A randomized controlled study comparing CMF plus TAM with UFT plus TAM as postoperative adjuvant therapy in women with node-positive breast cancer

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 586-586 ◽  
Author(s):  
H. Inaji ◽  
Y. Park ◽  
K. Okamura ◽  
S. Mitsuyama ◽  
T. Saito ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Adjuvant Therapy ◽  
Randomized Controlled Study ◽  
Controlled Study ◽  
Postoperative Adjuvant Therapy ◽  
Node Positive ◽  
Randomized Controlled ◽  
Positive Breast Cancer

scholarly journals CTCs-oriented adjuvant personalized cytostatic therapy non-metastatic breast cancer patients: continuous non-randomized prospective study and prospective randomized controlled study

2021 ◽  
Author(s):  
Ya A. Shliakhtunou
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Adjuvant Therapy ◽  
Prospective Study ◽  
Metastatic Breast ◽  
Randomized Controlled Study ◽  
Controlled Study ◽  
Control Group ◽  
Randomized Controlled ◽  
Experimental Group

Abstract The aim To conduct a prospective randomized controlled study of the optimization of adjuvant therapy in patients with non-metastatic breast cancer, taking into account the presence of circulating tumor cells (CTCs) with an assessment of tumor-specific OS and DFS. Materials Stage 1 Continuous non-randomized prospective study (n = 102) to study the clinical and prognostic value of CTCs and evaluate the effectiveness of adjuvant systemic therapy in relation to CTC eradication; Stage 2 Prospective randomized controlled study (n = 128) of optimization of adjuvant therapy taking into account CTCs with an assessment of the effectiveness of the standard therapy and an optimized therapy regimen. Results Monitoring of CTCs during adjuvant drug treatment has established that a significant decrease in the frequency of CTC identification can be achieved only by sequential administration of anthracyclines and taxanes (paclitaxel) AC-T, which allows reducing CTCs compared to other regimens from 52.6 to 15.8% (p = 0.006). CTC-oriented personalized adjuvant therapy in the experimental group, based on the timely transition from an ineffective adjuvant chemotherapy regimen to taxanes, as well as additional monochemotherapy with gemcitabine can achieve 100% eradication CTCs. In the adjuvant therapy experimental group taking into account CTCs (n = 68), the OS 5-year tumor-specific rate was 90.3 ± 3.8%, (control group 78.7 ± 3.9%, p = 0.036). DFS tumor-specific in the experimental group was 88.0 ± 4.4%, (control group 80.6 ± 3.3%, p = 0.023). Conclusions The use of the method of treatment of CTC-oriented personalized adjuvant therapy for non-metastatic breast cancer makes it possible to reliably increase DFS 5-year by 7.4% and OS 5-year by 11.6%.

A randomized, controlled study of Internet peer-to-peer interactions among women newly diagnosed with breast cancer

2010 ◽  
Vol 19 (4) ◽  
pp. 441-446 ◽  
Author(s):  
Mark S. Salzer ◽  
Steven C. Palmer ◽  
Katy Kaplan ◽  
Eugene Brusilovskiy ◽  
Thomas Ten Have ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Peer Interactions ◽  
Peer To Peer ◽  
Randomized Controlled Study ◽  
Controlled Study ◽  
Newly Diagnosed ◽  
Randomized Controlled

Adjuvant Therapy for Patients Who Have Node-Positive Breast Cancer

2006 ◽  
Vol 40 ◽  
pp. 77-98 ◽  
Author(s):  
Quyen D. Chu ◽  
John C. McDonald ◽  
Benjamin D.L. Li
Keyword(s):  
Breast Cancer ◽  
Adjuvant Therapy ◽  
Node Positive ◽  
Positive Breast Cancer
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