The Aqueous Extract of a Popular Herbal Nutrient Supplement, Angelica sinensis, Protects Mice against Lethal Endotoxemia and Sepsis

2006 ◽  
Vol 13 (5Supplement 1) ◽  
pp. S43-S43 ◽  
Author(s):  
H. Wang
Keyword(s):  
Aqueous Extract ◽  
Angelica Sinensis ◽  
Nutrient Supplement

scholarly journals The Aqueous Extract of a Popular Herbal Nutrient Supplement, Angelica sinensis, Protects Mice against Lethal Endotoxemia and Sepsis

2006 ◽  
Vol 136 (2) ◽  
pp. 360-365 ◽  
Author(s):  
Haichao Wang ◽  
Wei Li ◽  
Jianhua Li ◽  
Beatriz Rendon-Mitchell ◽  
Mahendar Ochani ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Angelica Sinensis ◽  
Nutrient Supplement

The Aqueous Extract of Angelica sinensis, a Popular Chinese Herb, Inhibits Wear Debris-Induced Inflammatory Osteolysis in Mice

2012 ◽  
Vol 176 (2) ◽  
pp. 476-483 ◽  
Author(s):  
Chongfei Yang ◽  
Shun Niu ◽  
Lifeng Yu ◽  
Shu Zhu ◽  
Jinyu Zhu ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Wear Debris ◽  
Chinese Herb ◽  
Angelica Sinensis

scholarly journals An Aqueous Extract of Radix Astragali,Angelica sinensis, andPanax notoginsengIs Effective in Preventing Diabetic Retinopathy

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Dehong Gao ◽  
Yijuan Guo ◽  
Xuejun Li ◽  
Xiumin Li ◽  
Zhipeng Li ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Aqueous Extract ◽  
Panax Notoginseng ◽  
Vascular Leakage ◽  
Endothelial Cell Migration ◽  
Inflammatory Factors ◽  
Angelica Sinensis ◽  
Radix Astragali ◽  
Gk Rats ◽  
Acellular Capillaries

Diabetic retinopathy (DR), in which inflammation has been implicated playing important roles, is one of the most common diabetes complications. Dang Gui Bu Xue Tang (DBT), an aqueous extract of Radix Astragali and RadixAngelica sinensis, is a classical prescription in Traditional Chinese Medicine for treating inflammation and ischemic diseases. Here, we investigated the effects of a modified recipe of DBT, with addition ofPanax notoginseng, in treating diabetic retinopathy. An aqueous extract of Radix Astragali, RadixAngelica sinensis, andPanax notoginseng(RRP) was given to Goto-Kakizaki (GK) rats and streptozotocin-induced Sprague-Dawley (SD) rats. Leukostasis, vascular leakage, and acellular capillaries in retinal vasculature of animals were determined. Expression of retinal inflammatory biomarkers was assessed. We found that RRP reduced leukostasis, acellular capillaries, and vascular leakage compared to diabetic control rats. We also found that RRP decreased the expression of inflammatory factors including IL-1β, IL-6, TNF-α, NF-κB, MCP-1, ICAM-1, or VCAM-1 in the retinas of GK rats and reversed high glucose-induced inhibition of endothelial cell migration and proliferation in vitro. We conclude that RRP has a potent effect in preventing the pathogenesis and/or progression of DR and thus may serve as a promising nontoxic therapeutic approach of DR.

Mechanistic study of proliferation induced by Angelica sinensis in gastric epithelial cells

2001 ◽  
Vol 120 (5) ◽  
pp. A145-A145
Author(s):  
C CHO ◽  
Y YE ◽  
E LIU ◽  
V SHIN ◽  
N SHAM
Keyword(s):  
Epithelial Cells ◽  
Mechanistic Study ◽  
Angelica Sinensis ◽  
Gastric Epithelial Cells

Effects of Mixed Dietary Supplements on Total Plasma Homocysteine Concentrations (tHcy): A Randomized, Double-Blind, Placebo-Controlled Trial

2012 ◽  
Vol 82 (4) ◽  
pp. 260-266 ◽  
Author(s):  
Salah E. Gariballa ◽  
Sarah J. Forster ◽  
Hilary J. Powers
Keyword(s):  
Older Patients ◽  
Controlled Trial ◽  
Plasma Homocysteine ◽  
Acute Illness ◽  
Vitamin B ◽  
Total Plasma ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Nutrient Supplement ◽  
Plasma Thcy

Background: Although a number of studies have reported raised total plasma homocysteine (tHcy) concentrations in free-living older people, there are no data on homocysteine response to a mixed nutrient supplement in older patients. A raised plasma homocysteine concentration in older patients is partly a reflection of their co-morbidity, including impaired renal function, and there is uncertainty about the extent to which dietary interventions can improve plasma tHcy. Aim: To determine the plasma tHcy response to dietary supplements during acute illness. Methods: Two-hundred and thirty-six hospitalized, acutely ill older patients, who were part of a randomized double-blind placebo-controlled trial, were assigned to receive a daily oral nutritional supplement drink containing 1.3 mg of vitamin B2, 1.4 mg of vitamin B6, 1.5 μg of B12, 200 μg of folic acid, or a placebo, for 6 weeks. Outcome measures were plasma tHcy concentration at baseline, 6 weeks, and 6 months. Results: The mean plasma tHcy concentration fell among patients given the supplements (mean difference 4.1 µmol/L [95 % C.I, 0.14 to 8.03), p = 0.043], but tHcy concentration increased between 6 weeks and 6 months, after patients stopped taking the supplements [mean difference -2.0 µmol/L (95 % C.I, -03.9 to -0.18), p = 0.033]. About 46 % of patients in the placebo group and 55 % of patients in the supplement group had hyperhomocysteinemia (>14 µmol/L) at baseline compared with 45 % and 29 % at the end of the treatment period. Conclusions: A mixed nutrient supplement containing physiological amounts of B vitamins significantly reduced plasma tHcy concentrations in older patients recovering from acute illness.

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