Cellular DNA content and prognosis of high-grade soft tissue sarcoma: the Scandinavian Sarcoma Group experience.

1990 ◽  
Vol 8 (3) ◽  
pp. 538-547 ◽  
Author(s):  
T A Alvegard ◽  
N O Berg ◽  
B Baldetorp ◽  
M Fernö ◽  
D Killander ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Soft Tissue ◽  
Dna Content ◽  
Nuclear Dna ◽  
Single Agent ◽  
Soft Tissue Sarcomas ◽  
Nuclear Dna Content ◽  
High Grade ◽  
Dna Aneuploidy

The nuclear DNA content of 148 high-grade soft tissue sarcomas of the extremities and trunk was determined by flow cytometry, using tumor material from paraffin-embedded tissue. The patients were part of a prospective randomized clinical trial on the efficacy of adjuvant single-agent chemotherapy with doxorubicin. Chemotherapy did not improve the metastasis-free survival (MFS). After a median follow-up time of 48 months (range, 2 to 97), a multivariate analysis of prognostic factors for developing metastatic disease was performed. DNA aneuploidy was found to be an independent prognostic risk factor in addition to histologic malignancy grade IV, intratumoral vascular invasion, tumor size over 10 cm, and male sex. Patients with none or one risk factor had a 5-year MFS of 79%, with two risk factors 65%, with three risk factors 43%, and with four and five risk factors 0%. About one half (78 of 148) of the patients with three factors or less belonged to a group with a MFS over 60%. The combination of different risk factors, including DNA aneuploidy, seems to be a useful prognostic model for soft tissue sarcomas, which could be of value to select high-risk patients for further trials with adjunctive therapy.

Association of DNA Aneuploidy with Human Papillomavirus-Induced Malignant Transformation of Sinonasal Transitional Papillomas

1989 ◽  
Vol 100 (6) ◽  
pp. 563-567 ◽  
Author(s):  
Pekka J. Klemi ◽  
Heikki Joensuu ◽  
Lasse Siivonen ◽  
Erkki Virolainen ◽  
Stina Syrjänen ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Malignant Transformation ◽  
Dna Content ◽  
Nuclear Dna ◽  
Nuclear Dna Content ◽  
Hybridization Technique ◽  
Dna Index ◽  
Dna Aneuploidy ◽  
Hpv Dna ◽  
Dna Types

The nuclear DNA content of 19 transitional papillomas of the sinonasal region and 9 maxillary squamous cell carcinomas was studied by flow cytometry; the presence of human papillomavirus (HPV) DNA types 11 and 16 was determined by the in situ hybridization technique from paraffin-embedded tissue. Thirteen (68%) of the papillomas and none of the carcinomas contained HPV genome. Six (32%) of the papillomas and 4 (44%) of the carcinomas had an aneuploid DNA content. The relative DNA content (DNA Index) of the aneuploid maxillary carcinomas was larger than that of aneuploid papillomas ( p = 0.004). Three of the papillomas underwent malignant transformation, all three of which contained HPV type 16 DNA; two were also aneuplold. Data Indicate that papillomas containing HPV type 16 DNA have a tendency ( p = 0.06) to undergo malignant transformation, and that this tendency Is greater If DNA aneuploidy or HPV type 11 DNA Is also present ( p = 0.02).

scholarly journals What Are Risk Factors for Local Recurrence of Deep High-grade Soft-tissue Sarcomas?

2011 ◽  
Vol 470 (3) ◽  
pp. 700-705 ◽  
Author(s):  
Chigusa Sawamura ◽  
Seiichi Matsumoto ◽  
Takashi Shimoji ◽  
Taisuke Tanizawa ◽  
Keisuke Ae
Keyword(s):  
Risk Factors ◽  
Soft Tissue ◽  
Local Recurrence ◽  
Soft Tissue Sarcomas ◽  
High Grade

Risk Factors for Grade 3 Pivot Shift in Knees With Acute Anterior Cruciate Ligament Injuries: A Comprehensive Evaluation of the Importance of Osseous and Soft Tissue Parameters From the SANTI Study Group

2020 ◽  
Vol 48 (10) ◽  
pp. 2408-2417 ◽  
Author(s):  
Andrea Ferretti ◽  
Edoardo Monaco ◽  
Edoardo Gaj ◽  
Valerio Andreozzi ◽  
Alessandro Annibaldi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Soft Tissue ◽  
Comprehensive Evaluation ◽  
Pivot Shift ◽  
Cruciate Ligament ◽  
High Grade ◽  
Multivariate Logistic Regression ◽  
Anterior Cruciate ◽  
Grade 3

