The Short-Term Outcome of Neurotic Disorders in the Community: The Relation of Remission to Clinical Factors and to ‘Neutralizing’ Life Events

SummaryA longitudinal study of neurotic disorder in the community showed that half the cases identified at first interview had remitted one month later. Remission was significantly related to four variables: recency of onset and of peak of the disorder, the occurrence of recent threatening life events and the occurrence of subsequent ‘neutralizing’ life events. A neutralizing event was defined a priori as one which neutralized the impact of an earlier threatening life event or difficulty. One third of all remissions were caused by such an event. Remission of disorder was not significantly related to demographic variables, symptom severity, syndrome type, medical consultation or psychotropic drug prescription. The implications for neurotic disorder in the community are discussed, in particular its relation to life events and the favourable outcome in the absence of treatment.

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School Phobia: A Therapeutic Trial with Clomipramine and Short-Term Outcome

The British Journal of Psychiatry ◽

10.1192/bjp.138.2.110 ◽

1981 ◽

Vol 138 (2) ◽

pp. 110-118 ◽

Cited By ~ 142

Author(s):

T. Berney ◽

I. Kolvin ◽

S. R. Bhate ◽

R. F. Garside ◽

J. Jeans ◽

...

Keyword(s):

School Refusal ◽

Therapeutic Trial ◽

Short Term ◽

Neurotic Disorder ◽

Double Blind ◽

Term Outcome ◽

School Phobia ◽

Short Term Outcome ◽

Rapid Relief ◽

Better Than

SummaryA double-blind trial failed to demonstrate any significant short-term effects of clomipramine in doses recommended for use in general practice (in addition to the usual range of psychotherapeutic help) in the treatment of children with school refusal and neurotic disorder. Patterns of improvement were also studied for the sample as a whole irrespective of treatment. Neither age nor sex were significantly related to improvement, except on one behavioural measure where girls initially did better than boys. In addition, it was found that there was a rapid relief of depression but neurotic symptomatology tended to persist.

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Prediction of outcome in neurotic disorder: a 5-year prospective study

Psychological Medicine ◽

10.1017/s0033291798007119 ◽

1998 ◽

Vol 28 (5) ◽

pp. 1149-1157 ◽

Cited By ~ 54

Author(s):

H. SEIVEWRIGHT ◽

P. TYRER ◽

T. JOHNSON

Keyword(s):

Initial Response ◽

Favourable Outcome ◽

Dysthymic Disorder ◽

Response To Treatment ◽

Behaviour Therapy ◽

Neurotic Disorder ◽

Term Outcome ◽

Long Term Outcome ◽

Predicting Outcome

Background. There have been no previous studies of the outcome of different neurotic disorders in which a prospective group with original randomization to treatment have been followed up over a long period. Such studies are important in identifying the factors associated with good and poor outcome.Methods. A 5-year follow-up assessment was made of a cohort of 210 psychiatric out-patients seen in general practice psychiatric clinics with a DSM-III diagnosis of generalized anxiety disorder (71), panic disorder (74) or dysthymic disorder (65) and randomized to drug treatment, cognitive and behaviour therapy, and self-help. A total of 182 of the patients (87%) were assessed after 5 years by examination of hospital and GP records using a standardized procedure and outcome determined with a four-point outcome scale.Results. One hundred and seven (60%) of the patients had a favourable outcome but the remainder continued to be handicapped either intermittently or continuously throughout the 5-year period. Analysis of the value of initial data in predicting outcome using polychotomous step-wise logistic regression revealed that five variables were significant predictors of poor prognosis: older age; recurrent episodes; the presence of personality disorder at entry; general neurotic syndrome at entry; and symptom severity after 10 weeks. The initial DSM diagnosis and original treatment given, together with ten other variables, were of no predictive value.Conclusions. The long-term outcome of neurotic disorder is better predicted by age, personality and recency of onset than by other clinical variables with the exception of initial response to treatment.

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The Impact of the Duration of Untreated Psychosis On the Short-term Outcome in Schizophrenia

European Psychiatry ◽

10.1016/s0924-9338(15)31326-2 ◽

2015 ◽

Vol 30 ◽

pp. 1726

Author(s):

H. Rebhi ◽

W. Cherif ◽

L. Chennoufi ◽

A. Belkhiria ◽

M. Cheour

Keyword(s):

Duration Of Untreated Psychosis ◽

Short Term ◽

Term Outcome ◽

Short Term Outcome ◽

The Impact

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Medical students’ mood adversely affected by COVID-19 pandemic: An interim analysis from the SPICE-19 prospective cohort study of 2075 medical students and interim foundation doctors

10.21203/rs.3.rs-40503/v1 ◽

2020 ◽

Cited By ~ 3

Author(s):

Soham Bandyopadhyay ◽

Ioannis Georgiou ◽

Bibire Baykeens ◽

Conor S Gillespie ◽

Marta de Andres Crespo ◽

...

