Association of low serum albumin concentration with reduced overall survival for patients with metastatic head and neck cancer receiving anti-programmed death receptor-1 therapy.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. 6057-6057
Author(s):  
Sara Kochanny ◽  
Corey Christian Foster ◽  
Arun Khattri ◽  
Rajesh Acharya ◽  
Allison Dekker ◽  
...  
Keyword(s):  
Overall Survival ◽  
Head And Neck Cancer ◽  
Serum Albumin ◽  
Head And Neck ◽  
Neck Cancer ◽  
Death Receptor ◽  
Albumin Concentration ◽  
Serum Albumin Concentration ◽  
Programmed Death ◽  
Low Serum

Relationship Between Serum Albumin Concentration and Periodontal Condition in Patients With Head and Neck Cancer

2012 ◽  
Vol 83 (9) ◽  
pp. 1110-1115 ◽  
Author(s):  
Takayuki Maruyama ◽  
Reiko Yamanaka ◽  
Aya Yokoi ◽  
Daisuke Ekuni ◽  
Takaaki Tomofuji ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Serum Albumin ◽  
Head And Neck ◽  
Neck Cancer ◽  
Albumin Concentration ◽  
Serum Albumin Concentration ◽  
Periodontal Condition

scholarly journals Bioelectrical impedance phase angle as a prognostic indicator of survival in head-and-neck cancer

2016 ◽  
Vol 23 (5) ◽  
pp. 481 ◽  
Author(s):  
M.S. Wladysiuk ◽  
R. Mlak ◽  
K. Morshed ◽  
W. Surtel ◽  
A. Brzozowska ◽  
...  
Keyword(s):  
Overall Survival ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Phase Angle ◽  
Neck Cancer ◽  
Bioelectrical Impedance ◽  
Impedance Analysis ◽  
Neck Surgery ◽  
Department Head ◽  
Nutrition Status

Background Phase angle could be an alternative to subjective global assessment for the assessment of nutrition status in patients with head-and-neck cancer.Methods We prospectively evaluated a cohort of 75 stage iiib and iv head-and-neck patients treated at the Otolaryngology Department, Head and Neck Surgery, Medical University of Lublin, Poland. Bioelectrical impedance analysis was performed in all patients using an analyzer that operated at 50 kHz. The phase angle was calculated as reactance divided by resistance (Xc/R) and expressed in degrees. The Kaplan–Meier method was used to calculate survival.Results Median overall survival in the cohort was 32.0 months. At the time of analysis, 47 deaths had been recorded in the cohort (62.7%). The risk of shortened overall survival was significantly higher in patients whose phase angle was less than 4.733 degrees than in the remaining patients (19.6 months vs. 45 months, p = 0.0489; chi-square: 3.88; hazard ratio: 1.8856; 95% confidence interval: 1.0031 to 3.5446).Conclusions Phase angle might be prognostic of survival in patients with advanced head-and-neck cancer. Further investigation in a larger population is required to confirm our results.

scholarly journals Tumor cells with low proteasome subunit expression predict overall survival in head and neck cancer patients

BMC Cancer ◽  
2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Chann Lagadec ◽  
Erina Vlashi ◽  
Sunita Bhuta ◽  
Chi Lai ◽  
Paul Mischel ◽  
...  
Keyword(s):  
Overall Survival ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Neck Cancer ◽  
Proteasome Subunit ◽  
Subunit Expression

Compliance and Outcomes in Locally Advanced Head and Neck Cancer Patients Treated with Alternating Chemoradiotherapy in Clinical Practice

2003 ◽  
Vol 89 (1) ◽  
pp. 20-25 ◽  
Author(s):  
Vittorio Franciosi ◽  
Marco Fumagalli ◽  
Luciana Biscari ◽  
Roberto Martinelli ◽  
Teore Ferri ◽  
...  
Keyword(s):  
Overall Survival ◽  
Head And Neck Cancer ◽  
Clinical Practice ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Locally Advanced ◽  
Hematologic Toxicity ◽  
Advanced Head ◽  
Grade 3

