scholarly journals Comprehensive Audiometric Analysis of Hearing Impairment and Tinnitus After Cisplatin-Based Chemotherapy in Survivors of Adult-Onset Cancer

2016 ◽  
Vol 34 (23) ◽  
pp. 2712-2720 ◽  
Author(s):  
Robert D. Frisina ◽  
Heather E. Wheeler ◽  
Sophie D. Fossa ◽  
Sarah L. Kerns ◽  
Chunkit Fung ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Middle Ear ◽  
Odds Ratio ◽  
Noise Exposure ◽  
Geometric Mean ◽  
Hearing Threshold ◽  
Adult Onset ◽  
Hearing Status ◽  
Hearing Thresholds ◽  
Loss Severity

Purpose Cisplatin is widely used but highly ototoxic. Effects of cumulative cisplatin dose on hearing loss have not been comprehensively evaluated in survivors of adult-onset cancer. Patients and Methods Comprehensive audiological measures were conducted on 488 North American male germ cell tumor (GCT) survivors in relation to cumulative cisplatin dose, including audiograms (0.25 to 12 kHz), tests of middle ear function, and tinnitus. American Speech-Language-Hearing Association criteria defined hearing loss severity. The geometric mean of hearing thresholds (0.25 to 12 kHz) summarized overall hearing status consistent with audiometric guidelines. Patients were sorted into quartiles of hearing thresholds of age- and sex-matched controls. Results Increasing cumulative cisplatin dose (median, 400 mg/m2; range, 200 to 800 mg/m2) was significantly related to hearing loss at 4, 6, 8, 10, and 12 kHz (P trends, .021 to < .001): every 100 mg/m2 increase resulted in a 3.2-dB impairment in age-adjusted overall hearing threshold (4 to 12 kHz; P < .001). Cumulative cisplatin doses > 300 mg/m2 were associated with greater American Speech-Language-Hearing Association–defined hearing loss severity (odds ratio, 1.59; P = .0066) and worse normative-matched quartiles (odds ratio, 1.33; P = .093) compared with smaller doses. Almost one in five (18%) patients had severe to profound hearing loss. Tinnitus (40% patients) was significantly correlated with reduced hearing at each frequency (P < .001). Noise-induced damage (10% patients) was unaffected by cisplatin dose (P = .59). Hypertension was significantly related (P = .0066) to overall hearing threshold (4 to 12 kHz) in age- and cisplatin dose–adjusted analyses. Middle ear deficits occurred in 22.3% of patients but, as expected, were not related to cytotoxic drug dosage. Conclusion Follow-up of adult-onset cancer survivors given cisplatin should include routine inquiry for hearing status and tinnitus, referral to audiologists as clinically indicated, and hypertension control. Patients should be urged to avoid noise exposure, ototoxic drugs, and other factors that further damage hearing.

Hearing loss as a predictor for hearing protection attenuation among miners

2021 ◽  
pp. oemed-2020-106838
Author(s):  
Elon D Ullman ◽  
Lauren M Smith ◽  
Marjorie C McCullagh ◽  
Richard L Neitzel
Keyword(s):  
Hearing Loss ◽  
Noise Exposure ◽  
Hearing Threshold ◽  
Weighted Average ◽  
Hearing Protection ◽  
Mining Sites ◽  
Speech In Noise ◽  
Midwestern Usa ◽  
Hearing Thresholds ◽  
Fit Testing

ObjectiveThis study investigated risk factors for poor earplug fit, with a focus on the association between hearing loss and personal attenuation ratings (PARs).MethodsEarplug fit was assessed by obtaining PARs using a real ear at attenuation threshold (REAT) system. Hearing loss was assessed using the unoccluded hearing thresholds measured during the REAT testing and the results of a speech-in-noise test. Potential predictors of PARs were modelled using both simple and multiple linear regression. Hearing loss was the primary predictor of interest.ResultsData were collected from 200 workers at ten above-ground mining sites in the Midwestern USA. Workers reported wearing their hearing protection on average 73.9% of the time in a high noise environment (mean 8-hour time-weighted average noise exposure 85.5 dBA, range 65–103 dBA). One-quarter (26.7%) of workers were found to have a hearing loss (hearing threshold ≥25 dB across 1–4 kHz), and 42% reported symptoms of tinnitus. Workers with a hearing loss had a significantly lower PAR than those without a hearing loss (β=−5.1, SE=1.7).ConclusionsThe results of the adjusted regression models suggest that workers with hearing loss achieved significantly lower PARs than those without hearing loss. This association between hearing loss and hearing protection devices (HPD) fit brings into focus the potential benefit of fit checks to be included in hearing conservation programmes. Workers found to have hearing loss should be prioritised for fit testing, as their hearing impairment may be associated with poor HPD fit.

