How Destination Social Responsibility Shapes Resident Emotional Solidarity and Quality of Life: Moderating Roles of Disclosure Tone and Visual Messaging

This study investigates how destination social responsibility (DSR) improves resident quality of life (QOL) through the lenses of signaling theory and emotional solidarity theory. The study demonstrates the mediating role of resident emotional solidarity toward the destination and the moderating roles of disclosure tone and visual messages. Three experiments indicate that continuous (vs. one-time) DSR positively affects resident emotional solidarity and QOL, whereas emotional solidarity has a mediating role. Emotional solidarity elicited by continuous (vs. one-time) DSR is significantly higher when the disclosure tone of DSR is vivid (vs. pallid). However, when DSR is disclosed using visual messages, emotional solidarity effects of DSR types are not different in vivid tone but have significant differences in pallid tone. This study expands the application of signaling theory and emotional solidarity theory to resident QOL studies and provides suggestions on improving residents’ QOL through DSR.

Quality of life and its predictors among adult patients with haemophilic arthropathy. An observational study

Background Recurrent hemarthrosis that begin in childhood lead to progressive joint deterioration. Patients with haemophilia have chronic pain, functional disability and a reduced perception of health-related quality of life. Purpose To analyse the perceived quality of life of adult patients with haemophilic arthropathy and its relationship with pain, joint condition, kinesiophobia and catastrophism. Methods Eighty-three adult patients with haemophilia were included in this multicentre, cross-sectional, descriptive study. Perceived quality of life (36-Item Short Form Health Survey), perceived usual and maximum pain (visual analogue scale), joint condition (Haemophilia Joint Health Score), kinesiophobia (Tampa Scale of Kinesiophobia) and catastrophism (Pain Catastrophizing Scale) were assessed. Sociodemographic, clinical and therapeutic variables and drug consumption for pain control were collected. Descriptive statistics used means and standard deviations. The correlation of quality of life with the dependent variables was calculated with the Pearson correlation test. The differences in quality of life as a function of the binomial variables were calculated with Student’s t-test for independent samples. Results Physical component of quality of life perceived by patients with hemophilia is lower than Spanish population (30.51 VS 48.85). Regarding the mental component, patients with hemophilia showed higher values (56.07 VS 49.97). Catastrophism correlated (p < .05) with all items of quality of life questionnaire. Kinesiophobia correlated (p < .05) with all items of quality of life except to role-emotional (r = -.18; p > .05). Habitual and maximal joint pain correlated with all items except to role-emotional (r = − .19 and r = − .09, respectively) and mental component score (r = − .16 and r = − .07, respectively). Catastrophism and weekly drug intake were inversely correlated with quality of life. Age was positively correlated with perceived quality of life. There were differences in quality of life as a function of the severity of haemophilia and the intake of drugs for pain control. Conclusions The perceived quality of life of adult patients with haemophilia is worse than that of the Spanish population. Pain, kinesiophobia, catastrophism, haemophilia severity and the intake of pain-control medication influence the quality of life of these patients.

Health related quality of life and buffering factors in adult survivors of acute pediatric lymphoblastic leukemia and their siblings

Background The improvement in treatment of pediatric acute lymphatic leukemia (ALL) has introduced new challenges for pediatric oncology care in understanding and handling long-term treatment-related complications later in adult life. The aim of this study was to describe health related quality of life (HRQoL) and the relation to buffering factors among young adult (YA) pediatric ALL survivors and their siblings. Methods This cross-sectional study was performed among 227 adults, treated for pediatric ALL in Sweden between 1985 and 1997 and their siblings (n = 70). Group means of HRQoL (SF-36) were compared between YA ALL survivors and the siblings, as well as to normative values from the general population. Self-efficacy (GSES) and social support (SS-13 subscale AVSI) was considering potential buffering factors for HRQoL and mental health. Associations between HRQoL and mental health respectively and self-efficacy and social support was analyzed. Results The YA ALL survivors scored significantly lower on the HRQoL parameters general health (69.6 vs. 78.4, p = 0.004) and role emotional (77.1 vs. 88.1, p = 0.014), than the siblings. Further, they reported significantly lower general health (69.6 vs. 75.8), vitality (56.9 vs. 68.8), social functioning (84.5 vs. 88.6), role emotional (77.1 vs. 85.7) and mental health (71.3 vs. 80.9) compared with Swedish norms. Both YA ALL survivors and the siblings reported lower vitality and worse mental health than the general population. The HRQoL parameters, depression, stress and anxiety were all associated with both self-efficacy and social support among the YA ALL survivors. Among the siblings however, only general health, vitality, role emotional, mental health and depression were associated with social support, and only general health and mental health were associated with general self-efficacy. Conclusion The results from this study show that buffering factors, like social support and self-efficacy, may play an important role for psychosocial outcomes and HRQoL among YA ALL survivors later in life. The results suggest that this group could benefit from continuous support in adult life to handle consequences of their pediatric disease.

