Interobserver correlation of morphometric data obtained from routine preoperative abdominal CT scans in pancreatic surgery.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e20714-e20714
Author(s):  
Tiffani Dawn Shelton ◽  
Jan Franko ◽  
Charles David Goldman ◽  
Shawna Grimm

e20714 Background: Quantification of frailty is necessary for estimation of therapy tolerance. Sarcopenia is a recognized measure of frailty and predicts long-term survival in both non-surgical and surgical cohorts. Here we set to evaluate interobserver agreement for certain sarcopenia parameters on routine abdominal CT scans among patients undergoing Whipple procedure for suspicion of neoplasm. Methods: Two observers using a standardized protocol for measurements of linear and surface morphometric parameters independently reviewed thirty abdominal CT scans. Results: Mean morphometric data for the entire group were: total psoas area 2237±868 mm2, mean psoas muscle density 46±9 HU, mean psoas antero-posterior diameter 40±8mm, mean psoas latero-lateral diameter 36±8 mm, mean rectus muscle thickness 9.2±2.6 mm, mean distance between anterior vertebral L4 surface and linea alba 115±28 mm (L4-alba distance), mean subcutaneous fat thickness 23.7 ±11.5mm, mean L4 vertebra antero-posterior diameter 37.6±5.2 mm. Excellent inter-observer correlation was observed for total psoas area is R2=0.788, p<0.001. Similarly good correlation was detected between observers for rectus muscle thickness (R2=0.6019, p<0.001), subcutaneous fat thickness (R2=0.731, p<0.001), and L4-alba distance (R2=0.601, p<0.001). Poor correlation was observed for L4 diameter (R2=0.392,p=0.0014). No interobserver correlation was observed for psoas muscle density (R2=0.005, p=0.743). Conclusions: Excellent degree of interobserver correlation was observed for the following morphometric data obtained from abdominal CT scans: Total psoas muscle area, L4-alba distance, rectus muscle and subcutaneous fat thickness. Further studies are needed to evaluate utility of morphometric parameters for prediction of surgical outcomes.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e17599-e17599
Author(s):  
Shawna Grimm ◽  
Tiffani Dawn Shelton ◽  
Charles David Goldman ◽  
Jan Franko

e17599 Background: Patient frailty is imparative to surgical planning, post-operative morbidity and mortality, and ultimately the ability to undergo adjuvant therapy in cancer treatment. Sarcopenia has been correlated with long term survival in the setting of pancreatic resection for cancer. However, it has not been evaluated in the early post-operative setting. Here, we evaluate the prognostic value of morphometric parameters measured on abdominal CT scans in fifty patients undergoing pancreatic resections and comparing with postoperative complications. Methods: Post-operative complications of fifty patients who underwent pancreatic resection for suspected neoplasm were graded via Clavien Dindo classification and then correlated with standardized morphometric measurements from CT scans. Results: Thirty-two men and 18 women (age 63±13 years) underwent pancreatic resection for cancer. Total psoas muscle area (2555±791 vs 1821±805,p=0.008), L4-alba distance (113±29 vs 119±27,p=0.597), rectus muscle (10.1±2.5 vs 7.8±4.5,p=0.016) and SQ fat thickness (20±11 vs 29±10,p=0.024). Logistic regression modeling including age, gender, and total psoas area predicted complication occurance (pseudo R2=0.350, p=0.008) and their number (pseudo R2=0.191,p=0.002), but not grade 3 and higher complications (pseudo R2=0.68,p=0.451) or pancreatic leak (pseudo R2=0.020,p=0.873). Similar results were obtained when age and gender variables were combined with rectus muscle thickness (pseudo R2=0.422), L4-alba distance (pseudo R2=0.377), and SQ fat thickness (pseudo R2=0.392). In each case, > Grade 3 complications and pancreatic leak was not predicted with morphometric data, age and gender. Conclusions: There are significant age and gender-related differences in morphometric data obtained from abdominal CT scans. Prognostic models provide statistically significant prediction of complication occurrence, but explain only up to 42% of variability in complication occurrence. Moreover, clinically important complications (grade 3 and higher) and pancreatic leak was not predicted with this model based on our limited dataset.


2014 ◽  
Author(s):  
Ozen Oz Gul ◽  
Murat Pekgoz ◽  
Sumeyye Gullulu ◽  
Soner Cander ◽  
Ahmet Tutuncu ◽  
...  

1988 ◽  
Vol 59 (4) ◽  
pp. 335-343
Author(s):  
Yoshitaka NAGAMINE ◽  
Takashi HAYASHI ◽  
Hiroshi SATO ◽  
Akira NISHIDA ◽  
Shigeki KOMATSU

2021 ◽  
pp. 104694
Author(s):  
Francisco Fernandes Junior ◽  
Amanda de Freitas Pena ◽  
Fernando Augusto Grandis ◽  
Natalia Albieri Koritiaki ◽  
Fabíola Cristine de Almeida Rego ◽  
...  

2012 ◽  
Vol 41 (6) ◽  
pp. 1426-1432 ◽  
Author(s):  
Tiago Roque Pinheiro ◽  
Maria Eugênia Zerlotti Mercadante ◽  
Lucia Galvão de Albuquerque ◽  
Sarah Figueiredo Martins Bonilha ◽  
Fábio Morato Monteiro

1992 ◽  
Vol 72 (4) ◽  
pp. 1589-1594 ◽  
Author(s):  
J. Smolander ◽  
O. Bar-Or ◽  
O. Korhonen ◽  
J. Ilmarinen

Eight minimally dressed pre- and early pubescent boys (age 11–12 yr) and 11 young adult men (age 19–34 yr) rested for 20 min and exercised on a cycle ergometer for 40 min at approximately 30% of their maximum oxygen consumption (VO2max) at 5 degrees C. To quantify the added increase in metabolic rate because of cold, a separate test was carried out at 21 degrees C at rest and at equal work rates as in the cold. Both groups were similar in subcutaneous fat thickness and VO2max per kilogram body weight. Rectal temperature increased slightly during the exposure to the cold, but no significant difference was observed between the boys and men. In the cold, the boys had lower skin temperatures than the adults in their extremities but not in the trunk. The boys increased their metabolic rates in the cold more than did the men. As a result, the boys maintained their core temperature as effectively as the adults. Similar age-related differences in thermoregulatory responses to cold were observed when two boys and two men with equal body sizes were compared. Our results suggest that there may be maturation-related differences in thermoregulation in the cold between children and adults.


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