Hearing threshold shifts among military pilots of the Israeli Air Force

2017 ◽  
Vol 164 (1) ◽  
pp. 46-51 ◽  
Author(s):  
Liyona Kampel-Furman ◽  
Z Joachims ◽  
H Bar-Cohen ◽  
A Grossman ◽  
Y Frenkel-Nir ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Air Force ◽  
Military Service ◽  
Noise Exposure ◽  
Cohort Analysis ◽  
Mean Shift ◽  
Hearing Threshold ◽  
Hearing Thresholds ◽  
Significant Difference ◽  
Potential Risk Factors

BackgroundMilitary aviators are potentially at risk for developing noise-induced hearing loss. Whether ambient aircraft noise exposure causes hearing deficit beyond the changes attributed to natural ageing is debated. The aim of this research was to assess changes in hearing thresholds of Israeli Air Force (IAF) pilots over 20 years of military service and identify potential risk factors for hearing loss.MethodsA retrospective cohort analysis was conducted of pure-tone air conduction audiograms of pilots, from their recruitment at 18 years of age until the last documented medical check-up. Mean hearing thresholds were analysed in relation to age, total flight hours and aircraft platform. Comparisons were made to the hearing thresholds of air traffic controllers (ATCs) who were not exposed to the noise generated by aircraft while on duty.ResultsOne hundred and sixty-three pilots were included, with flying platforms ranging from fighter jets (n=54), combat helicopters (n=27), transport helicopters (n=52) and transport aircraft (n=30). These were compared with the results from 17 ATCs. A marked notch in the frequency range of 4–6 kHz was demonstrated in the mean audiograms of all platforms pilots, progressing with ageing. Hearing threshold shifts in relation to measurements at recruitment were first noted at the age of 30 years, particularly at 4 kHz (mean shift of 2.97 dB, p=0.001). There was no statistical association between flying variables and hearing thresholds adjusted for age by logistic regression analysis.ConclusionsThe audiometric profile of IAF pilots has a pattern compatible with noise exposure, as reflected by characteristic noise notch. However, no flight variable was associated with deterioration of hearing thresholds, and no significant difference from non-flying controls (ATCs) was seen.

scholarly journals Audiological analysis in military police officers with exposure to occupational noise in motorized patrol activity

2018 ◽  
Vol 2 (1) ◽  
pp. 38-45
Author(s):  
K.C.S. De Lima ◽  
L.B. Da Silva ◽  
V.S.B. Gonçalves ◽  
E.L. De Souza ◽  
J.G.B. Fernandes
Keyword(s):  
Hearing Loss ◽  
Service Time ◽  
Police Officers ◽  
Noise Exposure ◽  
Hearing Threshold ◽  
Occupational Noise ◽  
Military Police ◽  
Hearing Thresholds ◽  
Personal Dosimeter ◽  
Selection Of

The aim of this article is to present the results of audiological findings from a selection of military police officers with exposure to occupational noise, in the motorized patrol activity, in João Pessoa city. The data collected from the motorcycle police sample were compared with the ISO 1999: 2013 Standard. The research was performed in 46 police officers, whose mean age was 32.7 years old and a mean service time of 10.5 years. For the subjects’ selection and inclusion in the study, interviews were conducted, in addition to questionnaires, ontological examination, audiometric tests and the respective noise level measurements performed by a personal dosimeter, according to ISO 9612:2009 Standard recommendations. Findings from questionnaires showed that 51% of the police officers reported to have some type of hearing complaints; through audiometric tests, 36.1% of the cases suggested hearing loss. The most significant hearing threshold change occur in the range from 3000Hz and 4000Hz. Hearing thresholds shifts suggest the occurrence of some Noise Induced Hearing Loss (NIHL) level in motorcycle police officers who are over 30 years and 10 years of service. Besides, compared with the data from ISO 1999:2013 standard, there is a decrease in the auditory level of these professionals after three years on service, and a noise exposure of Lex, 8h = 96.9 dB(A).