Impact of acne on quality of life among university students

Objective: To know the impact of acne among female university students on their quality of life. Methodology: A cross sectional study conducted included 260 female students at the King Khalid University. A self-administered questionnaire was used in Arabic for data collection. It consisted of personal data, practices and conditions related to health, specific questions on acne vulgaris and the Acne Quality of Life (QOL) questionnaire. Results: Prevalence of acne among participant students was 87%. Its severity among 48% of participants was mild, 39.6% was moderate, while 12.3% had severe acne. Its prevalence did not differ significantly according to participants’ personal characteristics. The mean score for self-perception was 18.4+8.0, for role emotional was 14.4+8.8, for role social was 14.4+6.4, for acne symptoms was 13.4+5.2, while mean overall score was 60.5+24.4. Acne QOL scores for all domains were significantly lower among students who have acne. Scores for all domains and overall scores were lowest among students having severe acne. Students’ acne QOL scores differed significantly according to their family monthly income regarding “self-perception” (p=0.005), role emotional (p=0.037) and overall (p=0.012). Conclusions: Prevalence of facial acne is very high among students and significantly affects their QOL. During management of acne patients, health care professionals should consider its psychosocial aspect. Limitations: Generalizability of the results is limited to female university students only and limited personal characteristics were assessed in the present study. Conflict of interest: There is no conflict of interest involved with this study Key words: Acne, quality of life, female university students.

Is casual employment in Australia bad for workers’ health?

ObjectivesThis paper assessed the impact of working in casual employment, compared with permanent employment, on eight health attributes that make up the 36-Item Short Form (SF-36) Health Survey, separately by sex. The mental health impacts of casual jobs with irregular hours over which the worker reports limited control were also investigated.MethodsLongitudinal data from the Household, Income and Labour Dynamics in Australia Survey, over the period 2001–2018, were used to investigate the relationship between the eight SF-36 subscales and workers’ employment contract type. Individual, household and job characteristic confounders were included in dynamic panel data regression models with correlated random effects.ResultsFor both men and women, health outcomes for casual workers were no worse than for permanent workers for any of the eight SF-36 health attributes. For some health attributes, scores for casual workers were higher (ie, better) than for permanent workers (role physical: men: β=1.15, 95% CI 0.09 to 2.20, women: β=1.79, 95% CI 0.79 to 2.80; bodily pain: women: β=0.90, 95% CI 0.25 to 1.54; vitality: women: β=0.65, 95% CI 0.13 to 1.18; social functioning: men: β=1.00, 95% CI 0.28 to 1.73); role emotional: men: β=1.81, 95% CI 0.73 to 2.89, women: β=1.24, 95% CI 0.24 to 2.24). Among women (but not men), mental health and role emotional scores were lower for irregular casual workers than for regular permanent workers but not statistically significantly so.ConclusionsThis study found no evidence that casual employment in Australia is detrimental to self-assessed worker health.

QUALITY OF LIFE AMONG PATIENTS UNDERGOING HAEMODIALYSIS IN JAKARTA, INDONESIA

Haemodialysis is a continuous treatment provided to patients with chronic kidney disease as a replacement for renal function. It is important to assess the quality of life among these patients. The aim of this study was to evaluate quality of life among patients on haemodialysis using an Indonesian version of the KDQoL-SF24 questionnaire. This is a cohort observational study that included 145 haemodialysis patients in a haemodialysis centre in Jakarta, Indonesia. A translated and validated version of the KDQoL-SF24 was used in this survey. The participants in this study had lower mean scores than the standard form in the following 6 components: burden of kidney disease (44.22±33.23), cognitive function (74.94±20.32), sleep (57.07±24.15), patient satisfaction (60.11±18.56), role-physical (26.21±44.01), emotional well-being (69.19±24.25) and role-emotional (40.69±49.18). A significant relationship was found between sexual function, physical functioning, role emotional and age among haemodialysis patients (P <0.05). Based on the overall health rating from the KDQoL-SF24, the mean and standard deviation for the 21- to 30-year-old age group was lower than the standard form. The burden of kidney disease, cognitive function, sleep, patient satisfaction, role-physical, emotional well-being and role-emotional component scores were low for haemodialysis patients in Indonesia compared to the standard form. Additionally, age significantly affected sexual function, physical functioning and role-emotional.

