Familial Tourette's Syndrome in a Large British Pedigree

1990 ◽  
Vol 156 (4) ◽  
pp. 515-521 ◽  
Author(s):  
Mary M. Robertson ◽  
Alison Gourdie
Keyword(s):  
Tourette Syndrome ◽  
Autosomal Dominant ◽  
Tourette's Syndrome ◽  
Tourette’S Syndrome ◽  
Obsessive Compulsive ◽  
Autosomal Dominant Transmission ◽  
Trait Score ◽  
Compulsive Behaviour

A British pedigree multiply affected by the Gilles de la Tourette syndrome and spanning six generations is described. Of 122 members identified, 85 were individually interviewed, and 50 were diagnosed as ‘cases'. ‘Cases' consisted of 29 with definite or probable Gilles de la Tourette syndrome, 17 with definite or probable chronic multiple tics, and four with definite or probable obsessive-compulsive behaviour. Only eight of the 50 ‘cases' had consulted a doctor for their symptoms. ‘Cases' and ‘non-cases' could be distinguished on the basis of echo-phenomena, obsessive-compulsive features, self-injurious behaviour, and the trait score of the Leyton Obsessional Inventory, but did not differ significantly on any other psychopathological variables. The pattern of inheritance of the Gilles de la Tourette syndrome in this pedigree is consistent with autosomal dominant transmission.

Hereditary Agoraphobia and Obsessive-Compulsive Behaviour in Relatives of Patients with Gilles de la Tourette's Syndrome

1987 ◽  
Vol 151 (2) ◽  
pp. 195-199 ◽  
Author(s):  
D. E. Comings ◽  
B. G. Comings
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Panic Attacks ◽  
Tourette's Syndrome ◽  
Tourette’S Syndrome ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Genetic Subtypes ◽  
Compulsive Behaviour ◽  
Motor Tics ◽  
Vocal Tics

We present 11 pedigrees in which a propositus with Gilles de la Tourette's syndrome had first or second-degree relatives with obsessive-compulsive behaviour or agoraphobia with panic attacks, but only partially expressed the TS gene (i.e. had only motor tics or vocal tics, or neither). Of 90 females over the age of 18 presenting with TS, or with motor or vocal tics alone, nine had severe agoraphobia with panic attacks. There may be genetic subtypes of both obsessive-compulsive disorder and agoraphobia with panic attacks that are due to partial expression of the TS gene.

An idiot savant calendrical calculator with Gilles de la Tourette syndrome: implications for an understanding of the savant syndrome

1993 ◽  
Vol 23 (4) ◽  
pp. 1019-1021 ◽  
Author(s):  
J. Moriarty ◽  
H. A. Ring ◽  
M. M. Robertson
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Tourette Syndrome ◽  
Tourette's Syndrome ◽  
Tourette’S Syndrome ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Savant Syndrome ◽  
Psychological Studies

SynopsisWe describe the existence of the savant syndrome in association with Gilles de la Tourette's Syndrome (GTS). The presentation of savant abilities is typical of that previously described. Similarities between autism, the disorder most characteristically associated with savants, and GTS in terms of obsessionality are noted. Previously reported psychological studies of autistic savants are briefly reviewed and, together with evidence from neuroimaging in GTS, obsessive compulsive disorder (OCD), and autism, used to support a model of the underpinnings of savant skills.

Evidence for Autosomal Dominant Transmission in Tourette's Syndrome

1993 ◽  
Vol 162 (5) ◽  
pp. 593-596 ◽  
Author(s):  
V. Eapen ◽  
D. L. Pauls ◽  
M. M. Robertson
Keyword(s):  
Classification Scheme ◽  
Autosomal Dominant ◽  
Dominant Gene ◽  
Tourette's Syndrome ◽  
Tourette’S Syndrome ◽  
Genetic Inheritance ◽  
Autosomal Dominant Transmission ◽  
High Penetrance

Complex segregation analyses were performed on families ascertained through 40 unselected consecutive patients with Tourette's syndrome to examine the hypothesis that its transmission is consistent with genetic inheritance. Analyses were done using several diagnostic classifications. All results were consistent with an autosomal dominant gene with high penetrance. The penetrances ranged from 0.882 to 1.000 for males and 0.452 to 0.980 for females, depending upon the specific classification scheme incorporated into the analyses.

A Clinical Study of Gilles de la Tourette's Syndrome in Korea

1986 ◽  
Vol 149 (5) ◽  
pp. 644-647 ◽  
Author(s):  
Sung Kil Min ◽  
Helen Lee
Keyword(s):  
Clinical Study ◽  
Clinical Data ◽  
Tourette's Syndrome ◽  
Tourette’S Syndrome ◽  
Behaviour Problems ◽  
Obsessive Compulsive ◽  
Korean Patients ◽  
Family Histories ◽  
Compulsive Behaviour

Clinical data on 30 Korean patients of the authors with Gilles de la Tourettes's syndrome are described, as well as data on seven other Korean cases from the literature. The overall characteristics and EEG findings were similar to those of Western patients, but there were fewer obsessive-compulsive behaviour problems, and family histories were less often positive.

Mental Play in Gilles de la Tourette's Syndrome and Obsessive-Compulsive Disorder

1992 ◽  
Vol 161 (4) ◽  
pp. 542-545 ◽  
Author(s):  
D. C. Cath ◽  
B. J. M. van de Wetering ◽  
T. C. A. M. van Woerkom ◽  
C. A. L. Hoogduin ◽  
R. A. C. Roos ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Tourette's Syndrome ◽  
Tourette’S Syndrome ◽  
Obsessive Compulsive ◽  
Obsessive Compulsive Symptoms ◽  
Compulsive Disorder ◽  
Compulsive Behaviour

A new phenomenon, found only in Gilles de la Tourette (GTS) patients, and which we have called ‘mental play’, is described. It was compared with the phenomenon of counting, which occurred in both GTS and obsessive-compulsive patients. In the GTS patients both mental play and counting were best characterised as playful impulsions. In contrast to the GTS patients, the counting of the obsessive-compulsive patients was in line with their obsessive-compulsive behaviour. These findings suggest that repetitive symptoms in GTS patients, even when they share superficial similarities with obsessive-compulsive symptoms, should not be diagnosed automatically as obsessive-compulsive.

scholarly journals Gilles de la Tourette's Syndrome

2003 ◽  
Vol 30 (S1) ◽  
pp. S64-S71 ◽  
Author(s):  
Kia Faridi ◽  
Oksana Suchowersky
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Home Environment ◽  
Attention Deficit ◽  
Neurological Disorder ◽  
Autosomal Dominant ◽  
Tourette's Syndrome ◽  
Tourette’S Syndrome ◽  
Childhood Onset ◽  
Obsessive Compulsive ◽  
Hyperactivity Disorder

Tourette's syndrome (TS) is a childhood onset neurological disorder characterized by motor and vocal tics. It may be associated with a number of co-morbidities including attention deficit hyperactivity disorder, obsessive compulsive symptomatology, and behaviour disorders. Prevalence of TS is higher than previously thought, and may be present in up to 2% of the population. Tourette's syndrome has a significant genetic component. Inheritance may involve several mechanisms including autosomal dominant, bilinear, or polygenic mechanisms. Pathophysiology is still unknown, although is thought to involve striatocortical circuits. Treatment begins with modification of the work and home environment. For more severe cases, medications such as tetrabenazine and neuroleptics may be helpful. Treatment of co-morbidities needs to be considered, as these may result in more disability than the tics themselves.

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