Young age is not always an adverse prognostic factor in breast cancer

2005 ◽  
Vol 23 (16_suppl) ◽  
pp. 825-825 ◽  
Author(s):  
M. A. Seoud ◽  
M. Khalil ◽  
N. El- Saghir ◽  
Z. Salem ◽  
M. Charafeddine ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factor ◽  
Young Age ◽  
Adverse Prognostic Factor

Young Age as an Independent Adverse Prognostic Factor in Premenopausal Patients with Breast Cancer

2002 ◽  
Vol 3 (1) ◽  
pp. 65-72 ◽  
Author(s):  
Peter C. Dubsky ◽  
Michael F.X. Gnant ◽  
Susanne Taucher ◽  
Sebastian Roka ◽  
Daniela Kandioler ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factor ◽  
Young Age ◽  
Adverse Prognostic Factor ◽  
Premenopausal Patients ◽  
Independent Adverse Prognostic Factor

Young Age as an Adverse Prognostic Factor in Premenopausal Women with Operable Breast Cancer

2002 ◽  
Vol 2 (4) ◽  
pp. 294-298 ◽  
Author(s):  
Richard R. Love ◽  
Nguyen Ba Duc ◽  
Nguyen Van Dinh ◽  
Tran Tu Quy ◽  
Ye Xin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factor ◽  
Premenopausal Women ◽  
Operable Breast Cancer ◽  
Young Age ◽  
Adverse Prognostic Factor

Young Age is not an Ominous Prognostic Factor in Breast Cancer Patients

1987 ◽  
Vol 73 (3) ◽  
pp. 233-235 ◽  
Author(s):  
Giuseppe Muscolino ◽  
Corrado Villani ◽  
Amedeo Vittorio Bedini ◽  
Alberto Luini ◽  
Bruno Salvadori
Keyword(s):  
Breast Cancer ◽  
Prognostic Factor ◽  
Cancer Patients ◽  
Young Women ◽  
Survival Rates ◽  
Disease Free Survival ◽  
Young Age ◽  
Breast Cancer Patients ◽  
Free Survival ◽  
Disease Free

Analysis of a series of 137 women 20–30 years of age, operated for breast carcinoma, excluding patients pregnant, lactating or with inflammatory cancer, showed that disease-free survival rates were similar and not lower than those reported for a large series of 716 breast cancer patients of all ages, treated and followed at the same Institute. Ten-year disease-free survival rates for the two series of 137 young women and 716 patients of all ages were 43.7% and 47.1% respectively. Even when considering the subgroups of patients with and without nodal axillary involvement, the corresponding figures for the two series considered were 72.6% vs. 72.1% (N−) and 25.1% vs. 24.5% (N+). It can be concluded that young age cannot be considered as an unfavorable prognostic factor.

scholarly journals Recent childbirth is an adverse prognostic factor in breast cancer and melanoma, but not in Hodgkin lymphoma

2013 ◽  
Vol 49 (17) ◽  
pp. 3686-3693 ◽  
Author(s):  
Henrik Møller ◽  
Arnie Purushotham ◽  
Karen M. Linklater ◽  
Hans Garmo ◽  
Lars Holmberg ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factor ◽  
Hodgkin Lymphoma ◽  
Adverse Prognostic Factor

scholarly journals Proton Radiotherapy for Infant Rhabdomyosarcoma: Rethinking Young Age as an Adverse Prognostic Factor

2020 ◽  
Vol 108 (3) ◽  
pp. S179-S180
Author(s):  
A. Parekh ◽  
D.J. Indelicato ◽  
R. Mailhot Vega ◽  
R.L. Rotondo ◽  
C.G. Morris ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Young Age ◽  
Proton Radiotherapy ◽  
Adverse Prognostic Factor

Association of body mass index and outcome in advanced breast cancer.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 1044-1044
Author(s):  
Claudia Andreetta ◽  
Pamela Driol ◽  
Marta Bonotto ◽  
Lorenzo Gerratana ◽  
Francesca Valent ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Body Mass Index ◽  
Prognostic Factor ◽  
Advanced Breast Cancer ◽  
Body Mass ◽  
Menopausal Status ◽  
Advanced Breast ◽  
Consecutive Series ◽  
First Line ◽  
Adverse Prognostic Factor

1044 Background: Obesity represents a well-known risk factor for the development of breast cancer and an adverse prognostic factor in early disease. Overweight is associated with reduced efficacy of aromatase inhibitors in adjuvant setting. Few data have been reported about the potential relationship of overweight and outcome in advanced breast cancer (ABC). Methods: We retrospectively evaluated body mass index (BMI) in a consecutive series of 400 ABC patients treated at our institution. BMI was calculated at baseline of diagnosis of ABC. We evaluated association of BMI and other prognostic and predictive markers with Progression Free Survival (PFS) and Overall Survival (OS). We evaluated PFS at first and subsequent lines of chemotherapy (CT) and endocrine therapy (ET). Overweight patients were defined as having BMI > 25. Results: Overweight patients were 52%. Median age of the population was 58 years. Median OS was 33.7 months. Overall, 76% of patients presented with ER+ and 17.7% with HER2+ ABC.Overweight was associated with increased age at diagnosis, menopausal status and luminal B or triple negative immunophenotype. At multivariate analysis, BMI > 25 was associated with better PFS at first-line ET (HR= 0.68, 95% CI 0.46-0.99). BMI was not associated with OS. Conclusions: BMI at baseline does not seem to be an adverse prognostic factor for ABC patients. Overweight may be associated with better PFS in endocrine responsive ABC treated with ET, especially in first-line setting. The role of BMI in ABC deserves to be further investigated.

Is young age a poor prognostic factor in triple-negative breast cancer patients? Analysis of 363 patients from single institution registry.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e12023-e12023
Author(s):  
Mohamed Salah Fayaz ◽  
Gerges Attia Demian ◽  
Mustafa El-Sherify ◽  
Sadeq Abuzalouf ◽  
Thomas George ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Prognostic Factor ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Disease Free Survival ◽  
Young Age ◽  
Lymph Node Status ◽  
Poor Prognostic Factor ◽  
Free Survival

e12023 Background: Young age is a known independent poor prognostic factor for breast cancer. Few data exist about validating such prognostic factor in triple negative subtype of breast cancer. In this study, we evaluate the prognostic value of young age presentation in triple negative breast cancer (TNBC) patients who were diagnosed in Kuwait Cancer Control Center. Methods: This is a retrospective analysis of 363 patients diagnosed with TNBC between July 1999 and June 2009. Of these, 27% were diagnosed at or below the age of 40. Chi-square test was used to correlate the age with other prognostic factors. Survival measurements were estimated using Kaplan-Meier analysis. Statistical significance was calculated using the log-rank test. Results: There was no correlation between young age at presentation and other prognostic factors including grade, T stage, lymph node status, lymphovascular invasion, and Ki67 positivity. Similarly, young age was not statistically associated with poorer 5-years overall survival (78% for patients < 40 years compared to 72% for those > 40 years; p = 0.13), disease free survival (66% vs. 61%; p = 0.5) or locoregional recurrence free survival (81% vs. 83%; p = 0.7). Conclusions: Young age does not seem to negatively impact the survival of TNBC patients nor associated with poor prognostic factors in our study population. Further studies are needed to define new prognostic factors, e.g. molecular markers, in this subtype of patients rather than the conventional clinicopathologic prognostic factors.

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