Psychiatric Phenomena in Alzheimer's Disease. IV: Disorders of Behaviour

Out of a sample of 178 patients with AD, aggression was present in 20%, wandering in 19%, binge-eating in 10%, hyperorality in 6%, urinary incontinence in 48%, and sexual disinhibition in 7%. Behavioural abnormalities were greater in those with more severe dementia. Temporal-lobe atrophy correlated with aggression, and widening of the third ventricle with hyperorality. Features of the Kluver–Bucy syndrome were commonly seen, but the full syndrome occurred in only one subject. Patients with at least one feature of the Kluver–Bucy syndrome had greater temporal-lobe atropy than those without any of the features.

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Faculty Opinions recommendation of An evidence-based algorithm for the utility of FDG-PET for diagnosing Alzheimer's disease according to presence of medial temporal lobe atrophy.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725536731.793538926 ◽

2017 ◽

Author(s):

Craig Ritchie ◽

Abel Koshy

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Temporal Lobe ◽

Fdg Pet ◽

Medial Temporal Lobe ◽

Evidence Based ◽

Medial Temporal Lobe Atrophy ◽

Lobe Atrophy

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P3-363: VALIDITY OF QUALITATIVE AND SEMI-QUANTITATIVE HIPPOCAMPAL AND MEDIAL TEMPORAL LOBE ATROPHY ON MAGNETIC RESONANCE IMAGING IN COMPARISON TO VOLUMETRIC MRI ASSESSMENT IN CHINESE ALZHEIMER'S DISEASE PATIENTS

Alzheimer s & Dementia ◽

10.1016/j.jalz.2018.06.1725 ◽

2006 ◽

Vol 14 (7S_Part_23) ◽

pp. P1226-P1227

Author(s):

Leung-Wing Chu ◽

Simon Wong

Keyword(s):

Magnetic Resonance Imaging ◽

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Magnetic Resonance ◽

Temporal Lobe ◽

Medial Temporal Lobe ◽

Resonance Imaging ◽

Volumetric Mri ◽

Medial Temporal Lobe Atrophy ◽

Lobe Atrophy

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Anhedonia in Semantic Dementia—Exploring Right Hemispheric Contributions to the Loss of Pleasure

Brain Sciences ◽

10.3390/brainsci11080998 ◽

2021 ◽

Vol 11 (8) ◽

pp. 998

Author(s):

Siobhán R. Shaw ◽

Hashim El-Omar ◽

Siddharth Ramanan ◽

Olivier Piguet ◽

Rebekah M. Ahmed ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Temporal Lobe ◽

Rating Scale ◽

Right Hemisphere ◽

Semantic Knowledge ◽

Semantic Dementia ◽

Anterior Cingulate ◽

Functional Impairments ◽

Lobe Atrophy

Semantic dementia (SD) is a younger-onset neurodegenerative disease characterised by progressive deterioration of the semantic knowledge base in the context of predominantly left-lateralised anterior temporal lobe (ATL) atrophy. Mounting evidence indicates the emergence of florid socioemotional changes in SD as atrophy encroaches into right temporal regions. How lateralisation of temporal lobe pathology impacts the hedonic experience in SD remains largely unknown yet has important implications for understanding socioemotional and functional impairments in this syndrome. Here, we explored how lateralisation of temporal lobe atrophy impacts anhedonia severity on the Snaith–Hamilton Pleasure Scale in 28 SD patients presenting with variable right- (SD-R) and left-predominant (SD-L) profiles of temporal lobe atrophy compared to that of 30 participants with Alzheimer’s disease and 30 healthy older Control participants. Relative to Controls, SD-R but not SD-L or Alzheimer’s patients showed clinically significant anhedonia, representing a clear departure from premorbid levels. Overall, anhedonia was more strongly associated with functional impairment on the Frontotemporal Dementia Functional Rating Scale and motivational changes on the Cambridge Behavioural Inventory in SD than in Alzheimer’s disease patients. Voxel-based morphometry analyses revealed that anhedonia severity correlated with reduced grey matter intensity in a restricted set of regions centred on right orbitofrontal and temporopolar cortices, bilateral posterior temporal cortices, as well as the anterior cingulate gyrus and parahippocampal gyrus, bilaterally. Finally, regression and mediation analysis indicated a unique role for right temporal lobe structures in modulating anhedonia in SD. Our findings suggest that degeneration of predominantly right-hemisphere structures deleteriously impacts the capacity to experience pleasure in SD. These findings offer important insights into hemispheric lateralisation of motivational disturbances in dementia and suggest that anhedonia may emerge at different timescales in the SD disease trajectory depending on the integrity of the right hemisphere.

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