Keyword(s):

Medical Students ◽

A Priori ◽

Workforce Planning ◽

Short Term ◽

The United Kingdom ◽

Exam Preparation ◽

Course Material ◽

The Impact ◽

Exam Preparation Course

Abstract Background:Currently, we can only speculate on what the effects of the COVID-19 pandemic have been on medical students and interim foundation year doctors. In order to support them appropriately both now and, in the future, it is imperative that we understand the impact it has had upon them. This study assessed the effects of the COVID-19 pandemic on medical students and interim foundation year doctors across the United Kingdom (UK), and the support that they received and sought. Methods:A prospective, observational, multicentre study was conducted. All medical students and interim foundation year doctors were eligible to participate. The data analysis was carried out as detailed a priori in the protocol. Findings:A total of 2075 individuals participated in the SPICE-19 survey from 33 medical schools. There was a significant (p < 0.0001) decrease in participants’ mood when comparing their mood before the pandemic to during the pandemic. Social distancing and more time at home/with family were the factors that negatively and positively respectively impacted the mood of the greatest number of participants. All areas of life included in the survey were found to have been significantly more negatively impacted than positively impacted (p < 0.0001). 931 participants wanted more support from their university. Participants were mainly seeking support with exam preparation, course material, and financial guidance. Discussion:Medical and foundation schools need to prepare adequate and effective support. If no action is taken, there may be a knock-on effect on workforce planning and the health of our future workforce. When medical students return to their universities, there is likely to be need for enhanced wellbeing support, adaptations in the short-term and long-term strategies for medical education, and provision of financial guidance.

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Short-Term Outcome of Major Depression: II. Life Events, Family Dysfunction, and Friendship Difficulties as Predictors of Persistent Disorder

Journal of the American Academy of Child & Adolescent Psychiatry ◽

10.1097/00004583-199704000-00009 ◽

1997 ◽

Vol 36 (4) ◽

pp. 474-480 ◽

Cited By ~ 79

Author(s):

IAN M. GOODYER ◽

JOE HERBERT ◽

ALISON TAMPLIN ◽

SANDRA M. SECHER ◽

JOSEPHINE PEARSON

Keyword(s):

Major Depression ◽

Life Events ◽

Family Dysfunction ◽

Short Term ◽

Term Outcome ◽

Short Term Outcome

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A study proposal on short term outcome and prognosis of primary and delayed fulguration in posterior urethral valve

International Surgery Journal ◽

10.18203/2349-2902.isj20203999 ◽

2020 ◽

Vol 7 (10) ◽

pp. 3389

Author(s):

Jeevarathi T. ◽

Gomathi Vadivelu

Keyword(s):

Urinary Tract ◽

Renal Insufficiency ◽

Urinary Tract Obstruction ◽

Posterior Urethral Valve ◽

Short Term ◽

Term Outcome ◽

Current Series ◽

Lower Urinary Tract Obstruction ◽

Urethral Valve ◽

The Impact

Background: Posterior urethral valve (PUV) is the most common cause of lower urinary tract obstruction in male neonates. The incidence is 1 in 4000, 1 in 7500 births PUV occur exclusively in males. This disease has a broad spectrum of presentations. They may present at any age during childhood and may vary from ascites in the neonate to renal failure in infants and only minor voiding dysfunction in an older child. Urinary tract infection is common at all ages. The objectives of the study were to assess the impact of primary impaction on short term outcomes and to assess the outcome of diversion and delayed fulguration.Methods: This retrospective study was conducted at the Pediatric Urology outpatient department (OPD) at the Institute of Child Health and Hospital for Children, Madras Medical College, Chennai including the patients who attended the pediatric surgery from August 2008 to December 2011.Results: In the current series, the incidence of renal insufficiency in patients with urosepsis was 45%. Recurrent urosepsis >3 episodes in a year (fever with urine culture showing infection) primarily due to poor patient compliance lead to progressing pyelonephritis and nephron damage and plays an important role in the outcome of these children.Conclusions: The incidence of renal insufficiency in children with posterior urethral valves in this series was 38% (30-45%) with an average follow up 3 years. Several factors were important in prognosticating the progression towards renal insufficiency and bladder dysfunction. Urodynamics is of immense help in cases having symptoms despite good stream. The use of anticholinergic for abnormal urodynamics gives encouraging results.