Vocal Performance Teachers and Hearing Loss

2015 ◽  
Vol 16 (1) ◽  
pp. 15-24
Author(s):  
Vance Gunnell ◽  
Jeff Larsen
Keyword(s):  
Hearing Loss ◽  
Otoacoustic Emissions ◽  
Noise Exposure ◽  
Vocal Performance ◽  
Occupational Noise ◽  
Hearing Conservation ◽  
Occupational Noise Exposure ◽  
Distortion Product ◽  
Hearing Thresholds ◽  
Performance Teachers

Hearing thresholds and distortion product otoacoustic emissions were measured for teachers of vocal performance who were gathered for a national conference. Results showed mean audiometric thresholds to be consistent with noise induced hearing loss, more than what would be expected with normal aging. Years of instruction and age were considered as factors in the hearing loss observed. It was concluded that hearing conservation should be initiated with this group to help raise awareness and protect them from hearing loss due to occupational noise exposure.

scholarly journals Monitoring of the auditory pathway maturation after early intervention during the first year of life in infants with sensorineural hearing loss

2020 ◽  
Author(s):  
F. Matin ◽  
S. Haumann ◽  
W. Roßberg ◽  
D. Mitovska ◽  
T. Lenarz ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Early Intervention ◽  
Hearing Aids ◽  
Hearing Threshold ◽  
Auditory Pathway ◽  
Auditory Brainstem Responses ◽  
First Year ◽  
Early Therapy ◽  
Hearing Thresholds ◽  
First Year Of Life

Abstract Purpose The objective of this study was to investigate the auditory pathway maturation monitored by auditory brainstem responses (ABR) in infants with hearing loss during the first year of life. ABR were used to estimate hearing thresholds and the effect of early intervention strategies using hearing aids (HA). Methods Click-evoked ABRs were measured in 102 infants aged from 0 to 12 months to determine their individual auditory threshold. Early therapy intervention was recommended before 12 months of age and analyzed. To evaluate the effect of hearing amplification on auditory maturation, different subgroups of infants with moderate hearing loss were analyzed and the auditory pathway maturation was determined based on IPL I–V shortening. Results Overall, 110 ears (54.0% of 204 ears) with mild to profound HL showed threshold changes of 10 dB up to 60 dB in the follow-up ABR testing. HA were prescribed at the age of 3.8 ± 3.9 months. Cochlear implantation (CI) was performed in cases of repeated profound HL at the age of 9.9 months ± 4.5 months. A significant shortening of IPL I–V in all subgroups of infants (with and without risk factors) who received HA was shown and assumed auditory pathway maturation. Conclusion An early intervention using optimally fitted HA influenced auditory pathway maturation and may lead to improvements of hearing thresholds during the first year of life in infants. This study underscores the importance of not only providing HAs to infants, but also controlling for hearing threshold changes ensuring that HAs provide the optimal level of intervention or CI is indicated.

Field Monitoring of Otoacoustic Emissions During Noise Exposure: Pilot Study in Controlled Environment

2017 ◽  
Vol 26 (3S) ◽  
pp. 352-368 ◽  
Author(s):  
Vincent Nadon ◽  
Annelies Bockstael ◽  
Dick Botteldooren ◽  
Jérémie Voix
Keyword(s):  
Hearing Loss ◽  
Pilot Study ◽  
Otoacoustic Emissions ◽  
Ambient Noise ◽  
Noise Exposure ◽  
High Temporal Resolution ◽  
Noise Induced Hearing Loss ◽  
Conservation Programs ◽  
Hearing Conservation ◽  
Hearing Status

