Annual rhythm in filgrastim use in southeast Florida.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e20697-e20697
Author(s):  
Dinah Huff ◽  
William J. Hrushesky ◽  
Sharon Davis ◽  
Laura Rose Bobolts ◽  
Akhil Kumar ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Cellular Proliferation ◽  
Human Growth ◽  
Life Forms ◽  
Infectious Complications ◽  
Temporal Organization ◽  
Late Winter ◽  
Human Beings ◽  
Annual Rhythm ◽  
Bone Marrow Damage

e20697 Background: Circadian, seasonal and annual temporal organization characterizes earth-evolved life forms. Cellular proliferation in human bone marrow shares this temporal organization. Careful clinical trials have documented that bone marrow damage from a range of cytotoxic anti-cancer drugs is predictably greater and lesser when these drugs are given at specific times of day and seasons of the year to human beings with cancer. Filgrastim is a human growth factor, which is given to stimulate the production of neutrophils that have been depressed to low levels by cancer chemotherapy, in order to prevent infectious complications. We hypothesized that administration of filgrastim, stimulated by dangerously low neutrophil counts, would be initiated non-randomly with reproducible seasonality and annual rhythmicity. Methods: All claims from contracted healthplans submitted by oncologists in southeast Florida were tabulated by month of service date, during the calendar years of 2010, 2011, and 2012 (n=2,506). These numbers were de-trended, tested by linear regression, ANOVA and multi-component least squares cosine curve fitting for annual rhythmicity. Results: Similar stable annual time structures characterize filgrastim use in this population for each of these three years. An overall increasing trend (p 0.004) was present in its use during this three year span. Time of year effects were present (ANOVA p<0.058), demonstrating a prominent annual rhythm (p 0.006). The annual use pattern peaks during late winter and early spring and is lower in summer and fall. Conclusions: A large literature documents expected annual rhythmicity of cytotoxic drug bone marrow damage as reflected in circulating neutrophil count. Substantial annual rhythms characterize the clinical use of filgrastim in southeast Florida for this indication. The relative contributions of “snowbird” migration and the temporal organization of hematopoiesis remain to be fully elucidated. [Table: see text]

Hydrogen Gas Inhalation Alleviates Radiation-Induced Bone Marrow Damage in Cancer Patients

2019 ◽  
Author(s):  
Shin-ichi Hirano ◽  
Yukimasa Aoki ◽  
Ryosuke Kurokawa ◽  
Xiao-Kang Li ◽  
Naotsugu Ichimaru ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Cancer Patients ◽  
Hydrogen Gas ◽  
Bone Marrow Damage ◽  
Radiation Induced ◽  
Gas Inhalation ◽  
Hydrogen Gas Inhalation

scholarly journals Conditioning with Fludarabine-Busulfan versus Busulfan-Cyclophosphamide Is Associated with Lower aGVHD and Higher Survival but More Extensive and Long Standing Bone Marrow Damage

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Xin He ◽  
YongBin Ye ◽  
XiaoJun Xu ◽  
Jing Wang ◽  
YuXian Huang ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Cells ◽  
Conditioning Regimen ◽  
Clinical Manifestations ◽  
Major Complication ◽  
Clinical Situation ◽  
Hematopoietic Stem ◽  
T Cell Infiltration ◽  
Bone Marrow Damage ◽  
The Impact

Acute graft-versus-host disease (aGVHD) is a major complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT) and a major cause of nonrelapse mortality after allo-HSCT. A conditioning regimen plays a pivotal role in the development of aGVHD. To provide a platform for studying aGVHD and evaluating the impact of different conditioning regimens, we established a murine aGVHD model that simulates the clinical situation and can be conditioned with Busulfan-Cyclophosphamide (Bu-Cy) and Fludarabine-Busulfan (Flu-Bu). In our study, BALB/c mice were conditioned with Bu-Cy or Flu-Bu and transplanted with 2×107 bone marrow cells and 2×107 splenocytes from either allogeneic (C57BL/6) or syngeneic (BALB/c) donors. The allogeneic recipients conditioned with Bu-Cy had shorter survivals (P<0.05), more severe clinical manifestations, and higher hepatic and intestinal pathology scores, associated with increased INF-γ expression and diminished IL-4 expression in serum, compared to allogeneic recipients conditioned with Flu-Bu. Moreover, higher donor-derived T-cell infiltration and severely impaired B-cell development were seen in the bone marrow of mice, exhibiting aGVHD and conditioned with Flu-Bu. Our study showed that the conditioning regimen with Bu-Cy resulted in more severe aGVHD while the Flu-Bu regimen was associated with more extensive and long standing bone marrow damage.

