Quality of Life in Patients With Colorectal Cancer 1 Year After Diagnosis Compared With the General Population: A Population-Based Study

2004 ◽  
Vol 22 (23) ◽  
pp. 4829-4836 ◽  
Author(s):  
Volker Arndt ◽  
Henrike Merx ◽  
Christa Stegmaier ◽  
Hartwig Ziegler ◽  
Hermann Brenner
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
General Population ◽  
Social Functioning ◽  
Cancer Patients ◽  
Population Based ◽  
Long Term Results ◽  
Financial Difficulties ◽  
Colorectal Cancer Patients

Purpose Quality of life (QOL) has become an important outcome measure for patients with cancer, but long-term results from population-based studies are rare. The objective of our study was to identify specific limitations of QOL in survivors of colorectal cancer in comparison with men and women from the general population 1 year after diagnosis when acute treatment effects are expected to have declined. Patients and Methods QOL was assessed 1 year after diagnosis in a population-based cohort of 439 patients with colorectal cancer from Saarland (Germany) using the EORTC-QLC30 questionnaire. Specific functional and symptom QOL scores were compared with published reference data from the general population. Results Of 439 patients, 378 of them survived the first year after tumor diagnosis (86.1%). Of these, 309 returned the questionnaire (response rate, 81.7%). Compared with the general population, colorectal cancer patients scored their physical, role, cognitive, and global health functioning only slightly worse. More severe limitations were observed for the emotional and social functioning scales and for the symptom subscales of fatigue, dyspnea, insomnia, constipation, diarrhea, and financial difficulties. The differences regarding functional and symptom scores were predominantly found in younger age groups whereas older cancer patients and controls rated their health and QOL similarly. Conclusion Deficits in emotional and social functioning and specific limitations like fatigue, dyspnea, insomnia, constipation, diarrhea, and financial difficulties are main factors hampering the QOL among colorectal cancer patients and seem to affect predominantly younger patients.

Persistence of Restrictions in Quality of Life From the First to the Third Year After Diagnosis in Women With Breast Cancer

2005 ◽  
Vol 23 (22) ◽  
pp. 4945-4953 ◽  
Author(s):  
Volker Arndt ◽  
Henrike Merx ◽  
Christa Stegmaier ◽  
Hartwig Ziegler ◽  
Hermann Brenner
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
General Population ◽  
Social Functioning ◽  
Population Based ◽  
Breast Cancer Patients ◽  
Functional Changes ◽  
Role Emotional ◽  
Financial Difficulties

Purpose To assess whether detriments in quality of life (QOL) among women with breast cancer persist over years. Patients and Methods QOL was assessed in a population-based cohort of 314 women with breast cancer from Saarland (Germany) 1 and 3 years after diagnosis and compared internally and with reference data from the general population. Results Three years after diagnosis, deficits in QOL were still apparent for role, emotional, cognitive, and social functioning and for the symptoms of insomnia, fatigue, dyspnea, and financial difficulties. Differences between breast cancer patients and women from the general population were predominantly found in younger ages. Compared with the QOL scores measured 1 year after diagnosis, only minor functional changes were observed, but recurrence of breast cancer during the follow-up interval had a deleterious effect on QOL. Conclusion Deficits in role, emotional, cognitive, and social functioning persist over years in women with breast cancer and predominantly affect younger patients.

scholarly journals Age‐Specific Administration of Chemotherapy and Long‐Term Quality of Life in Stage II and III Colorectal Cancer Patients: A Population‐Based Prospective Cohort

2011 ◽  
Vol 16 (12) ◽  
pp. 1741-1751 ◽  
Author(s):  
Lina Jansen ◽  
Michael Hoffmeister ◽  
Jenny Chang‐Claude ◽  
Moritz Koch ◽  
Hermann Brenner ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Cancer Patients ◽  
Prospective Cohort ◽  
Population Based ◽  
Stage Ii ◽  
Colorectal Cancer Patients

Restrictions in quality of life in colorectal cancer patients over three years after diagnosis: A population based study

2006 ◽  
Vol 42 (12) ◽  
pp. 1848-1857 ◽  
Author(s):  
Volker Arndt ◽  
Henrike Merx ◽  
Christa Stegmaier ◽  
Hartwig Ziegler ◽  
Hermann Brenner
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Cancer Patients ◽  
Population Based ◽  
Population Based Study ◽  
Colorectal Cancer Patients