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The impact of being newly diagnosed with a bipolar disorder and the short-term outcome of disorder-specific management

Bipolar Disorders ◽

10.1111/bdi.12146 ◽

2013 ◽

Vol 16 (2) ◽

pp. 172-179 ◽

Cited By ~ 4

Author(s):

Gordon B Parker ◽

Rebecca K Graham ◽

Kathryn Fletcher ◽

Shulamit M Futeran ◽

Paul Friend

Keyword(s):

Bipolar Disorder ◽

Newly Diagnosed ◽

Short Term ◽

Term Outcome ◽

Short Term Outcome ◽

The Impact ◽

Specific Management

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The Nottingham Study of Neurotic Disorder: predictors of 12-year outcome of dysthymic, panic and generalized anxiety disorder

Psychological Medicine ◽

10.1017/s0033291704002569 ◽

2004 ◽

Vol 34 (8) ◽

pp. 1385-1394 ◽

Cited By ~ 74

Author(s):

PETER TYRER ◽

HELEN SEIVEWRIGHT ◽

TONY JOHNSON

Keyword(s):

Anxiety Disorder ◽

Personality Disorder ◽

Generalized Anxiety Disorder ◽

Depressive Disorders ◽

Favourable Outcome ◽

Dysthymic Disorder ◽

Generalized Anxiety ◽

Neurotic Disorder ◽

Term Outcome ◽

Long Term Outcome

Background. Controlled prospective studies of the simultaneous long-term outcome of several mental disorders are rare. This study sought to determine if there were important differences between the outcome of anxiety and depressive disorders after 12 years and to examine their main predictors.Method. A cohort of 210 people seen in general practice psychiatric clinics with a DSM-III diagnosis of generalized anxiety disorder (71), panic disorder (74), or dysthymic disorder (65), including combined anxiety-depressive disorder (cothymia) (67) was followed up after 12 years. Interview assessments of symptoms, social functioning and outcome were made, the latter using a new scale, the Neurotic Disorder Outcome Scale. Seventeen baseline predictors were also examined.Results. Data were obtained from 201 (96%) patients, 17 of whom had died. Only 73 (36%) had no DSM diagnosis at the time of follow-up. Using univariate and stepwise multiple linear regression those with cothymia, personality disorder, recurrent episodes and greater baseline self-rated anxiety and depression ratings had a worse outcome than others; initial diagnosis did not contribute significantly to outcome and instability of diagnosis over time was much more common than consistency.Conclusion. Only two out of five people with the common neurotic disorders have a good outcome despite alleged advances in treatment. Those with greater mood symptoms and pre-morbid personality disorder have the least favourable outcome. It is suggested that greater attention be paid to the concurrent treatment of personality disorder and environmental factors rather than symptoms as these may be the real cause of apparent treatment resistance.

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National Fontan Operation outcomes at or below 2-years-of-age compared to older than 2- years-of-age

10.22541/au.163828920.00545337/v1 ◽

2021 ◽

Author(s):

Sandeep Sainathan ◽

Chris Agala ◽

Sameh Said ◽

Leonardo Mulinari ◽

Mahesh Sharma

Keyword(s):

Statistical Tests ◽

Fontan Operation ◽

National Database ◽

White Female ◽

Endocardial Cushion ◽

Short Term ◽

Term Outcome ◽

White Ethnicity ◽

Endocardial Cushion Defect ◽

The Impact

Introduction: Opinion is divided about optimal early timing of the Fontan Operation (FO). While some studies have suggested 3 years-of-age, others have shown good outcomes below 2 years-of -age. We analyzed the impact of age ≤2-years as compared age >2-years on short-term outcome of the FO using a large national database. Methods: A retrospective analysis of the Kids Inpatient Database (2009-16) for the FO was done. The groups were divided into those who underwent FO at age ≤2-years (EF) as compared to age >2-years (LF). The data was abstracted for demographics, clinical characteristics, and operative outcomes. Standard statistical tests were used. Results: 3381 patients underwent FO during this period of which 1482 (44%) were EF. The mean ages of the EF and LF were 1.6 and 4.3, respectively (p< 0.001). LF were more likely to be non-White, female, and have Heterotaxy syndrome. HLHS was more common in EF. There was no difference in the discharge mortality, length of stay, disposition (majority went home), and mean total charges incurred. The overall discharge mortality was low at 0.7% (24/3381). In multivariate analysis: cardiac arrest, acute kidney injury, mechanical ventilation >96 hours, endocardial cushion defect and non-White ethnicity were predictors of a mortality and not age. Conclusion: Contemporary outcomes for FO are excellent with equivalent short-term outcomes in both the age groups. Occurrence of postoperative complications, non-white ethnicity and endocardial cushion defect diagnosis were predictive of a negative outcome.

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