Image-guided biopsy of non-palpable breast lesions: Experience of a university hospital in Mexico City.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e11098-e11098
Author(s):  
Daniela Morales-Espinosa ◽  
Lilian Monica Navarro-Garcia ◽  
Dan Green ◽  
Daniel Motola ◽  
Gabriela Alvarado-luna ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Family History ◽  
Mexico City ◽  
Medical Records ◽  
University Hospital ◽  
Past Medical History ◽  
Image Guided ◽  
History Of ◽  
Advanced Stages ◽  
Palpable Breast

e11098 Background: Breast cancer is the most common cancer in women in Mexico. It is mostly diagnosed at advanced stages. Objective: To describe the experience of image-guided biopsies of non-palpable breast tumors in a University Hospital in Mexico City. Methods: Medical records from the Radiology and Oncology Department (January 2007 - April 2011) were reviewed. Patients with incomplete medical records as well as those lacking imaging control and pathology report were excluded. Results: A total of 123 medical records were obtained,12 were excluded. The median age was 50 years (rank 21-88). Most patients were asymptomatic. Medical indications leading to biopsy: see table below. Of the studied population, 56% had a family history of any type of cancer; 40% had a family history of breast cancer. Nine patients had a past medical history positive for breast cancer, 8 patients had a past medical history of any type of cancer. 26 patients were nulligravid and 60 post-menopausal; of which 27 had received hormone replacement therapy. 24 patients had positive contraceptive use. Most patients were catalogued as BIRADs 4A. From all the imaged-marked lesions, only 18 were malignant; 72% of which were carcinoma in situ. Most procedures were ambulatory; only 15 patients had to be admitted. The complications rate was very low (6%), 1 procedure-related infection, 3 seromas and 3 hematomas. Conclusions: Imaging-guided biopsies are a safe, with very low morbidity, accessible procedure. It helps to prompt effective treatment; especially in patients with non-palpable lesions who would otherwise not be diagnosed until advanced stages. [Table: see text]

scholarly journals Attitude, Awareness and Experience of Women towards the Breast Self-examination in Saudi Arabia

2019 ◽  
pp. 1-6
Author(s):  
Nisar Haider Zaidi ◽  
Fatma K. Althoubaity
Keyword(s):  
Breast Cancer ◽  
Family History ◽  
Breast Biopsy ◽  
Cultural Beliefs ◽  
Breast Cancer Incidence ◽  
University Hospital ◽  
Cancer Awareness ◽  
Breast Self Examination ◽  
History Of ◽  
Self Examination

Objective: To evaluate the attitude, awareness and experience of Women towards the breast self-examination. Methods: This is population-based study with the total number of the participants were 349 between 25-70 yrs of age, between December 2017 to February 2018 at King Abdulaziz University Hospital, Jeddah. A questionnaire was given to females attending the clinic or attending a lecture for breast cancer awareness. Results: A total of 349 patients were studied. Saudi was 76.5% and non-Saudi was 23.5%. Patients less than 25 years were 26.4% and above 25 years were 73.6%. The majority were between 25 to 45 years of age which was 66.4%. The majority were married 64.5%, single 30.4%, widow 2.9% and divorced were 2.3%. 65% had children and 59.3% did lactate their kids. Use of contraceptive pills was 50.4%. Family history of breast cancer was in 18.1% and sister had breast cancer in 3.46%, aunt 3.7%, stepdaughter in 6%, grandmother in 3.2% and mother in 2% of cases. Smokers were 10.6%. Family history of other malignancy was in 9.7% with colon cancer in 6.3% and uterus in 3.4%. History of taking herbs was in 14.6% of cases of which soya in 3.4%, baboon 2.6%, green tea 2.3%, ginger 2.3% and weight lowering herbs 1.7%. 12.3% of patient had breast biopsy and 12% had another tumour like thyroid, uterus, colon etc. 22.1% admitted that they did self- breast examination. Their source of knowledge about breast self-examination was Television in 13.5%, hospital 5.7% and doctor in 2.9%. Routine clinical examination was done in 82.2% and the reason for it was not known to the majority of them. Examination by doctors was done in 25.5% of cases. Mammography was done by 16.9%, ultrasound in 16.9%. 12.3% preferred mammography. Regarding the belief that biopsy will lead to spreading of the tumour, 16.3% said that they believe it. 3.4% believed that cancer is infective disease and 86.2% believed that breastfeeding decreases breast cancer incidence. Conclusions: Breast self-examination is an effective tool to detect early breast cancer especially in poor and underdeveloped countries which lack resources for proper screening of breast cancer. Cultural beliefs and ritual practices may affect early detection of breast cancer.

scholarly journals Benign breast tumors: epidemiological profile and therapeutic conduct at the escola paulista de medicina