Validation of Patient's Self-Reported Social Functioning As an Independent Prognostic Factor for Survival in Metastatic Colorectal Cancer Patients: Results of an International Study by the Chronotherapy Group of the European Organisation for Research and Treatment of Cancer

2008 ◽  
Vol 26 (12) ◽  
pp. 2020-2026 ◽  
Author(s):  
Fabio Efficace ◽  
Pasquale F. Innominato ◽  
Georg Bjarnason ◽  
Corneel Coens ◽  
Yves Humblet ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Social Functioning ◽  
Cancer Patients ◽  
Life Questionnaire ◽  
European Organisation ◽  
Wbc Count ◽  
Colorectal Cancer Patients

Purpose A recent study identified a prognostic model for survival in metastatic colorectal cancer patients which included WBC count, alkaline phosphatase (AP), number of metastatic sites, and patients’ self-reported social functioning. The aim of this research is to validate this model on data from an independent sample. Patients and Methods This validation study is based on a prospective randomized controlled trial in patients with metastatic colorectal cancer conducted by the European Organisation for Research and Treatment of Cancer (EORTC) Chronotherapy Group. Overall, 564 patients in 10 countries were enrolled. For the purpose of this independent validation, patients with health-related quality of life (HRQOL) baseline data were analyzed. HRQOL was assessed using the EORTC Quality of Life Questionnaire C30 (QLQ-C30). The Cox proportional hazards regression model was used for both univariate and multivariate analyses of survival. Results The previous model with an additional adjustment, by stratification for sex, was replicated and its parameters were confirmed to independently predict survival: WBC count with an hazard ratio (HR) of 1.31 (95% CI, 1.021 to 1.698; P = .034); AP with an HR of 1.53 (95% CI, 1.188 to 1.979; P = .001); number of sites involved with an HR of 1.90 (95% CI, 1.531 to 2.364; P < .0001); and patients’ self-reported social functioning with an HR of 0.94 (95% CI, 0.905 to 0.976; P = .001). The latter translates into a 6% increase in the likelihood of an earlier death for every 10-point decrease in the social functioning scale of the EORTC QLQ-C30. Conclusion This study provides confirmatory evidence of the independent prognostic value of patients’ self-reported social functioning in patients with advanced colorectal cancer.

Safety and Quality of Life in the Treatment of Non-metastasic Colorectal Cancer Patients: 5-fluorouracil Versus Capecitabine

2019 ◽  
Author(s):  
Julia Sánchez-Gundín ◽  
Cristina Martín-Sabroso ◽  
Ana M. Fernández-Carballido ◽  
D. Barreda-Hernández ◽  
Ana I. Torres-Suárez
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Cancer Patients ◽  
Colorectal Cancer Patients

Are gender-associated differences in quality of life in colorectal cancer patients disease-specific?

2009 ◽  
Vol 18 (5) ◽  
pp. 547-555 ◽  
Author(s):  
Johannes Giesinger ◽  
Georg Kemmler ◽  
Verena Mueller ◽  
August Zabernigg ◽  
Beate Mayrbaeurl ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Cancer Patients ◽  
Colorectal Cancer Patients ◽  
Disease Specific

Depression, Fatigue, and QoL in Colorectal Cancer Patients During and After Treatment

2016 ◽  
Vol 38 (7) ◽  
pp. 893-908 ◽  
Author(s):  
Hong-Yi Tung ◽  
Tung-Bo Chao ◽  
Yu-Hua Lin ◽  
Shu-Fen Wu ◽  
Hui-Yen Lee ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Health Care ◽  
Cancer Patients ◽  
Health Care Professionals ◽  
Nursing Intervention ◽  
Prevalence Of Depression ◽  
Study Population ◽  
Colorectal Cancer Patients

In this study, we sought to explore the prevalence of depression and fatigue in colorectal cancer patients during and after treatment to examine how these variables affect quality of life (QoL). In total, 170 patients with colorectal cancer participated in this study. The study population was divided into two groups: one receiving treatment and another that had finished treatment. The results showed that depression and fatigue measurements were higher in patients receiving treatment. Depression was a strong and significant predictor of QoL in both groups, whereas fatigue was not, with the exception of the symptom score. These findings underscore the importance of early detection and management of depression and fatigue during the treatment and survival stages of patients with colorectal cancer. Our findings indicate that health care professionals should provide appropriate nursing intervention to decrease depression and fatigue and enhance patient QoL.

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