Background and Aims To evaluate the feasibility in clinical practice of alternating chemo-radiotherapy in locally advanced head and neck cancer patients. Patients and Methods From August 1993 to April 1998 at the Division of Medical Oncology of Parma, 48 consecutive patients were observed, and 38 (79%) started the Merlano chemo-radiotherapy. The characteristics of the patients were: males (32, 84%); median age, 57 years; PS <2 (32, 84%). The primary sites were the oropharynx (18, 47%), oral cavity (8, 21%), hypopharynx (7, 19%), larynx (5, 13%); stage IV disease was present in 29 (76%) patients. Twenty-five (66%) patients were married, and 24 (63%) resided outside of the city. Results The compliance was very low: 21 patients (55%) performed all the programmed cycles of chemotherapy, whereas only 5 patients (13%) performed the chemo-radiotherapy at full doses without any delay. The objective responses were 3 (8%) complete and 21 (55%) complete plus partial responses. Failures were 2 (5%) stable disease and 2 (5%) progressive disease, and the response was not assessable in 10 (26%). The median duration of the response was 8 months. The median overall survival and the time to progression were 18 and 13 months, respectively; the 5-year overall and relapse-free survival were 36% and 26%, respectively. Nine (24%) patients were still alive as of August 30, 2001, 8 (21%) of them without progression. Twenty-six patients (68%) died with a local-regional relapse. One patient (3%) died for a second cancer. Grade 3–4 hematologic toxicity was leukopenia (n = 25, 66%) and thrombocytopenia (n = 9, 24%); grade 3–4 non-hematologic toxicity was diarrhea (n = 3, 8%) and mucositis (n = 2, 5%). Two patients (5%) died for intestinal infarction and perforation possibly related to treatment. Conclusions Compliance to the chemo-radiotherapy was very poor. The response rate was lower than that reported in clinical trials, whereas overall survival was comparable. The alternating chemo-radiotherapy is a very complex treatment that cannot be easily applied in clinical practice; a careful selection of patients is mandatory not only considering oncologic and medical criteria, but also the level of awareness of the patient and his family.

scholarly journals Changing functional status within 6 months posttreatment is prognostic of overall survival in patients with head and neck cancer: NRG Oncology Study

Head & Neck ◽  
2019 ◽  
Vol 41 (11) ◽  
pp. 3924-3932 ◽  
Author(s):  
Ronald C. Eldridge ◽  
Stephanie L. Pugh ◽  
Andy Trotti ◽  
Kenneth Hu ◽  
Sharon Spencer ◽  
...  
Keyword(s):  
Overall Survival ◽  
Head And Neck Cancer ◽  
Functional Status ◽  
Head And Neck ◽  
Neck Cancer

scholarly journals Serum Albumin and Future Risk of Hip, Humeral, and Wrist Fractures in Caucasian Men: New Findings from a Prospective Cohort Study

2019 ◽  
Vol 28 (5) ◽  
pp. 401-409 ◽  
Author(s):  
Setor K. Kunutsor ◽  
Ari Voutilainen ◽  
Michael R. Whitehouse ◽  
Samuel Seidu ◽  
Jussi Kauhanen ◽  
...  
Keyword(s):  
Serum Albumin ◽  
Area Under The Curve ◽  
Fracture Prevention ◽  
Albumin Concentration ◽  
Serum Albumin Concentration ◽  
Baseline Serum ◽  
Increased Risk ◽  
New Findings ◽  
Caucasian Men ◽  
Low Serum

Objective: Low serum albumin concentration is associated with poor health outcomes, but its relationship with the risk of fractures has not been reliably quantified. We aimed to assess the prospective association of serum albumin with the risk of fractures in a general population. Subjects and Methods: Baseline serum albumin concentrations were measured in 2,245 men aged 42–61 years in the Kuopio Is­chemic Heart Disease study. Hazard ratios (HRs) (95% confidence intervals) were calculated for incident fractures. Results: A total of 121 fractures (hip, humeral, or wrist) were recorded during a median follow-up of 25.6 years. The risk of fractures increased linearly below a serum albumin concentration of ∼48 g/L. The age-adjusted HR (95% CI) for fractures per 1 standard deviation lower serum albumin was 1.24 (1.05–1.48). On further adjustment for several conventional and emerging risk factors, the HR was attenuated to 1.21 (1.01–1.45). Comparing the bottom versus top quartile of serum albumin levels, the corresponding adjusted HRs were 2.48 (1.37–4.48) and 2.26 (1.23–4.14). The association of serum albumin with fracture risk did not differ substantially according to age, body mass index, blood pressure, physical activity, alcohol consumption, socioeconomic status, inflammation, prevalent diseases, and smoking. Serum albumin at a threshold of 41.5 g/L demonstrated an area under the curve of 0.5850. Conclusion: In middle-aged Caucasian men, low serum albumin is associated with an increased risk of future fractures. The potential relevance of serum albumin concentrations in fracture prevention and prediction deserves further evaluation.

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