Mastology ◽  
2020 ◽  
Vol 30 (Suppl 1) ◽  
Author(s):  
João Bueno Vitor Peixoto ◽  
Joaquim Teodoro Araújo ◽  
Simone Elias ◽  
Afonso Celso Pinto Nazário ◽  
Gil Facina
Keyword(s):  
Breast Cancer ◽  
Family History ◽  
Medical Records ◽  
Dropout Rate ◽  
Sao Paulo ◽  
São Paulo ◽  
History Of ◽  
Epidemiological Profile ◽  
Epidemiological Characteristics

Introduction: Breasts represent an important site for the development of diseases. It is known that 80% of the palpable masses of the breast are of benign origin. Benign breast diseases range from inflammatory to neoplastic processes. Objectives: to evaluate the clinical and epidemiological characteristics of patients diagnosed with benign breast tumor at the Mastology outpatient clinic of the Universidade Federal de São Paulo (UNIFESP). Methods: 1,532 medical records, available on the electronic platform PEP-HUHSP through the ICD D24 (benign breast cancer) and N63 (unspecified breast nodule), of patients referred to the service between July 2008 and July 2017 were reviewed. After applying exclusion criteria, 403 medical records were submitted to data collection and tabulation in Excel, followed by statistical analysis using the IBM SPSS Statistics 23 software. The study in question was approved by the Research Ethics Committee of UNIFESP (CEP UNIFESP), in the Teaching and Research Coordination of Hospital São Paulo – Hospital Universitário/UNIFESP (CoEP of HSP-HU/UNIFESP) and exempted from the application of the Informed Consent by the same organs. Results: In the 9-year period, the following results were obtained: mean age was 39.3 years. Comorbidities: smoking (16.4%), SAH (16.8%) and dyslipidemia (6.3%). Family history of breast and/or ovarian cancer accounted for 16.6%. Mean age of menarche and menopause, respectively, were 12.7 and 42.5 years. Causes of referral: "alteration in image examination" (38.3%), "lump in the breast" (33.3%), "follow-up due to previous nodules" (16.5%). Anatomopathological report: fibroadenoma (41%), breast cysts (16%), phylloid tumors (3%), and papilloma (1%). Mean number of consultations per patient until discharge or abandonment of follow-up: three. Choice behavior: expectant (85.2%). Conclusion: The epidemiological profile of patients referred to the UNIFESP tertiary mastology service was mainly composed of women of childbearing age and nulliparous women, whose main comorbidities were smoking and SAH, in the great majority with no family history of breast cancer. Regarding the consultation, the main reason for referral is the findings on imaging exams, and, specially, patients would bring their breast USG along, which surpassed mammography by 34.1%. The choice for biopsy was restricted, present in approximately 1/3 of the cases, but pointed out that the most prevalent nodule is fibroadenoma, followed by phylloid and papilloma tumors. Nevertheless, there was a predilection for expectant conduct. On average, there were regular follow-ups for 1.5 years, followed by a significant dropout rate.

Hereditary breast cancer associated with the CHEK2 gene: Study through NGS in a Spanish cohort.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e22502-e22502
Author(s):  
Natalia Alonso Marin ◽  
Maitane Ocáriz ◽  
Marta Gascon Ruiz ◽  
Andrea Sesma Goñi ◽  
Maria Zurera Berjaga ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Family History ◽  
Genetic Variants ◽  
Missense Variant ◽  
Develop Breast Cancer ◽  
University Hospital ◽  
Chek2 Gene ◽  
Increased Risk ◽  
Study Results ◽  
History Of

e22502 Background: Inherited mutations in the CHEK2 gene have been associated with an increased lifetimerisk of develop breast cancer (BC). The main objective of the study is to identify in our population the prevalence of mutations in the CHEK2 gene in diagnosed BC patients, as well as to evaluate the phenotypic characteristics of the tumour and family history. Methods: A genetic study was performed in 396 patients diagnosed of BC at the University Hospital Lozano Blesa of Zaragoza (Spain). We selected 9 patients with genetic variants in the CHEK2 gene and performed a descriptive analysis of the clinical variables, a bibliographic review of the genetic variants and a co-segregation study. Results: We identified 2 pathogenic variants ( CHEK2 c.349 A>G and c.507delT) and 6 variants of uncertain significance (VUS). The genotypic characteristics of the VUS are summarized in the table. In all cases there was a family history of BC in first and /or second degree relatives. The variant cosegregated with the disease in one of the families. Conclusions: The pathogenic missense variant c.349A>G was found in two families. This is a rare missense variant. Studies have shown that this variant had a significant impact on the protein based on in silico prediction and has been associated with BC. In our study, this variant was found in a patient with renal carcinoma and was identified in a proband with a strong family history of pancreatic and ovarian cancer (OC). However, there aren’t exist data about the risk of developing other cancer, different of BC, with this specific mutation. The other pathogenic variant detected was CHEK2 c.507delT in a family with history of BC and OC. This variant is a frameshift mutation, predicted to cause loss of normal protein function. CHEK2 507delT was reported in one of 12 BC families in one series and is possible its relation with OC. With regard to the VUS the cosegregation analysis in selected families may help understand if a variant could have played a role in developing cancer. In conclusion, CHEK2 mutations have been associated with increased risk for BC. However, the frequency of carriers may vary depending on the population, and different mutations may be associated with different cancer risks. More studies are needed to establish a complete range of risks associated with CHEK2 mutations. [Table: see text]

