Ordered Self-assembly of Protonated Porphyrin Induced by the Aqueous Environment of Biomimetic Systems

2008 ◽  
Vol 1130 (1) ◽  
pp. 305-313 ◽  
Author(s):  
Suzana M. Andrade ◽  
Sílvia M. B. Costa
Keyword(s):  
Self Assembly ◽  
Aqueous Environment ◽  
Biomimetic Systems

scholarly journals Self-assembly of tholins in environments simulating Titan liquidospheres: implications for formation of primitive coacervates on Titan

2013 ◽  
Vol 12 (4) ◽  
pp. 282-291 ◽  
Author(s):  
Jun Kawai ◽  
Seema Jagota ◽  
Takeo Kaneko ◽  
Yumiko Obayashi ◽  
Yoshitaka Yoshimura ◽  
...  
Keyword(s):  
Organic Compounds ◽  
Self Assembly ◽  
Aqueous Ammonia ◽  
Aqueous Environment ◽  
Plasma Discharges ◽  
Atmospheric Gases ◽  
Polar Solvents ◽  
Average Temperature ◽  
Magnetosphere Of Saturn ◽  
Complex Organic

AbstractTitan, the largest satellite of Saturn, has a thick atmosphere containing nitrogen and methane. A variety of organic compounds have been detected in the atmosphere, most likely produced when atmospheric gases are exposed to ultraviolet light, electrons captured by the magnetosphere of Saturn and cosmic rays. The Cassini/Huygens probe showed that the average temperature on the surface of Titan is 93.7 K, with lakes of liquid ethane and methane. Sub-surface mixtures of liquid ammonia and water may also be present. We have synthesized complex organic compounds (tholins) by exposing a mixture of nitrogen and methane to plasma discharges, and investigated their interactions with several different liquids that simulate Titan's liquidosphere. We found that coacervates formed when tholins were extracted in non-polar solvents followed by exposure to aqueous ammonia solutions. The results suggest that coacervates can self-assemble in Titan's liquidosphere which have the potential to undergo further chemical evolution. Similar processes are likely to occur in the early evolution of habitable planets when tholin-like compounds undergo phase separation into microscopic structures dispersed in a suitable aqueous environment.

scholarly journals Plasmalogen-Based Liquid Crystalline Multiphase Structures Involving Docosapentaenoyl Derivatives Inspired by Biological Cubic Membranes

2021 ◽  
Vol 9 ◽  
Author(s):  
Angelina Angelova ◽  
Borislav Angelov ◽  
Markus Drechsler ◽  
Thomas Bizien ◽  
Yulia E. Gorshkova ◽  
...  
Keyword(s):  
Self Assembly ◽  
Liquid Crystalline ◽  
Membrane Vesicles ◽  
Membrane Curvature ◽  
Aqueous Environment ◽  
Peroxisomal Disorders ◽  
Parkinson’S Diseases ◽  
Ethanolamine Plasmalogen ◽  
Shell Particles ◽  
Double Diamond

Structural properties of plasmenyl-glycerophospholipids (plasmalogens) have been scarcely studied for plasmalogens with long polyunsaturated fatty acid (PUFA) chains, despite of their significance for the organization and functions of the cellular membranes. Elaboration of supramolecular assemblies involving PUFA-chain plasmalogens in nanostructured mixtures with lyotropic lipids may accelerate the development of nanomedicines for certain severe pathologies (e.g., peroxisomal disorders, cardiometabolic impairments, and neurodegenerative Alzheimer’s and Parkinson’s diseases). Here, we investigate the spontaneous self-assembly of bioinspired, custom-produced docosapentaenoyl (DPA) plasmenyl (ether) and ester phospholipids in aqueous environment (pH 7) by synchrotron small-angle X-ray scattering (SAXS) and cryogenic transmission electron microscopy (cryo-TEM). A coexistence of a liquid crystalline primitive cubic Im3m phase and an inverted hexagonal (HII) phase is observed for the DPA-ethanolamine plasmalogen (C16:1p-22:5n6 PE) derivative. A double-diamond cubic Pn3m phase is formed in mixed assemblies of the phosphoethanolamine plasmalogen (C16:1p-22:5n6 PE) and monoolein (MO), whereas a coexistence of cubic and lamellar liquid crystalline phases is established for the DPA-plasmenyl phosphocholine (C16:1p-22:5n6 PC)/MO mixture at ambient temperature. The DPA-diacyl phosphoinositol (22:5n6-22:5n6 PI) ester lipid displays a propensity for a lamellar phase formation. Double membrane vesicles and multilamellar onion topologies with inhomogeneous distribution of interfacial curvature are formed upon incorporation of the phosphoethanolamine plasmalogen (C16:1p-22:5n6 PE) into dioleoylphosphocholine (DOPC) bilayers. Nanoparticulate formulations of plasmalogen-loaded cubosomes, hexosomes, and various multiphase cubosome- and hexosome-derived architectures and mixed type nano-objects (e.g., oil droplet-embedding vesicles or core–shell particles with soft corona) are produced with PUFA-chain phospholipids and lipophilic antioxidant-containing membrane compositions that are characterized by synchrotron SAXS and cryo-TEM imaging. The obtained multiphase nanostructures reflect the changes in the membrane curvature induced by the inclusion of DPA-based PE and PC plasmalogens, as well as DPA-PI ester derivative, and open new opportunities for exploration of these bioinspired nanoassemblies.

scholarly journals Supramolecular Reactor from Self-Assembly of Rod—Coil Molecule in Aqueous Environment.

