A Chromosomal Inversion within a Quantitative Trait Locus Has a Major Effect on Adipogenesis and Osteoblastogenesis

Previously we reported the construction of a congenic strain, S.LEW( 5 ), spanning a large region of rat chromosome 5. The Lewis (LEW) strain was the donor, and the Dahl salt-sensitive (S) strain was the recipient. The congenic strain included a blood pressure quantitative trait locus (QTL). In the present work, a series of nine congenic substrains were constructed from S.LEW( 5 ) which defined two closely linked blood pressure QTL in the region previously thought to contain only one. LEW low-blood-pressure alleles at both QTL were required for a major effect on blood pressure. Neither LEW allele alone had a significant effect on blood pressure. The two QTL were localized to regions 6.3 and 4.6 cM, and these were 1.0 cM apart.

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The Ability to Detoxify the Mycotoxin Deoxynivalenol Colocalizes With a Major Quantitative Trait Locus for Fusarium Head Blight Resistance in Wheat

Molecular Plant-Microbe Interactions ◽

10.1094/mpmi-18-1318 ◽

2005 ◽

Vol 18 (12) ◽

pp. 1318-1324 ◽

Cited By ~ 263

Author(s):

Marc Lemmens ◽

Uwe Scholz ◽

Franz Berthiller ◽

Chiara Dall'Asta ◽

Andrea Koutnik ◽

...

Keyword(s):

Quantitative Trait Locus ◽

Fusarium Head Blight ◽

Quantitative Trait ◽

Fusarium Head Blight Resistance ◽

Close Relation ◽

Major Effect ◽

Head Blight ◽

Fhb Resistance ◽

Trait Locus ◽

Wheat Lines

We investigated the hypothesis that resistance to deoxynivalenol (DON) is a major resistance factor in the Fusarium head blight (FHB) resistance complex of wheat. Ninety-six double haploid lines from a cross between ‘CM-82036’ and ‘Remus’ were examined. The lines were tested for DON resistance after application of the toxin in the ear, and for resistances to initial infection and spread of FHB after artificial inoculation with Fusarium spp. Toxin application to flowering ears induced typical FHB symptoms. Quantitative trait locus (QTL) analyses detected one locus with a major effect on DON resistance (logarithm of odds = 53.1, R2 = 92.6). The DON resistance phenotype was closely associated with an important FHB resistance QTL, Qfhs.ndsu-3BS, which previously was identified as governing resistance to spread of symptoms in the ear. Resistance to the toxin was correlated with resistance to spread of FHB (r = 0.74, P < 0.001). In resistant wheat lines, the applied toxin was converted to DON-3-O-glucoside as the detoxification product. There was a close relation between the DON-3-glucoside/DON ratio and DON resistance in the toxintreated ears (R2 = 0.84). We conclude that resistance to DON is important in the FHB resistance complex and hypothesize that Qfhs.ndsu-3BS either encodes a DON-glucosyltransferase or regulates the expression of such an enzyme.

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Limited genetic parallels underlie convergent evolution of quantitative pattern variation in mimetic butterflies

10.1101/2020.06.15.151613 ◽

2020 ◽

Cited By ~ 1

Author(s):

Hannah E. Bainbridge ◽

Melanie N. Brien ◽

Carlos Morochz ◽

Patricio A. Salazar ◽

Pasi Rastas ◽

...

Keyword(s):

Quantitative Trait Locus ◽

Qtl Analysis ◽

Quantitative Trait ◽

Convergent Evolution ◽

Genetic Basis ◽

Major Effect ◽

Multivariate Approach ◽

Trait Variation ◽

Heliconius Melpomene ◽

Trait Locus

AbstractMimetic systems allow us to address the question of whether the same genes control similar phenotypes in different species. Although widespread parallels have been found for major effect loci, much less is known about genes that control quantitative trait variation. In this study, we identify and compare the loci that control subtle changes in the size and shape of forewing pattern elements in two Heliconius butterfly co-mimics. We use quantitative trait locus (QTL) analysis with a multivariate phenotyping approach to map the variation in red pattern elements across the whole forewing surface of Heliconius erato and Heliconius melpomene. These results are compared to a QTL analysis of univariate trait changes, and show that our resolution for identifying small effect loci is improved with the multivariate approach. QTL likely corresponding to the known patterning gene optix were found in both species but otherwise, a remarkably low level of genetic parallelism was found. This lack of similarity indicates that the genetic basis of convergent traits may not be as predictable as assumed from studies that focus solely on Mendelian traits.

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