Quality of Life in Long-Term Survivors of Testicular Cancer: A Population-Based Case-Control Study

2002 ◽  
Vol 20 (1) ◽  
pp. 73-80 ◽  
Author(s):  
F. Joly
Dermatology ◽  
2014 ◽  
Vol 228 (3) ◽  
pp. 261-268 ◽  
Author(s):  
G.R. Vinding ◽  
K.M. Knudsen ◽  
C. Ellervik ◽  
A.B. Olesen ◽  
G.B.E. Jemec

Neurology ◽  
2000 ◽  
Vol 55 (5) ◽  
pp. 629-635 ◽  
Author(s):  
R. B. Lipton ◽  
S. W. Hamelsky ◽  
K. B. Kolodner ◽  
T. J. Steiner ◽  
W. F. Stewart

2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Ida Kathrine Gravensteen ◽  
Linda Bjørk Helgadottir ◽  
Eva-Marie Jacobsen ◽  
Per Morten Sandset ◽  
Øivind Ekeberg

2002 ◽  
Vol 20 (1) ◽  
pp. 73-80 ◽  
Author(s):  
F. Joly ◽  
J. F. Héron ◽  
L. Kalusinski ◽  
P. Bottet ◽  
D. Brune ◽  
...  

PURPOSE: To evaluate quality of life and social problems in long-term survivors of testicular cancer. PATIENTS AND METHODS: In 1998, 71 testicular cancer survivors (cases) identified from the Calvados General Tumor Registry were enrolled onto a case-control study. One hundred nineteen healthy control subjects (controls), matched by age and location of residence, were selected at random from electoral rolls. Three self-administered questionnaires were used: two health-related quality-of-life questionnaires (Short Form-36 and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30 core questionnaires) and one life situation questionnaire. Specific questions concerning sexuality were also added. RESULTS: With a mean follow-up of 11 years, health-related quality-of-life scores did not differ significantly between cases and controls, nor did general symptom scores. Psychosocial problems were reported equally by cases and controls. Cases reported more modification of sexual life (P = .04) with decreased sexual enjoyment (P < .01), decreased desire (P = .02), and infertility (P < .01). Cases did not report more divorce than controls; they reported fewer changes in relationships with friends (P = .03). Although a similar proportion of cases and controls were at work, cases expressed less ambitious professional plans (P = .002). Cases had greater difficulty in borrowing from banks (P < .001). CONCLUSION: French long-term survivors of testicular cancer do not express more impairment of health-related quality of life or familial or professional life in comparison with healthy men. They did have more sexual life problems and found difficulty in borrowing from banks. This information should be used by practitioners to help their patients cope with their disease and return to normal life.


BMJ Open ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. e032583
Author(s):  
Helen Marshall ◽  
Mark McMillan ◽  
Bing Wang ◽  
Robert Booy ◽  
Hossein Afzali ◽  
...  

IntroductionInvasive meningococcal disease (IMD) primarily causes disease in young children and adolescents and can cause long-term disability. Many countries are considering implementation of meningococcal B and/or meningococcal ACWY vaccines to control meningococcal disease. Estimating the cost-effectiveness of meningococcal vaccine programme is hampered due to a lack of good quality costing and burden of disease data. This study aims to address this evidence gap by assessing the clinical, physical, neurocognitive, economic and societal impact of IMD on adolescents and young adults.Methods and analysisA case–control study of 64 participants with confirmed IMD (15–24 years 11 months at time of disease) and 64 control participants (17–34 years 11 months) will be conducted in Australia from 2016 to 2020. All participants will undergo a neurocognitive assessment, full medical examination, pure tone audiometry assessment and complete quality of life and behavioural questionnaires. Meningococcal cases will be assessed 2–10 years posthospitalisation and a subset of cases will be interviewed to explore in depth their experiences of IMD and its impact on their life. Primary outcome measures include general intellectual functioning from the Wechsler Adult Intelligence Scale and overall quality of life from the Health Utilities Index. Secondary outcome measures include academic achievement, executive functioning, behaviour, hearing, psychological and physical functioning. Outcome measures will be compared between cases and controls using independent t-tests or ORs, or if any significant confounders are identified, adjusted analyses (analysis of covariance or adjusted ORs) will be conducted. Thematic analysis will be used to analyse transcribed interviews and a costing model will be used to project lifetime costs.Ethics and disseminationThe Adolescent MENingococcal Disease (AMEND) study has been approved by the Human Research Ethics Committee of the Women’s and Children’s Health Network (HREC/14/WCHN/024). The results will be disseminated via peer-reviewed publications, conference presentations, study participants, and meningococcal and meningitis foundations.Trial registration numberNCT03798574.


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