The Effects of Weight Change on the Dexamethasone Suppression Test in Depressed and Anorexic Patients

1986 ◽  
Vol 149 (6) ◽  
pp. 751-755 ◽  
Author(s):  
I. Schweitzer ◽  
K. P. Maguire ◽  
J. W. G. Tiller ◽  
A. H. Gee ◽  
L. C. Harrison ◽  
...  
Keyword(s):  
Weight Loss ◽  
Weight Change ◽  
Ideal Body Weight ◽  
Dexamethasone Suppression Test ◽  
Depressed Patients ◽  
Significant Difference ◽  
History Of ◽  
Suppression Test ◽  
Hpa Axis Functioning ◽  
Dexamethasone Suppression

Prior studies on weight change and hypothalmic-pituitary-adrenal (HPA) axis functioning are reviewed. Data on 58 depressed and eight anorexic patients is presented. No significant difference in the frequency of cortisol non-suppression in the dexamethasone suppression test (DST) was found between depressed patients with a history of weight loss and those without, nor between depressed patients who lost weight during their first week in hospital and those who did not. Mean weight loss of suppressors did not significantly differ from that of non-suppressors. Of 12 patients whose DST normalised during their stay in hospital, only four gained weight. Five anorexics who were non-suppressors were <70% of their ideal body weight (IBW), while three suppressor anorexics were ≧70% IBW. These results indicate that mild to moderate weight change is not a significant influence on DST response in depression.

Depression, Weight Loss and the Dexamethasone Suppression Test

1984 ◽  
Vol 145 (1) ◽  
pp. 88-90 ◽  
Author(s):  
Alec Coppen ◽  
Janet Harwood ◽  
Keith Wood
Keyword(s):  
Weight Loss ◽  
Major Depressive Disorder ◽  
Depressive Illness ◽  
Dexamethasone Suppression Test ◽  
Necessary Condition ◽  
Major Depressive ◽  
Significant Difference ◽  
History Of ◽  
Suppression Test ◽  
Dexamethasone Suppression

SummaryThe dexamethasone suppression test (DST) was carried out on 143 patients with a major depressive disorder, who were classified into those with a history of weight loss (n = 89) and those without (n = 54). Seventy-three per cent of patients with weight loss and 61% of patients without had an abnormal DST; this difference was not statistically significant. Of the patients receiving prophylactic lithium therapy, 13 were found to have changed their DST status on retesting after a period of 14 months, but there was no significant difference in their weight. It is concluded that weight loss is not a necessary condition for an abnormal DST in depressive illness.

Dexamethasone Suppression Test and REM Sleep in Patients with Major Depressive Disorder

1984 ◽  
Vol 145 (4) ◽  
pp. 383-388 ◽  
Author(s):  
Julien Mendlewicz ◽  
Myriam Kerkhofs ◽  
Guy Hoffmann ◽  
Paul Linkowski
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Dexamethasone Suppression Test ◽  
Major Depressive ◽  
Depressed Patients ◽  
Significant Difference ◽  
Rem Latency ◽  
Suppression Test ◽  
Dexamethasone Suppression ◽  
Normal Controls

SummaryDexamethasone suppression Test (DST) and sleep electroencephalogram (EEG) recordings were carried out during three consecutive nights in 39 depressed patients who met Research Diagnostic Criteria (RDC) for major depressive disorder and in nine normal controls. Cortisol response to DST was abnormal in 26 patients and normal in all controls. REM latency and REM density were compared in patients with abnormal DST (n = 26) to values obtained in patients with normal DST (n = 13) and in normal controls (n = 9). Rapid Eye Movement (REM) latencies were significantly lower in depressed patients showing cortisol non-suppression after dexamethasone than in patients with a normal DST or in controls. REM densities were significantly higher in depressed patients than in normal controls (P <0.025), but there was no significant difference between DST suppressors and non–suppressors. The DST provided high specificity (100%) and a sensitivity of 67%, while REM latency showed a lower specificity (78%), but a higher sensitivity (85%).

The Dexamethasone Suppression Test in Bulimia Nervosa

1988 ◽  
Vol 152 (5) ◽  
pp. 654-656 ◽  
Author(s):  
G. O'Brien ◽  
F. Hassanyeh ◽  
A. Leake ◽  
K. Schapira ◽  
M. White ◽  
...  
Keyword(s):  
Weight Loss ◽  
Anorexia Nervosa ◽  
Bulimia Nervosa ◽  
Previous History ◽  
Dexamethasone Suppression Test ◽  
Clinical Correlates ◽  
History Of ◽  
State Marker ◽  
Suppression Test ◽  
Dexamethasone Suppression

In a study of the dexamethasone suppression test (DST) in patients with bulimia nervosa, a non-suppression rate of about 50% was found. The only clinical correlates of DST non-suppression were a previous history of weight loss and/or of anorexia nervosa. These results suggest that DST non-suppression in these subjects may be a trait rather than a state marker of anorexia nervosa.

