Transdermal estrogen therapy improves cholesterol levels and lipid profiles in men with prostate cancer

AbstractDyslipidemia is one of the main risk factors for coronary heart disease (CHD). The E3 ubiquitin ligase which is encoded by the ring finger protein 145 (RNF145) gene is very important in the mediation of cholesterol synthesis and effectively treats hypercholesterolemia. Thus, the purpose of the present research is to investigate the connection between the polymorphism of the RNF145 gene and cholesterol levels in the populations in Xinjiang, China. A total of 1396 participants (Male: 628, Female: 768) were included in this study for genetic analysis of RNF145 gene, and we used the modified multiple connection detection response (iMLDR) technology to label two SNPs (rs17056583, rs12188266) of RNF145 genotyping. The relationship between the genotypes and the lipid profiles was analyzed with general linear model analysis after adjusting confounding variables. Through the analysis of the two SNPs in RNF145 gene, we discovered that both rs17056583 and rs12188266 were related to total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) concentrations (All P < 0.001). In addition, the association of rs17056583 and rs12188266 with lipid profiles concentrations is still statistically significant after multivariate adjustment of sex, age, smoking, obesity, drinking, diabetes, hypertension and lipid profiles. Meanwhile, we also found that rs17056583 was associated with high triglycerides concentrations before and after adjustment (All P < 0.001). Our study shows that both rs17056583 and rs12188266 SNPs of RNP145 gene are related to TC and LDL-C concentrations in Xinjiang population.

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Exogenous Pubertal Induction by Oral versus Transdermal Estrogen Therapy

Journal of Pediatric and Adolescent Gynecology ◽

10.1016/j.jpag.2011.09.012 ◽

2013 ◽

Vol 26 (2) ◽

pp. 71-79 ◽

Cited By ~ 11

Author(s):

Lisa Kenigsberg ◽

Sadana Balachandar ◽

Kris Prasad ◽

Bina Shah

Keyword(s):

Estrogen Therapy ◽

Transdermal Estrogen

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Herbal Supplement PC-Spes for Prostate Cancer

Annals of Pharmacotherapy ◽

10.1345/aph.1a193 ◽

2002 ◽

Vol 36 (5) ◽

pp. 921-926 ◽

Cited By ~ 2

Author(s):

Mário L de Lemos

Keyword(s):

Prostate Cancer ◽

Cancer Patients ◽

Estrogenic Activity ◽

Estrogen Therapy ◽

Herbal Supplement ◽

Limited Data ◽

History Of ◽

Abnormal Bleeding ◽

Androgen Suppression ◽

American Society

OBJECTIVE: To determine the efficacy and toxicity of the herbal supplement PC-Spes in prostate cancer patients. METHODS: Literature search through MEDLINE (1966–October 2001), PubMed, and abstracts from the Annual Meeting of the American Society of Clinical Oncology (1995–2001). RESULTS: PC-Spes was associated with biochemical and clinical response in some prostate cancer patients. The mechanisms of action of PC-Spes appeared to be related to its estrogenic activity. CONCLUSIONS: PC-Spes is associated with some efficacy in prostate cancer patients. Due to the limited data available, it should not be used to replace standard androgen suppression therapy in androgen-dependent patients. PC-Spes may have a role for patients who have failed standard treatments for androgen-independent disease and have no history of thromboembolism or abnormal bleeding. PC-Spes has a toxicity profile similar to those of androgen suppression and estrogen therapy.

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Microdose transdermal estrogen therapy for relief of vulvovaginal symptoms in postmenopausal women

Menopause The Journal of The North American Menopause Society ◽

10.1097/gme.0b013e3181a15606 ◽

2009 ◽

Vol 16 (5) ◽

pp. 877-882 ◽

Cited By ~ 20

Author(s):

Gloria A. Bachmann ◽

Matthias Schaefers ◽

Alkaz Uddin ◽

Wulf H. Utian

Keyword(s):

Postmenopausal Women ◽

Estrogen Therapy ◽

Transdermal Estrogen

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PROGNOSTIC FACTORS FOR ESTROGEN THERAPY OF RELAPSED PROSTATE CANCER AFTER MAXIMAL ANDROGEN BLOCKADE (MAB)

The Japanese Journal of Urology ◽

10.5980/jpnjurol.101.597 ◽

2010 ◽

Vol 101 (4) ◽

pp. 597-602

Author(s):

Seiji Nakata ◽

Yoshiyuki Miyazawa ◽

Yasushi Sasaki ◽

Katsuya Nakano ◽

Hirotomo Takahashi

Keyword(s):

Prostate Cancer ◽

Prognostic Factors ◽

Estrogen Therapy ◽

Maximal Androgen Blockade ◽

Androgen Blockade

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Dietary Protein Source and Plasma Lipid Profiles of Infants

PEDIATRICS ◽

10.1542/peds.85.4.548 ◽

1990 ◽

Vol 85 (4) ◽

pp. 548-552

Author(s):

Emily Tseng ◽

Susan M. Potter ◽

Mary Frances Picciano

Keyword(s):

Amino Acids ◽

Human Milk ◽

Dietary Protein ◽

Plasma Cholesterol ◽

Plasma Lipid ◽

Lipid Profiles ◽

Plasma Triglyceride ◽

Term Infants ◽

Cholesterol Levels ◽

The Impact

Total cholesterol and triglyceride concentrations were measured in plasma samples taken at 4 and 8 weeks of age from 40 full-term infants who had been fed either human milk or one of three formulas containing casein-to-whey ratios of 82:18, 66:34, or 50:50 to investigate whether dietary protein influenced the development of plasma lipid profiles. Infants fed the formula with the casein-to-whey ratio of 82:18 had significantly higher plasma cholesterol levels at both 4 and 8 weeks of age compared with other groups of infants (P < .05). Infants fed the high-casein formula also showed an increase in plasma cholesterol levels with time (P < .001). Plasma triglyceride concentrations decreased as concentration of casein decreased (P < .05) among the formula-fed groups and increased with time. Infants fed human milk had plasma triglyceride concentrations similar to those infants who had been fed the 82:18 formula at 4 weeks of age; however, triglyceride concentrations eventually fell and were similar to those concentrations in infants who had been fed the 50:50 formula at 8 weeks of age. Results indicate that constituent lipids of human milk or formulas were not determining factors for changes observed in plasma cholesterol levels and triglyceride concentrations among groups. Since formulas differed only in proteins and their constituent amino acids, further investigation of the impact of dietary protein (amino acids) on development of blood lipid profiles in infants is warranted.

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