Family history of breast cancer and local recurrence after breast conserving therapy

1998 ◽  
Vol 34 ◽  
pp. S12
Author(s):  
C.T.M. Brekelmans ◽  
A.C. Voogd ◽  
G. Botke ◽  
A.N. van Geel ◽  
P. Rodrigus ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Family History ◽  
Local Recurrence ◽  
Breast Conserving Therapy ◽  
History Of

A Group Therapy Approach to Facilitate Integration of Risk Information for Women at Risk for Breast Cancer

1998 ◽  
Vol 43 (4) ◽  
pp. 375-380 ◽  
Author(s):  
Mary Jane Esplen ◽  
Brenda Toner ◽  
Jonathan Hunter ◽  
Gordon Glendon ◽  
Kate Butler ◽  
...  
Keyword(s):  
Breast Cancer ◽  
At Risk ◽  
Family History ◽  
Group Therapy ◽  
Perceived Risk ◽  
Positive Family History ◽  
Risk Information ◽  
Degree Relative ◽  
Therapy Approach ◽  
History Of

Objective: To describe and illustrate elements of a group counselling approach designed to enhance the communication of risk information on breast cancer (BC) to women with a family history of this disease. Breast cancer is a leading cause of female cancer death. The most important risk factor for BC is a positive family history in at least 1 first-degree relative, and approximately one-third of women with BC have a family history of the disease. Recent evidence suggests that there is a significant psychological impact associated with having a family history of BC, and this may influence the psychological adjustment and response to being counselled for personal risk. New counselling approaches are required. Method: This paper describes a group therapy approach that incorporates principles of supportive-expressive therapy designed to address the emotional impact of being at risk for BC and to promote accuracy of perceived risk. The key elements of the intervention are described along with clinical illustrations from groups that are part of an ongoing study to develop and standardize the group therapy. Conclusion: Qualitative data from the groups suggest that this model of therapy is both feasible and effective.

scholarly journals Evaluation of a surveillance programme for women with a family history of breast cancer

2009 ◽  
Vol 46 (5) ◽  
pp. 319-323 ◽  
Author(s):  
M M Reis ◽  
M Tavakoli ◽  
J Dewar ◽  
D Goudie ◽  
A Cook ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Family History ◽  
Surveillance Programme ◽  
History Of

Obtaining a Family Psychiatric History: Is it Worth the Effort?

1993 ◽  
Vol 38 (9) ◽  
pp. 590-594 ◽  
Author(s):  
Ronald A. Remick ◽  
Adele D. Sadovnick ◽  
Boris Gimbarzevsky ◽  
Raymond W. Lam ◽  
Athanasios P. Zis ◽  
...  
Keyword(s):  
Family History ◽  
Psychiatric Disorder ◽  
Mood Disorder ◽  
Mood Disorders ◽  
Medical Records ◽  
Psychiatric History ◽  
First Degree Relatives ◽  
History Of ◽  
Generated Family ◽  
Index Cases

The purpose of this study was to determine whether, for first-degree relatives of patients presenting to a mood disorders clinic, family history information on psychiatric conditions collected by a psychiatrist and incorporated into the patient's medical records is as informative as that gathered during an interview specifically designed to collect family history data. The study group consisted of 472 first-degree relatives of 78 randomly selected index cases from a large mood disorders genetic database. Family history of psychiatric disorders recorded in regular psychiatric medical records (“clinician history”), and data obtained by a genetic counsellor administering specific family psychiatric history questionnaires to patients and multiple family informants (“family history”) were compared using a kappa statistic. Good agreement between the two methods on the presence or absence of a psychiatric disorder was found among first-degree relatives of index cases, but poor agreement was found with respect to the presence or absence of a specific mood disorder diagnosis(es) in a relative. The results suggest that a clinician-generated family psychiatric history is sensitive to the presence or absence of a psychiatric disorder when compared to a more structured detailed genetic interview. However, for research purposes, a clinician-generated family psychiatric history of a specific mood disorder diagnosis, without supporting collateral information, may not be reliable for use in supporting a mood disorder diagnosis in a patient and/or his relatives.

scholarly journals Improving the management of people with a family history of breast cancer in primary care: before and after study of audit-based education

2013 ◽  
Vol 14 (1) ◽  
Author(s):  
Imran Rafi ◽  
Susmita Chowdhury ◽  
Tom Chan ◽  
Ibrahim Jubber ◽  
Mohammad Tahir ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Primary Care ◽  
Family History ◽  
Before And After ◽  
History Of ◽  
Before And After Study
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