Purpose In spite of all the efforts to implement workplace hearing conservation programs, noise-induced hearing loss remains the leading cause of disability for North American workers. Nonetheless, an individual's susceptibility to noise-induced hearing loss can be estimated by monitoring changes in hearing status in relation to the level of ambient noise exposure. The purpose of this study was to validate an approach that could improve workplace hearing conservation practices. The approach was developed using a portable and robust system designed for noisy environments and consisted of taking continuous measurements with high temporal resolution of the health status of the inner ear using otoacoustic emissions (OAEs). Method A pilot study was conducted in a laboratory, exposing human subjects to industrial noise recordings at realistic levels. In parallel, OAEs were measured periodically using the designed OAE system as well as with a commercially available OAE system, used as a reference. Results Variations in OAE levels were analyzed and discussed along with the limitations of the reference and designed systems. Conclusions This study demonstrates that the monitoring of an individual's OAEs could be useful in monitoring temporary changes in hearing status induced by exposure to ambient noise and could be considered as a new tool for effective hearing conservation programs in the workplace.

scholarly journals Partial Hearing Restoration after ERBB2 Induction in Deafened Adult Mice

2019 ◽  
Author(s):  
Jingyuan Zhang ◽  
Daxiang Na ◽  
Miriam Dilts ◽  
Kenneth S. Henry ◽  
Patricia M. White
Keyword(s):  
Cell Proliferation ◽  
Hearing Loss ◽  
Noise Exposure ◽  
Supporting Cell ◽  
Supporting Cells ◽  
Adult Mice ◽  
Hearing Thresholds ◽  
Brainstem Response ◽  
Noise Damage ◽  
Cochlear Supporting Cells

AbstractNoise induced hearing loss (NIHL) affects over ten million adults in the United States, and there is no biological treatment to restore endogenous function after damage. We hypothesized that activation of signaling from ERBB2 receptors in cochlear supporting cells could mitigate NIHL damage. We used the Tet-On genetic expression system to drive a constitutively active variant of ERBB2 (CA-ERBB2) in cochlear supporting cells three days after permanent noise damage in young adult mice. Hearing thresholds were assessed with auditory brainstem response tests prior to noise damage, and hearing recovery was assessed over a three month period. We evaluated supporting cell proliferation, inner and outer hair cell (IHC and OHC) survival, synaptic preservation, and IHC cytoskeletal alterations with histological techniques. Mice harboring CA-ERBB2 capability had similar hearing thresholds to control littermates prior to and immediately after noise exposure, and incurred similar levels of permanent hearing loss. Two and three months after noise exposure, CA-ERBB2+ mice demonstrated a partial but significant reversal of NIHL threshold shifts at the lowest frequency tested, out of five frequencies (n=19 total mice, p=0.0015, ANOVA). We also observed improved IHC and OHC survival (n=7 total cochleae, p=5 × 10−5, Kruskal-Wallis rank sum test). There was no evidence for sustained supporting cell proliferation. Some mortality was associated with doxycycline and furosemide treatments to induce the Tet-ON system. These data suggest that ERBB2 signaling in supporting cells promotes HC repair and some functional recovery. Funded by NIH R01 DC014261, and grants from the Schmitt Foundation and UR Ventures.

Evaluation of Hearing Thresholds by Using a Mobile Application in Children with Otitis Media with Effusion

2020 ◽  
Vol 25 (3) ◽  
pp. 120-124 ◽  
Author(s):  
Osman Durgut ◽  
Buse Ekim ◽  
Oğuzhan Dikici ◽  
Fevzi Solmaz ◽  
Betül Ağırgöl ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Mobile Phone ◽  
Otitis Media ◽  
Mobile Application ◽  
Otitis Media With Effusion ◽  
Hearing Threshold ◽  
School Age Children ◽  
Mobile Phone Application ◽  
Hearing Thresholds ◽  
Speech And Language Development

Objective: Otitis media with effusion (OME) is the most common cause of hearing loss in children. Early diagnosis is important as hearing loss affects speech and language development in children. The aim of this study was to compare conventional audiometry with the Android mobile operating system application Hearing TestTM in the evaluation of hearing thresholds in children with OME and to determine the accuracy and reliability of the mobile application. Design and Study Sample: Fifty school-age children aged between 5 and 15 years with OME in at least 1 ear were included in the study. First, hearing thresholds were obtained by conventional audiometric methods and the degree of hearing loss was determined. Then, the hearing thresholds of the patients were measured using the smartphone-based Hearing TestTM application. The data were compared using Cohen’s kappa analysis. Results: OME was detected in 88 ears. There was no statistically significant correlation between the hearing threshold results obtained with the mobile phone and conventional audiometry at 500, 1,000, 2,000, and 4,000 Hz. Conclusion: The Android mobile phone application Hearing TestTM (version 1.1.3) is not an appropriate screening test to detect hearing loss in children with OME.