Background: Preoperative grade 3 pivot shift has been reported to be associated with higher rates of anterior cruciate ligament (ACL) failure, persistent instability, and inferior patient-reported outcomes. The etiology of a high-grade pivot shift is multifactorial, and numerous factors have been suggested to be responsible. More attention has recently been focused on injury to the anterolateral structures (ALS) as a risk factor for a grade 3 pivot shift. Purpose: To determine risk factors for grade 3 pivot shift, including soft tissue and osseous parameters. Study Design: Cross-sectional study; Level of evidence, 3. Methods: A prospective evaluation was undertaken of 200 consecutive patients undergoing acute ACL reconstruction (within 10 days of injury). An open exploration of the lateral side of the injured knee was performed at the time of the index procedure. Details regarding patient and injury characteristics were recorded, as were details of soft tissue injuries, including meniscal tears, ALS lesions, medial collateral ligament tears, and chondral injuries. Osseous parameters (tibial slope and condylar ratios) were determined per established magnetic resonance imaging protocols. A multivariate logistic regression with penalized maximum likelihood was used to identify risk factors associated with International Knee Documentation Committee (IKDC) grade 3 pivot shift. Results: The mean ± SD age of the population was 28.3 ± 9.8 years; 67.5% of patients were male. Among patients, 35 (17.5%) had a high-grade pivot shift (IKDC grade 3), and 165 (82.5%) had a low-grade pivot shift (IKDC grades 1 and 2). Univariate and multivariate logistic regression analysis demonstrated that injury to the ALS was the only significant risk factor for grade 3 pivot shift (odds ratio, 13.49; 95% CI, 1.80-1725.53). Conclusion: This comprehensive evaluation of soft tissue and osseous factors has identified that injury to the ALS is the most important risk factor for grade 3 pivot shift in acute ACL-injured knees.

Nuclear DNA content characteristics of 129 high grade malignancy non-Hodgkin lymphomas

1987 ◽  
Vol 23 (11) ◽  
pp. 1775
Author(s):  
T. Lehtinen ◽  
R. Aine ◽  
M. Lehtinen ◽  
T. Leino ◽  
O.-P. Kallioniemi ◽  
...  
Keyword(s):  
Dna Content ◽  
Nuclear Dna ◽  
Nuclear Dna Content ◽  
High Grade ◽  
Grade Malignancy ◽  
High Grade Malignancy ◽  
Content Characteristics

Myxofibrosarcoma: clinical and prognostic value of MRI features

2020 ◽  
Vol 16 ◽  
Author(s):  
Paolo Spinnato ◽  
Andrea Sambri ◽  
Tomohiro Fujiwara ◽  
Luca Ceccarelli ◽  
Roberta Clinca ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Local Recurrence ◽  
Contrast Enhancement ◽  
Imaging Modality ◽  
Soft Tissue Sarcomas ◽  
The Elderly ◽  
High Rate ◽  
Imaging Features ◽  
High Grade ◽  
Mri Features

: Myxofibrosarcoma is one of the most common soft tissue sarcomas in the elderly. It is characterized by an extremely high rate of local recurrence, higher than other soft tissue tumors, and a relatively low risk of distant metastases.Magnetic resonance imaging (MRI) is the imaging modality of choice for the assessment of myxofibrosarcoma and plays a key role in the preoperative setting of these patients.MRI features associated with high risk of local recurrence are: high myxoid matrix content (water-like appearance of the lesions), high grade of contrast enhancement, presence of an infiltrative pattern (“tail sign”). On the other hand, MRI features associated with worse sarcoma specific survival are: large size of the lesion, deep location, high grade of contrast enhancement. Recognizing the above-mentioned imaging features of myxofibrosarcoma may be helpful to stratify the risk for local recurrence and disease-specific survival. Moreover, the surgical planning should be adjusted according to the MRI features

Prognostic value of nuclear DNA content in papillary and follicular thyroid cancer

1988 ◽  
Vol 12 (4) ◽  
pp. 503-507 ◽  
Author(s):  
Jaap F. Hamming ◽  
Lodewijk J. D. M. Schelfhout ◽  
Cees J. Cornelisse ◽  
Cornelis J. H. van de Velde ◽  
Bernard M. Goslings ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Dna Content ◽  
Prognostic Value ◽  
Nuclear Dna ◽  
Nuclear Dna Content ◽  
Follicular Thyroid Cancer
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