEq/liter. A similar reduction of plasma FFA also was observed when hexamethonium was administered during fat infusion or after heparin. Hexamethonium did not affect the increase in plasma lipolytic activity following the administration of fat emulsion or heparin. It seems probable that the increase in plasma FFA observed after intravenous infusion of fat emulsion or heparin is mainly due to the result of intravascular lipolysis.

Central and peripheral adrenoceptors affect glucose, free fatty acids, and insulin in exercising rats

1988 ◽  
Vol 255 (4) ◽  
pp. R547-R556 ◽  
Author(s):  
A. J. Scheurink ◽  
A. B. Steffens ◽  
L. Benthem
Keyword(s):  
Fatty Acids ◽  
Blood Glucose ◽  
Free Fatty Acids ◽  
Blood Samples ◽  
Beta Adrenoceptor ◽  
Plasma Ffa ◽  
Glucose Plasma ◽  
Exercise Induced ◽  
Counter Current ◽  
Lateral Area

The effects of intravenously and intrahypothalamically administered alpha- and beta-adrenoceptor antagonists on exercise-induced alterations in blood glucose, plasma free fatty acids (FFA), and insulin were investigated in rats. Exercise consisted of strenuous swimming against a counter current for 15 min. Before, during, and after swimming, blood samples were withdrawn through a permanent heart catheter. Intravenous administration of the alpha-blocker phentolamine led to a reduction in glucose and a substantial increase in insulin levels. Infusion of phentolamine through permanent bilateral cannulas into either the ventromedial or lateral area of the hypothalamus (VMH and LHA, respectively) completely prevented the increase in glucose while the decline in insulin was unaffected. Infusion of phentolamine into the VMH caused much higher plasma FFA levels than in controls. The beta-blocker timolol given intravenously caused a delayed increase in glucose and prevented the increase in FFA. Infusion of timolol into either VMH or LHA caused a delay in the increase in both glucose and FFA. The results suggest that 1) both peripheral and hypothalamic adrenoceptors are involved in energy metabolism during exercise and 2) FFA, glucose, and insulin concentrations in blood are independently regulated by VMH and LHA.

scholarly journals Effects of free fatty acids on hepatic glycogenolysis and gluconeogenesis in conscious dogs

2002 ◽  
Vol 282 (2) ◽  
pp. E402-E411 ◽  
Author(s):  
Chang An Chu ◽  
Stephanie M. Sherck ◽  
Kayano Igawa ◽  
Dana K. Sindelar ◽  
Doss W. Neal ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Free Fatty Acids ◽  
Glucose Level ◽  
Conscious Dogs ◽  
Arterial Blood ◽  
Plasma Ffa ◽  
Arterial Plasma ◽  
Arterial Blood Glucose

The aim of this study was to determine the effect of high levels of free fatty acids (FFA) and/or hyperglycemia on hepatic glycogenolysis and gluconeogenesis. Intralipid was infused peripherally in 18-h-fasted conscious dogs maintained on a pancreatic clamp in the presence (FFA + HG) or absence (FFA + EuG) of hyperglycemia. In the control studies, Intralipid was not infused, and euglycemia (EuG) or hyperglycemia (HG) was maintained. Insulin and glucagon were clamped at basal levels in all four groups. The arterial blood glucose level increased by 50% in the HG and FFA + HG groups. It did not change in the EuG and FFA + EuG groups. Arterial plasma FFA increased by ∼140% in the FFA + EuG and FFA + HG groups but did not change significantly either in the EuG or HG groups. Arterial glycerol levels increased by ∼150% in both groups. Overall (3-h) net hepatic glycogenolysis was 196 ± 26 mg/kg in the EuG group. It decreased by 96 ± 20, 82 ± 16, and 177 ± 22 mg/kg in the HG, FFA + EuG, and FFA + HG groups, respectively. Overall (3-h) hepatic gluconeogenic flux was 128 ± 22 mg/kg in the EuG group, but it was suppressed by 30 ± 9 mg/kg in response to hyperglycemia. It was increased by 59 ± 12 and 56 ± 10 mg/kg in the FFA + EuG and FFA + HG groups, respectively. In conclusion, an increase in plasma FFA and glycerol significantly inhibited hepatic glycogenolysis and markedly stimulated hepatic gluconeogenesis.

Factors Affecting Plasma Free Fatty Acids Rise during Hemodialysis

1988 ◽  
Vol 11 (2) ◽  
pp. 95-98 ◽  
Author(s):  
G. Mingardi ◽  
E. Branca ◽  
M. Cini ◽  
A.M. Codegoni ◽  
G. Mecca ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Plasma Lipids ◽  
Unknown Mechanism ◽  
Factors Affecting ◽  
Plasma Free Fatty Acids ◽  
Plasma Triglycerides ◽  
Plasma Ffa ◽  
Acute Changes

We studied the mechanisms responsible for causing acute changes in plasma lipids during hemodialysis. Dialysis decreased plasma triglycerides to the same extent as when heparin was given without dialysis. Cholesterol increased in proportion to hemoconcentration. Plasma free fatty acids (FFA) levels were also increased, but more so than with heparin alone. Glucose and acetate did not play a role, nor did carnitine loss, and hemofiltration elicited similar effects. The rise in plasma FFA is therefore likely to be caused by other as yet unknown mechanism.

Epinephrine-insulin antagonism on free fatty acid release

1961 ◽  
Vol 201 (5) ◽  
pp. 815-818 ◽  
Author(s):  
John J. Spitzer ◽  
William T. McElroy
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Free Fatty Acid ◽  
Free Fatty Acids ◽  
Blood Sugar ◽  
Drug Administration ◽  
Hepatic Uptake ◽  
Fatty Acid Release ◽  
Plasma Ffa ◽  
Acid Release

The effects of epinephrine or norepinephrine were studied in dogs receiving insulin plus glucose prior to and during administration of the amine. Epinephrine caused a significantly smaller elevation of free fatty acids (FFA) with than without insulin plus glucose administration. Blood sugar responses were quantitatively similar. Epinephrine increased both hepatic uptake of FFA and hepatic release of glucose; these changes were similar to the ones found previously in dogs not receiving insulin plus glucose. The action of norepinephrine on elevating plasma FFA was only slightly and not significantly affected by the administration of insulin plus glucose. When the order of drug administration was reversed, infusion of insulin plus glucose lowered plasma FFA levels and hepatic FFA uptake in animals already receiving either epinephrine or nonepinephrine.

Sign in / Sign up

Export Citation Format

Share Document