The dexamethasone suppression test in bulimic outpatients without major depression

1992 ◽  
Vol 7 (2) ◽  
pp. 85-89
Author(s):  
D Bailly ◽  
N Regnaut ◽  
PJ Parquet
Keyword(s):  
Anorexia Nervosa ◽  
Major Depression ◽  
Past History ◽  
Dexamethasone Suppression Test ◽  
Low Weight ◽  
Significant Difference ◽  
Abnormal Eating ◽  
History Of ◽  
Suppression Test ◽  
Dexamethasone Suppression

SummaryRecent studies have examined the effectiveness of the dexamethasone suppression test (DST) in the evaluation of bulimia. In a series of 18 female bulimic outpatients without major depression, 9 (50%) failed to suppress on the DST. No significant difference was found between suppressors and nonsuppressors in personal and family histories of affective disorder, levels of anxious and depressive symptoms, psychoactive substance abuse, and severity of abnormal eating-related behaviours. In contrast, non-suppression was significantly associated with low weight. There is a trend to differentiate non-suppressors from suppressors in the current diagnosis of anorexia nervosa and in past history of anorexia nervosa. Seven patients received fluvoxamine for 8 weeks. Five patients were suppressors and showed a significant decrease in the frequency of their binges while the 2 non-suppressors did not improve. These preliminary results suggest that DST non-suppression might be typical of bulimic patients with anorexia nervosa and that pretreatment DST results might predict the response of bulimic behaviour to treatment with fluvoxamine.

Biochemically silent phaeochromocytoma presenting with non-specific loin pain

2021 ◽  
Vol 14 (8) ◽  
pp. e244258
Author(s):  
Annalisa Montebello ◽  
Etienne Ceci Bonello ◽  
Miriam Giordano Imbroll ◽  
Mark Gruppetta
Keyword(s):  
Adrenal Adenoma ◽  
Dexamethasone Suppression Test ◽  
Adrenal Lesion ◽  
Genetic Mutations ◽  
Large Size ◽  
History Of ◽  
Loin Pain ◽  
Suppression Test ◽  
Aldosterone To Renin Ratio ◽  
Dexamethasone Suppression

A 55-year-old woman presented with a 4-month history of right-sided non-specific loin pain and 6 kg weight loss. A CT scan of the abdomen and pelvis showed an incidental 4.5 cm right-sided adrenal lesion which was not typical of an adrenal adenoma. This was further confirmed on MRI of the adrenals. Biochemical investigations to investigate for a functional adrenal lesion included serum catecholamines and metanephrines, an aldosterone to renin ratio and an overnight dexamethasone suppression test. These were all negative. A laparoscopic adrenalectomy was performed in view of the large size of the lesion. Histology was consistent with a phaeochromocytoma, which confirmed the diagnosis of a non-secreting phaeochromocytoma. Non-secreting phaeochromocytomas are rare and usually found in patients with known genetic mutations. Adrenal lesions not related to any mutations similar to our case are even rarer and reported even less in the literature.

Pre-Pubertal Depressive Stupor: A Case Report

1988 ◽  
Vol 153 (5) ◽  
pp. 689-692 ◽  
Author(s):  
J. C. Powell ◽  
W. R. Silveira ◽  
R. Lindsay
Keyword(s):  
Case Report ◽  
Family History ◽  
Affective Disorder ◽  
Dexamethasone Suppression Test ◽  
Clinical State ◽  
Affective Illness ◽  
History Of ◽  
Suppression Test ◽  
Dexamethasone Suppression ◽  
Maternal Side

A case of childhood affective disorder with episodes of depressive stupor in a 13-year-old pre-pubertal boy is described. Changes in the patient's clinical state were accompanied by changes in the dexamethasone suppression test. A family history of affective illness on the maternal side, with phenomenological similarities, is noted.

A study of the dexamethasone suppression test in hospitalized depressed patients

1984 ◽  
Vol 144 (3) ◽  
pp. 311-313 ◽  
Author(s):  
D. Ames ◽  
G. Burrows ◽  
B. Davies ◽  
K. Maguire ◽  
T. Norman
Keyword(s):  
Dexamethasone Suppression Test ◽  
Depressed Patients ◽  
Suppression Test ◽  
Dexamethasone Suppression
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