Educational program for coronary artery disease patients: results after one year

ASTRACT Objective: To evaluate the long-term results of an educational program compared to usual care. Method: A longitudinal study in which 56 participants from a previous study (randomized controlled clinical trial) were evaluated twelve months after the percutaneous coronary intervention (PCI). Health-related quality of life (HRQoL) was assessed by the Medical Outcomes Study: 36-item Short Form (SF-36), and anxiety and depression symptoms were assessed by the Hospital Anxiety and Depression Scale (HADS). A repeated measures analysis of variance was performed (significance level 0.05). Results: Participants in the educational program showed improvement of HRQoL in the Role-Emotional domain, while those in the usual care did not present changes (p=0.05). Both groups showed improvement in the Role-Physical (p = 0.001) and Bodily Pain (p=0.01) domains over time. There were no differences in the symptoms of anxiety and depression. Conclusion: One year after the PCI, there were significant differences between groups only for the Role-Emotional domain of the SF-36.

1356. Improvement in Quality of Life for Adults With Acute Bacterial Skin and Skin Structure Infections Following Treatment With Omadacycline or Linezolid

Background The appearance of multidrug-resistant Gram-positive bacteria is a major challenge in clinical care. Omadacycline is the first aminomethylcycline antibiotic (semisynthetic compounds related to tetracyclines) in late-stage clinical development for acute bacterial skin and skin structure infections (ABSSSI), and demonstrates potent in vitro activity against many pathogens. Methods Seven hundred thirty-five patients were enrolled in the OASIS-2 randomized controlled trial comparing omadacycline and linezolid for the treatment of adult subjects with ABSSSI known or suspected to be due to a Gram-positive pathogen, with 368 and 367 enrolled in each group, respectively. Subjects completed the 36-Item Short Form Health Survey Version 2 (SF-36v2), a validated questionnaire on physical and mental health, at both screening and post-treatment evaluation. Results of the SF-36v2 were analyzed in accordance with established norm-based standards for the survey (Ware 2000) for the intention-to-treat population. Results Subjects who received omadacycline experienced a 3.25 point mean improvement in overall physical health (P &lt; 0.001, Figure 1) and reported significant improvements across all but one component parameter of overall physical and mental health, including physical functioning, bodily pain, role physical, vitality, role emotional, mental health, and social functioning (Figure 2). In contrast, while overall physical health improved for subjects who received linezolid, the improvement in vitality, role emotional, mental health, and general health was not significant (Figure 2). Although omadacycline achieved greater increase from baseline than linezolid across all domains analyzed, the difference in scores was not statistically significant at the P &lt; 0.05 level (Figure 1). Conclusion Omadacycline provides significant improvement in the physical component of quality of life over baseline for adult subjects with ABSSSI known or suspected to be due to a Gram-positive pathogen. Although the OASIS-2 trial was neither designed nor powered to measure differences in quality of life following treatment, trends identified in this analysis merit further investigation. References 1. Ware JE. SF-36 Health Survey Update. SPINE 2000; 25(24); 3130–3139. Disclosures E. Tzanis, Paratek Pharmaceuticals: Employee, Salary. M. Curran, Paratek Pharmaceuticals: Employee, Salary. P. McGovern, Paratek Pharmaceuticals: Employee, Salary. J. Hinahara, Paratek Pharmaceuticals: Consultant, Consulting fee. T. Goss, Paratek Pharmaceuticals: Consultant, Consulting fee.

PENGARUH FAKTOR YANG BERHUBUNGAN DENGAN USIA TERHADAP KUALITAS HIDUP PASIEN EPILEPSI

Pendahuluan: Epilepsi merupakan penyakit neurologis yang mempengaruhi kualitas hidup penderitanya. Hanya ada sedikit penelitian tentang kualitas hidup pasien epilepsi di Indonesia. Tujuan: Melihat hubungan antara usia, usia saat onset pertama muncul, dan durasi epilepsi terhadap kualitas hidup pasien epilepsi. Metode: Penelitian cross-sectional ini dilakukan di Departemen Neurologi, Rumah Sakit Bethesda, Yogyakarta, Indonesia pada November 2017 sampai Februari 2018. Pasien epilepsi yang berusia ≥ 18 tahun diikutkan dalam penelitian ini. Kualitas hidup diukur menggunakan instrument Short form 8 (SF-8). Hasil: Terkumpul 27 pasien yang memenuhi kriteria inklusi. Pasien dengan usia ≥ 60 tahun secara signifikan mengalami penurunan kualitas hidup dalam beberapa aspek, yaitu: physical functioning (42.44±8.243), general health (40.04±7.641), role emotional (39.60±7.638), mental health (43.50±10.347), dan mental component score (42.04±10.282). Pasien dengan usia saat onset pertama muncul ≥ 55 tahun secara signifikan memiliki role emotional (40.54±7.245) dan mental component score (42.98±10.155) yang lebih rendah. Durasi epilepsi tidak memiliki hubungan yang signifikan terhadap kualitas hidup pasien epilepsi. Kesimpulan: Penelitian ini menunjukkan bahwa usia dan usia saat onset epilepsi pertama muncul berhubungan dengan kualitas hidup pasien epilepsi. Kata kunci: Epilepsi, faktor risiko yang berhubungan dengan usia, kualitas hidup, SF-8.