ChemInform ◽  
2004 ◽  
Vol 35 (44) ◽  
Author(s):  
Myongsoo Lee ◽  
Cheong-Jin Jang ◽  
Ja-Hyoung Ryu
Keyword(s):  
Self Assembly ◽  
Aqueous Environment

scholarly journals Self-assembly processes in the prebiotic environment

2006 ◽  
Vol 361 (1474) ◽  
pp. 1809-1818 ◽  
Author(s):  
David Deamer ◽  
Sara Singaram ◽  
Sudha Rajamani ◽  
Vladimir Kompanichenko ◽  
Stephen Guggenheim
Keyword(s):  
Origin Of Life ◽  
Organic Compounds ◽  
Self Assembly ◽  
Initial Study ◽  
Aqueous Environment ◽  
Organic Solutes ◽  
Mineral Surfaces ◽  
Molecular Systems ◽  
Intermediate Temperature Range ◽  
The Origin Of Life

An important question guiding research on the origin of life concerns the environmental conditions where molecular systems with the properties of life first appeared on the early Earth. An appropriate site would require liquid water, a source of organic compounds, a source of energy to drive polymerization reactions and a process by which the compounds were sufficiently concentrated to undergo physical and chemical interactions. One such site is a geothermal setting, in which organic compounds interact with mineral surfaces to promote self-assembly and polymerization reactions. Here, we report an initial study of two geothermal sites where mixtures of representative organic solutes (amino acids, nucleobases, a fatty acid and glycerol) and phosphate were mixed with high-temperature water in clay-lined pools. Most of the added organics and phosphate were removed from solution with half-times measured in minutes to a few hours. Analysis of the clay, primarily smectite and kaolin, showed that the organics were adsorbed to the mineral surfaces at the acidic pH of the pools, but could subsequently be released in basic solutions. These results help to constrain the range of possible environments for the origin of life. A site conducive to self-assembly of organic solutes would be an aqueous environment relatively low in ionic solutes, at an intermediate temperature range and neutral pH ranges, in which cyclic concentration of the solutes can occur by transient dry intervals.

Novel biomimetic systems based on amphiphilic compounds with a diterpenoid fragment: Role of counterions in self-assembly

2013 ◽  
Vol 405 ◽  
pp. 125-133 ◽  
Author(s):  
Mikhail A. Voronin ◽  
Dinar R. Gabdrakhmanov ◽  
Ravil N. Khaibullin ◽  
Irina Yu. Strobykina ◽  
Vladimir E. Kataev ◽  
...  
Keyword(s):  
Self Assembly ◽  
Biomimetic Systems ◽  
Amphiphilic Compounds

Self-assembly of isotropic colloids into colloidal strings, Bernal spiral-like, and tubular clusters

2020 ◽  
Vol 56 (46) ◽  
pp. 6309-6312 ◽  
Author(s):  
Yong Guo ◽  
Bas G. P. van Ravensteijn ◽  
Willem K. Kegel
Keyword(s):  
Self Assembly ◽  
Aqueous Environment ◽  
Competing Interactions

Colloidal strings, Bernal spiral-like, and tubular clusters comprising isotropic colloids are formed in an aqueous environment by competing interactions.

Preparation of Biocompatible Micelles as Drug Delivery via RAFT Polymerization

2011 ◽  
Vol 322 ◽  
pp. 219-223
Author(s):  
Lian Lai Cui ◽  
Tao Yu ◽  
Xin Tan ◽  
Yue Zhao ◽  
Jian Ping Li ◽  
...  
Keyword(s):  
Self Assembly ◽  
Ring Opening ◽  
Raft Polymerization ◽  
Aqueous Environment ◽  
Poly Ethylene Glycol ◽  
Block Polymers ◽  
Reversible Addition ◽  
Raft Agent ◽  
Poly Ethylene ◽  
Glycol Methyl Ether

Block copolymers D,L-Polylactide-b-poly(poly(ethylene glycol) methyl ether acrylate) (D,L- P(LA)-b-P(PEGMA)) were prepared via ring-opening polymerization and reversible addition fragmentation chain transfer (RAFT) polymerization. The block polymers generated in the reaction reveal the living behavior with the molecular weight increasing with time. The copolymer D,L-P(LA)200-b-P(PEGMA)225 was synthesized successfully with D,L-P(LA) macro-RAFT agent, and was self-assembled in an aqueous environment, leading to the formation of self-assembly micelles. A distinct critical micelle concentration (CMC) was observed of the self-assembly system. The size of it was characterized by both DLS and TEM.

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