Hearing loss associated with weapons noise exposure: when to investigate an asymmetrical loss

1995 ◽  
Vol 109 (4) ◽  
pp. 291-295 ◽  
Author(s):  
H. J. Cox ◽  
G. R. Ford
Keyword(s):  
Hearing Loss ◽  
Noise Exposure ◽  
Hearing Threshold ◽  
Routine Testing ◽  
Threshold Levels ◽  
Average Loss ◽  
The Right ◽  
Air Conduction ◽  
Selection Of

AbstractThe air conduction thresholds in the right and left ears, and the interaural asymmetry of thresholds at 0.5, 1, 2, 3, 4 and 6 kHz were measured in a group of 225 soldiers exposed to a variety of weapon noise who were referred for assessment because of a deterioration in hearing on routine testing. At 0.5 and I kHz the threshold levels rarely exceeded 25 dB and the interaural asymmetry was 10 dB or less in 90 per cent of cases. The degree of hearing loss and interaural asymmetry increased as the frequency increased, with the average loss being significantly greater in the left ear at 2, 3, 4 and 6 kHz.Recommendations are made for the selection of cases of asymmetrical hearing loss exposed to weapon noise which require further investigation to exclude a retrocochlear cause or to define spurious hearing threshold levels.

Academic, behavioural and quality of life outcomes of slight to mild hearing loss in late childhood: a population-based study

2019 ◽  
Vol 104 (11) ◽  
pp. 1056-1063 ◽  
Author(s):  
Jing Wang ◽  
Jon Quach ◽  
Valerie Sung ◽  
Peter Carew ◽  
Ben Edwards ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Hearing Loss ◽  
Child Outcomes ◽  
Hearing Threshold ◽  
Population Based ◽  
Life Outcomes ◽  
Quality Of Life Outcomes ◽  
Hearing Thresholds ◽  
Mild Hearing Loss

ObjectiveTo investigate the associations of hearing thresholds and slight to mild hearing loss with academic, behavioural and quality of life outcomes in children at a population level.MethodsDesign and participants:children aged 11–12 years in the population-based cross-sectional Child Health CheckPoint study within the Longitudinal Study of Australian Children. Audiometry:mean hearing threshold across 1, 2 and 4 kHz (better and worse ear); slight/mild hearing loss (threshold of 16–40 decibels hearing loss (dB HL)). Outcomes: National Assessment Program – Literacy and Numeracy, language, teacher-reported learning, parent and teacher reported behaviour and self-reported quality of life. Analysis:linear regression quantified associations of hearing threshold/loss with outcomes.ResultsOf 1483 children (mean age 11.5 years), 9.2% and 13.1% had slight/mild bilateral and unilateral hearing loss, respectively. Per SD increment in better ear threshold (5.7 dB HL), scores were worse on several academic outcomes (eg, reading 0.11 SD, 95% CI 0.05 to 0.16), parent-reported behaviour (0.06 SD, 95% CI 0.01 to 0.11) and physical (0.09 SD, 95% CI 0.04 to 0.14) and psychosocial (0.06 SD, 95% CI 0.01 to 0.11) Pediatric Quality of Life Inventory (PedsQL). Compared with normally hearing children, children with bilateral slight/mild losses scored 0.2–0.3 SDs lower in sentence repetition, teacher-reported learning and physical PedsQL but not other outcomes. Similar but attenuated patterns were seen in unilateral slight/mild losses.ConclusionsHearing thresholds and slight/mild hearing loss showed small but important associations with some child outcomes at 11–12 years. Justifying hearing screening or intervention at this age would require better understanding of its longitudinal and indirect effects, alongside effective management and appropriate early identification programmes.

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