scholarly journals Infectious Complications in Bone Marrow Transplant Patients

BMJ ◽  
1971 ◽  
Vol 1 (5739) ◽  
pp. 18-23 ◽  
Author(s):  
C. O. Solberg ◽  
H. J. Meuwissen ◽  
R. N. Needham ◽  
R. A. Good ◽  
J. M. Matsen
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplant ◽  
Marrow Transplant ◽  
Infectious Complications ◽  
Transplant Patients

scholarly journals Bone marrow matrix modulation of HL-60 phenotype

Blood ◽  
1987 ◽  
Vol 70 (4) ◽  
pp. 1119-1123
Author(s):  
SD Luikart ◽  
JL Sackrison ◽  
CA Maniglia
Keyword(s):  
Bone Marrow ◽  
Stromal Cell ◽  
Cellular Proliferation ◽  
Phenotypic Expression ◽  
Leukemic Cell ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Leukemic Cells ◽  
Nonspecific Esterase ◽  
Marrow Stroma

The initiation and maintenance of cellular differentiation for a variety of cell types has been shown to be influenced by the microenvironment. To investigate the influence of bone marrow stroma on leukemic cell differentiation, HL-60 human promyelocytic leukemia cells were grown in the presence of Triton-treated extracellular matrix derived from normal human bone marrow stromal cells. This bone marrow matrix microenvironment had a dramatic impact on the phenotypic expression of this malignant line. HL-60 cellular proliferation, morphology, nonspecific esterase activity, formation of Fc rosettes, and sensitivity to induction by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) were all influenced by the presence of matrix molecules. In contrast, stromal cell-conditioned media did not alter HL-60 phenotype. Thus, HL-60 cells appear to retain responsiveness to a human bone marrow stromal cell-derived matrix despite their ability to grow autonomously. Studies of the interaction of leukemic cells and marrow stroma in vitro may provide important information concerning the regulation of leukemic cell behavior.

scholarly journals Ecologicala Spectsin Relation to Digenean Trematodeparasites in Fresh Water Fish Channa Striatus (BLOCH)

2021 ◽  
Vol 7 (09) ◽  
pp. 119-129
Author(s):  
Singh Prashant and Mishra D. B
Keyword(s):  
Research Work ◽  
Life Forms ◽  
Water Sources ◽  
Considerable Change ◽  
Fresh Water Fish ◽  
Human Beings ◽  
Infection Level ◽  
Fish Food ◽  
Food Borne ◽  
Different Water Sources

Fishes are found adequately in the different water sources of Jaunpur India. Five rivers (Gomti, Sai,Varuna,Pili and Basuhi) ,Gujar tal and different pond are available here as a aquatic habitat. In research work author consider only two sites of river Gomti and two different ponds in district Jaunpur, U.P. They are external as well as internal .In this studyauthor focused on digenetic trematodes parasites. Digenean trematodes are completing their life cycle in two hosts so both are susceptible to the infection. There are considerable change occur in the environment wih the passage of time. We also know that environmental factors affect the life forms of any place. So it is important to study the different ecological terms in relation to the host and their infectious agents. From ancient time humans beings use large amount of fish food for survival because they are easily available from different water sources. When human beings eat unadequate cooked fish then suffered with food borne tremadiases.So it is important to know the infection level in the fishes.

scholarly journals COVID-19 in the International Year of Plant Health

2022 ◽  
Vol 39 (4) ◽  
Author(s):  
José Jorge Gutiérrez-Samperio
Keyword(s):  
Life Forms ◽  
Plant Health ◽  
World Health ◽  
Human Beings ◽  
Pests And Diseases ◽  
The Bible ◽  
United Nations General ◽  
The World ◽  
The Face ◽  
Health Organization

<p>Pests, in their broad sense, have played an important part in the history of humankind. We could say that humans, crops and pests have walked together through life. Codices, glyphs, paintings and countless ancient documents, including the Bible and the Koran, bear witness to this. Humanity has been attacked by its own diseases, but also by those that limit them from obtaining food and deteriorate the environment. COVID-19, which is now troubling us and was declared a pandemic by the World Health Organization in March of 2020, became a part of the list of experiences we have suffered in the past, with pests or epidemics that caused millions of deaths by diseases or famines. It is paradoxical that this health contingency occurs when the United Nations General Assembly, on December 20th, 2018, in its resolution A/RES/73/252 decides to declare 2020 the International Year of Plant Health in order to “highlight the importance of plant health to improve food security, protect the environment and biodiversity and boost economic development” according to the pronouncement by the FAO. For the first time, in an era with great technological and scientific breakthroughs, humanity was aware of its vulnerability against the inevitable evolution of life forms in the face of dilemmas global impact caused by human beings. Thus, the pest or parasite makes its own declaration of existential preeminence through SARS-CoV-2 to remind us that the health of humans or plants is the essence of life and its continuity. But perhaps absolute health is not enough. It is necessary to find a balance in a world overwhelmed by giving so much in return for almost nothing to everyone living on it. If the sensor of our anthropocentric intervention of the world is climate change, then biological chaos is a masterpiece. The reemergence of pests and diseases considered eradicated, or those of zoonotic origin that had never accompanied our existence is a surreal dystopia that we will never be able to deny again.</p>

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